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Ionic-microenvironment stabilizes the disulfide engineered lysine decarboxylase for efficient cadaverine production

Green Chemical engineering 2023年第2期4卷 224-232页

作者： Zhuang Li Yaju Xue Xiuling Ji Yuhong Huang Beijing Key Laboratory of Ionic Liquids Clean Process CAS Key Laboratory of Green Process and EngineeringState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing100190China Zhengzhou Institute of Emerging Industrial Technology Zhengzhou450000China Zhongke Langfang Institute of Process Engineering Langfang065001China

Cadaverine is the key monomer for the synthesis of nylon *** and alkaline stable lysine decarboxylases are highly desirable for cadaverine production as the reaction pH increasing from 6.3 to ***,the most studied lysine decarboxylase CadA(***)lost almost all activity at pH 8.0,which is the foremost challenge for the industrial-cadaverine *** this study,we first found that the Na^(+)-microenvironment significantly improved the alkaline stability of the disulfide engineered lysine decarboxylaseΔLdcEt3(P233C/L628C)(half-life 362 h),compared to the conventional buffer(half-life 0.66 h)at pH ***,the whole-cell conversion efficiency of the industrial-grade L-lysine withΔLdcEt3 could reach up to 99%in 2 h in the ***-mental investigation and molecular dynamics confirmed that Na^(+)-microenvironment could improve active-aggregation state and affect secondary structure ofΔ***,Na^(+)-microenvironment stabilizesΔLdcEt3 providing a great potential industrial application for high-level cadaverine production.

关键词： Na^(+)-microenvironment Lysine decarboxylase ΔLdcEt3 Alkaline stability Cadaverine

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ZnO HoMS@ZIF-8 Nanoreactors for Efficient Enrichment and Photoreduction of Atmospheric CO_(2)

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CCS Chemistry 2024年第12期6卷 3065-3076页

作者： Yanze Wei Juan Li Decai Zhao Yasong Zhao Qinghua Zhang Lin Gu Jiawei Wan Dan Wang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190 Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049 Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190

The ultimate goal of photocatalytic CO_(2)reduction is to efficiently convert atmospheric CO_(2)into value-added products by designing hierarchical photocatalysts that combine effective harvesting and accelerate activation capabilities of CO_(2)*** this work,we demonstrated direct air-level CO_(2)reduction by hollow multishell structure(HoMS)nanoreactors with zeolitic imidazolate framework-8(ZIF-8)-modified ZnO heteroshells,which offers a promising solution to optimize the mass transfer process via selective sieving and effective enrichment of CO_(2)molecules from the atmospheric ***,heteroshells with ZIF-8 matrix act as pumps that effectively capture CO_(2)molecules,while the cavities serve as tanks to hold these molecules,thus significantly enhancing the transfer kinetics for CO_(2)*** periodic shell-cavity configuration allows the nanoreactor to effectively gather CO_(2)molecules near the catalytic sites,thus increasing conversion opportunities for activated ***,the surface atomic steps on the ZnO/ZIF-8 heterointerfaces with staggered geometry expedite charge transfer and adsorption efficiency,which synergistically boosts the CO_(2)-CO yield up to 3.7μmol/h under CO_(2)flow and 0.7μmol/h under atmospheric conditions with almost complete CO ***,the HoMS nanoreactors offer a potential strategy for solving the“last mile”challenge in practical CO_(2)valorization.

关键词： hollow multishelled structures atmospheric CO_(2)photoreduction ZnO ZIF-8 heterointerface

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Optimization of decoupling combustion characteristics of coal briquettes and biomass pellets in household stoves

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Chinese Journal of Chemical engineering 2023年第7期59卷 182-192页

