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arXiv 2025年

作者： Hu, Chuan Ge, Sicheng Shi, Yingkui Gao, Weinan Guo, Wenfeng Zhang, Xi Intelligent Vehicle Institute School of Mechanical Engineering Shanghai Jiao Tong University Shanghai200240 China School of Mechanical Engineering Shanghai Jiao Tong University Shanghai200240 China State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Shenyang110819 China School of Vehicle and Mobility Tsinghua University Beijing100190 China

This article presents a composite nonlinear feedback (CNF) control method using self-triggered (ST) adaptive dynamic programming (ADP) algorithm in a human-machine shared steering framework. For the overall system dynamics, a two-degrees-of-freedom (2-DOF) vehicle model is established and a two-point preview driver model is adopted. A dynamic authority allocation strategy based on cooperation level is proposed to combine the steering input of the human driver and the automatic controller. To make further improvements in the controller design, three main contributions are put forward. Firstly, the CNF controller is designed for trajectory tracking control with refined transient performance. Besides, the self-triggered rule is applied such that the system will update in discrete times to save computing resources and increase efficiency. Moreover, by introducing the data-based ADP algorithm, the optimal control problem can be solved through iteration using system input and output information, reducing the need for accurate knowledge of system dynamics. The effectiveness of the proposed control method is validated through Carsim-Simulink co-simulations in diverse driving scenarios. © 2025, CC BY.

关键词： Steering

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Quantized Distributed Nonconvex Optimization Algorithms with Linear Convergence under the Polyak–Lojasiewicz Condition

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IEEE Transactions on Automatic Control 2025年

作者： Xu, Lei Yi, Xinlei Sun, Jiayue Shi, Yang Johansson, Karl H. Yang, Tao Northeastern University State Key Laboratory of Synthetical Automation for Process Industries Shenyang110819 China University of Victoria Department of Mechanical Engineering VictoriaBCV8W 2Y2 Canada Tongji University Shanghai Institute of Intelligent Science and Technology Shanghai201804 China KTH Royal Institute of Technology Division of Decision and Control Systems School of Electrical Engineering and Computer Science Stockholm100 44 Sweden

This paper considers distributed optimization for minimizing the average of local nonconvex cost functions, by using local information exchange over undirected communication networks. To reduce the required communication capacity, we introduce an encoder–decoder scheme. By integrating it with distributed gradient tracking and proportional integral algorithms, respectively, we then propose two quantized distributed nonconvex optimization algorithms. Assuming the global cost function satisfies the Polyak–Lojasiewicz condition, which does not require the global cost function to be convex and the global minimizer is not necessarily unique, we show that our proposed algorithms linearly converge to a global optimal point. Moreover, we show that a low data rate is sufficient to guarantee linear convergence when the algorithm parameters are properly chosen. The theoretical results are illustrated by numerical examples. © 1963-2012 IEEE.

关键词： Cost functions

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Three-dimensional numerical study of flow characteristics and membrane fouling evolution in an enzymatic membrane reactor

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Journal of Hydrodynamics 2018年第5期30卷 851-858页

作者： Xu-qu Hu Pai-qing Wu Xing-yi Wang Hai-cheng Zhang Jian-quan Luo State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

In order to enhance the understanding of the membrane fouling mechanism, the hydrodynamics of the granular flow in a stirred enzymatic membrane reactor is numerically investigated in the present paper. A three-dimensional Euler-Euler model, coupled with the k-ε mixture turbulence model and the drag function proposed by Syamlal and O＇Brien（1989） for the interphase momentum exchange, is built to simulate the two-phase（fluid-solid） turbulent flow. Numerical simulations of single-or two-phase turbulent flows at various stirring speeds are carried out. The numerical results agree very well with the published experimental data. Results include the distributions of the velocity, the shear stress and the turbulent kinetic energy. It is shown that the increase of the stirring speed not only enlarges the circulation loops in the reactor, but also increases the shear stress on the membrane surface and accelerates the mixing process for the granular materials. The time evolution of the volumetric function of the granular materials on the membrane surface can qualitatively explain the evolution of the membrane fouling.

