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Advanced Sensor and Energy Materials 2024年第3期3卷 11-22页

作者： Qing Tao Yanli Wen Wen Liang Lele Wang Ruiyan Guo Min Ding Ming Luo Juan Yan Feiyan Gong Chengming Cao Lanying Li Gang Liu Key Laboratory of Bioanalysis and Metrology for State Market Regulation Shanghai Institute of Measurement and Testing TechnologyShanghai 201203China Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation(Shanghai) Ministry of AgricultureShanghai Engineering Research Center of Aquatic-Product Process&PreservationCollege of Food Science and TechnologyShanghai Ocean UniversityShanghai 201306China

Ratiometric DNA biosensors,which utilize DNA as the recognition element and integrate dual signals from diverse sensing platforms including fluorescence,electrochemistry,and surface-enhanced Raman scattering(SERS),have demonstrated remarkable proficiency in detecting a wide range of *** this review,we showcase the significant progress achieved by ratiometric ***,ratiometric biosensors have made notable advancements in analyzing real *** include the analysis of pH values near cancer cells,quantification of miRNA in human cell lysates,detection of human telomerase RNA in cell extracts,and performing DNA logicgated in situ bioimaging on cell ***,excellent sensitivity has been attained through the utilization of effective amplification methods such as RCA,HCR,and CHA,among ***,the construction of stable reference signals has resulted in significantly improved precision for ratiometric *** breakthrough has overcome matrix effects,enabling reliable detection in real samples with high *** review provides a comprehensive overview of recent advancements in strategies employed by ratiometric DNA *** present three types of biosensors based on distinct sensing platforms:fluorescent,electrochemical,and SERS ***,we discuss future directions and primary challenges in the development of ratiometric DNA biosensors.

关键词： Ratiometric biosensor DNA Nanomaterials Fluorescent biosensor Electrochemical biosensor SERS biosensor

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Inside-out assembly of viral antigens for the enhanced vaccination

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3144-3157页

作者： Fengqiang Cao Sha Peng Yaling An Kun Xu Tianyi Zheng Lianpan Dai Kenji Ogino To Ngai Yufei Xia Guanghui Ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190PR China Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology2-24-16 NakachoKoganeiTokyo184-8588Japan Institute of Global Innovation Research Tokyo University of Agriculture and Technology2-24-16 NakachoKoganei-shiTokyo184-8588Japan CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101PR China Savaid Medical School University of Chinese Academy of SciencesBeijingPR China Key Laboratory of Tropical Translational Medicine of Ministry of Education School of Tropical Medicine and Laboratory MedicineThe First Affiliated HospitalHainan Medical UniversityHainan571199PR China Zhejiang University School of Medicine Hangzhou310058PR China Department of Chemistry The Chinese University of Hong KongShatinN.T.Hong Kong999077PR China University of Chinese Academy of Sciences Beijing100049PR China Innovation Academy for Green Manufacture Chinese Academy of Sciences Beijing100190PR China

Current attempts in vaccine delivery systems concentrate on replicating the natural dissemination of live pathogens,but neglect that pathogens evolve to evade the immune system rather than to provoke *** the case of enveloped RNA viruses,it is the natural dissemination of nucleocapsid protein(NP,core antigen)and surface antigen that delays NP exposure to immune ***,we report a multi-layered aluminum hydroxide-stabilized emulsion(MASE)to dictate the delivery sequence of the *** this manner,the receptor-binding domain(RBD,surface antigen)of the spike protein was trapped inside the nanocavity,while NP was absorbed on the outside of the droplets,enabling the burst release of NP before *** with the natural packaging strategy,the inside-out strategy induced potent type I interferon-mediated innate immune responses and triggered an immune-potentiated environment in advance,which subsequently boosted CD40+DC activations and the engagement of the lymph *** both H1N1 influenza and SARS-CoV-2 vaccines,rMASE significantly increased antigen-specific antibody secretion,memory T cell engagement,and Th1-biased immune response,which diminished viral loads after lethal *** simply reversing the delivery sequence of the surface antigen and core antigen,the inside-out strategy may offer major implications for enhanced vaccinations against the enveloped RNA virus.

