检索结果-内蒙古大学图书馆

Mild photothermal therapy-enhanced nano-ferroptosis inducer for potent treatment of advanced prostate cancer

Nano Research 2025年第4期18卷 375-387页

作者： Xiao Hu Fei Li Xin-Hang Qian Yu-Sen Zhang Shuai Ke Yun-Xia Jin Shuai Yuan Yuan-Yuan Zhang Rui Li Lei Cao Lang Rao Xian-Tao Zeng Ling-Ling Zhang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhen 518132China Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules&College of Chemistry and Chemical EngineeringHubei UniversityWuhan 430062China Xinjiang Key Laboratory of Solid State Physics and Devices School of Physics Science and TechnologyXinjiang UniversityUrumqi 830017China

Androgen deprivation therapy(ADT)and androgen receptor signaling inhibitors(ARSis)often have limited efficacy in patients with advanced prostate cancer(PCa)(especially AR-negative).Inducing ferroptosis in PCa cells is an attractive therapeutic *** this work,mesoporous polydopamine nanoparticles(MPDA NPs)were developed to simultaneously deliver Cu^(+)/Cu^(2+)ion pairs and glutathione peroxidase 4(GPX4)inhibitor RSL3 to tumor sites for enhanced treatment of *** prepared MPDA-Cu-RSL3@HA(MPCRH)NPs induced ferroptosis by promoting lipid peroxidation and regulating phospholipid profiles in PCa cells,and the above effects were further enhanced by mild photothermal therapy(mPTT)without damaging normal *** can promote reactive oxygen species(ROS)generation and degrade tumor extracellular matrix in vivo to promote nanodrugs intratumoral *** short,this work shows the great application potential of mPTT-enhanced nano-ferroptosis inducers in the field of PCa treatment,in order to provide a reasonable paradigm for nanodrug development and PCa treatment.

关键词： prostate cancer ferroptosis mild photothermal therapy chemodynamic therapy mesoporous polydopamine

来源：评论

学校读者我要写书评

暂无评论

Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut

引用

Signal Transduction and Targeted Therapy 2025年第2期10卷 885-902页

作者： Xina Xiao Meng Hu Li Gao Huan Yuan Baochen Chong Yu Liu Rou Zhang Yanqiu Gong Dan Du Yong Zhang Hao Yang Xiaohui Liu Yan Zhang Huiyuan Zhang Heng Xu Yi Zhao Wenbo Meng Dan Xie Peng Lei Shiqian Qi Yong Peng Tao Tan Yang Yu Hongbo Hu Biao Dong Lunzhi Dai National Clinical Research Center for Geriatrics State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduChina Advanced Mass Spectrometry Center Research Core FacilityFrontiers Science Center for Disease-Related Molecular NetworkNHC Key Lab of Transplant Engineering and ImmunologyWest China HospitalSichuan UniversityChengduChina School of Life Sciences Tsinghua UniversityBeijingChina Department of Rheumatology and Immunology West China HospitalSichuan UniversityChengduChina The First School of Clinical Medicine Lanzhou UniversityLanzhouChina State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingChina Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction Ministry of EducationCenter for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third HospitalBeijingChina Frontiers Medical Center Tianfu Jincheng LaboratoryChengduChina

