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Food, Pharmaceutical and Bioengineering Division 2018 - Core Programming Area at the 2018 AIChE Annual Meeting

作者： Guo, Shiwei Luo, Jianquan Yang, Qiangjian Qiang, Xiufu Feng, Shichao Wan, Yinhua State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing100190 China University of Chinese Academy of Sciences Beijing100049 China

ISBN: (纸本)9781510876200

Membrane technology provides a green approach to recover sucrose from cane molasses. However, the trade-off between color removal and sucrose permeation by membrane filtration debases the efficiency and limits the application. In this study, ten commercially-available and one self-made ultrafiltration (UF) and nanofiltration (NF) membranes were used for decoloration of molasses. By investigating the effect of membrane properties, molasses components, and operating parameters on the molasses filtration behaviors, the mechanisms of high sucrose retention were clarified. For polyether sulfone (PES) membrane, the high retention of pigments and sucrose was mainly caused by the serious irreversible fouling as an additional selective layer. Polyamide (PA) NF membranes showed high antifouling ability, and a suitable pore size (~ 500 Da) was important to achieve high color removal and sucrose permeation. Although regenerated cellulose (RC) membranes exhibited excellent antifouling performance to molasses, the severe membrane swelling induced by salts and high temperature (60 °C) limited their application. Reducing sugar in molasses produced negligible effect on the sucrose retention, while inorganic salts resulted in pore swelling and solute dehydration due to Bsalting-out^ effect, thus improving the sucrose permeation. However, such positive effect was weakened or eliminated by the pigments in molasses, and irreversible fouling became more serious in the presence of the molasses salts, especially for PES membranes. Based on the underlying mechanisms, the pore swelling and sucrose dehydration effects were Breappeared^ by simply removing the non-polar pigments via macroporous resin adsorption, thus decreasing sucrose retention. High temperature could accelerate the sucrose permeation, but it also attenuated concentration polarization layer, thus intensifying the sucrose retention increase induced by high permeate flux. If a loose NF membrane was selected for decoloration of m

关键词： Nanofiltration membranes

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Corrigendum to “Modified polyether gylcols supported ionic liquids for CO 2 adsorption and chemical fixation” [Mol. Catal. 492 (2020) 111008-111016]

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Molecular Catalysis 2020年 493卷

作者： Ying Liu Yan Song Jianhua Zhou Xiangping Zhang CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Multiphase Complex System Beijing Key Laboratory of Ionic Liquids Clean Process Institute of Process Engineering Chinese Academy of Science Beijing 100190 China School of Chemistry and Pharmaceutical Engineering Qilu University of Technology Jinan 250353 China

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Anisotropic Hollow Structure with Chemotaxis Enabling Intratumoral Autonomic Therapy

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Angewandte Chemie 2024年第2期137卷

作者： Dr. Ping Hou Dr. Lingeng Xie Dr. Ludan Zhang Prof. Xin Du Dr. Decai Zhao Prof. Yuguang Wang Prof. Nailiang Yang Prof. Dan Wang State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and Delivery Institute of Process Engineering Chinese Academy of Sciences 1 North 2nd Street Zhongguancun Haidian District Beijing 100190 P. R. China University of Chinese Academy of Sciences 19 A Yuquan Road Beijing 10049 P. R. China These authors contributed equally to this work Department of General Dentistry II Peking University School and Hospital of Stomatology National Center for Stomatology & National Clinical Research Center for Oral Diseases National Engineering Research Center of Oral Biomaterials and Digital Medical Devices 22 Zhongguancun South Avenue Beijing 100081 P. R. China Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology 22 Zhongguancun South Avenue Beijing 100081 P. R. China First Clinical Division Peking University School and Hospital of Stomatology 22 Zhongguancun South Avenue Beijing 100081 P. R. China School of Chemistry and Biological Engineering Beijing Key Laboratory for Bioengineering and Sensing Technology University of Science and Technology Beijing 30 Xueyuan Road Beijing 100083 P. R. China College of Chemistry and Environment Engineering Shenzhen University 3688 Nanhai Avenue Shenzhen 518060 P. R. China

