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The potential of ionic liquids in biopharmaceutical engineering

Chinese Journal of Chemical engineering 2021年第2期34卷 236-243页

作者： Xuan Lin Zhiguo Su Yanli Yang Songping Zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Biopharmaceuticals,such as proteins,peptides,nucleic acids and vaccines,bring about great hopes for the prevention and treatment of various diseases,but the industrialization of these products still faces challenges such as structural instability,inefficient bioactivity and low *** liquids(ILs),the marvelous solvent media with inimitable and tunable properties,may provide alternative solutions to overcome the above problems of biopharmaceutical *** has gradually been made through studies by combination of ILs with *** applications involved the stabilization,protection,and delivery of *** trends are being forwarded to using ILs in vaccines and nucleic acid ***,challenges remain on the toxicity and safety ***,the cost of adding ILs to the benefits of biopharmaceuticals need to be considered.

关键词： Ionic liquids Biopharmaceutical engineering Biomacromolecules Stabilization Vaccine Delivery

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Anti-fatigue activity and mechanism of crocetin loaded nanoliposome in acute exercise-treated mice

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Food Science and Human Wellness 2024年第6期13卷 3361-3370页

作者： Jian Nan Jinglei Li Haishan Wu Haoran Cheng Hyun Jin Park Qingsheng Zhao Liu Yang School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China Engineering Research Center of Bio-process Ministry of EducationHefei University of TechnologyHefei 230009China School of Life Sciences and Biotechnology Korea UniversitySeoul 02841South of Korea National Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Crocetin displays strong antioxidant,anti-inflammatory and anti-depression activity which is promising to relieve symptoms of *** a carotenoid,crocetin is difficult to dissolve in water and highly unstable against many environmental *** is used to encapsulate crocetin to improve its water *** the present study,the antifatigue activities and potential mechanism of crocetin loaded nanoliposome(CLN)was extensively *** potential antifatigue pathway of CLN was ***,impact of CLN on the gut microbiota structure was examined which contributes to its antifatigue *** significantly increases exhaustive swimming time of fatigue mice,decreases the blood contents of lactic,blood urea nitrogen(BUN)and malondialdehyde(MDA).At the same time,CLN improves the activity of glutathione peroxidase(GSH-Px)and succinate dehydrogenase(SDH)enzyme,attenuates the oxidant stress in *** activates the adenosine monophosphate-activated kinase(AMPK)/peroxisome proliferator-activated receptor gamma coactivator-1α(PGC-1α)signaling pathway of fatigue mice,increases the mRNA expression of ATP *** also increases mRNA expression of mitochondrial transcription factor A(TFAM)which promotes mitochondrial ***,CLN ameliorates the gut microbiota structure by increasing the abundance of genus such as Lactobacillus in fatigue *** summary,CLN exerts strong anti-fatigue properties by decreasing the oxidant stress and the contents of harmful metabolites,augmenting the production of ATP,and potentially ameliorating the gut microbiota structure.

关键词： Crocetin Nanoliposome Fatigue AMPK/PGC-1αpathway Gut microbiota

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Facile Surface engineering of NiCo_(2)O_(4) to Boost Propane Oxidation Activity

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China Petroleum processing & Petrochemical Technology 2024年第1期26卷 19-26页

作者： Yang Jialei Wang Fengyi Lei Yang Zhang Mingchao Sun Shiqiang Xu Wenfan Ke Jiaxiang Wu Haojie Li Xingyun Qi Jian Institute of Materials for Energy and Environment College of Materials Science and EngineeringQingdao UniversityQingdao 266071China School of Chemistry and Chemical Engineering Hubei Key Laboratory of Coal Conversion and New Carbon MaterialsWuhan University of Science and TechnologyWuhan 430081China Department of Burn and Plastic Surgery Qingdao Municipal Hospital Affiliated to Rehabilitation UniversityQingdao 266000China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Spinel oxide(NiCo_(2)O_(4))has demonstrated great potential to replace noble metal catalysts for the oxidation reaction of air *** further boost the oxidation ability of such catalysts,in this study,a facile surface-engineering strategy wherein NiCo_(2)O_(4) was treated with different alkali solvents was *** obtained catalyst(NiCo_(2)O_(4)-OH)showed a higher surface alkalinity and more surface defects compared to the pristine spinel oxide,including enhanced structural distortion as well as promoted oxygen *** propane oxidation ability of NiCo_(2)O_(4)-OH was greatly enhanced,with a propane conversion rate that was approximately 6.4 times higher than that of pristine NiCo_(2)O_(4) at a reaction temperature 193℃.This work sets a valuable paradigm for the surface modulation of spinel oxide via alkali treatment to ensure a high-performance oxidation catalyst.