Oxidative stress plays a crucial role in organ aging and related diseases, yet the endogenous regulators involved remain largelyunknown. This work highlights the importance of metabolic homeostasis in protecting against oxidative stress in the large *** developing a low-input and user-friendly pipeline for the simultaneous profiling of five distinct cysteine (Cys) states, includingfree SH, total Cys oxidation (Sto), sulfenic acid (SOH), S-nitrosylation (SNO), and S-glutathionylation (SSG), we shed light on Cysredox modification stoichiometries and signaling with regional resolution in the aging gut of monkeys. Notably, the proteinsmodified by SOH and SSG were associated primarily with cell adhesion. In contrast, SNO-modified proteins were involved inimmunity. Interestingly, we observed that the Sto levels ranged from 0.97% to 99.88%, exhibiting two distinct peaks and increasingwith age. Crosstalk analysis revealed numerous age-related metabolites potentially involved in modulating oxidative stress and Cysmodifications. Notably, we elucidated the role of fumarate in alleviating intestinal oxidative stress in a dextran sulfate sodium (DSS)-induced colitis mouse model. Our findings showed that fumarate treatment promotes the recovery of several cell types, signalingpathways, and genes involved in oxidative stress regulation. Calorie restriction (CR) is a known strategy for alleviating oxidativestress. Two-month CR intervention led to the recovery of many antioxidative metabolites and reshaped the Cys redoxome. Thiswork decodes the complexities of redoxomics during the gut aging of non-human primates and identifies key metabolic regulatorsof oxidative stress and redox signaling.

关键词： metabolic homeostasis total cys oxidation cysteine modifications sulfenic acid gut aging redoxomics oxidative stress

来源：评论

学校读者我要写书评

暂无评论

Selection for Schottky Barrier Diodes with Various On-Resistance in Full-SiC Voltage Source Converters

引用

IEEE Transactions on Industry Applications 2025年

作者： Chen, Yuzhi Li, Chi Liu, Jianwei Wu, Yifan Liu, Zicheng Zheng, Zedong Tsinghua University State Key Laboratory of Power System Operation and Control Department of Electrical Engineering Beijing 100084 China Huazhong University of Science and Technology State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic Engineering Wuhan 430074 China

In Silicon Carbide based voltage source converters (VSCs), pairing Schottky barrier diodes (SBDs) presents trade-offs. While SBDs reduce the freewheeling loss and mitigate the adverse effects of bipolar conduction, their junction capacitance also contributes to increased switching loss. This paper proposes a systematic selection strategy for SBDs aimed at enhancing converter efficiency, using on-resistance as the design variable. A three-phase VSC with 1.2 kV MOSFETs and four sets of 1.2 kV SBDs is demonstrated as the case study. The static and switching characteristics for MOSFET/SBD pair are measured and analyzed over a wide temperature range. VSC efficiency is evaluated in both inverter and rectifier modes under different operating conditions. It appears that VSC using SBDs with 126% of the MOSFETs' resistance exhibits an overall superior performance. A 4 kW full-SiC VSC prototype is developed to validate the proposed selection strategy. Compared to other SBDs, using the recommended selection enhances VSC efficiency by up to 2% (± 0.5%) under light loads while maintaining high performance under medium and heavy loads. Compared to freewheeling by the body diode, using the recommended selection enhances VSC efficiency by an average of 0.4% (± 0.1%) across nearly the entire load range. © 1972-2012 IEEE.

关键词： efficiency on-resistance Schottky barrier diodes selection strategy SiC MOSFETs voltage source converter

来源：评论

学校读者我要写书评

暂无评论

Investigation on tensile modulus of lumen-bast fiber reinforced composites using multiscale simulation method

引用

Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica 2025年第5期42卷 2528-2537页

作者： Xia, Fan He, Liping Chen, Dachuan State Key Laboratory of Advanced Design and Manufacturing Technology for Vehicles Hunan University Changsha410082 China College of Mechanical and Vehicle Engineering Hunan University Changsha410082 China College of Civil Engineering Hunan University Changsha410082 China

