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A phenylboronic-acid functionalized liquid photonic crystal reagent for convenient and reliable detection of glucose

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Nano Research 2025年第2期18卷 699-707页

作者： Yanxuan Zhao Huimin Zhu Jianping Ge State Key Laboratory of Petroleum Molecular&Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Institute of Eco-Chongming Shanghai 202162China

Photonic crystal sensing is an emerging technique that directly indicates the physicochemical changes with the change of structural ***,there are still challenges in material synthesis,ease of use,and reproducibility of detection for traditional photonic crystal(PC)***,a phenylboronic-acid functionalized SiO2 liquid photonic crystal(PBA-LPC)reagent was developed for reliable detection of glucose *** is convenient to prepare/use the LPC reagent because people only need to mix the responsive substance or the analyte solution with the LPCs in synthesis/*** sensing was based on the mechanism that the mixing of PBA-LPC reagent with glucose could release H+cations from PBA,which inhibited the deprotonation of the silanol group,weakened the particle surface charge,and blue-shifted the reflection of *** PBA LPC reagents responded to the glucose in different concentration ranges depending on the dosage of PBA,which ensured both a broad range detection and an accurate detection within a specific ***,it reported reproducible results due to the precise introduction of PBA and its sufficient interaction with ***,the PBA-LPC reagent showed a selective response to glucose and good anti-interference capability against the presence of NaCl,CaSO_(4),KH_(2)PO_(4),and Vitamin *** to these properties,the PBA-LPC reagent could serve as a new material for blood sugar tests and it also demonstrated the great potential of LPCs in sensing applications.

关键词： phenylboronic-acid liquid photonic crystal detection reagent glucose sensing

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PEGylated graphene oxide-mediated stimulation of vascular endothelial cells and responsive release of PD-1/PD-L1 inhibitor for efficient chemo-immunotherapy against cancer Author links open overlay panel

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Particuology 2024年第8期91卷 280-290页

作者： Yan Wang Feng Li Shuang Wang Jiaqi Meng Xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Immune checkpoint blockade(ICB)has emerged as a promising immunotherapeutic modality against cancer in the ***,only 10-30%of patients respond to ICB,primarily due to poor immunogenicity and insufficient T cell infiltration in solid ***,we presented an approach for high-performance cancer treatment using the programmed cell death protein-1 and programmed cell death ligand-1(PD-1/PD-L1)inhibitor(BMS-202)-loaded PEGylated graphene oxide(GPi).On the one hand,GPi dissociated tight junctions of vascular endothelial cells(VECs)in tumor,thus promoting the extravasation and intratumoral accumulation of liposomal doxorubicin(LipDox),which then effectively induced immunogenic cell death of tumor *** the other hand,GPi also stimulated VECs to upregulate the expression of cell-cell interaction molecules,such as intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1,which facilitated the infiltration of T cells in *** acting as a stimulator of VECs,GPi could exert responsive release of BMS-202 under the acidic tumor microenvironment and blockade PD-1/PD-L1 axis in ***,the alternating administration of GPi and LipDox effectively inhibited tumor growth in a 4T1 tumor model,providing a novel treatment mode for chemo-immunotherapy.

关键词： PEGylated graphene oxide Vascular endothelial cells Immune checkpoint blockade Immunogenic cell death Chemo-immunotherapy

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A two-pronged strategy utilizing exosomes extracted from antigenpresenting cells to combat hepatitis B

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Nano Research 2024年第10期17卷 9084-9094页

作者： Fumin Hu Dangyang Wang Ting Lu Guanghui Ma Hua Yue State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100190China