关键词： vaccination outside evolve

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Dynamic control of moirépotential in twisted WS_(2)-WSe_(2)heterostructures

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Nano Research 2022年第8期15卷 7688-7694页

作者： Shaofei Li Haihong Zheng Junnan Ding Biao Wu Jun He Zongwen Liu Yanping Liu School of Physics and Electronics Hunan Key Laboratory for Super-microstructure and Ultrafast ProcessCentral South UniversityChangsha 410083China State Key Laboratory of High-Performance Complex Manufacturing Central South UniversityChangsha 410083China School of Chemical and Biomolecular Engineering The University of SydneyNSW 2006Australia The University of Sydney Nano Institute The University of SydneyNSW 2006Australia Shenzhen Research Institute of Central South University Shenzhen 518057China

Moirésuperlattices are formed by a lattice mismatch or twist angle in two-dimensional materials,which can generate periodical moirépotentials leading to strong changes in the band structure,resulting in new quantum ***,the experimental engineering of in-situ deformation of moiréheterostructures remains ***,we demonstrate a dynamic local deformation of the twisted heterostructures using a diamond anvil cell(DAC),enabling in-situ dynamic modulation of moirépotential in twisted WS_(2)–WSe_(2)heterostructures at room *** of the twisted heterostructure increases the moirépotential,causing a red shift of the moiréexciton resonance,and observed the red shift of the intralayer exciton resonance up to 16.3 meV(less than 1.1 GPa).The blue shift of the interlayer excitons of twisted WS_(2)–WSe_(2)heterostructures shows an evident transition of the pressure sensitive exciton,induced by the dominant effect of modifying the band structure on optical *** with the spectral changes of pressurized Raman,which further demonstrated that the DAC can efficiently regulate the interlayer *** results offer an effective strategy for in-situ dynamic modulation of moirépotential,providing a promising platform for the development of novel quantum devices.

关键词： moirésuperlattices twisted heterostructures moirépotential diamond anvil cell(DAC)

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Efficient Conversion of Formaldehyde and Propanal to Methacrolein on Ionic Liquid-Functionalized Polymer Catalyst

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SSRN 2024年

作者： Bian, Yuhang Zheng, Xiaoyan Li, Jie Peng, Zhijian Wang, Gang Li, Chunshan School of Science China University of Geosciences Beijing100083 China State Key Laboratory of Mesoscience and Engineering CAS Key Laboratory of Green Process and Engineering Beijing Key Laboratory of Ionic Liquids Clean Process Institute of Process Engineering Chinese Academy of Sciences Beijing100190 China School of Chemical Engineering University of Chinese Academy of Sciences Beijing100049 China Langfang Technological Center of Green Industry Langfang065801 China Longzihu New Energy Laboratory Zhengzhou Institute for Emerging Industrial Technology China

In recent years, the methacrolein (MAL) synthesis through the aldol condensation of formaldehyde (FA) with propanal (PA) has received great attention of researchers. Herein, an ionic liquid-functionalized polymer catalyst, which exhibited higher performance than common homogenous sec-amine catalyst, was developed for catalytic synthesis of MAL via aldol condensation of FA with PA. FT-IR, XPS, TG-DTA, and 13C MAS NMR were used to characterize the structural and physicochemical features. The influences of solvent and reaction conditions on the catalytic performance were also systematically studied and optimized. The in situ FT-IR spectroscopic experiments was performed to investigate the catalytic mechanism. Kinetic studies revealed that the activation energy of aldol condensation between the FA and PA was 51.6 kJ/mol. No obvious decay of catalytic performance was observed after twelve times cycle. © 2024, The Authors. All rights reserved.

关键词： Catalysis

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Rapid and mass manufacturing of soft hydrogel microstructures for cell patterns assisted by 3D printing

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Bio-Design and Manufacturing 2022年第4期5卷 641-659页

作者： Chaofan He Xuechun Chen Yuan Sun Mingjun Xie Kang Yu Jing He Jinwei Lu Qing Gao Jing Nie Yi Wang Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Orthopedic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Key Laboratory of Materials Processing and Mold Zhengzhou UniversityZhengzhou 450002China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Cancer Center Zhejiang UniversityHangzhou 310058China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 300072China

Micro-/nano-patterns on hydrogels are widely used in cell ***,manufacturing molds with traditional lithography is time-consuming and *** addition,the excessive demolding force can easily damage patterns since biocompatible hydrogels are ultra-soft or ***,we presented a novel method for rapid and mass fabrication of cell ***-precision three-dimensional(3D)printing was used to manufacture a mold with a resolution of 2µm,and the gelatin-based hydrogel was cured by thermal–photo-crosslinking so that the low-concentration and low-substitutionrate hydrogel could be demolded *** found that pre-cooling before illumination made gelatin-based hydrogels resilient due to the partial regain of triple-helix *** this method,arbitrarily customized hydrogel patterns with a feature size of 6–80µm can be fabricated stably and at low *** cardiomyocytes were seeded on ultra-soft hydrogels with parallel groove structures,a consistent and spontaneous beating with 216 beats per minute(BPM)could be observed,approaching the natural beating rate of rat hearts(300 BPM).Overall,this work provides a general scheme for manufacturing cell patterns which has great potential for cell ethology and tissue repair.