Currently, the models for predicting the tensile modulus of bast fiber reinforced composites have not considered unique lumen microstructure of bast fibers. Therefore, in the present work, an equivalent model of lumen-bast fiber and its theoretical formula for calculating the elastic modulus were proposed in this study by combining the rule of mixture and Micro-CT technology. On this basis, a representative volume element (RVE) model of ramie fiber reinforced composite (RFPC) which considered lumen microstructures was established using multiscale simulation method, and its tensile modulus was computed. The validity of the RVE model was verified by experimental results. Additionally, the influence weights of four parameters (fiber content, fiber lumen ratio, fiber orientation, and aspect ratio) on the tensile elastic modulus of RFPC were investigated using orthogonal experimental design and variance analysis. It was found that fiber content and fiber orientation are the primary factors affecting the tensile modulus of RFPC. A polynomial fitting method was employed to obtain a predictive equation for estimating the tensile modulus of RFPC using these four parameters as independent variables. The main effects and synergistic effects of parameters on the tensile modulus of RFPC were systematically analyzed. This research provides a prediction method for estimating the tensile modulus of lumen-bast fiber reinforced composites and can be served as a theoretical basis for controlling their tensile performance. © 2025 Beijing University of Aeronautics and Astronautics (BUAA). All rights reserved.

关键词： Jute fibers

来源：评论

学校读者我要写书评

暂无评论

Quantitative insight into fracture distribution during supercritical CO2 fracturing in tight sandstone formation

引用

Petroleum Science 2025年第4期22卷 1670-1685页

作者： Yang, Bing Huang, Hai Ren, Qian-Qian Wang, Hai-Zhu Wang, Bin Ni, Jun Zheng, Yong Zhang, Wen-Tong The Key Laboratory of Well Stability and Fluid & Rock Mechanics in Oil and Gas Reservoir of Shaanxi Province Xi'an Shiyou University Shaanxi Xi'an710065 China College of Petroleum Engineering Xi'an Shiyou University Shaanxi Xi'an710065 China Shaanxi Key Laboratory of Advanced Stimulation Technology for Oil & Gas Reservoirs Xi'an Shiyou University Shaanxi Xi'an710065 China State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum Beijing102249 China Co. Ltd Shaanxi Xi'an710065 China College of New Energy Xi'an Shiyou University Shaanxi Xi'an710065 China

Supercritical CO2 (SC-CO2) fracturing stands out a promising waterless stimulation technique in the development of unconventional resources. While numerous studies have delved into the induced-fracture mechanism of SC-CO2, the small scale of rock samples and synthetic materials used in many studies have limited a comprehensive understanding of fracture propagation in unconventional formations. In this study, cubic tight sandstone samples with dimensions of 300 mm were employed to conduct SC-CO2 fracturing experiments under true-triaxial stress conditions. The spatial morphology and quantitative attributes of fracture induced by water and SC-CO2 fracturing were compared, while the impact of in-situ stress on fracture propagation was also investigated. The results indicate that the SC-CO2 fracturing takes approximately ten times longer than water fracturing. Furthermore, under identical stress condition, the breakdown pressure (BP) for SC-CO2 fracturing is nearly 25% lower than that for water fracturing. A quantitative analysis of fracture morphology reveals that water fracturing typically produces relatively simple fracture pattern, with the primary fracture distribution predominantly controlled by bedding planes. In contrast, SC-CO2 fracturing results in a more complex fracture morphology. As the differential of horizontal principal stress increases, the BP for SC-CO2 fractured rock exhibits a downward trend, and the induced fracture morphology becomes more simplified. Moreover, the presence of abnormal in-situ stress leads to a further increase in the BP for SC-CO2 fracturing, simultaneously enhancing the development of a more conductive fracture network. These findings provide critical insights into the efficiency and behavior of SC-CO2 fracturing in comparison to traditional water-based fracturing, offering valuable implication for its potential applications in unconventional reservoirs. © 2025 The Authors

关键词： Sandstone

来源：评论

学校读者我要写书评

暂无评论

MXene/Carboxylated Cellulose Nanofiber Inks for Direct Ink Writing electromagnetic Interference Shielding, Humidity Sensing, and Joule Heating