Chronic hepatitis B(CHB)is consistently challenging to conquer with numerous complications and *** the effectiveness of antiviral therapies in suppressing hepatitis B virus(HBV)replication,there is an urgent need for novel and more effective treatment *** strategies predominantly emphasize immune activation but still face challenges in sufficiently eliciting T cell *** into account the targeted delivery of nanoparticles to the liver and spleen via intravenous injection,we have proposed a dual-pronged therapeutic strategy based on antigen-presenting cells(APCs)-derived ***,exosomes targeted to the spleen can activate specific immune responses,while those targeted to the liver can modulate or reverse the liver’s immunosuppressive *** immunization,exosome formulations exhibit the remarkable ability to effectively activate APCs,thereby triggering the proliferation of CD8^(+)T ***,they also play an immunoregulatory role by converting M2 macrophages into M1 *** two-pronged therapeutic strategy precisely addresses the issues of T cell dysfunction and immune suppression,both characteristic features of CHB *** combined with Aluminum(Alum)-adjuvanted vaccine,these exosome formulations not only demonstrate a high level of cellular immune response but also secrete specific antibodies comparable to those induced by Alum *** combined approach effectively enhances both cellular and humoral immunity,offering a promising avenue for the development of therapeutic hepatitis B vaccines based on exosome formulations.

关键词： chronic hepatitis B antigen-presenting cells(APCs)-derived exosomes immunoregulatory role two-pronged therapeutic strategy

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Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： Feng Li Yuan Yang Hua Yue Shuang Wang Xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

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Current collectors’ effects on the electrochemical performance of LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2) suspension electrodes for lithium slurry battery

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green Energy & Environment 2024年第8期9卷 1306-1313页

作者： Linshan Peng Yufei Ren Zhaoqiang Yin Zhitong Wang Xiangkun Wu Lan Zhang CAS Key Laboratory of Green Process and Engineering Beijing Key Laboratory of Ionic Liquids Clean ProcessState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China Hefei University Hefei230601China Institute of Mechanics Chinese Academy of SciencesBeijing100190China Langfang Green Industrial Technology Center Hebei065001China

Take after the advantages of lithium-ion battery (LIB) and redox flow battery (RFB), semi-solid flow battery (SSFB) is a promising electrochemical energy storage device in renewable energy utilization. The flowable slurry electrode realizes decouple of energy and power density, while it also brings about new challenge to SSFBs, electron transport between active material and the out circuit. In this consideration, three types of current collectors (CCs) are applied to study the resistance and electrochemical performances of slurry cathodes within pouch cells for the first time. It proves that the electronic resistance (Re) between slurry electrode and the CC plays a decisive role in SSFB operation, and it is so large when Al foil is adopted that the cell cannot even work. Contact angle between Ketjen black (KB) slurry without active material (AM) and the CC is a preliminarily sign for the Re, the smaller the angle, the lower the resistance, and the better electrochemical performance of the cell.

关键词： Semi-solid flow battery Slurry electrode Current collector Electronic resistance Carbon coated Al

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Synthesis of NaY zeolite from a submolten depolymerized perlite:Alkalinity effect and crystallization kinetics

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Chinese Journal of Chemical engineering 2024年第6期70卷 130-138页

作者： Yanli Qu Peng Dong Li Yang Yuanyuan Yue Haoliang Wang Jingcai Cheng Chao Yang CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Petroleum Molecular&Process EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100190China Qingyuan Innovation Laboratory Quanzhou 362801China National Engineering Research Center of Chemical Fertilizer Catalyst College of Chemical EngineeringFuzhou UniversityFuzhou 350108China

