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engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy

Angewandte Chemie 2017年第6期130卷

作者： Yanlan Liu Xiaoyuan Ji Winnie W. L. Tong Diana Askhatova Tingyuan Yang Hongwei Cheng Yuzhuo Wang Jinjun Shi Center for Nanomedicine and Department of Anesthesiology Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. China State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 P. R. China Department of Experimental Therapeutics British Columbia Cancer Agency Vancouver BC V5Z 1L3 Canada

Cancer hallmarks allow the complexity and heterogeneity of tumor biology to be better understood, leading to the discovery of various promising targets for cancer therapy. An amorphous iron oxide nanoparticle (NP)‐based RNAi strategy is developed to co‐target two cancer hallmarks. The NP technology can modulate the glycolysis pathway by silencing MCT4 to induce tumor cell acidosis, and concurrently exacerbate oxidative stress in tumor cells via the Fenton‐like reaction. This strategy has the following features for systemic siRNA delivery: 1) siRNA encapsulation within NPs for improving systemic stability; 2) effective endosomal escape through osmotic pressure and/or endosomal membrane oxidation; 3) small size for enhancing tumor tissue penetration; and 4) triple functions (RNAi, Fenton‐like reaction, and MRI) for combinatorial therapy and in vivo tracking.

关键词： Eisenoxid-Nanopartikel Kernspintomographie Krebsmarker RNAi Tumorpenetration

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Polymeric nanocomposites loaded with fluoridated hydroxyapatite Ln^(3+)(Ln = Eu or Tb)/iron oxide for magnetic targeted cellular imaging

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Cancer Biology & Medicine 2015年第3期12卷 175-183页

作者： Jie Pan Wei-Jiao Liu Chao Hua Li-Li Wang Dong Wan Jun-Bo Gong State Key Laboratory of Hollow Fiber Membrane Materials and Processes School of Environmental and Chemical EngineeringTianjin Polytechnic University Key Laboratory of Green Process and Engineering Institute of Process Engineering Chinese Academy of Science Department of Chemical Engineering School of Chemical Engineering and Technology Tianjin University

Objective： To fabricate polymeric nanocomposites with excellent photoluminescence, magnetic properties, and stability in aqueous solutions, in order to improve specificity and sensitivity of cellular imaging under a magnetic field. Methods： Fluoridated LnS＋-doped HAP （Ln3＋-HAP） NPs and iron oxides （lOs） can be encapsulated with biocompatible polymers via a modified solvent exaction/evaporation technique to prepare polymeric nanocomposites with fluoridated Ln3＋-HAP/iron oxide. The nanocomposites were characterized for surface morphology, fluorescence spectra, magnetic properties and in vitro cytotoxicity. Magnetic targeted cellular imaging of such nanocomposites was also evaluated with confocal laser scanning microscope using A549 cells with or without magnetic field. Results： The fabricated nanocomposites showed good stability and excellent luminescent properties, as well as low in vitro cytotoxicity, indicating that the nanocomposites are suitable for biological applications. Nanocomposites under magnetic field achieved much higher cellular uptake via an energy-dependent pathway than those without magnetic field. Conclusion： 1tie nanocomposites fabricated in this study will be a promising tool for magnetic targeted cellular imaging with improved specificity and enhanced selection.

关键词： Cancer cellular imaging nanocomposites magnetic targeted hydroxyapatite （HAP） doped with rare earth

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Preparation and adsorption capacity evaluation of graphene oxide-chitosan composite hydrogels

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Science China Materials 2015年第10期58卷 811-818页

作者：赵恒焦体峰张乐欣周靖欣张庆瑞彭秋明闫学海 Hebei Key Laboratory of Applied Chemistry School of Environmental and Chemical Engineering Yanshan University State Key Laboratory of Metastable Materials Science and Technology Yanshan University National Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences

Graphene oxide(GO)-chitosan composite hydrogels were successfully prepared via the self-assembly of chitosan molecules and GO. These as-prepared hydrogels were characterized by different techniques. The morphology of the internal network structure of the nanocomposite hydrogels was investigated. The adsorption capacity results demonstrate that the prepared GObased composite hydrogels can efficiently remove three tested dye molecules, Congo red, methylene blue and Rhodamine B, from wastewater in accordance with the pseudo-second-order model. The dye adsorption capacity of the obtained hydrogels is mainly attributed to the GO sheets, whereas the chitosan molecule was incorporated to facilitate the gelation process of the GO sheets. The present study indicates that the as-prepared composite hydrogels can serve as good adsorbents for wastewater treatment as well as the removal of harmful dyes.

关键词：复合水凝胶 GO 壳聚糖分子氧化石墨烯吸附性能

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Synthesis of Multi-shelled Manganese Oxide Hollow Microspheres With Superior Supercapacitor Performance Through a pH-regulated Hard Template Method

Synthesis of Multi-shelled Manganese Oxide Hollow Microspher...

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The 6th International Conference on Nanoscience & Technology, China 2015

作者： Jiangyan Wang Hongjie Tang Dan Wang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of Sciences

Supercapacitors are intermediate devices between conventional batteries and dielectric capacitors that can be used in various electric systems. The pseudo-capacitors have drawn great attentions because of their ability to embrace the advantages of both lithium ion batteries(high energy density) and capacitors(high power density).[1] Among various supercapacitor electrode materials, the manganese oxide is one of the most promising candidates due to its high specific capacitance, environmental compatibility and cost effectiveness. Nevertheless, they still suffer from some drawbacks, such as low specific surface area and poor conductivity. Hollow micro-/nano-structured materials can overcome the above drawbacks due to their large specific surface area, short transport length and good structural stability.[2] In this manuscript, by precisely controlling the p H value of the precursor solution, thus controlling the negative charge of the CMSs and the positive charge of Mn cations. As a result, multi-shelled Mn2O3 hollow microspheres with controlled shell thickness and shell number, as well as Mn2O3 nanoparticles were achieved. The unique architecture of these designed nanostructures allows efficient use of pseudo-capacitive Mn2O3 nanomaterials for charge storage due to the facilitated transport of both electrolyte ions and electrons, thus rendering them with a new record high supercapacitor performance. Wherein, the as-synthesized triple-shelled Mn2O3 hollow microspheres with thin porous shells show an extremely high specific capacitance up to 1651 F/g at a current density of 0.5 A/g, and remarkable cycling stability with 92% retention after 2000 consecutive cycles. Besides, the rate capability is also impressive, showing a specific capacitance as high as 1422 F/g at a high current density of 10 A/g.

关键词： pH-regulated,manganese oxide,multi-shelled hollow microspheres,supercapacitor

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Multi-compartment Microcapsules Prepared by Post-Healing of Porous Microspheres

Multi-compartment Microcapsules Prepared by Post-Healing of ...

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第七届中日化工学术研讨会

作者： Xiangming Na Weiqing Zhou Guanghui Ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of Science

The micr W1 d micr emu from swel micr treat wrin twosuch relea water-in-oilospheres. ho droplets expa rospheres can ulsion ripenin m the externa lling or inf rocapsules fr tment the sur nkled surface-step emulsif h as the shear ase during the-in-water dou oneycomb-lik anding and bu n be adjusted g. Core mate al water phase frared irradi om different rface of micr would appea fication, the r destruction,e emulsificati uble emulsio ke or one-hol ursting out w d by the evol erials, such as e. Then, the iation to fo t routes exhib rocapsules w ar. Compared proposed po solvent eros ion. on method w e morpholog when oil phase lution of doub s proteins or l pores in the orm closed bited very di as relatively d with traditio st-healing ap ion to delica as applied to gy of microsp e transforms ble emulsion latex particles surface could microcapsu ifferent surfa smooth, wh onal encapsul proach could ate core mater o prepare ma pheres would into solid. Th n, and we cal s, could be lo d heal up trig ules. Irradiat ace appearanc hile after infr lations which d overcome rials, or even acroporous P be obtained he morpholog ll this behavi oaded by diffu ggered by so tion. Self-he ces. After so rared irradiati h are based o some drawb n their unexpe ELA with gy of ior as usion olvent ealed olvent ion a n the acks, ected