引用

ACS Applied Materials and Interfaces 2025年第21期17卷 31487-31498页

作者： Xu, Li Zhao, Sai Jiang, Peizhu Deng, Zhiming Gao, Zijie Min, Peng Liang, Fuxin Yu, Zhong-Zhen Zhang, Hao-Bin State Key Laboratory of Organic−inorganic Composites Beijing University of Chemical Technology Beijing 100029 China Department of Physics the City University of Hong Kong 83 Tat Chee Avenue Kowloon 999077 Hong Kong Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical Technology Beijing 100029 China Department of Chemical Engineering Tsinghua University Beijing 100084 China

Two-dimensional transition metal carbide/nitride (MXene)-based conductive inks are promising in the scalable production of printed electronics and wearable devices. Nevertheless, to realize desirable rheological properties of MXene-based inks and the multifunction of the resulting printed devices is still challenging. Herein, MXene inks with tunable rheological properties were developed by inducing carboxylated cellulose nanofibers (C-CNFs) modifier. The versatile rheological properties of MXene inks facilitate the preparation of MXene gratings by direct ink writing (DIW) and multifunctional devices integrated with electromagnetic interference (EMI) shielding, Joule heaters, and humidity sensors. The highest average EMI shielding effectiveness (SE) is 33.0 dB, with specific EMI SE up to 137481.5 dB cm² g^-1. Meanwhile, when functioning as a Joule heater, a low-voltage drive and excellent cyclic and long-term stability can be observed. In addition, the humidity-sensing function integrated with wireless transmission shows a maximum response value of 2768%. The MXene gratings fabricated by DIW are multifunctional and can be applied to the next generation of wearable devices. © 2025 American Chemical Society.

关键词： direct ink writing electromagnetic interference shielding humidity sensing Joule heating MXene ink

来源：评论

学校读者我要写书评

暂无评论

Enhancing IC substrate manufacturing through differential geometry and lightweight networks for etching defect detection

引用

Journal of Manufacturing Systems 2025年 80卷 902-915页

作者： Yu, Yongxing Huang, Dan Hu, Yueming School of Automation Science and Engineering South China University of Technology Guangzhou510641 China Engineering Research Center of Precision Electronic Manufacturing Equipment Ministry of Education and Guangdong Provincial Engineering Laboratory for Advanced Chip Intelligent Packaging Equipment South China University of Technology Guangzhou510641 China Department of Automation North China Electric Power University Baoding071003 China Baoding key Laboratory of State Detection and Optimization Regulation for Integrated Energy System North China Electric Power University Baoding071003 China

With the advancement of high-density interconnect technology in semiconductor manufacturing, the precision and complexity of integrated circuit (IC) substrates have significantly increased, placing higher demands on quality control. Efficient and accurate detection of complex etching defects, which often occur during manufacturing, has become critical to preventing potential product defects. A defect detection method is proposed that combines a lightweight network with differential geometry tools to address the issue of etching defects in IC substrates. First, an improved deformable model is used to rapidly extract regular circuit trace contours from complex metallographic images, and morphological processing is applied to enhance the details, achieving precise image segmentation. For under-etching defects between circuit traces, differential processing of the original and segmented images is performed to locate abnormal regions. Subsequently, an optimized lightweight network based on MobileNet, termed OMNet, is designed to achieve the rapid identification of under-etching defects in these regions. For etching defects occurring on circuit traces, the DGEtch method employs a high-precision discrete curvature calculation based on the Frenet frame to evaluate angular discontinuities in contours, enabling accurate detection of etching defects. Experimental results demonstrate that the proposed method achieves an average recall rate of over 95% and maintains a precision above 90%. It exhibits high accuracy and stability in detecting etching defects and consistently outperforms existing models, particularly in handling complex mixed defects. This study provides an effective solution for detecting complicated defects in high-density IC substrate manufacturing. © 2025 The Society of Manufacturing Engineers

关键词： Inspection

来源：评论

学校读者我要写书评

暂无评论

Synergistic effects of precursor reduction and ion migration blocking result in highly sensitive MAPbI₃ X-ray detectors with a low detection limit