NaY zeolites are synthesized using submolten salt depolymerized natural perlite mineral as the main silica and alumina sources in a 0.94 L stirred *** of alkalinity ranging from 0.38 to 0.55(n(Na_(2)O)/n(SiO_(2)))on the relative crystallinity,textural properties and crystallization kinetics were *** results show that alkalinity exerts a nonmonotonic influence on the relative crystallinity and textural properties,which exhibit a maximum at the alkalinity of *** nucleation kinetics are studied by fitting the experimental data of relative crystallinity with the Gualtieri *** is shown that the nucleation rate constant increases with increasing alkalinity,while the duration period of nucleation decreases with increasing *** n(Na_(2)O)/n(SiO_(2))ratios ranging from 0.38 to 0.55,the as-synthesized NaY zeolites exhibit narrower crystal size distributions with the increase in *** growth rates determined from the variations of average crystal size with time are 51.09,157.50,46.17 and 24.75 nm·h^(-1),*** is found that the larger average crystal sizes at the alkalinity of 0.38 and 0.43 are attributed to the dominant role of crystal growth over ***,the combined action of prominent crystal growth and the longer duration periods of nucleation at the alkalinity of 0.38 and 0.43 results in broader crystal size *** findings demonstrate that control of the properties of NaY zeolite and the crystallization kinetics can be achieved by conducting the crystallization process in an appropriate range of alkalinity of the reaction mixture.

关键词： NaY zeolite Submolten salt depolymerized perlite Alkalinity Crystallization kinetics

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Enhanced light harvesting ability in hollow Pt/TiO2 nanoreactor for boosting tetracycline photodegradation

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Progress in Natural Science:Materials International 2024年第4期34卷 767-775页

作者： Danyang Li Yongqi Li Dagui Liao Mengqing Cao Lulu Zhang Shasha Zhang Ling Chen Yawen Chen Huan Wang Jian Qi Feifei You College of Textile and Clothing Yancheng Institute of Technology Hebei Key Laboratory of Flexible Functionals Materials School of Materials Science and Engineering Hebei University of Science and Technology State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences School of Chemical Engineering University of Chinese Academy of Sciences

Utilizing solar energy to decompose tetracycline（TC） is a green strategy to treat wastewater. Herein, a heterogeneous hollow structured TiO2decorated Pt nanoparticles were successfully designed and synthesized via hardtemplate approach and photo-deposition process toward TC photodegradation. The Pt nanoparticles loaded on the surface of hollow structured TiO2can increase the visible light absorption due to the local surface plasmon resonance（LSPR） effect. Furthermore, owing to the tough electron oscillation of the LSPR excitation, the plasmonic hot holes on the surface of Pt nanoparticles can capture the electrons of TiO2, effectively facilitating the separation of photo-excited charge carriers because of the formation of Schottky junction constructed between Pt and TiO2. Combined the natural merits of shorten conveying path of charge carriers and physical structural stability for hollow structure, the optimal Pt/TiO2hetero-junction hybrid showed superior photocatalytic activity and durability for TC photodegradation with the degradation efficiency of 93.8 % after 30 min and the rate constant of 0.09196 min-1under 300 W Xe lamp irradiation. This work displays a heterogeneous hybrids catalyst based on eco-friendly metal and semiconductor materials which can be used in the fields including without limitation TC photodegradation.

关键词： Pt/TiO2 Hollow structure Photodegradation Tetracycline Hetero-junction

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Dendrimer-induced synthesis of porous organosilica capsules for enzyme encapsulation

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Frontiers of Chemical Science and engineering 2024年第4期18卷 41-48页

作者： Ziyi Chu Boyu Zhang Zhenhua Wu Jiaxu Zhang Yiran Cheng Xueying Wang Jiafu Shi Zhongyi Jiang School of Environmental Science&Engineering Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Organic matter-induced mineralization is a green and versatile method for synthesizing hybrid nanostructured materials,where the material properties are mainly influenced by the species of natural biomolecules,linear synthetic polymer,or small molecules,limiting their ***,we adopted dendrimer poly(amidoamine)(PAMAM)as the inducer to synthesize organosilica-PAMAM network(OSPN)capsules for mannose isomerase(MIase)encapsulation based on a hard-templating *** structure of OSPN capsules can be precisely regulated by adjusting the molecular weight and concentration of PAMAM,thereby demonstrating a substantial impact on the kinetic behavior of the MIase@OSPN *** MIase@OSPN system was used for catalytic production of mannose from Dfructose.A mannose yield of 22.24% was obtained,which is higher than that of MIase in organosilica network capsules and similar to that of the free *** overall catalytic efficiency(kcat/Km)of the MIase@OSPN system for the substrate D-fructose was up to 0.556 s^(-1)·mmol^(-1)·***,the MIase@OSPN system showed excellent stability and recyclability,maintaining more than 50% of the yield even after 12 cycles.

