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Degradable PRGD/PDLLA/β-TCP/NGF composites promote differentiation and regulate gene expression in rat pheochromocytoma cells

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Chinese Science Bulletin 2013年第24期58卷 2979-2983页

作者： QIU Tong YU Chang YAN QiongJiao LI ShiPu Biomedical Materials and Engineering Center Wuhan University of Technology State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

In this study, we synthesized degradable PRGD/PDLLA/β-TCP/NGF composites to facilitate neuronal repair. To this end, we (1) examined the release of nerve growth factor (NGF) from the composites, (2) evaluated the differentiation status of the cells and (3) address how transcriptional activity may regulate the differentiation mechanism of these cells. NGF content was determined using enzyme-linked immunosorbent assay, while the cellular mRNA expression was examined by real-time PCR analysis. Our results indicated that NGF release was robust during the first 10 days and then stabilized at a lower level thereafter. Treatment of PC12 cells with the extract of the NGF-embedded composites induced the formation of neurites and, in some cases, net-like neurites. Analysis of the expression level of differentiation-related genes, such as TrkA, VGF, Rab1, GAP43 and β-tubulin Ⅱ, were significantly up-regulated. These findings suggest that these composites might be a suitable delivery system for growth factors like NGF that can be used to facilitate neuronal repair after injury.

关键词：细胞分化复合材料 PDLLA 基因表达合成降解嗜铬细胞瘤神经生长因子神经元损伤

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Pvdf/Carbon Directional Microchannels-Enhanced Ion Diode-Like Hydrogel-Based Pressure Sensors

SSRN

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SSRN 2025年

作者： Wen, Xuezhong Zhang, Hongjian Eom, Taeuk Jeong, Chang Kyu Zhang, Yong State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and Engineering Wuhan University of Technology Wuhan430070 China Center for Smart Materials and Device Integration Wuhan University of Technology Wuhan430070 China Department of JBNU-KIST Industry-Academia Convergence Research Jeonbuk National University Jeonbuk Jeonju54896 Korea Republic of Division of Advanced Materials Engineering Jeonbuk National University Jeonbuk Jeonju54896 Korea Republic of Department of Energy Storage/Conversion Engineering of Graduate School Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonbuk Jeonju54896 Korea Republic of

Hydrogels are promising candidates for flexible electronics but are often constrained by narrow pressure-sensing ranges and unstable ion migration. To overcome these limitations, we developed an ionic hydrogel sensor incorporating diode-inspired bipolar architectures (PSSNa/PDACl) and poly(vinylidene fluoride)/carbon directional microchannels (PCDMC). The optimized 5-PCNPC hydrogel exhibits a broad pressure-sensing range (2.3–100 kPa) with a sensitivity of 0.360 mV·kPa−1 (a 35.6% enhancement) and a rectification ratio of 12.9, enabled by PCDMC-guided anisotropic ion transport and rapid stress dissipation (337 ms recovery). With excellent durability over 500 cycles and a power density of 1.17 mW·m−2, the hydrogel sensor demonstrates its potential in practical applications, including a 5×5 touchpad for spatial pressure mapping and real-time monitoring of respiration, swallowing, and locomotion. This study underscores the potential of hydrogel-based sensors with wide-range operability for next-generation wearables and interactive systems. © 2025, The Authors. All rights reserved.

关键词： Flexible electronics

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Acidic oxygen evolution reaction:Mechanism,catalyst classification,and enhancement strategies

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Interdisciplinary materials 2023年第1期2卷 53-90页

作者： Qianli Ma Shichun Mu Fuel cell Materials Laboratory Foshan Xianhu LaboratoryFoshanChina State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhanChina

As the most desirable hydrogen production device,the highly efficient acidic proton exchange membrane water electrolyzers(PEMWE)are severely limited by the sluggish kinetics of oxygen evolution reaction(OER)at the *** IrO2 is a commercial acid-stable OER catalyst with poor activity and high cost,which has motivated the development of ***,hitherto most of the designed acidic OER catalysts have disadvantages of low activity or stability,which cannot meet the requirement of industrial ***,exploring suitable strategies to enhance the activity and stability of cost-effective acidic OER catalysts is crucial for developing the PEMWE *** this review,the main OER mechanisms,different types of catalysts,and their activity and stability characteristics are summarized and discussed,and then possible strategies to improve activity and stability are ***,the problems and prospects of such catalysts are generalized to shed some light on the future research of advanced catalysts for acidic OER.

