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MET fusions and splicing variants convergently defne a subgroup of glioma sensitive to MET inhibitors

Holistic Integrative Oncology 2022年第1期1卷 244-254页

作者： Ke-Nan Zhang Zheng Zhao Jing Chen Zhaoshi Bao Rui-Chao Chai Zhiyan Sun Lingxiang Wu Zhiliang Wang Hanjie Liu Quanhua Mu Huimin Hu Fan Zeng Zheng Wang Guanzhang Li Yuanhao Chang Qiangwei Wang Fan Wu Ying Zhang Yuqing Liu Chunjie Jiang Ulf Dietrich Kahlert Do-Hyun Nam Wei Zhang Chunsheng Kang Jiguang Wang Rongjie Tao Qianghu Wang Tao Jiang Beijing Neurosurgical Institute Capital Medical UniversityBeijingChina Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Bioinformatics Nanjing Medical UniversityNanjingJiangsuChina Department of Chemical and Biological Engineering Divison of Life ScienceCenter for Systems Biology and Human Healthand State Key Laboratory of Molecular NeuroscienceThe Hong Kong University of Science and TechnologyHong KongChina Division of Diabe‑tes Endocrinologyand MetabolismDepartment of MedicineBaylor College of MedicineHoustonTXUSA Molecular and Experimental Surgery Faculty of Medicine and University Medicine MagdeburgMagdeburgGermany Institute for Refractory Cancer Research Samsung Medical CenterSeoulRepublic of Korea Department of Health Science&Technology Samsung Advanced Institute for Health Sciences&Technology(SAIHST)Sungkyunkwan UniversitySeoulRepublic of Korea Department of Neurosurgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Laboratory of Neuro‑Oncology Ministry of Education and Tianjin CityTianjin Neurological InstituteTianjin Medical University General HospitalKey Laboratory of PostNeuro Injury Neuro-Repair and Regeneration in Central Nervous SystemTianjinChina Departments of Neurosurgery Shandong Cancer Hospital and InstituteShandong UniversityJinanShandongChina Center of Brain Tumor Beijing Institute for Brain DisordersBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Research Unit of Accurate Diagnosis Treatmentand Translational Medicine of Brain TumorsChinese Academy of Medical SciencesBeijingChina

Purpose:Our previous study has shown that PTPRZ1-MET(ZM)fusion is a viable target for MET inhibitors in ***,the diversity and prevalence of somatic MET alterations in difuse gliomas are still elusive and need to be extensively characterized for identifying novel therapeutic ***:Totally,1,350 glioma patients and 31 patient-derived cells were collected from the Chinese Glioma Genome Atlas(CGGA)and published *** kinds of MET fusions and/or splicing variants(MET F/SVs)were identifed by bioinformatical ***-cell RNA sequencing(scRNA-seq)were used for *** vitro experiments of drug resistance were conducted for the possibility of MET-targeted ***:MET F/SVs but not genomic amplifcation,were highly enriched in the secondary glioblastomas(sGBM)and marked worse *** molecular and scRNA-seq analysis revealed that MET F/SVs were induced in the course of glioma evolution and highly associated with MET *** in vitro and the clinical study showed that cells and patients harboring MET F/SVs have better response to MET ***:Our fndings expanded the percentage of gliomas with abnormal MET alterations and suggested that a subgroup of gliomas harboring MET F/SVs may beneft from MET-targeted therapy.

