SDF-1/CXCR4 has been recognized as one of the most relevant chemokine signaling pathways to cancer metastasis,and siRNA targeting CXCR4 may provide potential improvements to treat those highly metastatic cancers,espec...
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SDF-1/CXCR4 has been recognized as one of the most relevant chemokine signaling pathways to cancer metastasis,and siRNA targeting CXCR4 may provide potential improvements to treat those highly metastatic cancers,especially when combined with *** the present study,we constructed riboflavin-modified lipo-polyplexes to co-deliver CXCR4 siRNA and doxorubicin for cancer *** was covalently conjugated to polyethyleneimine(PEI)with acid-cleavable hydrazine bond,and the obtained acid-sensitive conjugate was efficiently condensed with siRNA to form polyplexes,which were further coated with riboflavin-tailed lipid-membrane to prepare the lipo-polyplexes *** the fact that tumor cells overexpress riboflavin receptors,the riboflavin modification effectively enhanced uptake of lipo-polyplexes by tumor cells in a receptor-mediated *** riboflavin-modified lipo-polyplexes co-delivering CXCR4 siRNA and doxorubicin effectively decreased viability and invasiveness of tumor cells in vitro,and inhibited primary tumor growth and tumor metastasis in vivo.
Fluorescence imaging has become an indispensable technique in cancer research because it can reveal informative molecular,cellular,anatomical,and func-tional *** of advanced fluores-cent probes with superior sensitivi...
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Fluorescence imaging has become an indispensable technique in cancer research because it can reveal informative molecular,cellular,anatomical,and func-tional *** of advanced fluores-cent probes with superior sensitivity and biological selectivity for fluorescence imaging is thus *** move forward in this direction,we developed an easy self-assembly method for fabricating apta-mer-anchored rubrene-loaded organic fluorescent *** aptamer-modified organic nanop-robes integrated the best features of the organic light-emitting materials and the aptamers,thus endowing them with excellent cell-targeting capabil-ity,high stability,and good *** using this general method,a variety of biocompatible and highly bright organic fluorescent nanoprobes based on novel organic light-emitting materials with specific recognition could be easily constructed for real-time biosensing and long-term biomedical imaging.
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