关键词： catalyst hydrogen energy oxygen evolution reaction proton exchange membrane water electrolyzer water oxidation

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Bioprocess-inspired preparation of silica with varied morphologies and potential in lithium storage

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Journal of materials Science & technology 2021年第13期72卷 61-68页

作者： Fuqiang Wan Wenxuan Wang Zhaoyong Zou Hao Xie Hang Ping Zhengyi Fu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China School of Chemistry Chemical Engineeringand Life ScienceWuhan University of TechnologyWuhan430070China

As one of the most delicate bioprocesses in nature,biosilicification is closely related to biosilica with various morphologies,and has provided abundant inspiration to materials *** the present study,to explore the biosilica formation process and fabricate silica with an exquisite microstructure for lithiumion battery(LIB)electrodes,a bacterial phage(M13)is used as a biotemplate to synthesize silica with diverse morphologies:cylinders,hexagonal prisms,assemblies of smaller cylinders and nanowires.A facile ethanol bath method is conducted to coat the nanowires with nitrogen-containing carbon and carbon-coated SiO_(2) nanowires with mesochannels(C@msSiO_(2) NWs)are first used as anode materials for *** to the uniform carbon coating and parallel mesochannel structure,the electronic conductivity and capacity to accommodate volume variations were significantly *** the electrochemical perfo rmance test,the composites calcined at 750℃(C@msSiO_(2) NWs-750)show an impressive capacity of 653 mA h g^(-1) at a current density of 500 mA g^(-1) and stability(1000 cycles).In view of the electrochemical test outcomes,the prepa ration of a sophisticated structure with an outstanding potential is easily achieved via a biomimetic strategy.

关键词： Biomimetic preparation Biosilicification M13 phage Silica nanowires Mesochannel

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Hierarchically nanostructured porous TiO_2(B) with superior photocatalytic CO_2 reduction activity

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Science China Chemistry 2018年第3期61卷 344-350页

作者： Tingmin Di Jinfeng Zhang Bei Cheng Jiaguo Yu Jingsan Xu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Department of Physics Faculty of Science King Abdulaziz University School of Chemistry Physics and Mechanical Engineering Queensland University of Technology

Hierarchically nanostructured, porous TiO_2(B) microspheres were synthesized by a microwave-assisted solvothermal method combined with subsequent heat treatment in air. The materials were carefully characterized by scanning and transmission electron microscopy, X-ray diffraction, CO_2 adsorption, and a range of spectroscopies, including Raman, infrared, X-ray photoelectron and UV-Vis spectroscopy. The hierarchical TiO_2(B) particles are constructed by ultrathin nanosheets and possess large specific surface area, which provided many active sites for CO_2 adsorption as well as CO_2 conversion. The TiO_2(B)nanostructures exhibited marked photocatalytic activity for CO_2 reduction to methane and methanol. Anatase TiO_2 and P25 were used as the reference photocatalysts. Transient photocurrent measurement also proved the higher photoactivity of TiO_2(B) than that of anatase TiO_2. In-situ infrared spectrum was measured to identify the intermediates and deduce the conversion process of CO_2 under illumination over TiO_2(B) photocatalyst.

关键词： photocatalytic CO2 reduction TiO2（B） hierarchical nanostructure anatase TiO2

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Defect chemistry engineering of Ga-doped garnet electrolyte with high stability for solid-state lithium metal batteries

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Chinese Physics B 2024年第8期33卷 560-567页

作者：陈思汗黎俊刘可可孙笑晨万京伟翟慧宇唐新峰谭刚健 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China International School of Materials Science&Engineering Wuhan University of TechnologyWuhan 430070China

Ga-doped Li_(7)La_(3)Zr_(2)O_(12)(Ga-LLZO)has long been considered as a promising garnet-type electrolyte candidate for all-solid-state lithium metal batteries(ASSLBs)due to its high room temperature ionic ***,the typical synthesis of Ga-LLZO is usually accompanied by the formation of undesired LiGaO_(2) impurity phase that causes severe instability of the electrolyte in contact with molten Li metal during half/full cell *** this study,we show that by simply engineering the defect chemistry of Ga-LLZO,namely,the lithium deficiency level,LiGaO_(2) impurity phase is effectively inhibited in the final synthetic ***,defect chemistry engineered Ga-LLZO exhibits excellent electrochemical stability against lithium metal,while its high room temperature ionic conductivity(~1.9×10^(-3)S·cm^(-1))is well *** assembled Li/Ga-LLZO/Li symmetric cell has a superior critical current density of 0.9 mA·cm^(-2),and cycles stably for 500 hours at a current density of 0.3 mA·cm^(-2).This research facilitates the potential commercial applications of high performance Ga-LLZO solid electrolytes in ASSLBs.

