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Delivery systems for theranostics in neurodegenerative diseases

Nano Research 2018年第10期11卷 5535-5555页

作者： Yan Li Ruiyuan Liu Weihong Ji Yanhui Li Linying Liu Xin Zhang State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Neurodegenerative diseases are characterized by progressive nervous system dysfunction, which affects over 90,000 people every year. Although numerous contrast agents and therapeutic drugs are available for the diagnosis and therapy of neurodegenerative diseases, there are several limitations to their application. Particularly, these contrast agents and drugs are restricted from entering into the brain because of the blood-brain barrier, which represents a major bottleneck to efficacious and safe theranostics of neurodegenerative diseases. Nanoparticles can offer impressive improvement in the theranostics of neurodegenerative diseases, as they can effectively deliver contrast agents and drugs to target sites in the central nervous system. In this review, we describe various delivery systems, including lipid nanoparticles, polymeric nanoparticles, inorganic nanoparticles, and exosomes useful for the theranostics of neurodegenerative diseases. Finally, we outline current challenges and our perspectives on the development of delivery systems for theranostics of neurodegenerative diseases.

关键词： neurodegenerative diseases theranostics blood-brain barrier delivery systems

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Enzymatic hydrolysis of cellulose materials treated with ionic liquid [BMIM] Cl

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Chinese Science Bulletin 2006年第20期51卷 2432-2436页

作者： LIU Liying CHEN Hongzhang State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100080 China

A new cellulose solvent ionic liquid 1-butyl-3-methylimidazolium chloride ([BMIM]Cl) was used to treat wheat straw and steam-exploded wheat straw (SEWS) in order to improve the enzymatic hy- drolysis rates, while the water was used as the con- trol. The enzymatic hydrolysis results showed that the hydrolysis rates of materials treated with [BMIM]Cl were improved. The hydrolysis rate of treated wheat straw could reach 70.37% and the SEWS could be completely hydrolyzed, while hydrolysis rates of the wheat straw and SEWS treated with water were 42.78% and 68.78% under the same conditions, re- spectively. The FTIR analysis and polymerization degree measurement indicated that the hydrolysis rates improvement was attributed to the decrease of the polymerization degrees of cellulose and hemi- cellulose, the absolute crystallinity degree of cellu- lose and the increase of its reaction accessibility.

关键词：纤维素材料离子性液体丁基氯化物酶水解 FTIR 生化工程

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Facile one-pot emulsion/sol-gel method for preparing wrinkled silica microspheres

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Particuology 2021年第3期19卷 33-42页

作者： Yuning Hu Dongxia Hao Fangling Gong Yuanyuan Gao Xingran Yan Guanghui Ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of ScienceBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China

The present manuscript describes a facile and versatile method for preparing uniform wrinkled silica microspheres with diameters of tens of *** method comprises a one-pot emulsion/sol-gel method using silica precursors of organosilane and *** controlling the sol-to-gel transition of the silica precursors,a series of silica microspheres based on uniform emulsion droplets was synthesized by membrane *** silica microspheres had a variety of surface morphologies ranging from smooth,maze-like wrinkles to polygon-like *** was possible to alter the surface morphologies of the microspheres by controlling the amount of organosilane in the dispersed phase and the amount of ammonia catalyst in the continuous phase of the *** grooves on the wrinkled microspheres were able to trap polymer nanoparticles of matching size,thereby demonstrating the potential usefulness of the microspheres in separation science and drug delivery.

关键词： Wrinkled silica microsphere Membrane emulsification Emulsion/sol-gel method

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Preparation of double-emulsion-templated microspheres with controllable porous structures by premix membrane emulsification

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Particuology 2019年第3期17卷 22-27页

作者： Xiangming Na Weiqing Zhou Tong Li Ding Hong Juan Li Guanghui Ma State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

A scalable and versatile strategy was developed for the fabrication of uniform polymeric microspheres with controllable interconnected porous structures. Uniform water-in-oil-in-water emulsions with linear poly(methyl methacrylate-glycidyl methacrylate) in the oil phase were generated by two-step premix membrane emulsification and used for constructing the microspheres. During the emulsion solidification process, internal water droplets were packed densely together, forming a thin oil film between the internal and external water phases. After solvent diffusion, the thin film can be ruptured and pores can be templated from the internal water droplets to form interconnected porous structures. Membranes with various pore sizes were obtained. The osmotic pressure and Laplace pressure balance were used to control the porosity and pore size precisely. The proposed method enables the fabrication of functional polymeric microspheres with uniform and controllable porous structures and particle sizes. This improves their performance and broadens the scope of their applications, especially in chromatographic separation.