关键词： MET variation Secondary glioblastoma Biomarker MET inhibitor Precision neuro-oncology

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Comprehensive Theoretical Quantification of Secondary Electron Emission from Silicon

SSRN

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SSRN 2023年

作者： Khan, Muhammad Saadat Shakoor Mao, Shifeng Zou, Yanbo Lu, Dabao Da, Bo Li, Yonggang Ding, Zejun Department of Physics University of Science and Technology of China Anhui Hefei230026 China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Anhui Hefei230026 China Department of Nuclear Science and Engineering University of Science and Technology of China Anhui Hefei230026 China School of Physics and Electronic Engineering Xinjiang Normal University Xinjiang Urumchi830054 China Microscope Science and Technology Limited Anhui Hefei230093 China Research and Services Division of Materials Data and Integrated System National Institute for Materials Science 1-1 Namiki Ibaraki Tsukuba305-0044 Japan Research Center for Advanced Measurement and Characterization National Institute for Materials Science 1-2-1 Sengen Ibaraki Tsukuba305-0047 Japan Key Laboratory of Materials Physics Insititute of Solid State Physics Chinese Academy of Sciences Anhui Hefei230031 China

Though intensive experimental studies have been carried out on electron emission properties in past decades, the reliable data from accurate experimental measurements for clean and smooth surfaces are still quite limited. In this work, we have performed a comprehensive Monte Carlo simulation of electron emission yields, the secondary electron yield (SEY,δ), backscattered electron coefficient (BSC,η) and total electron yield (TEY,σ=δ+η), from silicon and the uncertainty quantification of the theoretical calculation results for the first time. The considered uncertainty factors in the physical modelling include work function data, optical energy loss function data, dielectric function models for electron inelastic scattering and the scattering potentials for electron elastic scattering. The calculation results show that δ is significantly influenced by the work function while the dielectric function model has a slight effect. Elastic scattering potential and energy loss function affects both δ and η. Our simulatedσ η data agree with most of the experimental measurements while the simulated mean σ data are well below most of the experimental data. The experimental σ data measured by Goto lie within the uncertainty range of our simulation results. This work has provided sufficient ground for the necessity of building a theoretical database of electron emission yield. © 2023, The Authors. All rights reserved.

关键词： Silicon

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Facile Hydrogen-Bonding Assisted Crystallization Modulation for Large-area High-quality CsPbI2Br Films and Efficient Solar Cells

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Angewandte Chemie 2024年第10期136卷

作者： Ming-Hua Li Xueyuan Gong Shuo Wang Liang Li Jiaju Fu Jinpeng Wu Prof. Zhan'ao Tan Prof. Jin-Song Hu College of Chemical Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 China Beijing National Laboratory for Molecular Sciences (BNLMS) Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources School of New Energy North China Electric Power University Beijing 102206 China School of Chemical Sciences University of Chinese Academy of Sciences Beijing 100049 China

The thermally stable inorganic cesium-based perovskites promise efficient and stable photovoltaics. Unfortunately, the strong ionic bonds lead to uncontrollable rapid crystallization, making it difficult in fabricating large-area black-phase film for photovoltaics. Herein, we developed a facile hydrogen-bonding assisted strategy for modulating the crystallization of CsPbI 2 Br to achieve uniform large-area phase-pure films with much-reduced defects. The simple addition of methylamine acetate in precursors not only promotes the formation of intermediate phase via hydrogen bonding to circumvent the direct crystallization of CsPbI 2 Br from ionic precursors but also widens the film processing window, thus enabling to fabricate large-area high-quality phase-pure CsPbI 2 Br film under benign conditions. Combining with stable dopant-free poly(3-hexylthiophene), the CsPbI 2 Br solar cells achieve the record-high efficiencies of 18.14 % and 16.46 % for 0.1 cm 2 and 1 cm 2 active area, respectively. The obtained high efficiency of 38.24 % under 1000 lux illumination suggests its potential in indoor photovoltaics for powering the Internet of Things, etc.