关键词： Ga-doped Li_7La_3Zr_2O_(12)(Ga-LLZO) defect chemistry engineering high room temperature ionic conductivity electrochemical stability

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Chiral effect on Aβ fibrillation from molecular-scale to nanoscale

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Nano Research 2022年第7期15卷 6721-6729页

作者： Guanbin Gao Guowei Zhu Liangchong Yu Zijun Zhang Ting Zhang Xinglin Liu Cheng Zhang Lin Zhou Taolei Sun State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Chemistry Chemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070China

β-Amyloid(Aβ)peptide fibrillation,one of the characteristic hallmarks of Alzheimer’s disease,is determined by many interfacial physical-chemical factors,e.g.,charge,hydrophobicity,*** extensive research,chiral effect in different-scales on the fibrillation process of Aβremains ***,molecular-scale,sub-nanoscale,and nanoscale chiral-structures were constructed to investigate their chiral effect on the fibrillation of Aβ_(40) *** structures from molecular-scale to nanoscale were obtained from the different periods of the chemosynthesis process of chiral ZnS quantum-dots(QDs),confirmed by real-time monitoring of circular dichroism *** molecular-scale,both L-penicillamine(L-P)and D-P ligands accelerated the fibrillation of Aβ_(40),and the speed-up effect of D-P was slightly stronger than *** sub-nanoscale,both two chiral Zncomplexes(L-Zn and D-Zn)induced the agglomeration of Aβ_(40) without chirality *** nanoscale,both L-ZnS and DZnS QDs inhibited the fibrillation of Aβ_(40),and the inhibition effect of L-ZnS was notably better than that of ***-situ kinetics experiments of Aβ_(40) co-incubated with two chiral QDs demonstrated that L-ZnS completely prevents the misfolding of Aβ_(40) from unfolded toβ-sheet,while D-ZnS cannot achieve *** site-replacement experiments and simulation results revealed the underlying molecular mechanisms of the different inhibition efficiency of chiral ZnS QDs on Aβ_(40) fibrillation,which mainly attribute to the stereoselectivity interaction between the chiral ligands of ZnS QDs and electro-positive amino acid residues(R5,K16,and K28)of Aβ_(40).This work offers a microscopic insight of chiral effect on Aβfibrillation exerted by structures in different-scales,and provides a guidance in precise regulation of protein fibrillation via manipulating chiral structures in different-scales.

关键词： chirality molecular-scale sub-nanoscale nanoscale Aβ_(40) fibrillation

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Rational synthesis of Cylindrical Silver Single-crystalline Nanowires via Poly(vinyl pyrrolidone) Reduction of AgCl

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Journal of Wuhan University of technology(materials Science) 2020年第3期35卷 473-481页

作者： DUAN Junyuan YANG Rui HAN Meng LIU Bingxin WANG Yilong GUAN Jianguo State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Mechanical Engineering Qinghai UniversityXining 810016China

We presented a simple yet convenient hydrothermal approach for the large-scale synthesis of uniform cylindrical silver (Ag) single-crystalline nanowires with diameters of about 25 nm and lengths of 1-4 μm. Poly(vinyl pyrrolidone) (PVP) was used as a reducing agent, and AgCl was used as a precursor to deliberately control [Ag^+] at a low degree in the overall reaction process through its dynamic equilibrium by directly reducing AgCl with PVP at a quasi-equilibrium growth condition. The as-obtained products were characterized by powder X-ray diffraction (XRD) patterns, field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), infrared spectra (IR) and Raman spectra. Factors such as [PVP], reaction temperature, time, and species of reducing agents and precursors were investigated to have strong influences on the morphologies and structures of the resultant Ag nanostructures. The wire diameter can conveniently be adjusted between 25 and 50 nm by simply adjusting [PVP], reaction temperature and reducing agent species. The as-synthesized silver nanowires can be self-assembled into perfect order arrays after being dried on tin foil due to the PVP coating on the surface, the circular cross-section and the uniform diameter of the Ag nanowires. These special silver nanowires with a core-shell structure as well as their spontaneous self-assembly of order arrays are expected to provide potential applications in flexible conductors, dielectric materials, electromagnetic shielding materials and nano-devices.