关键词： NiCo_(2)O_(4) surface defects alkali treatment propane oxidation

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Volatolomics in Fritillarias and Their Identification by Orientation Controlled cMOF Thin Film Chemiresistors

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Chinese Journal of Chemistry 2025年第4期43卷 371-377页

作者： Lin-An Cao Yi-Qian Li Yun-Fei Huo Lu Sun Xiao-Qin Li Lu Chen Xue-Tong Yang Fang-Li Yuan Ming-Shui Yao Ningxia Key Laboratory of Green Catalytic Materials and Technology College of Chemistry and Chemical EngineeringNingxia Normal UniversityGuyuanNingxia 756000China state Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

As one of the famous traditional Chinese herbal medicines,Fritillariae Cirrhosae Bulbus(FCB)is widely used in the prevention and treatment of respiratory diseases and has the best curative effect among the known fritillarias *** to the variety,complex sources,similar appearance and shape,it is difficult to distinguish FCB with high curative effect(h-FCB)from other common fritillarias(c-FCB)in the *** this paper,a very simple chemiresistor is used to identify FCB from three commonly used fritillarias *** sensors are fabricated by anisotropic electrically conductive metal-organic framework(cMOF)thin film Cu_(3)(HHTP)_(2)(Cu-HHTP_([001])and Cu-HHTP_([100]))as active materials owing to their ability to detect specific groups of volatile organic compounds(volatolomics)as the functional motifs of *** a result,the sensors show orientation-dependence identification ability to ***-HHTP_([001])-based sensor shows the highest response(344.17%)to 0.5 g h-FCB powder volatiles among its three other c-FCB which is much higher than Cu-HHTP_([100])(135.50%).Ultimately,Cu-HHTP_([001])can realize the identification of FCB with an accuracy of 97.2% in a simple and real-time manner.

关键词： Volatolomics Anisotropic cMOF thin film Chemiresistor Traditional Chinese herbal medicines identification Matteridentification

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Microfluidic reactors for paired electrosynthesis:Fundamentals,applications and future prospects

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Green Energy & Environment 2025年第3期10卷 471-499页

作者： Hao Xue Zhi-Hao Zhao Menglei Yuan Guangjin Zhang Queen Mary University of London Engineering School Northwestern Polytechnical University710129Xi'anChina State Key Laboratory of Solidification Processing and School of Materials Science and Engineering Northwestern Polytechnical University710072Xi'anChina CAS Key Laboratory of Green Process Engineering Institute of Process EngineeringChinese Academy of Sciences100190BeijingChina Center of Materials Science and Optoelectronics Engineering University of ChineseAcademy of Sciences100049BeijingChina

Paired electrosynthesis has received considerable attention as a consequence of simultaneously synthesizing target products at both cathode and anode,whereas the related synthetic efficiency in batch reactors is still undesirable under certain ***,laminar microfluidic reactor offers prospective options that possess controllable flow characteristics such as enhanced mass transport,precise laminar flow control and the ability to expand production scale *** this comprehensive review,the underlying fundamentals of the paired electrosynthesis are initially summarized,followed by categorizing the paired electrosynthesis including parallel paired electrosynthesis,divergent paired electrosynthesis,convergent paired electrosynthesis,sequential paired electrosynthesis and linear paired ***,a holistic overview of microfluidic reactor equipment,integral fundamentals and research methodology as well as channel extension and scale-up strategies is *** established fundamentals and evaluated metrics further inspired the applications of microfluidic reactors in paired *** work stimulated the overwhelming investigation of mechanism discovery,material screening strategies,and device assemblies.

