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Multicomponent coassembled nanodrugs based on ovalbumin, pheophorbide a and Zn²⁺ for in vitro photodynamic therapy

Supramolecular Materials 2022年第1期1卷 100010-100010页

作者： Ma, Xiaoyan Liu, Yamei Li, Shukun Ogino, Kenji Xing, Ruirui Yan, Xuehai Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology Tokyo Japan State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China School of Chemical Engineering University of Chinese Academy of Sciences Beijing 100049 China Center for Mesoscience Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China

Photodynamic therapy (PDT) has been considered as a therapeutic method based on non-invasiveness and lower side effect. However, photosensitizers (PS), as a major component of PDT, suffer from aggregation and limit reactive oxygen species (ROS) generation in the delivery process, thus causing unsatisfactory therapeutic effect of PDT. Herein, we demonstrate a multicomponent coordination coassembly strategy based on the combination of metal-binding protein (ovalbumin, OVA), metal ions (Zn²⁺) and a photosensitive drug (pheophorbide a, PheoA) for constructing supramolecular photosensitive nanodrugs towards antitumor PDT. The resulting photosensitizer nanodrugs exhibit well-defined nanorod structures, good colloidal dispersity, and high encapsulation efficiency. Most importantly, multicomponent coassembled nanorods possess favorable stability of physiological environment and on-demand release of PS in response to an acidic ambient in tumor cells. These features result in the high level of ROS generation in tumor cells, benefiting for enhanced therapeutic effect of in vitro PDT. © 2022

关键词： Controlled release Multicomponent coassembly Nanodrugs Nanorods Photodynamic therapy

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Haze episodes elevate PM2.5-bound PAH and BFR loads without increasing bioaccessibility: Toward improved inhalation risk assessment

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Science of the Total Environment 2025年 982卷 179640页

作者： Zhang, Xian Liu, Zijuan Chen, Bianjie Shi, Fengqiong Hebei Key Laboratory of Public Health Safety Hebei University Baoding071002 China School of Public Health Hebei University Baoding071002 China State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of Sciences Beijing100190 China Institute of Process Engineering Chinese Academy of Sciences Beijing100190 China

Inhalation bioaccessibility is critical for accurate health risk assessment of airborne pollutants. This study systematically investigated PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) and brominated flame retardants (BFRs) during haze episodes and normal periods in northern China, focusing on their concentration profiles, bioaccessibility (via artificial lysosomal fluid [ALF] and Gamble's solution [GS] models), and inhalation risks. Results revealed haze-driven elevations in PAHs (4.93 vs. 3.14 ng/m3, 1.57 times) and BFRs (1566 vs. 926 pg/m3, 1.69 times). Despite elevated concentrations, bioaccessibility showed no significant haze-normal differences for PAHs (22.3–95.3 % vs. 25.9–83.9 %, p > 0.05) or BFRs (12.7–56.6 % vs. 14.9–74.1 %, p > 0.05). Total concentration-based incremental lifetime carcinogenic risks (ILCRinh) overestimated hazards by 5.71–20.6 times compared to bioaccessibility-adjusted risks (9.57 × 10−9–1.28 × 10−8 for haze;5.33 × 10−9–6.27 × 10−9 for normal), though all values remained below safety thresholds (ILCRinh −6). Our results emphasize the importance of inhalation bioaccessibility in risk assessment for PM2.5-bound PAHs and BFRs. © 2025 Elsevier B.V.

关键词： Risk assessment

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Hemin with strong adsorption on zinc anode as a multi-functional interface layer for highly reversible Zn-ion batteries

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Chinese Chemical Letters 2025年

作者： Liang Wang Weitao Li Lei Zheng Mengmin Jia Dai-Huo Liu Dongmei Dai Zhuangzhuang Zhang Chunyu Ma Bao Wang Shengli Zhang Li Su Bao Li Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and Reactions Ministry of Education School of Chemistry and Chemical Engineering Henan Normal University Xinxiang 453007 China Nanjing Univ Sci & Technol Coll Mat Sci & Engn MIIT Key Lab Adv Display Mat & Devices Nanjing 210094 China State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China