关键词： Double emulsion Membrane emulsification Porous microsphere Uniform structure

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Apoferritin nanoparticle based dual-antigen influenza conjugate vaccine with potential cross-protective efficacy against heterosubtypic influenza virus

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Particuology 2022年第5期20卷 56-64页

作者： Yanan Sheng Jiangxue Wei Zhengjun Li Zhiguo Su Guanghui Ma Songping Zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Ferritin nanoparticles with self-assembling properties have been widely explored as vaccine carrier by displaying foreign antigens through genetic fusion *** the present work,an apoferritin(AFt)nanoparticle was tested as influenza vaccine carrier by chemically conjugating a matrix protein 2 ectodomain(M2e)antigen peptide or/and the full-length hemagglutinin(HA)antigen on the outer surface of the AFt,with heterobifunctional sSMCC or SM(PEG)_(24) containing PEG chain as *** each AFt nanoparticle,about 30-32 M2e or 1.8 HA antigen could be *** AFt-(PEG)24-M2e,in which the M2e was coupled through SM(PEG)_(24) containing PEG chain,conferred higher protective efficacy in immunized mice than AFt-M2e did,but was less effective than AFt-(PEG)_(24)-*** both M2e and HA were coupled,the synthesized dual-antigen vaccine candidate AFt-(PEG)_(24)-M2e/HA elicited high level of M2e and HA antigen-specific antibodies and conferred 100%protection against lethal infection of homologous PR8 HI N1 virus strain and 70%protection against a heterologous A/FM/1/47(FM1,H1N1)strain,which was more effective than the M2e or HA single antigen vaccine *** potential cross-protective effect of the dual-antigen vaccine was further demonstrated by significant specific hemagglutination inhibition(HAI)titers in serum of the immunized mice against three other heterologous viral strains including A/Singapore/GPl908/2015(IVR-180)H1N1,A/Anhui/1/2005 H5N1,and A/Hong Kong H3N2.

关键词： Influenza vaccine Apoferritin nanoparticle Hemagglutinin M2e Conjugate vaccine

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The development of hollow multishelled structure: from the innovation of synthetic method to the discovery of new characteristics

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Science China Chemistry 2022年第1期65卷 7-19页

作者： Jiangyan Wang Zumin Wang Dan Mao Dan Wang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Hollow multishelled structure(HoMS)is one of the most promising multifunctional *** high complexity of its structure makes the general and controllable synthesis of HoMS rather *** integration of multidisciplinary knowledge,a great achievement in HoMSs has been obtained in the past ***,the developed sequential templating approach has significantly boomed the progress of HoMS in composition and structure diversity and application *** implementation of the temporal-spatial ordering in HoMS makes it indispensable in solving the key scientific problems in energy conversion,catalysis and drug delivery *** development in HoMSs with novel intricate structures will bring new *** this review,we systematically introduce the development history of HoMSs,summarize the inspiration inherited from the previous research on hollow structures,and discuss the milestones in the development of HoMSs,with a focus on the sequential templating approach for HoMS fabrication,attractive temporal-spatial ordering property and dynamic smart behavior for advanced *** hope to reveal the inherent relationship between the precise synthesis of HoMS and its highly tunable compositional and structural characteristics,and point out its future direction to boost HoMS area further.

关键词： hollow multishelled structure sequential templating approach temporal-spatial ordering smart dynamic behavior

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Mesenchymal Stem Cells Proliferation on Konjac Glucomannan Microcarriers:Effect of Rigidity

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Chinese Journal of Polymer Science 2022年第9期40卷 1080-1089页

作者： Xing-Ran Yan Juan Li Xiang-Ming Na Tong Li Yu-Fei Xia Wei-Qing Zhou Guang-Hui Ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Mesenchymal stem cells(MSCs)have attracted great attention as a source of cells for regenerative medicine owing to their self-renewal ability and multiple differentiation ***,the serious shortage of MSCs and the difficulty of maintaining the differentiation potential during culture in vitro limit their *** culture technology is an effective method to realize large-scale culture of MSCs,whereas the effect of microcarriers properties on MSCs proliferation and differentiation potential maintenance should be *** this study,Konjac glucomannan(KGM)microcarriers with a wide range of rigidity from 0.2 MPa to 10 MPa were prepared using water-in-oil emulsion *** was found that the microcarriers rigidity had great influence on MSCs by regulating cell spreading *** proliferation and good differentiation potential maintenance of MSCs were achieved on the intermediate rigidity about 2.51±0.65 MPa with the faster spreading rate of *** a result,MSCs on 2.51±0.65 MPa KGM microcarriers proliferated about 27 times,which was 1.7 times as much as MSCs cultured on the commercial microcarriers *** differentiation potential was also improved about 3.2 times compared to ***,it is indispensable to regulate microcarriers rigidity,especially for application of MSCs.