关键词： inorganic perovskite solar cell hydrogen bonding crystallization regulation large area

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Optically Active Nanostructured ZnO Films

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Angewandte Chemie 2015年第50期127卷

作者： Yingying Duan Lu Han Jialiang Zhang Shunsuke Asahina Zhehao Huang Lin Shi Bo Wang Yuanyuan Cao Yuan Yao Liguo Ma Cui Wang Rina K. Dukor Lu Sun Chun Jiang Zhiyong Tang Laurence A. Nafie Shunai Che School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 (P.R. China) http://*** SMBU JEOL Akishima Tokyo 196‐8558 (Japan) Key Laboratory of Nanosystem and Hierarchical Fabrication Chinese Academy of Sciences National Center for Nanoscience and Technology No.11 Beiyitiao Zhongguancun Beijing 100190 (P. R. China) BioTools Inc. 17546 Bee Line Hwy Jupiter FL 33458 (USA) School of Electronic Information and Electrical Engineering State Key Laboratory of Advanced Optical Communication System and Network Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 (P.R. China) Department of Chemistry Syracuse University Syracuse NY 13244 (USA)

Inorganic nanomaterials endowed with hierarchical chirality could open new horizons in physical theory and applications because of their fascinating properties. Here, we report chiral ZnO films coated on quartz substrates with a hierarchical nanostructure ranging from atomic to micrometer scale. Three levels of hierarchical chirality exist in the ZnO films: helical ZnO crystalline structures that form primary helically coiled nanoplates, secondary helical stacking of these nanoplates, and tertiary nanoscale circinate aggregates formed by several stacked nanoplates. These films exhibited optical activity (OA) at 380 nm and in the range of 200–800 nm and created circularly polarized luminescence centered at 510 nm and Raman OA at 50–1400 cm −1 , which was attributed to electronic transitions, scattering, photoluminescent emission, and Raman scattering in a dissymmetric electric field. The unprecedented strong OA could be attributed to multiple light scattering and absorption‐enhanced light harvesting in the hierarchical structures.

关键词： Anorganische Filme Chiralität Lumineszenz Raman‐optische Aktivität Zirkulardichroismus

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Meet the challenges in the “Carbon Age”

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Carbon Research 2022年第1期1卷 1-2页

作者： Wu, Fengchang Li, Fangbai Zhao, Xiaoli Bolan, Nanthi S. Fu, Pingqing Lam, Su Shiung Mašek, Ondřej Ong, Hwai Chyuan Pan, Bo Qiu, Xueqing Rinklebe, Jörg Tsang, Daniel C. W. Van Zwieten, Lukas Vithanage, Meththika Wang, Shaobin Xing, Baoshan Zhang, Gan Wang, Hailong State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing China Institute of Eco-environmental and Soil Sciences Guangdong Academy of Sciences Guangzhou China School of Agriculture and Environment The University of Western Australia Perth Australia Institute of Surface-Earth System Science School of Earth System Science Tianjin University Tianjin China Higher Institution Centre of Excellence (HICoE) Institute of Tropical Aquaculture and Fisheries (AKUATROP) Universiti Malaysia Terengganu Kuala Nerus Malaysia School of GeoSciences University of Edinburgh Edinburgh UK School of Information Systems and Modelling University of Technology Sydney Sydney Australia Faculty of Environmental Science & Engineering Kunming University of Science & Technology Kunming China School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou China School of Architecture and Civil Engineering University of Wuppertal Wuppertal Germany Department of Civil and Environmental Engineering The Hong Kong Polytechnic University Kowloon Hong Kong China New South Wales Department of Primary Industries Wollongbar Australia Ecosphere Resilience Research Center University of Sri Jayewardenepura Nugegoda Sri Lanka School of Chemical Engineering and Advanced Materials University of Adelaide Adelaide Australia Stockbridge School of Agriculture University of Massachusetts Amherst USA Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou China School of Environmental and Chemical Engineering Foshan University Foshan China

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Nanofabrication: Programmable Bidirectional Folding of Metallic Thin Films for 3D Chiral Optical Antennas (Adv. Mater. 19/2017)

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advanced Materials 2017年第19期29卷