Aqueous zinc-ion batteries (AZIBs) are regarded as one of the most promising energy conversion and storage devices. Nevertheless, side reactions and dendrite growth on the zinc metal anode hinder their widespread application. In this study, hemin was employed as a multi-functional artificial interface for the first time to inhibit the disordered growth of zinc dendrites and mitigate side reactions. Theoretical calculations indicate that hemin is preferentially adsorbed onto the zinc anode, thus blocking the interaction between the active zinc anode and electrolyte. Compared with zinc foil, the Hemin@Zn anode demonstrates enhanced corrosion resistance, a decrease in hydrogen evolution, and more orderly deposition of zinc. As expected, the symmetric cell with Hemin@Zn anode can sustain up to 4000 h at 0.2 mA/cm 2 , 0.2 mAh/cm 2 . Asymmetric Zn//Cu cells exhibit an average coulombic efficiency exceeding 99.72% during 500 cycles. Moreover, the full cell Hemin@Zn//NH 4 V 4 O 10 delivers a superior capacity up to 367 mAh/g and the discharge capacity retention reaches 124 mAh/g after 1200 cycles even at a current density of 5 A/g. This work provides a simple and effective method for constructing a robust artificial interface to promote the application of long-life AZIBs.

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Building Rapid Charge Transfer Channel Via engineering Ni Coordinated Flexible Polymer for Efficient Solar Hydrogen Evolution

SSRN

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SSRN 2022年

作者： Zhang, Yiming Wang, Xu-Sheng Ren, Xiaohui Luo, Shunqin Huang, Hengming Chen, Rongsheng Shao, Shibo Liu, Dan Gui, Jianzhou Ye, Jinhua State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metal School of Materials Science and Engineering Lanzhou University of Technology Lanzhou730050 China 1-1 Namiki Ibaraki Tsukuba305-0044 Japan State Key Laboratory of Separation Membranes and Membrane Processes Tianjin Key Laboratory of Green Chemical Technology and Process Engineering School of Chemical Engineering and Technology Tiangong University Tianjin300387 China School of Materials Science and Engineering Zhejiang Sci-Tech University Hangzhou310018 PR China The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Wuhan430081 China School of Engineering The University of Edinburgh EdinburghEH9 3BF United Kingdom Graduate School of Chemical Sciences and Engineering Hokkaido University Sapporo060-0814 Japan TJU-NIMS International Collaboration Laboratory School of Material Science and Engineering Tianjin University Tianjin300072 China

Building rapid charge transfer channel from photocatalysts to cocatalysts can greatly improve the photocatalytic performance, yet remains a grand challenge. In this work, a flexible polymer engineering strategy was utilized to fabricate a homogeneous conductive N-doped carbon (NC) layer between CdS photo-absorber and surface NiO cocatalyst. The detailed formation procedure of NC layers was unraveled by a series of in-situ and ex-situ temperature-dependent analysis. Such a bifunctional layer can serve as not only a rapid charge transfer channel for photo-induced charge carriers, but also modulate the adsorption of H on NiO cocatalyst for concertedly boosting solar hydrogen production performance (101.92 mmol h-1 g-1). The DFT calculation together with SI-XPS, PL, TRPL, EIS and photocurrent plots indicated that the generated built-in electric field with the direction from NiO nanoparticles to NC layers could accelerate the excited electrons transfer to active sites. Furthermore, the adsorption and desorption energy of hydrogen on NiO nanoparticles was also optimized by the NC layers, as verified by DFT calculation. This work provides new insights into interfacial engineering between catalysts and cocatalysts for highly efficient photocatalysis. © 2022, The Authors. All rights reserved.

关键词： Charge transfer

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Computational chemistry-assisted design of hydrazine-based fluorescent molecular rotor for viscosity sensors

Smart Molecules

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Smart Molecules 2023年第3期1卷 89-97页

作者： Miao Dong Dazhuang Wang Jinrong Yang Pingping Sun Weilu Ding Jianxin Yang Jinwu Yan Weijie Chi Collaborative Innovation Center of One Health Key Laboratory of Green Catalysis and Reaction Engineering of HaikouSchool of Chemistry and Chemical EngineeringHainan UniversityHaikouChina MOE International Joint Research Laboratory on Synthetic Biology and Medicines School of Biology and Biological EngineeringSouth China University of TechnologyGuangzhouChina Beijing Key Laboratory of Ionic Liquids Clean Process CAS Key Laboratory of Green Process and EngineeringState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBeijingChina

Deep understanding of the fluorescence quenching mechanisms of probes plays a crucial role in developing their practical *** fluorescence quenching mechanism of hydrazine-based fluorescence probes needs to be clarified up to the ***,we designed and synthesized a new hydrazine-based fluorescence probe(HA-Na)based on the naphthalimide *** clarified the molecular origin of the non-fluorescence of this probe with the aid of computational chemistry and spectroscopic *** showed that the significant rotation of the hydrazine group in the excited state potential energy surface,which caused the complete charge separation,was responsible for the fluorescence quenching of the probe in an organic *** the rotation was prevented in an aggregative state or high-viscosity solution,the fluorescence of the probe *** other words,the fluorescence quenching mechanism of hydrazine-based fluorescence probes was attributed to the formation of a twisted intramolecular charge transfer(TICT)*** importantly,we demonstrated that this fluorescence molecular rotor could be used to monitor the autophagy process in living cells by detecting lysosomal viscosity changes during ***,this work provides an essential theoretical basis for the developing potential hydrazine-based fluorescence molecular rotors.

关键词： computational chemistry fluorescence probes fluorescence quenching mechanisms twisted intramolecular charge transfer

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Nanocomposite Substrate-Supported Nanofiltration Membrane for the Efficient Treatment of Rare Earth Wastewater

SSRN

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SSRN 2022年

作者： Wang, Yiwen Jiang, Qinliang Li, Yi Fan, Hua Gui, Shuanglin Xiong, Jihai Luo, Jianquan Institute of Energy Conversion Jiangxi Academy of Sciences Nanchang330096 China Key Laboratory of Poyang Lake Environment and Resource Utilization Ministry of Education School of Resources Environmental & Chemical Engineering Nanchang University Nanchang330031 China Advanced Membranes & Porous Materials Center King Abdullah University of Science and Technology Division of Physical Sciences and Engineering Thuwal 23955-6900 Saudi Arabia State Key Laboratory of Biochemical Engineering Institute of Process Engineering University of Chinese Academy of Sciences Chinese Academy of Sciences Beijing100190 China

Rare earth wastewater is an emerging wastewater featuring high salinity, strong acidity and a complex background with multiple contaminants. A nanofiltration (NF) membrane with better performance is desired to tackle the challenge of rare earth wastewater to reduce its negative impact on the environment. Herein, a novel nanocomposite substrate-supported thin film composite (TFC) NF membrane with good stability and superior separation performance was reported. The inorganic two-dimensional O-MoS2 nanosheets were embedded into the PSf substrate via a nonsolvent-induced phase inversion method. The PSf/O-MoS2 nanocomposite was used as the support for the interfacial polymerization. the pore structure of the substrate shifted from a larger irregular bubble pore structure into a finger-like porous structure when the content of O-MoS2 was 0.06 wt%. As a result, the nanocomposite substrate-supported TFC membrane had a 1.7 times higher water flux and improved salt rejections compared to that of the control membrane. The obtained NF membrane showed excellent separation performance with a high salinity removal efficiency of 95% in treating real rare earth wastewater (diluted 50 times, pH: 2.46). This work also highlights the modification of the substrate by functional nanomaterials could provide versatile ways to improve the separation performance and stability of TFC membranes. © 2022, The Authors. All rights reserved.

关键词： Nanofiltration membranes

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Corrigendum to "Investigating the stability of chimeric murine polyomavirus VP1 Capsomeres via molecular dynamics simulations and experimental analysis" [Int. J. Biol. Macromol., volume 286, January 2025, 138372]

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International journal of biological macromolecules 2025年 303卷 140511页

作者： Hong Luo Yanyan Ma Zhiguo Su Yanhao Gu Songping Zhang Lukas Gerstweiler School of Chemical Engineering Faculty of Science Engineering and Technology University of Adelaide Adelaide 5005 Australia State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and Delivery (CAS) Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 PR China Institute of Pharmaceutical and Food Engineering Shanxi University of Chinese Medicine Jinzhong 030619 PR China. State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and Delivery (CAS) Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 PR China. School of Chemical Engineering Faculty of Science Engineering and Technology University of Adelaide Adelaide 5005 Australia. School of Chemical Engineering Faculty of Science Engineering and Technology University of Adelaide Adelaide 5005 Australia. Electronic address: lukas.gerstweiler@adelaide.edu.au.