关键词： Paired electrosynthesis Microfluidic reactor Laminar flow Scaling-up strategy

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Self-assembly of nanoparticles at solid-liquid interface for electrochemical capacitors

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Rare Metals 2022年第11期41卷 3591-3611页

作者： Xue Li Chen Chen Qian Niu Nian-Wu Li Le Yu Bao Wang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China StateKey Lab of Organic-Inorganic Composites Beijing UniversityofChemicalTechnologyBeijing100029China

Self-assembly of nanoparticles at solid-liquid interface could be promising to realize the assembled functions for various applications,such as rechargeable batteries,supercapacitors,and *** review summarizes the self-assembly of the nanoparticles at solid-liquid interface according to the different driving forces of assembly,including hydrophilic-hydrophobic interactions,solvophobic and electrostatic *** be specific,the self-assembly can be divided into the following two types:surfactant-assisted self-assembly and direct self-assembly of Janus particles(inorganic and amphiphilic copolymer-inorganic Janus nanoparticles).Using the emulsion stabilized by nanoparticles as the template,the self-assembly constructed by the interaction of the nanostructure unit(including metal,metal oxide,and semiconductor,etc.)not only possesses the characteristic of nanostructure unit,but also exhibits the excellent assembly performance in electrochemistry *** application of these assemblies in the area of electrochemical capacitors is ***,the current research progress and perspectives toward the self-assembly of nanoparticles at stabilized solid-liquid interface are proposed.

关键词： Self-assembly Solid-liquid interface Driving force Electrochemical capacitors

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Smart antioxidant function enhancing(SAFE)nucleic acid therapy for ROS-related chronic diseases and comorbidities

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Bioactive Materials 2024年第1期31卷 509-524页

作者： Zhiguo Lu Ruichen Zhao Yi Li Jianze Wang Jing Guo Chaobo Bai Jing Chen Jun Yang Yiwan Geng Tianlu Zhang Yanyue Wu Xiyue Jiao Yining Wang Junliang Yuan Xin Zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190PR China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049PR China Department of Neurology Peking University Sixth HospitalPeking University Institute of Mental HealthBeijing100191PR China Department of Radiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730PR China Key Laboratory of Biopharmaceutical Preparation and Delivery Institute of Process EngineeringChinese Academy of SciencesBeijing100190PR China

Reactive oxygen species(ROS)-mediated oxidative stress exacerbates chronic diseases such as organ damage and neurodegenerative *** Keap1-Nrf2-ARE pathway is a widely distributed endogenous antioxidant ***,ROS under redox homeostasis regulates a wide range of life ***,smart scavenging of excess ROS under pathological conditions is essential to treat chronic diseases *** study reports a smart antioxidant function enhancement(SAFE)***-demand release of nucleic acid drugs in a pathological ROS environment smartly activates the endogenous antioxidant system,thereby smartly alleviating oxidative stress in an exogenous antioxidant-independent *** structural modulation and ligand modification,we develop SAFE nanoparticles based on nanohybrid complexes(SAFE-complex)adapted to brain delivery of nucleic acid ***-complex with homogeneous monodisperse structure efficiently treat ROS-related neurodegenerative diseases while protecting the major organ from oxidative stress ***,SAFE-complex can stabilize storage in the form of freeze-dried *** data indicate that SAFE nanoparticles hold promise for treating ROS-related chronic diseases and comorbidities through rational transformation.

关键词： Smart antioxidant function enhancing(SAFE)strategy Reactive oxygen species Nucleic acid drugs Keap1-Nrf2-ARE pathway ROS-Associated chronic diseases and comorbidities

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Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer’s disease-like mouse model

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Signal Transduction and Targeted Therapy 2023年第2期8卷 813-826页

作者： Xiao-ying Sun Xiao-lin Yu Jie Zhu Ling-jie Li Lun Zhang Ya-ru Huang Dong-qun Liu Mei Ji Xun Sun Ling-xiao Zhang Wei-wei Zhou Dongming Zhang Jianwei Jiao Rui-tian Liu State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemistry and Chemical Engineering University of Chinese Academy of ScienceBeijing 100049China Innovation Academy for Green Manufacture Institute Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China

Passive immunotherapy is one of the most promising interventions for Alzheimer’s disease(AD).However,almost all immune-modulating strategies fail in clinical trials with unclear causes although they attenuate neuropathology and cognitive deficits in AD animal ***,we showed that Aβ-targeting antibodies including their lgG1 and lgG4 subtypes induced microglial engulfment of neuronal synapses by activating CR3 or FcγRIIb via the complex of Aβ,antibody,and ***,anti-Aβantibodies without Fc fragment,or with blockage of CR3 or FcγRIIb,did not exert these adverse ***,Aβ-targeting antibodies,but not their Fab fragments,significantly induced acute microglial synapse removal and rapidly exacerbated cognitive deficits and neuroinflammation in APP/PS1 mice post-treatment,whereas the memory impairments in mice were gradually rescued *** the recovery rate of synapses in humans is much lower than that in mice,our findings may clarify the variances in the preclinical and clinical studies assessing AD ***,Aβ-targeting antibodies lack of Fc fragment,or with reduced Fc effector function,may not induce microglial synaptic pruning,providing a safer and more efficient therapeutic alternative for passive immunotherapy for AD.