关键词： Turbulent flow multiphase flow membrane fouling

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Laccase immobilized on magnetic nanoparticles by dopamine polymerization for 4-chlorophenol removal

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Green Energy & Environment 2017年第4期2卷 393-400页

作者： Di Zhang Manfeng Deng Hongbin Cao Songping Zhang He Zhao Beijing Engineering Research Center of Process Pollution Control Division of Environment Technology and Engineering Institute of Process EngineeringChinese Academy of Sciences Collaborative Innovation Center of Chemical Science and Engineering State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences

In this work, a new immobilization method based on dopamine(DA) self-polymerization was developed for laccase immobilization on magnetic nanoparticles(Fe_3O_4 NPs). To optimize the immobilization condition including reaction pH, DA concentration and enzyme concentration, a central composite response surface method was applied. The optimal condition was determined as p H value of 5.92, laccase concentration of 0.25 mg mL^(-1) and DA concentration of 12.74 mg mL^(-1), under which a high enzyme activity recovery of 88.17% was *** comparing with free laccase, the stabilities of immobilized laccase towards p H, thermostability, storage were enhanced *** 60% of relative activity for immobilized laccase was remained after being incubated for 6 h at 50℃, but the free laccase only remained 25%. After 40 days of storage at 4℃, the laccase immobilized by DA kept about 89% of its original activity, but the free laccase only retained 48%. After recycled 10 times, the relative activity of immobilized laccase still retained 70%. The immobilized laccase was then applied to catalyze the degradation of 4-chlorophenol(4-CP), 86% percentage of 4-CP was removed within 2 h. After degraded 10 times, the relative activity of immobilized laccase still remained 64% of its initial activity, which exhibits an excellent reusability and operational stability.

关键词： Magnetic nanoparticle Laccase Dopamine Immobilization 4-Chlorophenol removal

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A STIR nucleic acid drug delivery system for stirring phenotypic switch of microglia in Parkinson’s disease treatments

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Nano Research 2023年第5期16卷 7216-7226页

作者： Yanyue Wu Wenli Wang Xinyu Qiu Zhiguo Lu Weihong Ji Jie Shen Huan Peng Ruichen Zhao Jingwen Wang Tianlu Zhang Jun Yang Xin Zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Neuroinflammation is one of the three important pathological features in neurodegenerative diseases including Parkinson’s disease(PD).The regulation of neuroinflammation can reduce the severity of neurological damage to alleviate *** studies have shown that the phenotype switch of microglia is tightly associated with the nuclear factorκB(NF-κB)-mediated inflammatory ***,the small interfering RNA(siRNA)therapy for downregulating the expression of NF-κB,provides a promising therapeutic strategy for Parkinson’s disease *** the brain delivery challenges of siRNA,a sequential targeting inflammation regulation(STIR)delivery system based on poly(amino acid)s is developed to improve the therapeutic effects of Parkinson’s disease *** STIR system sequentially targets the blood–brain barrier and the microglia to enhance the effective concentration of siRNA in the targeted *** results demonstrate that the STIR nanoparticles can transform microglial phenotypes and regulate brain inflammation,thus achieving neuronal recovery and abnormal aggregation ofα-synuclein protein(α-syn)reduction in the treatment of Parkinson’s ***,this STIR delivery system provides a promising therapeutic platform in PD treatments and has great potential for other neurodegenerative diseases’therapies.