关键词： double emulsion Macroporous microsphere Drug encapsulation Post-healing

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Preparation and morphology control of double emulsion templated macroporous microspheres

Preparation and morphology control of double emulsion templa...

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The 5th Asian Symposium on Emulsion Polymerization and Functional Polymeric Microspheres

作者： Xiangming Na Weiqing Zhou Guanghui Ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of Science

The water-in-oil-in-water(W1/O/W2) double emulsion method was applied to prepare macroporous PELA microspheres. honeycomb-like or one-hole morphology would be obtained with W1 droplets expanding and bursting out when oil phase transforms into solid. The morphology of microspheres can be adjusted by the evolution of double emulsion. Core materials, such as proteins or latex particles, could be loaded by diffusion from the external water phase. Then, the pores in the surface could heal up triggered by solvent swelling or infrared irradiation to form closed microcapsules. Compared with traditional encapsulations which are based on the two-step emulsification, the proposed post-healing approach could overcome some drawbacks, such as the shear destruction, solvent erosion to delicate core materials, or even their unexpected release during the emulsification. Besides post-healing approach, These interconnecting macroporous microspheres can be achieved by high-strength polymer materials such as P(MMA-MAA) and P(MMA-GMA), and be utilized to separate and purify large-size protein. We hope these double emulsion templated macroporous microspheres can satisfy the requirements of various applications such as cell culture,tissue engineering, chromatography purification, and drug controlled release.

关键词： W/O/W double emulsion Macroporous microsphere Drug encapsulation Protein purification

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Enhanced saccharification of lignocellulosic biomass with1-allyl-3-methylimidazolium chloride(Amim Cl) pretreatment

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Chinese Chemical Letters 2014年第11期25卷 1485-1488页

作者： Jian-Fei Liu Yan Cao Mao-Hua Yang Xue-Jing Wang Hui-Quan Li Jian-Min Xing National Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Key Laboratory of Green Process Engineering Institute of Process Engineering Chinese Academy of Sciences

A simple and efficient method of enhancing biomass saccharification by microwave-assisted pretreatment with dimethyl sulfoxide/1-allyl-3-methylimidazolium chloride is proposed. Softwood（pine wood（PW））, hardwoods（poplar wood, catalpa bungi, and Chinese parasol）, and agricultural wastes（rice straw, wheat straw, and corn stover（CS）） were exploited. Results showed that the best pretreatment effect was in PW with 54.3% and 31.7% dissolution and extraction ratios, respectively. The crystal form of cellulose in PW extract transformed from I to II, and the contended cellulose ratio and glucose conversion ratio reached 85.1% and 85.4%, respectively. CS after steam explosion achieved a similar pretreating effect as PW, with its cellulose hydrolysis ratio reaching as high as 91.5% after IL pretreatment.

关键词： Ionic liquid Lignocellulosic biomass Pretreatment Saccharification

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Insights into cellulose dissolving in ionic liquids by molecular simulation

Insights into cellulose dissolving in ionic liquids by molec...