关键词： MSCs Proliferation Differentiation potential Rigidity Spreading

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Reductive leaching of low-grade manganese ore with pre-processed cornstalk

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International Journal of Minerals,Metallurgy and Materials 2015年第12期22卷 1245-1251页

作者： Ai-fei Yi Meng-ni Wu Peng-wei Liu Ya-li Feng Hao-ran Li School of Civil and Environment Engineering University of Science and Technology Beijing State Key Laboratory of High-Efficient Mining and Safety of Metal Mines (Ministry of Education) State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences

Cornstalk is usually directly used as a reductant in reduetive leaching manganese. However, low utilization of cornstalk makes low manganese dissolution ratio, In the research, pretreatment for cornstalk was proposed to improve manganese dissolution ratio. Cornstalk was preprocessed by a heated sulfuric acid solution （1.2 M of sulfuric acid concentration） for 10 min at 80℃. Thereafter, both the pretreated solution and the residue were used as a reductant for manganese leaching. This method not only exhibited superior activity for hydrolyzing cornstalk but also enhanced manganese dissolution. These effects were attributed to an increase in the amount of reductive sugars resulting from lignin hydrolysis. Through acid pretreatment for cornstalk, the manganese dissolution ratio was improved from 50.14% to 83.46%. The present work demonstrates for the first time the effective acid pretreatment of cornstalk to provide a cost-effective reductant for manganese leaching.

关键词： manganese ore treatment cornstalk reductants leaching

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Comparison of Mg^(2+)- and Ca^(2+)-enhancing anaerobic granulation in an expanded granular sludge-bed reactor

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Science China Chemistry 2014年第11期57卷 1596-1601页

作者： CAO XiaoLei SHENG YuXing CAO HongBin ZHANG Yi National Key Laboratory of Biochemical Engineering and Key Laboratory of Green Process and Engineering Institute of Process Engineering Chinese Academy of Sciences National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology Graduate University of Chinese Academy of Sciences

The mechanisms responsible for the fast granulation of anaerobic sludge caused by Mg2+ and Ca2+ addition was examined in four lab-scale expanded granular sludge bed(EGSB) reactors. Results indicated that both Mg2+ and Ca2+ accelerated the sludge-granulation process and increased the amount of polysaccharides and proteins in the sludge. Energy dispersive x-ray spectrometry(EDX) analysis revealed that, in a mature granule, both Mg2+ and Ca2+ composed as phosphate and calcium was distributed primarily in the periphery of the granule, while magnesium distributed mainly in the interior. The addition of Mg2+ was more favorable for the nuclei formation, whereas the addition of Ca2+ was more favorable for subgranule growth and maintaining the granules' rigid structure. Results showed that the addition of Mg2+ in the nuclei formation stage and Ca2+ in the granule-growth stage accelerated granulation more than adding only one of them in the granulation process.

关键词： anaerobic granulation Ca2＋ augmentation EPS Mg2＋ augmentation

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Preparation of basic magnesium carbonate and its thermal decomposition kinetics in air

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Journal of Central South University 2011年第6期18卷 1865-1870页

作者：刘欣伟冯雅丽李浩然 Civil and Environmental Engineering School University of Science and Technology Beijing National Key State Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences

The thermal decomposition process of basic magnesium carbonate was investigated. Firstly, Basic magnesium carbonate was prepared from magnesite, and the characteristics of the product were detected by X-ray diffraction （XRD） and scanning electron microscopy （SEM）. Subsequently, the thermal decomposition process of basic magnesium carbonate in air was studied by thermogravimetry-differential thermogravimetry （TG-DTG）. The results of XRD confirm that the chemical composition of basic magnesium carbonate is 4MgCO3·Mg（OH）2·4H2O. And the SEM images show that the sample is in sheet structure, with a diameter of 0.1-1 μm. The TG-DTG results demonstrate that there are two steps in the thermal decomposition process of basic magnesium carbonate. The apparent activation energies （E） were calculated by Flyrm-Wall-Ozawa method. It is obtained from Coats-Redfem＇s equation and Malek method that the mechanism functions of the two decomposition stages are D3 and A1.5, respectively. And then, the kinetic equations of the two steps were deduced as well.

关键词： basic magnesium carbonate TG-DTG thermal decomposition kinetics mechanism function

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