关键词： sequential targeting inflammation regulation phenotypic switch of microglia targeted drug delivery siRNA-based gene therapy responsive release Parkinson’s disease

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Surface charge of PLA microparticles in regulation of antigen loading,macrophage phagocytosis and activation,and immune effects in vitro

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Particuology 2014年第6期12卷 74-80页

作者： Yuying Liu Xiaoming Chen Lianyan Wang Tingyuan Yang Qipeng Yuan Guanghui Ma National Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of Sciences State Key Laboratory of Chemical Resource Engineering College of Life Science and TechnologyBeijing University of Chemical Technology University of Chinese Academy of Sciences

The use of microparticles（MPs） as adjuvants has attracted increasing interest in vaccine delivery *** physiochemical characteristics of MPs including hydrodynamic size,surface properties,and morphology can regulate the immune *** charge is an important characteristic of MPs,but how it affects their adjuvanticity remains *** this study,we prepared uniform-sized polylactide MPs coated with various polymers of different positive charge,and investigated how the surface charge affected antigen loading and macrophage phagocytosis and activation in vitro.A higher surface charge greatly enhanced antigen loading and antigen internalization into macrophages,promoted the expression of MHC 11 and CD80,and increased the secretion level of *** together,these results indicated that surface charge was an important parameter for improving the adjuvanticity of MPs.

关键词： Microparticle（MP） Macrophage Surface charge Antigen loading Phagocytosis Activation

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Recent advances in platelet engineering for anti-cancer therapies

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Particuology 2022年第5期20卷 2-13页

作者： Yanlin Lv Wei Wei Guanghui Ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Platelets contribute a major role in hemostasis by clumping and coagulation at the site of blood vessel *** light of recent findings of a close relationship between platelets and immunological response,as well as interactions between platelets and cancer cells,novel engineering strategies have emerged for the integration of platelets or platelet membrane(PM)with anti-cancer *** this review,we discuss several recent innovations that use platelets or their membranes to circumvent host immune responses and target tumor cells with high specificity to deliver a range of pharmacological,photothermal,or immunologic agents for eradication of recalcitrant tumor *** specifically,we compare the relative advantages of using whole platelets versus single or hybrid PM to coat nanoparticle *** cargoes range from well-established anti-tumor apoptosis-inducing agents,to relatively new photothermal agents that can induce a feedback cascade in which they induce vascular damage to the tumor which recruits more platelet-or membrane-encapsulated agents to induce further *** also discuss the use of engineered platelets to produce programmed cell death-inducing platelet derived *** review provides an overview and future directions for this promising platelet-based biomimetic approach to anti-cancer therapy.

关键词： engineering platelets Platelet-mimicking Drug delivery Anti-cancer therapy

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Fabrication of high-capacity cation-exchangers for protein adsorption: Comparison of grafting-from and grafting-to approaches

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Frontiers of Chemical Science and engineering 2019年第1期13卷 120-132页

作者： Ming Zhao Run Liu Jian Luo Yan Sun Qinghong Shi Department of Biochemical Engineering School of Chemical Engineering and Technology Tianjin University Tianjin 300350 China Key Laboratory of Systems Bioengineering (Ministry of Education) Tianjin University Tianjin 300072 China State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China

In this work, we have synthesized two polymer-grafted cation exchangers: one via the grafting-from approach, in which sulfopropyl methacrylate (SPM) is grafted through atom transfer radical polymerization onto Sepharose FF (the thus resulting exchanger is referred as Sep-g-SPM), and another via the grafting-to approach, in which the polymer of SPM is directly coupled onto Sepharose FF (the thus resulting exchanger is called as Sep-pSPM). Protein adsorption on these two cation exchangers have been also investigated. At the same ligand density, Sep-g-SPM has a larger accessible pore radius and a smaller depth of polymer layer than Sep-pSPM, due to the controllable introduction of polymer chains with the regular distribution of the ligand. Therefore, high-capacity adsorption of lysozyme and γ-globulin could be achieved simultaneously in Sep-g-SPM with an ionic capacity (IC) of 308 mmol·L^-1. However, Sep-pSPM has an irregular chain distribution and different architecture of polymer layer, which lead to more serious repulsive interaction to proteins, and thus Sep-pSPM has a lower adsorption capacity for γ-globulin than Sep-g-SPM with the similar IC. Moreover, the results from protein uptake experiments indicate that the facilitated transport of adsorbed γ-globulin occurs only in Sep-pSPM and depends on the architecture of polymer layers. Our research provides a clear clue for the development of high-performance protein chromatography.