作者： Jian Han Xinhua Liu Shanwei Hu Nan Zhang Jingjing Wang Bin Liang State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Burning coal briquettes or biomass pellets in household decoupling stoves is of significance to the reduction of residential pollutant emissions such as NO and CO. In order to make full use of the superiority of decoupling combustion technology, the household stoves should be specially designed and optimized to adapt to fuel types and combustion characteristics. Using numerical simulation and experimental validation, this study quantitatively clarified that the reducibility of devolatilization char plays an important role in the suppression of NO emission in the decoupling combustion of coal, while the reducibility of pyrolysis gases has a dominant effect on the reduction of NO in the decoupling combustion of biomass. An optimal parameter combination of throat height and grate angle was obtained for the simultaneous suppression of NO and CO emissions in the household decoupling stove burning coal briquettes. Two types of decoupling stoves were developed to enable the clean combustion of biomass pellets. The A-type biomass stove with a multi-pass smoke tunnel shows a better comprehensive NO and CO reduction effectiveness than the B-type biomass stove consisting of a two-stage grate structure and an S-shaped pyrolysis chamber. The optimal structural parameters provided references for the design and manufacture of commercial decoupling coal and biomass stoves.

关键词： Decoupling combustion Coal Biomass Numerical simulation Nitrogen oxide Carbon monoxide

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RSscore:Reaction superiority learned from reaction mapping hypergraph

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Chinese Journal of Chemical engineering 2024年第10期74卷 203-215页

作者： Chenyang Xu Lijuan Guo Kang Zhou Hai Yu Chaoliang Wei Fengqi Fan Lei Zhang State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringInstitute of Chemical Process Systems EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China PetroChina Lanzhou Lubricating Oil Research&Development Institute Lanzhou 730060China

The selection of chemical reactions is directly related to the quality of synthesis pathways,so a reasonable reaction evaluation metric plays a crucial role in the design and planning of synthesis *** reaction conditions also need to be considered in synthesis pathway design,a reaction metric that combines reaction time,temperature,and yield is required for chemical reactions of different reaction *** this study,a chemical reaction graph descriptor which includes the atom-atom mapping relationship is proposed to effectively describe ***,through pre-training using graph contrastive learning and fine-tuning through supervised learning,we establish a model for generating the probability of reaction superiority(RSscore).Finally,to validate the effectiveness of the current evaluation index,RSscore is applied in two applications,namely reaction evaluation and synthesis routes analysis,which proves that the RSscore provides an important agents-considered evaluation criterion for computer-aided synthesis planning(CASP).

关键词： Computer-aided synthesis planning Neural networks Reaction evaluation indicator Reaction graph Graph contractive learning

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Dynamic apertures with diffusion-regulatory functionality in soft porous crystals:A key to solving the century puzzle on isotopologues separation

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Nano Research 2023年第2期16卷 3254-3255页

作者： Yanhong Li Jianze Xiao Yangyang Guo Ning Han Fangli Yuan Yunfa Chen Ming-Shui Yao State Key Laboratory of Multi-phase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringInnovation Academy for Green ManufactureChinese Academy of SciencesBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100049China Key Laboratory of Science and Technology on Particle Materials Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

The separation of water isotopologues has been a“century-old”challenge,also known as“the Holy Grail”in separation *** water(D2O)is a stable non-radioactive water isotopologue that plays a critical role in scientific research,military,nuclear energy,and medical *** water was first reported in 1931 when *** discovered D2 and D2O,for which he was awarded the Nobel Prize in Chemistry in *** in 1933,*** et *** 0.5μL of heavy water at a concentration of around 65.7%when electrolyzing 10 liters of *** 1935,the world's first heavy water plant was built in Norway,producing 2 tons of heavy water by electrolysis,but the separation factor was merely 1.05,which was extremely *** 1943,the first heavy water plant employing the distillation method was built in the United states.