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Innovations of green process engineering for Sustainable Energy and Environment 2015 - Topical Conference at the 2015 AIChE Annual Meeting

作者： Liu, Xiaomin Li, Yao Zhao, Yuling Wang, Jianji Zhang, Suojiang State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing100190 China Key Laboratory of Green Chemical Media and Reactions Ministry of Education School of Chemistry and Environmental Science Henan Normal University Xinxiang Henan453007 China

ISBN: (纸本)9781510818521

Ionic liquids (ILs) have been used in an enormous number of chemical and biological processes. In recent years, great progress has been made in the dissolution of cellulose with ILs. However, the mechanism of cellulose dissolution has not been clearly understood. [1,2] Molecular simulations were performed to investigate the effects of cation and anion structures on cellulose dissolution in ILs. It was found that the presence of electron-withdrawing group in alkyl chain of the cation enhanced the interaction between the cation and cellulose by comparing the interaction energy between [Amim]+ and [C3mim]+ with cellulose.[3] Effects of anionic structure on the dissolution of cellulose in ILs revealed that hydrogen bonds (HBs) were formed between anions of the ILs and hydroxyl protons of cellulose. we also investigated the effects of electronegativity of HB acceptor atoms, steric effect of alkyl chain length and electron-withdrawing group of the anions on their HB acceptor ability. [4] Furthermore, molecular simulations were performed to depict the cosolvent effect of cellulose dissolution in imidazolium-based ILs. DMSO partially breaks down the ionic association of [C4mim][CH3COO] by solvation of the cation and anion, but no preferential solvation was observed. The dissociated anions would readily interact with cellulose to improve the dissolution of cellulose. [5] Besides, the spontaneous dissolution process was investigated through all-atom molecular dynamics simulations of cellulose bunche in EmimAc and EmimCl within 0.5∼2μs. Synergistic effect of cations and anions was revealed by analysing the whole dissolving process in EmimAc. Initially, cations bind to the side face of cellulose bunch and anions insert into the cellulose strands to form HBs with hydroxyl groups. Then cations start to intercalate into cellulose chains due to their strong electrostatic interaction with the anions.

关键词： Cellulose

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Comparison of Mg^(2+)- and Ca^(2+)-enhancing anaerobic granulation in an expanded granular sludge-bed reactor

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Science China Chemistry 2014年第11期57卷 1596-1601页

作者： CAO XiaoLei SHENG YuXing CAO HongBin ZHANG Yi National Key Laboratory of Biochemical Engineering and Key Laboratory of Green Process and Engineering Institute of Process Engineering Chinese Academy of Sciences National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology Graduate University of Chinese Academy of Sciences

The mechanisms responsible for the fast granulation of anaerobic sludge caused by Mg2+ and Ca2+ addition was examined in four lab-scale expanded granular sludge bed(EGSB) reactors. Results indicated that both Mg2+ and Ca2+ accelerated the sludge-granulation process and increased the amount of polysaccharides and proteins in the sludge. Energy dispersive x-ray spectrometry(EDX) analysis revealed that, in a mature granule, both Mg2+ and Ca2+ composed as phosphate and calcium was distributed primarily in the periphery of the granule, while magnesium distributed mainly in the interior. The addition of Mg2+ was more favorable for the nuclei formation, whereas the addition of Ca2+ was more favorable for subgranule growth and maintaining the granules' rigid structure. Results showed that the addition of Mg2+ in the nuclei formation stage and Ca2+ in the granule-growth stage accelerated granulation more than adding only one of them in the granulation process.

关键词： anaerobic granulation Ca2＋ augmentation EPS Mg2＋ augmentation

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Double sensitive microspheres preparation and application in enzyme immobilization

Double sensitive microspheres preparation and application in...

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The 5th Asian Symposium on Emulsion Polymerization and Functional Polymeric Microspheres

作者： Y.X.Wang E.P.Lai G.H.Ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of Sciences State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University

P(NIPAM-co-AA), as double sensitive hydrogel, can be widely applied in a variety of fields such as chemical engineering, medicine, pharmacy and life sciences [1]. Long and disaccord response-time of the block hydrogel or the small size microspheres limit their widely application. Therefore, it is necesarry to prepare small and uniform sized microspheres to realize fast and consistent response.

关键词： Membrane emulsification Temperature-pH sensitive enzyme immobilization

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