作者： Yifei Mao Yun Zheng Can Li Lin Guo Yini Pan Rui Zhu Jun Xu Weihua Zhang Wengang Wu National Key Laboratory of Science and Technology on Micro/Nano Fabrication Institute of Microelectronics Peking University Beijing 100871 P. R. China College of Engineering and Applied Sciences National Laboratory of Solid State Microstructures and Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing Jiangsu 210093 P. R. China Key Laboratory of Broadband Wireless Communication and Sensor Network Technology of Ministry of Education College of Internet of Things Nanjing University of Posts and Telecommunications Nanjing Jiangsu 210096 P. R. China Electron Microscopy Laboratory Peking University Beijing 100871 P. R. China Innovation Center for MicroNanoelectronics and Integrated System Beijing 100871 P. R. China

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A Stretchable and Tough Graphene Film Enabled by Mechanical Bond

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Angewandte Chemie 2024年第28期136卷

作者： Dr. Chunyu Wang Boyue Gao Fuyi Fang Wenhao Qi Dr. Ge Yan Dr. Jun Zhao Wenbin Wang Dr. Ruixue Bai Prof. Zhaoming Zhang Prof. Zhitao Zhang Prof. Wenming Zhang Prof. Xuzhou Yan School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong University Shanghai 200240 P. R. China School of Chemistry and Chemical Engineering Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University Shanghai 201203 P. R. China State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University Shanghai 200240 P. R. China

The pursuit of fabricating high-performance graphene films has aroused considerable attention due to their potential for practical applications. However, developing both stretchable and tough graphene films remains a formidable challenge. To address this issue, we herein introduce mechanical bond to comprehensively improve the mechanical properties of graphene films, utilizing [2]rotaxane as the bridging unit. Under external force, the [2]rotaxane cross-link undergoes intramolecular motion, releasing hidden chain and increasing the interlayer slip distance between graphene nanosheets. Compared with graphene films without [2]rotaxane cross-linking, the presence of mechanical bond not only boosted the strength of graphene films (247.3 vs 74.8 MPa) but also markedly promoted the tensile strain (23.6 vs 10.2 %) and toughness (23.9 vs 4.0 MJ/m 3 ). Notably, the achieved tensile strain sets a record high and the toughness surpasses most reported results, rendering the graphene films suitable for applications as flexible electrodes. Even when the films were stretched within a 20 % strain and repeatedly bent vertically, the light-emitting diodes maintained an on-state with little changes in brightness. Additionally, the film electrodes effectively actuated mechanical joints, enabling uninterrupted grasping movements. Therefore, the study holds promise for expanding the application of graphene films and simultaneously inspiring the development of other high-performance two-dimensional films.

关键词： Graphene Film Mechanical Bond Hidden Chains Strengthening and Toughening Intramolecular Motion

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High-density implantable neural electrodes and chips for massive neural recordings

Brain‐X

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Brain‐X 2024年第2期2卷

作者： Longchun Wang Yanxing Suo Jiahao Wang Xuanqi Wang Kai Xue Jingjing An Xun Sun Qinyu Chen Xiaochen Tang Yang Zhao Bowen Ji Jingquan Liu Department of Micro/Nano Electronics Shanghai Jiao Tong University Shanghai China National Key Laboratory of Advanced Micro and Nano Manufacture Technology Shanghai Jiao Tong University Shanghai China DCI Joint Team Collaborative Innovation Center of IFSA Shanghai Jiao Tong University Shanghai China Unmanned System Research Institute Northwestern Polytechnical University Xi'an Shaanxi China National Key Laboratory of Unmanned Aerial Vehicle Technology Xi'an Shaanxi China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical Engineering Northwestern Polytechnical University Xi'an Shaanxi China Institute of Guizhou Aerospace Measuring and Testing Technology Guiyang Guizhou China Leiden Institute of Advanced Computer Science (LIACS) Leiden University Leiden The Netherlands Klipsch School of Electrical and Computer Engineering New Mexico State University Las Cruces New Mexico USA Yang Zhao Bowen Ji and Jingquan Liu.

