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Fucoidan-modified PLGA nanoparticles for integrated diagnosis and treatment of thrombosis

Journal of Drug Delivery Science and technology 2025年 109卷

作者： Ma, Wentao Gong, Shiwen He, Xianbiao Hu, Die Cheng, Bo Yang, Jing Li, Binbin Wang, Xinyu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 China Sanya Science and Education Innovation Park Wuhan University of Technology Sanya 572000 China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen Valley Foshan 528200 China Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology Wuhan 430070 China School of Foreign Languages Wuhan University of Technology Wuhan 430070 China Department of Stomatology Zhongnan Hospital of Wuhan University Wuhan 430060 China

Thrombosis is a critical marker of cardiovascular diseases such as stroke and myocardial infarction. Timely diagnosis and dissolution of thrombi can significantly reduce patient mortality risk. Theranostic nanoparticles with targeting capabilities offer a promising solution to this issue. We developed fucoidan-modified PLGA nanoparticles loaded with indocyanine green (ICG) and lumbrokinase (LK) (FCP-ICG@LK NPs) to achieve integrated diagnosis and treatment of thrombotic diseases while minimizing hemorrhagic risks. Targeting experiments demonstrated the affinity of fucoidan for P-selectin. In a mouse model of carotid thrombosis, FCP-ICG@LK NPs demonstrated excellent diagnostic and monitoring capabilities while effectively dissolving thrombi under near-infrared light. Compared with free LK, FCP-ICG@LK NPs showed better thrombolysis effects at the same dose. Furthermore, bleeding risk assessment experiments indicated that FCP-ICG@LK NPs do not induce hemorrhagic risks. FCP-ICG@LK NPs showed no significant cytotoxicity or hemolysis. These results indicate that fucoidan-modified PLGA drug-loaded nanoparticles are a promising thrombus-targeted theranostic agent. © 2025 Elsevier B.V.

关键词： Fucoidan Lumbrokinase Theranostic Thrombolysis Thrombus targeting

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Influence of pore size optimization in catalyst layer on the mechanism of oxygen transport resistance in PEMFCs

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Progress in Natural Science:materials International 2020年第6期30卷 839-845页

作者： Shumeng Guan Fen Zhou Jinting Tan Mu Pan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Hubei Provincial Key Laboratory of Fuel Cells Wuhan University of Technology

In PEMFC, the oxygen transport resistance severely hinders the cell from achieving high performance. In this paper, pore-forming agent was used to optimize the pore size distribution of the catalyst layer(CL), and to study its effect on the mechanism of oxygen transport resistance, including molecular diffusion resistance, Knudsen diffusion resistance, and local O2resistance in CL. The results showed that with the pore formation the cell performance had a significant improvement at high current density, mainly due to its better oxygen transport properties, especially under low platinum conditions. The addition of pore-forming agent moved the pore diameter toward a larger pore diameter with a range from 70 to 100 nm, and also obtaining a higher cumulative pore volume. It was found that the increase of the cumulative pore volume and larger pore size were conducive to the diffusion of oxygen molecules in CL, and the resistance caused by which was the dominant part in total transport resistance. Further tests indicated that the improvement of molecular diffusion resistance was much larger than that of Knudsen diffusion resistance in the catalyst layer after pore formed. In addition, the optimized pore structure will also get a higher number of effective pores, which resulted in an increased effective area of the ionomer on the Pt surface. The higher effective area of the ionomer was particularly beneficial for the reduction of local O2resistance with low Pt loading.

关键词： Pore size optimization Pore-forming agent Oxygen transport resistance PEMFC

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In situ polysaccharide-based double-network hydrogels as a sustained kartogenin delivery system for cartilage tissue engineering

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Reactive and Functional Polymers 2025年 214卷

作者： Fan, Yaohui Yan, Junyi Zhao, Xinxin Wang, Wenyuan Gao, Chihao Lin, Xiaoli Wang, Yu Cheng, Bo Yang, Jing Li, Binbin Wang, Xinyu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan430070 China Hainan Institute Wuhan University of Technology Sanya572000 China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen Valley Foshan528200 China Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology Wuhan430070 China School of Foreign Languages Wuhan University of Technology Wuhan430070 China Department of Stomatology Zhongnan Hospital of Wuhan University Wuhan430060 China