关键词： separation porous distillation

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Effect of high stirring speed on the agglomerate behaviors for cohesive SiO_(2) powders in gas fluidization

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Particuology 2023年第9期80卷 192-201页

作者： Fan Liu Zhan Du Qingshan Zhu Xiaojun Guo Hebang Shi Pengpeng Lv Hongzhong Li School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChina Academy of SciencesBeijing100190China

The effects of superficial gas velocity and mechanical stirring speed on the precise regulation of flow regimes for cohesive SiO2 powders(mean diameter is 16μm)were experimentally investigated in a stirring-assisted fluidized *** results showed that compared with the agglomerates formed in the non-assisted fluidization of cohesive SiO2 powders,the introduction of mechanical stirring could effectively reduce the size of agglomerates and well disperse the agglomerates during *** best regulation range of agglomerate particulate fluidization can be achieved at 600 rpm when agglomerate sizes were reduced to below 200μ*** investigation based on the operational phase diagram revealed that transformations of flow regimes were dominated by both stirring speed and gas *** stirring applied enlarges the operational range of agglomerate particulate fluidization(APF)with a delayed onset of bubbling for cohesive ***,the exorbitant speed increases the collision velocity and contact area between small agglomerates,which results in the formation of unstable agglomerates and the whirlpool of powder.

关键词： Cohesive powders Stirring-assisted fluidized bed Agglomerate size Agglomerate particulate fluidization

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Ionic liquids inhibit the dynamic transition fromα-helices toβ-sheets in peptides

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Fundamental Research 2024年第4期4卷 777-784页

作者： Ju Liu Yanlei Wang Feng Huo Hongyan He Beijing Key Laboratory of Ionic Liquids Clean Process State Key Laboratory of Mesoscience and EngineeringCAS Key Laboratory of Green Process and EngineeringInstituteof Process EngineeringChineseAcademyof SciencesBeijing100190China Longzihu New Energy Laboratory Zhengzhou Institute of Emerging Industrial TechnologyHenan UniversityZhengzhou 450000China University of Chinese Academyof Sciences Beijing100049China

Abnormalities in the transition betweenα-helices andβ-sheets(α-βtransition)may lead to devastating neurodegenerative diseases,such as Parkinson's syndrome and Alzheimer's *** liquids(ILs)are potential drugs for targeted therapies against these diseases because of their excellent bioactivity and designability of ***,the mechanism through which ILs regulate the aα-βtransition remains ***,a combination of GPU-accelerated microsecond molecular dynamics simulations,correlation analysis,and machine learning was used to probe the dynamicalα-βtransition process induced by ILs of 1-alkyl-3-methylimidazolium chloride([C_(n)mim]cl)and its molecular ***,the cation of [C_(n)mim]+in ILs can spontaneously insert into the peptides as free ions(n≤10)and clusters(n≥11).Such insertion can significantly inhibit theα-β,transition and the inhibiting ability for the clusters is more significant than that of free ions,where[Ciomim]+and[C_(12)mim]+can reduce the maximumβ-sheet content of the peptide by 18.5% and 44.9%,***,the correlation analysis and machine learning method were used to develop a predictive model accounting for the influencing factors on theα-βtransition,which could accurately predict the effect of ILs on theα-β***,these quantitative results may not only deepen the understanding of the role of ILs in theα-βtransition but also guide the development of the IL-based treatments for related diseases.

关键词： α-βtransition Moleculardynamics simulation lonic liquids Machine learning Membrane channel protein

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Enhanced population of excited single state strategy:Irradiation and ultrasound dual-response and host tumor-driven nanosensitizers construction in triple synergistic therapy

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Nano Research 2024年第6期17卷 5501-5511页

作者： Yaning Li Mengyan Tian Tianyue Yang Jiayu Cao Hongli Chen Jun Guo Pai Liu Yi Liu State Key Laboratory of Separation Membranes and Membrane Processes School of Materials Science and EngineeringTiangong UniversityTianjin 300387China State Key Laboratory of Separation Membranes and Membrane Processes School of ChemistryTiangong UniversityTianjin 300387China State Key Laboratory of Separation Membranes and Membrane Processes School of Life ScienceTiangong UniversityTianjin 300387China State Key Laboratory of Separation Membrane and Membrane Process&Tianjin Key Laboratory of Green Chemical Technology and Process Engineering School of ChemistryTiangong UniversityTianjin 300387China School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China Cangzhou Institute of Tiangong University Cangzhou 061000China