关键词： Aβ Alzheimer inflammation

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Regulating Oxygen Vacancy Defects in Heterogeneous NiO-CeO_(2)−δ Hollow Multi-shelled Structure for Boosting Oxygen Evolution Reaction

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Chemical Research in Chinese Universities 2024年第3期40卷 475-483页

作者： WANG Huan GONG Guannan SUN Guohua QI Jian YU Ranbo WANG Dan Hebei Key Laboratory of Flexible Functionals Materials School of Materials Science and EngineeringHebei University of Science and TechnologyShijiazhuang 050000P.R.China Department of Physical Chemistry School of Metallurgical and Ecological EngineeringUniversity of Science&Technology BejingBeijing 100083P.R.China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China

CeO_(2) with excellent oxygen storage-exchange capacity and NiO with excellent surface activity were used to construct a heterogeneous NiO-CeO_(2)−δhollow multi-shelled structure(HoMS)by spray *** turned out that as the proportion of CeO_(2) increases,the overpotential and Tafel slope of NiO-CeO_(2)−δHoMSs first decreased and then *** is mainly because the construction of the NiO-CeO_(2)−δHoMSs not only increases the specific surface area,but also introduces oxygen vacancy defects,thus improving the interface charge transfer capability of the materials and further improving the oxygen evolution reaction(OER)***,the increase of the calcination temperature will induce the decay of the OER performance of NiO-CeO_(2)−δHoMSs,which is mainly due to the decrease of the specific surface area,the reduction of oxygen vacancy defects,and the weakening of interface charge transfer ***,a series of heterogeneous composite HoMSs,such as Ni/Co,Mo/Ni,Al/Ni and Fe/Ni oxides was successfully constructed by spray drying,which enriched the diversity of HoMSs.

关键词： Heterogeneous composite structure Hollow multishelled structure Oxygen vacancy defect Oxygen evolution reaction

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Thermal decomposition mechanism and particle size regulation in calcination of barium titanyl oxalate tetrahydrate for fabricating barium titanate nanoparticles

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Particuology 2025年第3期98卷 94-104页

作者： Yunfei Yan Haixia Zhang Junrong Yue Yu Guan Lei Shao State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Research Center of the Ministry of Education for High Gravity Engineering and Technology College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing100029China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Barium titanate(BaTiO_(3))is an important ferroelectric and electronic ceramic material because of its outstanding dielectric and ferroelectric *** demand for BaTiO_(3) nanoparticles with adjustable particle size has increased extensively due to the miniaturization of electronic *** oxalate precipitation method is regarded as a highly attractive technology for fabricating BaTiO_(3) nanoparticles,as it enables large-scale production at a low ***,the calcination process is a crucial step that significantly influences the particle size and morphology of the obtained BaTiO_(3) *** study investigates the thermal decomposition mechanism and particle size regulation strategies during the calcination of barium titanyl oxalate tetrahydrate(BTOT)for fabricating BaTiO_(3) *** Kissinger-Akahira-Sunose(KAS)model is used to calculate the kinetic parameters of BTOT thermal decomposition process,and the results indicate that the decomposition process can be divided as four stages,with the average activation energy of 60.77,269.89,484.72,and 199.82 kJ/mol,*** average activation energy reaches its maximum value in the third stage,indicating that the thermal decomposition reaction in this stage is more challenging to occur compared to the other *** gas release behaviors of H_(2)O,CO,and CO_(2) are analyzed on-line during the thermal decomposition of BTOT,and the overall reaction mechanism is ***,by adjusting the calcination parameters,the particle size of BaTiO_(3) could be effectively regulated within the range of 25-120 *** the heating rate from 10 to 40 K/min decreases the average particle size of BaTiO_(3) from 62 to 44 *** the calcination time from 0 to 120 min increases the average particle size from 25 to 71 *** the terminal temperature from 1173 to 1273 K significantly increases the average particle size from 56 to 120 ***,accelerating the heating rat

关键词： BaTiO_(3) Barium titanyl oxalate tetrahydrate Thermal decomposition Activation energy

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