In situ forming biodegradable hydrogel scaffolds are crucial in tissue engineering and drug delivery systems, with extensive applications in articular cartilage (AC) repair. Polysaccharide-based hydrogels are ideal materials for cartilage tissue engineering owning to their biochemical and structural resemblance to the native extracellular matrix (ECM). In this study, a double-network (DN) hydrogel was fabricated through Schiff base reaction and photocrosslinking, utilizing glycidyl methacrylate-modified chitosan (GCS) and aldehyde-modified hyaluronic acid methacrylate (AHM) as precursors. To prepare the drug-loaded hydrogel, we grafted the bioactive factor kartogenin (KGN) onto GCS, generating KGN-conjugated GCS (KGCS), which subsequently formed a crosslinked network with AHM. In contrast to conventional hydrogels encapsulating either drug alone or drug-loaded microspheres, the proposed hydrogel demonstrated a more stable and sustained release profile. Furthermore, the physicochemical properties of both hydrogels were systematically characterized, comprising morphology, mechanical properties and swelling rate. The biocompatibility of hydrogels was comprehensively investigated through in vitro cell proliferation assays, hemocompatibility analysis, and in vivo evaluation of subcutaneous implant. Subsequently, a cartilage defect model was utilized to assess their efficacy in cartilage regeneration. In summary, the two DN hydrogels exhibited suitable porous structure, mechanical properties, and swelling rates. Furthermore, they demonstrated excellent biocompatibility and significantly promoted cartilage defect regeneration. © 2024

关键词： Tissue regeneration

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Photo-responsive Carboxymethyl Chitosan/Laponite Hydrogel as a Potential Spinal Cord Injury Scaffold:Characterization and Cytocompatibility Study

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Journal of Wuhan University of technology(materials Science) 2024年第6期39卷 1628-1636页

作者： Jayanti Parajuli LI Yongtao CHANG Likun YE Liyuan HAN Yingchao YIN Yixia State Key Laboratory of Advanced Technology for Material Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of TechnologyWuhan 430070China

We synthesized photo-responsive carboxymethyl chitosan(CMC-MA)via free radical polymerization and utilized nanoclay laponite(LAP)as an inorganic crosslinking agent to develop an injectable and 3D-printable CMC-MA/LAP *** determined the optimal ratio of 2.5 w/v%CMC-MA/7.5 w/v%LAP based on injection molding,compression modulus,swelling properties,rheological properties,and 3D printing properties of the hydrogel ***-vitro cytocompatibility experiments showed that both CMC-MA and CMC-MA/LAP hydrogel had no inhibitory effect on cell proliferation and can promote cell growth when cultured on the surface of the hydrogel ***,the hydrogel containing LAP particles significantly facilitated cell adhesion(>60%)compared with the hydrogel without LAP(20%).Our findings demonstrate that the CMC-MA/LAP hydrogel has great potential for tissue repair in neural tissue engineering.

关键词： neural injectable hydrogels spinal cord injury CMC-MA/LAP hydrogel cytocompatibility

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Cr-doped Na_(3)V_(2)(PO_(4))_(3)@C enables high-capacity with V^(2+)/V^(5+)reaction and stable sodium storage

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Journal of materials Science & technology 2023年第34期165卷 1-7页

作者： Bo Mai Boyu Xing Yunfan Yue Nianyao Cai Congcong Cai Sitian Lian Hao Fan Mengyu Yan Ting Zhu Ping Hu Xuewen Wang Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong LaboratoryFoshan 528216China

Due to its abundant sodium content and low cost,sodium-ion battery(SIB)has become an effective substitute and supplement for lithium-ion batteries,which has a broad development prospect in largescale energy storage ***-super-ionic conductor(NASICON)structural materials have stable 3D skeleton structures and open Na+transport channels,which is a very promising SIB cathode *** in the typical NASICON material Na_(3)V_(2)(PO_(4))_(3)(NVP),the number of electrons involved in NVP per formula unit is less than 2 at the stable voltage window,which limits the further improvement of battery *** this work,we report another NASICON structured Na_(3)V_(4/3)Cr_(2/3)(PO_(4))_(3)@C(NVCP@C),which is obtained by Cr-doped NVP through spray *** taking full advantage of the voltage platforms of V^(5+/4+),V^(4+/3+),and V^(3+/2+)in the window of 1.5-4.4 V,NVCP@C delivered a high discharge capacity(175 mAh g^(-1))and durable cyclability(86%capacity retention for 2000 cycles).In-situ X-ray diffraction results demonstrate that the reversible structural evolution accompanies by solid-solution reaction and two-phase reaction mechanisms co-exist during charge/discharge *** coupled with Na^(+)preembedded hard carbon(HC),the assembled NVCP@C//HC full cell delivers a high capacity(105 mAh g^(-1))and long cycling performance(70%after 1000 cycles).This Cr-doped NVP method offers new insights into the design of high-energy NASICON-structured cathode materials.

关键词： Sodium-ion batteries NASICON Na_(3)V_(4/3)Cr_(2/3)(PO_(4))_(3)@C Spray drying V^(2+)/V^(5+)reaction

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synthesis of high-purity Ti_2AlN ceramic by hot pressing

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中国有色金属学会会刊：英文版 2008年第1期18卷 82-85页

作者：严明陈艳林梅炳初朱教群 College of Chemistry and Environmental Engineering Hubei University of Technology State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

High-purity Ti2AlN ceramic was prepared at 1300 ℃ by hot pressing(HP)of Ti/Al/TiN powders in stoichiometric *** sintered product was characterized using X-ray diffraction(XRD)and MDI Jade 5.0 software(materials Data Inc,Liverpool,CA).Scanning electron microscopy(SEM)and electron probe micro-analysis(EPMA)coupled with energy-dispersive spectroscopy(EDS)were utilized to investigate the morphology *** results show that Ti2AlN phase is well-developed with a close and lamellar *** grains are plate-like with the size of 3-5 μm,thickness of 8-10 μm and elongated *** density of Ti2AlN is measured to be 4.22 g/cm3,which reaches 97.9% of its theory *** distribution of Ti2AlN grains is homogeneous.