Phototheranostics is an emerging field in synergistic antitumor therapy in which irradiation and sensitizers are combined to produce reactive oxygen species(ROS),bio-images,and high *** of these are arrived from the energy of sensitizers,which located in excited single state(S_(1)).Undeniably,the decentralization of the S_(1)population indirectly decreases the effect of each individual *** this study,a strategy was proposed for enhancing the S_(1)population,and a sensitizer with mitochondrial targeting property,1,4-indolyl iodinated pyrrolo[3,2-b]pyrrole derivative(2I-TPIS),was assembled into adenosine triphosphate(ATP)-responsive nanoparticles(DPA-2I NPs)to achieve dual responses to irradiation and ultrasonication(US)for application to photo-sonodynamic therapy(PSDT).Compared with monotherapies,2I-TPIS generated more ROS in PSDT,inducing mitochondrial autophagy and apoptosis,which in turn triggered immunogenic cell death(ICD).Subsequently,DPA-2I NPs were constructed and self-assembled with the chemotherapeutic agents DPA-Cd and 2I-TPIS to achieve a triple synergistic strategy involving chemotherapy(CT)and ***-2I NPs exhibited absolute sensitization,intra-tumoral overexpression of ATP,and ***,the biosafety and potent antitumor efficiency of the DPA-2I NP-based“PSDT+CT”therapy were revealed using a 4T1 tumor *** study results provide insights into the design of sensitizers possessing a sufficient S_(1)population and a highly efficient tumor ablation capacity derived from molecular structural modulation,further enabling triple synergistic antitumor therapies,and expanding the clinical application of sensitizers.

关键词： triphosphate(ATP)-activated nano-sensitizers photo-sonodynamic therapy aggregation-induced emission enhanced excited state population

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Theoretical study on the stability of nanobubbles and its verification in molecular dynamics simulation

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Particuology 2024年第4期87卷 99-105页

作者： Sheng Mi Chaofeng Hou Wei Ge School of Chemical Engineering and Technology Tianjin UniversityTianjin300072China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing.100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

The stability of vapor nanobubbles in bulk liquid was investigated theoretically and the critical bubble size was derived from macroscale thermodynamic equations,below which the system destabilizes with sharp drop in *** critical size was quantitatively verified in molecular dynamic simulation using the Lennard-Jones model of argon,where stronger attraction between the molecules at lower density is found to contribute most to the drop of system pressure and,as the Laplace pressure on the curved bubble interface fails to balance the pressure difference across the interface,the bubbles become *** theoretical model could be extended to other systems where reliable equations of state and interfacial tension are available.

关键词： Nanobubble Stability Phase diagram Critical size

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Research Progress of Artificial Vertebral Body and Interbody Fusion Cage 1

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14th China Academic Conference on Printing and Packaging, CACPP 2023

作者： Yang, Zongwen Hu, Kun Li, Peng Xu, Xiangqian School of Printing and Packaging Engineering Beijing Institute of Graphic Communication Beijing102600 China State Key Laboratory of Biochemical Engineering Institute of Process Engineering CAS Beijing China Biotechnology CO. Ltd Fujian China

ISBN: (数字)9789819999552

ISBN: (纸本)9789819999545

The objective is to review the latest research on artificial vertebral body and interbody fusion cage and their application in spinal surgery. For the treatment of vertebral diseases such as spinal tumors and myelopathic cervical spondylosis, procedures like en bloc tumor resection and intervertebral disc excision with bone fusion are primarily employed. Following tumor resection surgery, it becomes necessary to reconstruct the deficient vertebral segments or intervertebral discs. In clinical practice, materials such as titanium alloys, PEEK, and ceramics are commonly used to manufacture artificial vertebral bodies and interbody fusion cage for vertebral reconstruction. Currently, the use of 3D printing for fabricating implantable metal medical devices, including 3D-printed titanium alloy or PEEK vertebral implants and interbody fusion cage, is gradually gaining prominence. This article reviews the latest research on artificial vertebral bodies and intervertebral fusion devices in recent years. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd 2024.

关键词： Titanium alloys

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