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Phase Structure, Microstructure and Electrical Properties of K_xNa_((1-x))NbO_3 Piezoelectric Ceramics with Different K/Na Ratio

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Journal of Wuhan University of Technology(Materials Science) 2019年第1期34卷 30-34页

作者： CHEN Jianchao ZHAO Pei Key Laboratory for Green Chemical Process of Ministry of Education Hubei Key Laboratory of Plasma Chemistry and Advanced Materials School of Material Science and Engineering Wuhan Institute of Technology Faculty of Materials and Chemistry China University of Geosciences State Key Laboratory of Geological Process and Mineral Resources China University of Geosciences

The K_xNa_((1-x))NbO_3(x=0.45, 0.46, 0.47, 0.48, 0.49, 0.50) lead-free piezoelectric ceramics was fabricated by conventional solid-state sintering method. It was found that the ratio of alkaline metal would affect the microstructure, bulk density, and optimum sintering temperatures of ceramics. Meanwhile, the electrical properties were also influenced by modulating the K/Na ratio, exhibiting corresponding composition-dependent properties. The optimum electrical properties of K_xNa_((1-x))NbO_3 such as piezoelectric constant d_(33) = 115 pC/N, mechanical quality factor Q_m = 20, Curie temperature Tc = 365 ~oC, ε_(33)~T/ε_0= 588.1, dielectric loss tan δ = 0.024, bulk density(ρ) = 3.08 g/cm^3, remnant polarization(P_r) = 8.87 μC/cm^2 and coercive field(Ec) = 13.79 kV/cm were obtained at x = 0.46.

关键词： lead-free piezoelectric ceramics solid-state sintering K/Na ratio electrical properties

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Fabrication of agarose hydrogel with patterned silver nanowiresfor motion sensor

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Bio-Design and Manufacturing 2019年第4期2卷 269-277页

作者： Qingquan Han Yang Chen Wei Song Milin Zhang Shengtao Wang Peng Ren Linna Hao Anhe Wang Shuo Bai Jian Yin Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China University of Chinese Academy of Sciences Beijing 100049China

In this work, a facile strategy is proposed to construct stretchable electronics based on agarose hydrogels. The hot agarose solution is casted onto a template with patterned Ag nanowires, endowing agarose hydrogel with patterned conductive surface. After further heating treatment, Ag nanowires can be embedded into the agarose hydrogel, which improves the stability of Ag pattern and has no obvious e ffect on the conductivity of hydrogels. The agarose hydrogel with patterned Ag nanowires is certi fied to be an e ffective stretchable electrode to record the motion of joints, which has great potential applications in the field of wearable devices.

关键词： Agarose hydrogel Ag nanowire Stretchable electronics Pattern Casting strategy

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Overall Structure Modeling and Modal Analysis of Liquid Rocket Engine Based on ABAQUS Secondary Development Platform

Overall Structure Modeling and Modal Analysis of Liquid Rock...

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Decision Science & Management (ICDSM), International Conference on

作者： Xueqin Du Qiong Wu Hanjun Gao Zhaojun Liu Shuai Yang Kun He Xuefei Li Zhaoyu Liu State Key Laboratory of Virtual Reality Technology and Systems Beijing Engineering Technological Research Center of High-Efficient & Green CNC Machining Process and Equipment Beihang University Beijing China Jingdezhen Research Institute of Beihang University Jingdezhen China Jingdezhen Research Institute of Beihang University Jingdezhen PR China Beijing Aerospace Propulsion Institute Beijing China

With the development of computer technology, dynamic simulation technology becomes more and more important in the engine design and development cycle. The development and use of relevant special programs greatly shorten the engine development cycle. In this paper, the components and connection modes of liquid rocket engine are simplified reasonably and efficiently, and a high-precision equivalent model with the maximum deviation of 9.754% and the minimum deviation of 0.423% of the natural frequency obtained by modal analysis is established; The ABAQUS secondary development technology is used to build a modal analysis platform, so as to quickly and accurately realize modal calculation, which is of guiding significance to the designers of liquid rocket engines.

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