关键词： Ti2AlN 合成方法热压制烧结方法

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Preparation, Characterization and Dielectric Properties of Sr_5RTi_3Ta_7O_(30) (R=Pr and Eu) Ferroelectric Ceramics

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Journal of Wuhan University of technology(materials Science) 2010年第2期25卷 291-294页

作者：胡长征方亮 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Key Laboratory of Nonferrous Materials and New Processing Technology Ministry of Education Guilin University of Technology

Polycrystalline samples of Sr5PrTi3Ta7O30 （SPTT） and Sr5EuTi3Ta7O30 （SETT） compounds were prepared by high-temperature solid-state reaction method and their formation, structure and dielectric properties were studied. They are found to be ferroelectric phase of filled tetragonal tungsten bronze （TB） structure at room temperature and undergoes diffuse type of ferroelectric-paraelectric phase transition around 34 ℃ and 31 ℃, respectively. At 1 MHz SPTT exhibits high dielectric constants of 177 and low dielectric losses of 3.5×10^-4 and SETT has high dielectric constants of 125 and low dielectric losses of 2.4×10^-3.

关键词： dielectrics ceramic ferroelectric tungsten-bronze

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Li3N film modified separator with homogenization effect of lithium ions for stable lithium metal battery

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Progress in Natural Science:materials International 2021年第6期31卷 845-851页

作者： Zhongyun Yan Cheng Zhou Cheng Li Yan Li Chunli Shen Kaijian Yan Xu Xu International School of Materials Science and Engineering State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

Lithium metal anode with high theoretical capacity is considered to be one of the most potential anode materials of the next generation. However, the growth of lithium dendrite seriously affects the application of lithium metal anode and the development of lithium metal batteries（LMBs）. Herein, an ultrathin Li3N film modified separator to homogenize the lithium ions and protect the lithium metal anode was reported. Due to the intrinsic properties of Li3N, the functional separator possessed good thermal stability, mechanical properties and electrolyte wettability, and the homogenization of the lithium ion was realized without increasing the interface impedance. With this functional separator, the Li/Li symmetrical cell could achieve a long cycle with low overpotential for 1000 h at a current density of 1 m A cm-2. Furthermore, when the full battery was assembled with Li FePO4and the discharge capacity could be maintained at 151 m Ah g-1after 400 cycles at 1 C. In addition, the full battery also showed good rate performance, and provided a high discharge capacity of 114 m Ah g-1at 5 C.

关键词： Functional separator Solid electrolyte interface Physical vapor deposition Li metal anode

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Improving Cyclic Stability and Rate Performance of Lithium Ion Batteries Using La^(3+)Modified LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)Cathode materials

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Journal of Wuhan University of technology(materials Science) 2023年第4期38卷 735-742页

作者：杜玉喆 RUAN Zhefei ZHANG Ruiming 张海宁 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan528200China

La_(4)NiLiO_(8)-coated NCM622 samples were prepared through a sol-gel method,and the electrochemical performance as cathode materials was *** is revealed that part of the introduced La^(3+)ions produce a coating layer on the surface of NCM622 particles,while the rest occupy the 3b position of the *** optimized sample exhibits a capacity retention of 96.54%after 100 cycles under 1C rate with a discharge specific capacity of 117.54 mAh·g^(-1)under 5C rate,much higher than those of the unmodified *** results show that the addition of La^(3+)ion can greatly improve the cyclic stability and the rate performance of NCM622.

关键词： lithium ion batter La^(3+)doping NCM622 cycling stability rate performance

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synthesis of Cr_2AlC from Elemental Powders with Modified Pressureless Spark Plasma Sintering

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Journal of Wuhan University of technology(materials Science) 2019年第2期34卷 287-292页

作者：葛梦妮 WANG Xiaofan LI Gaiye LU Chen 张建峰 TU Rong College of Mechanics and Materials Hohai University State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

We introduced a modified pressureless sintering strategy by SPS with a new T-shape die and tapered punches, which helps the evaporation of melted Al and reduces the sample sticking with the inner wall of the die. Thus, the die breaking risk in the sintering process or the de-molding process is avoided at all. At a low temperature and short holding time, a high purity of Cr_2 AlC was obtained in this SPS process from the optimization of different molar ratios of raw materials. Simultaneously, the high porosity of the as-obtained sample was also a distinguishing feature worth noticing. The reaction mechanism for this process was also discussed in detail. This study presented a new venue for future development of high purity "MAX" materials and others related materials by a modified pressureless sintering strategy.

关键词： pressureless spark plasma sintering Cr2AlC reaction mechanism

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