Effective intratumoral drug penetration is pivotal for successful cancer treatment. However, due to the disrupted capillary networks and poor perfusion in solid tumors, there exist challenges to realize autonomous directional drug penetration and controlled drug release within the tumor. Considering the specificity of glucose within tumor tissue, we draw inspiration from nature and engineer asymmetrical hollow structures exhibiting chemotaxis towards high glucose levels. By incorporating multiple shells into these structures, we enhance the local chemical concentration gradients, thereby improving cellular uptake and precise targeting. The advantages of anisotropic hollow multishell structure ( a -HoMS) can be reflected from the diffusion coefficient and directivity, which increase by 73.4 % and 273 % respectively compared to conventional isotropic hollow spheres, achieving the most linear movement while ensuring the speed of movement. Furthermore, the multi-level porosity and temporal-spatial order of a -HoMS enable sequential drug delivery that inhibits angiogenesis with inducing cell apoptosis. After the eradication of localized tumor cells, the a -HoMS can automatically migrate to the alive tumor cells under the glucose gradient, inducing another cycle of drug delivery and chemotaxis, resulting in excellent antitumor efficacy. These anisotropic HoMS demonstrate intelligence, adaptability, and precision in tumor therapy, providing valuable insights for programmable treatment within tissues.

关键词： hollow structure porous structure chemotaxis temporal-spatial ordering drug delivery

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Dual-Defects Adjusted Crystal-Field Splitting of LaCo1−xNixO3−δ Hollow Multishelled Structures for Efficient Oxygen Evolution

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Angewandte Chemie 2020年第44期132卷

作者： Wang H. Qi J. Yang N. Cui W. Wang J. Li Q. Zhang Q. Yu X. Gu L. Li J. Yu R. Huang K. Song S. Feng S. Wang D. Department of Physical Chemistry School of Metallurgical and Ecological Engineering University of Science & Technology Beijing Beijing 100083 China State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201210 China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130012 China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

To boost the performance for various applications, a rational bottom-up design on materials is necessary. The defect engineering on nanoparticle at the atomic level can efficiently tune the electronic behavior, which offers great opportunities in enhancing the catalytic performance. In this paper, we optimized the surface oxygen vacancy concentration and created the lattice distortion in rare-earth-based perovskite oxide through gradient replacement of the B site with valence alternated element. The dual defects make the electron spin state transit from low spin state to high spin state, thus decreasing the charge transport resistance. Furthermore, assembly the modified nanoparticle subunits into the micro-sized hollow multishelled structures can provide porous shells, abundant interior space and effective contact, which enables an enhanced mass transfer and a shorter charge transport path. As a result, the systemic design in the electronic and nano-micro structures for catalyst has brought an excellent oxygen evolution performance. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

关键词： defects hollow multishelled structures oxygen evolution reaction perovskite oxides rare-earth compounds

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Pd-Catalyzed C-S Cyclization via C-H Functionalization Strategy： Access to Sulfur-containing Benzoheterocyclics

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Chinese Journal of Chemistry 2018年第10期36卷 921-924页

作者： Shihao then Ming Wang Xuefeng Jiang Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular Engineering East China Normal Uni- versity 3663 North Zhongshan Road Shanghai 200062 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China

A C-H sulfurated cyclization protocol starting from thioacetates is developed for straightforward construction of sulfur-containing benzo- heterocyclics. The diversiform functional dihydrobenzothiophenes and thiochromans were comprehensively achieved through the Pd-catalyzed carbon- sulfur cyclization. Mechanistic studies indicated that C-H bond cleavage was involved in the rate-determining step. [1]Benzothieno-[3,2-b]- [1]benzothiophene （BTBT） and benzo[b]thieno[2,3-d]thiophene （BTT） were efficiently established as the well-known organic field-effect transistor （OFET） material molecules through this methodology.