引用

Journal of Materials Chemistry C 2025年第10期13卷 5317-5325页

作者： Jiang, Long Xue, Chengzhi Cheng, Jiatian Li, Nan Fan, Xinyu Yang, Yuanbo Li, Tiantian Li, Liwei Liu, Yucheng Feng, Jiangshan Liu, Shengzhong Yang, Zhou State Key Laboratory of Oil and Gas Equipment CNPC Tubular Goods Research Institute Shaanxi Xi’an 710077 China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy Devices Shaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and Engineering Shaanxi Normal University Xi'an 710119 China Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Dalian 116023 China Dalian National Laboratory for Clean Energy iChEM Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

Lead halide perovskites have emerged as promising materials for sensitive, low-dose-rate X-ray imaging. However, the dark current drift caused by ion migration poses challenges to their long-term operational stability and performance. To address this issue, we explored the synergistic effects of precursor reduction and ion migration blocking. Reducing the precursor solution decreases the defect density, enhancing the carrier lifetime and mobility-lifetime product, thus boosting X-ray sensitivity. However, this approach alone does not effectively suppress dark current drift. By incorporating an ion migration blocker, the optimized device exhibits a significantly reduced dark current drift of 3.62 × 10⁻⁴ nA cm⁻¹ s⁻¹ V⁻¹, an improved X-ray sensitivity of 1.22 × 10⁵ μC Gy_air⁻¹ cm⁻² and a low detection limit of 3.93 nGy_air s⁻¹ under a 40 kV X-ray source and 12.66 V mm⁻¹ electrical field, positioning it among the best of polycrystalline perovskite X-ray detectors. Additionally, it can capture a clear X-ray image of a metal key at an X-ray dose of 2.85 μGy_air s⁻¹, highlighting its potential for low-dose X-ray imaging applications. © 2025 The Royal Society of Chemistry.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Development of Ti–Mn alloys with low hysteresis and high capacity by introducing Cr

引用

International Journal of Hydrogen Energy 2025年 120卷 315-322页

作者： Zeng, Liang Luo, Liu He, Jian Zhu, Ding Mu, Shijia Wang, Wei Yan, Yigang Wu, Chaoling Chen, Yungui Institute of New Energy and Low-Carbon Technology Sichuan University Chengdu610041 China Engineering Research Center of Alternative Energy Materials & Devices Ministry of Education Sichuan University Chengdu610065 China State Key Laboratory of Environment-friendly Energy Materials Southwest University of Science and Technology Mianyang621010 China Department of Advanced Energy Materials College of Materials Science and Engineering Sichuan University Chengdu610065 China

Ti–Mn hydrogen storage alloys have excellent comprehensive advantages, including high reversible capacity, good cycling stability, and cost-effectiveness. However, the significant hydrogen absorption and desorption hysteresis hinders its practical applications. In this work, a systematic investigation is conducted into the effects of Cr content on the composition, structure, and hydrogen storage properties of Ti1.25Mn1.75-xCrx (x = 0, 0.05, 0.15, and 0.25) alloys, with a particular focus on the impact of Cr introduction on the hydrogen absorption and desorption hysteresis of these alloys. The experimental results indicate that the alloy exhibits the best overall hydrogen storage properties when x = 0.15, with a maximum reversible hydrogen storage capacity of 1.96 wt%. The introduction of Cr can significantly reduce hysteresis without notably altering the hydrogen absorption and desorption properties. The hysteresis factor decreases from 0.1881 (x = 0) to 0.0496 (x = 0.25). Notably, a reasonable explanation for how the introduction of Cr reduces hysteresis in Ti–Mn alloys based on the material's plastic deformation properties is given. This study provides insights for the design of Ti–Mn alloys with low hysteresis and high capacity. © 2025

关键词： Manganese alloys

来源：评论

学校读者我要写书评

暂无评论

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

引用

Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：