High-density neural recordings with superior spatiotemporal resolution powerfully unveil cellular-scale neural communication, showing great promise in neural science, translational medicine, and clinical applications. To achieve such, many design and fabrication innovations enhanced the electrode, chip, or both for biocompatibility improvement, electrical performance upgrade, and size miniaturization, offering several thousands of recording sites. However, an enormous gap exists along the trajectory toward billions of recording sites for brain scale resolution, posing many more design challenges. This review tries to find possible insight into mitigating the gap by discussing the latest progress in high-density electrodes and chips for neural recordings. It emphasizes the design, fabrication, bonding techniques, and in vivo performance optimization of high-density electrodes. It discusses the promising opportunities for circuit-level and architecture-level multi-channel chip design innovations. We expect that joint effort and close collaboration between high-density electrodes and chips will pave the way to high-resolution neural recording tools supporting cutting-edge neuroscience discoveries and applications.

关键词： brain-computer interface massive neural recording high density implantable electrodes implantable chips

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Research on Output Scenarios of Offshore Wind Power Considering Characteristics of Marine Weather

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Journal of Physics: Conference Series 2021年第1期1993卷

作者： Honglin Chen Xing Chen Hao Yu Suhua Lou Yong Lin Liang Xu Power System Planning Research Center of Guangdong Power Grid Co. Ltd. Guangzhou 510080 Guangdong Province China State Key Laboratory of Advanced Electromagnetic Engineering and Technology Huazhong University of Science and Technology Wuhan 430074 Hubei Province China China-EU Institute for Clean and Renewable Energy Huazhong University of Science and Technology Wuhan 430074 Hubei Province China Guangdong Power Grid Co. Ltd. Guangzhou 510080 Guangdong Province China

Accurate modeling of stochastic wind power output is one of the key links in the optimal operation of power systems with large-scale wind power. According to the output characteristics of offshore wind farms, a data-driven method that models offshore wind power output scenarios is proposed in this paper. This method takes full account of the marine climate characteristics to study the offshore wind farm output data seasonally and identifies the main climatic elements affecting the output of offshore wind farms through correlation analysis. Meanwhile, the evaluation index of output characteristics is established. In order to reflect the influence of marine climate on the output of offshore wind farms, the climatic factors are used as an indicator to distinguish different weather. Accordingly, the output scenarios of offshore wind farms in extreme and non-extreme weather are determined, and the corresponding probability calculation method is proposed.

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Resistance-Switchable Graphene Oxide–Polymer Nanocomposites for Molecular Electronics

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ChemElectroChem 2014年第3期1卷 478-478页

作者： Prof. Dr. Gang Liu Prof. Dr. Yu Chen Prof. Dr. Run-Wei Li Dr. Bin Zhang Prof. Dr. En-Tang Kang Cheng Wang Dr. Xiaodong Zhuang Key Lay for Advanced Materials Institute of Applied Chemistry East China University of Science and Technology Shanghai 200237(PR China) CAS Key Lab of Magnetic Materials and Devices Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201(PR China) The State Key Laboratory of ASIC & System Fudan University 220 Handan Road Shanghai 200433 (PR China) Yu Chen Key Lay for Advanced Materials Institute of Applied Chemistry East China University of Science and Technology Shanghai 200237(PR China) Run-Wei Li CAS Key Lab of Magnetic Materials and Devices Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201(PR China) En-Tang Kang Department of Chemical and Biomolecular Engineering National University of Singapore Kent Ridge 119260 (Singapore) Department of Chemical and Biomolecular Engineering National University of Singapore Kent Ridge 119260 (Singapore)

The front cover artwork is provided by Prof. Dr. Yu Chen and his co-workers. The image represents how deliberately designed, solution-processable, and electroactive polymer-functionalized graphene-oxide nanosheets can be reversibly switched ON and OFF for the development of next-generation nonvolatile information-storage applications. Read the full text of the article at 10.1002/celc.201300158 .

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