关键词： C-S cyclization C-H functionalization dihydrobenzothiophene thiochromans palladium

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The Linkage of Sulfonimidoyl Fluorides and Unactivated Alkenes via Hydrosulfonimidoylation

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Angewandte Chemie 2022年第44期134卷

作者： Daming Zeng Yinhao Ma Prof. Dr. Wei-Ping Deng Dr. Ming Wang Prof. Dr. Xuefeng Jiang Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular Engineering East China Normal University 3663 North Zhongshan Rd. Shanghai 200062 P. R. China School of Pharmacy and Shanghai Key Laboratory of New Drug Design East China University of Science and Technology Shanghai 200237 P. R. China State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 P. R. China Institute of Eco-Chongming Shanghai 202162 P. R. China

Sulfur(VI) fluoride cleavage and exchanging linkage, a new generation of linkage chemistry, exhibits enormous potential for combining a range of functional molecules in an increasing number of fields. Herein, we established a metal-free linkage of unactivated alkenes and sulfonimidoyl fluorides via hydrosulfonimidoylation to construct sulfoximines within minutes. An intermolecular hydride transfer process is the key step, and it occurs via overlap of the LUMO in the sulfonimidoyl cation and HOMO in the unactivated alkene, which was confirmed via control experiments with deuterated compounds. DFT calculations further demonstrated the concerted process involving formation of the S−C( sp 3 ) bond and hydride transfer. Remarkably, abundant natural products and pharmaceuticals with multiple heteroatoms and sensitive functional groups have been subjected to the current linkage reaction to achieve various sulfoximine linkages, furnishing the basis for drug discovery and drug conjugation.

关键词： Alkene Hydride Transfer Hydrosulfonimidoylation Linkage Sulfonimidoyl Fluoride

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Cover Image, Volume 95, Issue 6

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Journal of Chemical Technology & Biotechnology 2020年第6期95卷

作者： Lei Yuan Xiangping Zhang Baozeng Ren Yingliang Yang Yinge Bai Lu Bai Hongshuai Gao Shaojuan Zeng College of Chemical and Engineering Zhengzhou University Zhengzhou China Key Laboratory of Green Process and Engineering State Key Laboratory of Multiphase Complex Systems Beijing Key Laboratory of Ionic Liquids Clean Process Institute of Process Engineering Chinese Academy of Sciences Beijing China College of Chemical and Engineering University of Chinese Academy of Sciences Beijing China

The cover image is based on the Original Article Dual-Functionalized Protic Ionic Liquids for Efficient Absorption of NH3 through Synergistically Physicochemical Interaction by Shaojuan Zeng, Yingliang Yang, Lei Yuan ...

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Cover Picture: Phosphoric Acid: A key Role in Control of Structure and Properties of Vanadium Phosphorus Oxide Catalysts During Synthesis (04/2021)

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ChemistrySelect 2021年第4期6卷

作者： Ting Zhang Dr. Ruirui Zhang Yongkang Zhang Zhiqi Xie Yingwei Li Hui Wu Dr. Fei Dai Prof. Ruixia Liu Beijing Key Laboratory of Ionic Liquids Clean Process CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering CAS 1North 2nd Street Zhongguancun Haidian District Beijing 100190 CN Sino-Danish College University of Chinese Academy of Sciences Yuquan Road Shijingshan District Beijing 100049 CN The authors T. Zhang and R. Zhang contributed equally to this article. School of Chemical Engineering University of Chinese Academy of Sciences Yuquan Road Shijingshan District Beijing 100049 CN

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Deep hydroconversion of ethanol-soluble portion from the ethanolysis of Dahuangshan lignite to clean liquid fuel over a mordenite supported nickel catalyst

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Journal of Analytical and Applied Pyrolysis 2019年 139卷 13-21页