关键词： enzyme immobilization enzyme catalysis organosilica networks capsules sugar biosynthesis

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Smart ionic liquid/water mixture system with dual stimuli-response to temperature and CO_(2)

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Nano Research 2023年第3期16卷 4152-4159页

作者： Xiaoqing Yuan Ju Liu Jingyu Qin Weili Ma Guangyong Liu Yanlei Wang Hongyan He Beijing Key Laboratory of Ionic Liquids Clean Process State Key Laboratory of Multiphase Complex SystemsCAS Key Laboratory of Green Process and EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

Stimuli-responsive materials have important applications in chemistry and chemical ***,we synthesized five different polyetheramine-fatty acids(PEFA)ionic liquids(ILs),possessing the dual stimuli-responsive ability to temperature and CO_(2).These PEFA ILs have reversible lower critical solution temperature(LCST)phase behavior over a wide temperature range of 37-91℃,and reversible heterogeneous-homogeneous phase transition towards the addition and removal of CO_(2).Furthermore,the droplet size of the IL-water mixture system increased from 6.5 to 21.0 nm as the temperature increased from 25 to 56℃,and then recovered to 6.5 nm when the temperature decreased to 25℃.The addition and removal of CO_(2)also reversibly modulated the droplet size of the *** from nuclear magnetic resonance(NMR)and Fourier transform infrared(FTIR)spectra further showed that the temperature-dependent conformation of polyether amine chain in the cation dominates the temperature response,while the reversible formation of bicarbonate and fatty acids(FA)from CO_(2)and anion controls the CO_(2)-based reversible phase *** simulations revealed a microscopic response mechanism of the IL-water system to temperature and CO_(2),and a synergistic effect between the dual stimuli of temperature and CO_(2).These findings may provide a basis for the rational design and understanding of ILs-based stimuli-responsive materials and nanoreactors.

关键词： stimuli-responsive ionic liquids phase transitions temperature CO_(2)

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Liquid-phase esterification of methacrylic acid with methanol catalyzed by cation-exchange resin in a fixed bed reactor:Experimental and kinetic studies

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Chinese Journal of Chemical engineering 2023年第6期58卷 1-10页

作者： Junyang Liu Luming Wang Yuhang Bian Chunshan Li Zengxi Li Jie Li School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Beijing Key Laboratory of Ionic Liquids Clean Process Key Laboratory of Green Process and EngineeringState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Langfang Technological Center of Green Industry Langfang 065801China

The kinetic behavior of esterification between methacrylic acid and methanol catalyzed by NKC-9 resin was studied in a fixed bed *** reaction was conducted in the temperature range of 323.15 to 368.15 K with the molar ratio of reactants from 0.8 to 1.4 under certain *** measurement data were regression with the pseudo-homogeneous(P-H),Eley-Rideal(E-R),and Langmuir-Hinshelwood(L-H)heterogeneous kinetic *** adsorption experiments were implemented to gain the adsorption equilibrium constants of four *** the above three models,the L-H model exhibited the best fitting *** stability of NKC-9 was evaluated by long-term running with the yield of methyl methacrylate no decrease during 3000 h *** structure and physicochemical properties of the new and used catalyst were performed by several characterizations including thermogravimetric analysis(TG),scanning electron microscope(SEM),X-ray diffraction(XRD)and Fourier transform infrared spectroscopy(FT-IR)and so on.

关键词： Kinetics Esterification Methyl methacrylate Cation-exchange resin Fix bed reactor

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