关键词： silver nanowires poly(vinyl pyrrolidone) hydrothermal approach self-assembly

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synthesis and Compressive Response of Microcellular Foams Fabricated from Thermally Expandable Microspheres

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Chinese Journal of Polymer Science 2019年第3期37卷 279-288页

作者： Rui-Zhi Zhang Ju Chen Mao-Wei Huang Jian Zhang Guo-Qiang Luo Bao-Zhen Wang Mei-Juan Li Qiang Shen Lian-Meng Zhang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology School of Civil and Hydraulic Engineering Hefei University of Technology School of Chemistry Chemical Engineering and Life Sciences Wuhan University of Technology

Cellular foams are widely applied as protective and energy absorption materials in both civil and military fields. A facile and simple one-step heating method to fabricate polymeric foams is measured by adopting thermally expandable microspheres(TEMs). The ideal foaming parameters for various density foams were determined. Moreover, a mechanical testing machine and split Hopkinson bar(SHPB) were utilized to explore the quasi-static and dynamic compressive properties. Results showed that the cell sizes of the as-prepared TEMs foams were in the micrometer range of 11 μm to 20 μm with a uniform cell size distribution. All the foams exhibited good compressive behavior under both quasi-static and high strain rate conditions, and were related to both foam densities and strain rates. The compressive strength of the TEMs foams at 8400s^(-1) was up to 4 times higher than that at 10^(-4)s^(-1). The effects exerted by the strain rate and sample density were evaluated by a power law equation. With increasing density, the strain rate effect was more prominent. At quasistatic strain rates below 3000s^(-1) regime, initial cell wall buckling and subsequent cellular structure flattening were the main failure mechanisms. However, in the high strain rate(HSR) regime(above 5000s^(-1)), the foams were split into pieces by the following transverse inertia force.

关键词： Thermally expandable microspheres Compressive response Split Hopkinson bar(SHPB) Microcellular Failure mechanism

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Interfacial charge effects of supported-metal-cluster heterostructures on azo hydrogenation catalyzation

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Nano Research 2024年第5期17卷 3853-3862页

作者： Zhenhua Gu Jingli Zhang Zijun Zhang Qingxue Mu Liangchong Yu Taolei Sun Lei Shen Guanbin Gao State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases School of ChemistryChemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070China

The impact of interfacial charge on catalytic performance of supported-metal-cluster(SMC)heterostructures remains unclear,hindering efforts to develop high-performance SMC *** we systematically investigated interfacial charge effects of SMCs using a model system of graphene-supported gold-nanoclusters(AuNCs/rGO)for azo *** types of SMCs with different interfacial charges were synthesized by anchoring electropositive 2-aminoethanethiol(CSH),amphoteric cysteine(Cys),and electronegative 3-mercaptopropionic-acid(MPA)onto AuNCs/rGO,*** three SMCs exhibited high and selective catalytic activity to azo-hydrogenation in four representative azo *** catalytic activity of Cys@AuNCs/rGO was lower than that of CSH@AuNCs/rGO but higher than that of MPA@AuNCs/***,the cyclic stability of Cys@AuNCs/rGO was inferior to that of both CSH@AuNCs/rGO and MPA@AuNCs/*** mechanistic studies revealed that amino ligands modified CSH@AuNCs and Cys@AuNCs agglomerated into large-size gold nanoparticles on rGO surface during catalytic reaction under NaBH_(4) action,leading to reduced efficiency and cyclic ***,non-amino ligand modified MPA@AuNCs only partially detached from rGO surface without agglomeration,resulting in better cyclic *** of amino groups in ligands such as modifying-NH_(3)^(+)group in Cys into imine to form N-isobutyryl-L-cysteine(NIBC)substantially improved the cyclic stability while maintaining the high activity in the NIBC@AuNCs/rGO catalyst *** work provides an approach for developing a highly-active and stable SMC heterostructure catalyst via manipulating interfacial charges in SMC.

关键词： interfacial charge effect supported-metal-cluster catalyst azo hydrogenation graphene supported gold nanoclusters

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