作者： Guang-Hui Liu Zhi-Min Zong Fang-Jing Liu Xing-Long Meng Yang-Yang Zhang Sheng-Kang Wang Sheng Li Chen Zhu Xian-Yong Wei Feng-Yun Ma Jing-Mei Liu Key Laboratory of Coal Processing and Efficient Utilization Ministry of Education China University of Mining & Technology Xuzhou 221116 Jiangsu China State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering Ningxia University Yinchuan 750021 Ningxia China Laboratory of Coal Clean Conversion & Chemical Engineering Process Xinjiang Uyghur Autonomous Region College of Chemistry and Chemical Engineering Xinjiang University Urumqi 830046 Xinjiang China

A highly active mordenite ( M )-supported nickel catalyst Ni/ M was prepared via a modified deposition-percipitation and used for catalyzing hydroconversion of ethanol-soluble portion (ESP) from the ethanolysis of Dahuangshan lignite. The Ni nanoparticles were uniformly dispersed on the support without apparent agglomeration. Moreover, the number and yields of the species detected in ESP are obviously different from those detected in catalytically hydrogenated ESP (CHESP). The contents of aromatic ring (AR)-containing compounds and/or heteroatom-containing compounds (HACCs, some of which also contain an AR or ARs) in CHESP are significantly lower than those in ESP, while the alkanes (30.4%) and cyclanes (54.7%) contents in CHESP are much higher than those in ESP according to the analysis with a gas chromatograph/mass spectrometer. Furthermore, according to the analysis with a quadrupole exactive orbitrap mass spectrometer using atmospheric-pressure chemical ionization in positive-ion mode, the number and yields of HACCs in CHESP are significantly lower than those in ESP. The catalytic hydroconversion of lignite-related model compounds further confirms that the synergy between Ni nanoparticles and the M skeleton plays a crucial role in activating H 2 to H ··· H and further activating H ··· H to H · and H + , which is the key to achieving the AR hydrogenation and the heteroatom removal at 160 °C.

关键词： Deep hydroconversion Lignite Ethanol-soluble portion Clean fuel Ni/ M

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Synergistic Glutathione Depletion and STING Activation to Potentiate Dendritic Cell Maturation and Cancer Vaccine Efficacy

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Angewandte Chemie 2024年第10期136卷

作者： Dr. Jianping Liu Dr. Ye Zhang Bowei Yang Dr. Yingbo Jia Prof. Rui-Tian Liu Dr. Lingwen Ding Prof. Zheyu Shen Prof. Xiaoyuan Chen Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore School of Biomedical Engineering Southern Medical of University Guangzhou Guangdong 510515 P. R. China CAS Key Laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou Jiangsu 215123 P. R. China State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 P. R. China Department of Pathology Yong Loo Lin School of Medicine National University of Singapore Singapore 119074 Singapore Clinical Imaging Research Center Center for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive Proteos Singapore 138673 Singapore

Dendritic cell (DC) maturation and antigen presentation are key factors for successful vaccine-based cancer immunotherapy. This study developed manganese-based layered double hydroxide (Mn-LDH) nanoparticles as a self-adjuvanted vaccine carrier that not only promoted DC maturation through synergistically depleting endogenous glutathione (GSH) and activating STING signaling pathway, but also facilitated the delivery of model antigen ovalbumin (OVA) into lymph nodes and subsequent antigen presentation in DCs. Significant therapeutic-prophylactic efficacy of the OVA-loaded Mn-LDH (OVA/Mn-LDH) nanovaccine was determined by the tumor growth inhibition in the mice bearing B16-OVA tumor. Our results showed that the OVA/Mn-LDH nanoparticles could be a potent delivery system for cancer vaccine development without the need of adjuvant. Therefore, the combination of GSH exhaustion and STING pathway activation might be an advisable approach for promoting DC maturation and antigen presentation, finally improving cancer vaccine efficacy.

关键词： Antigen Delivery DC Maturation GSH Depletion ROS Upregulation STING Activation

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