关键词： polymer-grafted ionic exchanger grafting technique protein adsorption atom transfer radical polymerization γ-globulin

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Reaction mechanism and metal ion transformation in photocatalytic ozonation of phenol and oxalic acid with Ag^+/TiO_2

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Journal of Environmental Sciences 2014年第3期26卷 662-672页

作者： Yingying Chen Yongbing Xie Jun Yang Hongbin Cao Yi Zhang National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology Key Laboratory of Green Process and Engineering Institute of Process Engineering Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences

Photocatalytic ozonation of phenol and oxalic acid （OA） was conducted with a Ag^＋/TiO2 catalyst and different pathways were found for the degradation of different compounds. Ag^＋ greatly promoted the photocatalytic degradation of contaminants due to its role as an electron scavenger. It also accelerated the removal rate of OA in ozonation and the simultaneous process for its complex reaction with oxalate. Phenol could be degraded both in direct ozonation and photolysis, but the TOC removal rates were much higher in the simultaneous processes due to the oxidation of hydroxyl radicals resulting from synergetic effects. The sequence of photo-illumination and ozone exposure in the combined process showed quite different effects in phenol degradation and TOC removal. The synergetic effects in different combined processes were found to be highly related to the properties of the target pollutants. The color change of the solution and TEM result confirmed that Ag＋ was easily reduced and deposited on the surface of Tit2 under photo-illumination, and dissolved again into solution in the presence of ozone. This simple cycle of enrichment and distribution of Ag^＋ can greatly benefit the design of advanced oxidation processes, in which the sequences of ozone and photo-illumination can be varied according to the needs for catalyst recycling and the different properties of pollutants.

关键词： photocatalytic ozonation phenoloxalic acid Ag＋/TiO2

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Preparation and sintering behavior of pre-synthesized Mg-Al-Cr ternary spinel ceramic powders

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Materials Letters 2025年 396卷

作者： Hui, Shichang Yan, Jingmin Zhao, Wenkai Zhang, Teng Yuan, Chengzong Li, Huixing Qian, Peng Zhang, Xiaomeng Ye, Shufeng State Key Laboratory of Mesoscience and Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing100190 China School of Chemistry and Chemical Engineering of University of Chinese Academy of Sciences Beijing100049 China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing100049 China Innovation Academy for Green Manufacture Chinese Academy of Sciences Beijing100190 China Ganjiang Innovation Academy Chinese Academy of Sciences Ganzhou341119 China Jinzhou Great Wall Refractory Material Co. Ltd Jinzhou121000 China

Achieving highly dense spinel materials remains challenging due to significant volume expansion during binary spinel (MgAl2O4 and MgCr2O4) formation and sluggish ionic diffusion during sintering. In this research, ternary spinel powders (Mg(Al,Cr)2O4) were synthesized via a hydrothermal method followed by calcination, and their sintering behavior without additives was investigated. Results indicated that the Mg(Al,Cr)2O4 powders were single-phase with the characteristic spinel structure, uniform particle sizes ranging from 50 to 100 nm, high specific surface area (34.61 m2/g), and a low onset sintering temperature (1010 °C). After sintering at 1500 °C for 6 h, the powders exhibited excellent densification with an apparent porosity as low as 5.03 % and a bulk density reaching 3.52 g/cm3. Remarkably, this represents a reduction in the sintering temperature by approximately 200 °C compared to previously reported values for achieving similar densification. The enhanced low-temperature densification behavior of pre-synthesized Mg-Al-Cr spinel primarily arises from abundant oxygen vacancy defects within the spinel lattice. These findings offer valuable insights into designing ternary spinel powders and fabricating dense, pre-synthesized spinel ceramics. © 2025

关键词： Semiconductor doping

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