关键词： 3D printing Gelatin-based hydrogel Cell pattern Cardiomyocytes beating

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Review of construction methods for whole-cell computational models

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Systems Microbiology and Biomanufacturing 2022年第2期2卷 259-270页

作者： Jingru Zhou Xingcun Fan Lingfeng Cao Huijie Sun Jianye Xia XueFeng Yan State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Tianjin Institute of Industrial Biotechnology Chinese Academy of ScienceTianjin 300308China Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237People’s Republic of China

The complex mechanisms of the internal operation of cellular functions have not been fully resolved and these functions are regulated by multiple effects,such as transcription regulation,signal transduction,and enzyme catalysis,forming complex interactive *** makes the construction of a whole-cell computational model,containing various complex cellular functions,very ***,biological models have played a significant role in the field of systems biology,such as guiding gene-target mining and studying cell metabolic ***,there is increasing research interest in the construction of whole-cell computational *** two classical languages of systems biology,this review expounds on the development and challenges of whole-cell computational modeling from the two classical methods of steady-state and dynamic ***,we propose a new approach for constructing whole-cell computational models.

关键词： Whole-cell computational model Systems biology Steady-state Dynamic modeling

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Intelligent Manufacturing for the process Industry Driven by Industrial Artificial Intelligence

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engineering 2021年第9期7卷 1224-1230页

作者： Tao Yang Xinlei Yi Shaowen Lu Karl HJohansson Tianyou Chai State Key Laboratory of Synthetical Automation for Process Industries Northeastern UniversityShenyang 110819China School of Electrical Engineering and Computer Science KTH Royal Institute of TechnologyStockholm 10044Sweden

Based on the analysis of the characteristics and operation status of the process industry,as well as the development of the global intelligent manufacturing industry,a new mode of intelligent manufacturing for the process industry,namely,deep integration of industrial artificial intelligence and the Industrial Internet with the process industry,is *** paper analyzes the development status of the existing three-tier structure of the process industry,which consists of the enterprise resource planning,the manufacturing execution system,and the process control system,and examines the decision-making,control,and operation management adopted by process *** on this analysis,it then describes the meaning of an intelligent manufacturing framework and presents a vision of an intelligent optimal decision-making system based on human–machine cooperation and an intelligent autonomous control ***,this paper analyzes the scientific challenges and key technologies that are crucial for the successful deployment of intelligent manufacturing in the process industry.

关键词： Industrial artificial intelligence Industrial Internet Intelligent manufacturing process industry

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Bilayer separator enabling dendrite-free zinc anode with ultralong lifespan >5000 h

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Green Energy & Environment 2024年第4期9卷 771-776页

作者： Lu Wang Feifei Wang Zhe Ding Yingxin Liu Ziyi Zhang Chunpeng Yang Kian Ping Loh Quan-Hong Yang Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou350207China Nanoyang Group State Key Laboratory of Chemical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China Department of Chemistry National University of Singapore117543Singapore Institute of Process Engineering Chinese Academy of SciencesBeijing100190China

Aqueous zinc(Zn)batteries with Zn metal anodes are promising clean energy storage devices with intrinsic safety and low ***,Zn dendrite growth severely restricts the use of Zn *** effectively suppress Zn dendrite growth,we propose a bilayer separator consisting of commercial butter paper and glassfiber *** dense cellulose-based butter paper(BP)with low zincophilicity and high mechanical properties prevents the pore-filling behavior of deposited Zn and related separator piercing,effectively suppressing the Zn dendrite *** a result,the bilayer separators endow the ZnjjZn symmetrical batteries with a superlong cycling life of Zn anodes(over 5000 h)at 0.5 mA cm^(-2) and the full batteries enhanced capacity retention,demonstrating the advancement of the bilayer separator to afford excellent cyclability of aqueous metal batteries.

关键词： Zn battery Bilayer separator Butter paper Zn metal anode Zn dendrite

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Physics-guided graph learning soft sensor for chemical processes

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Chemometrics and Intelligent laboratory Systems 2024年 249卷

作者： Liu, Yi Jia, Mingwei Xu, Danya Yang, Tao Yao, Yuan Institute of Process Equipment and Control Engineering Zhejiang University of Technology Hangzhou310023 China State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Shenyang110819 China Department of Chemical Engineering National Tsing Hua University Hsinchu300044 Taiwan

The surge in data-driven soft sensors for industrial processes is evident. However, most of them suffer from the limitation of being black-box models and this will hamper their widespread use. In response to this challenge, this study proposes a physics-guided graph-learning soft sensor that integrates a physical understanding of industrial processes by incorporating graph-based concepts with process physics. The soft sensor first constructs physical information based on causal relationships between variables using the conditional Granger causality test. Subsequently, it autonomously learns the unique sample information of each observation while employing a regularization loss to ensure the sparsity of the learned information. The model employs a two-stream structure for spatiotemporal encoding of both the physical and sample information. The modeling and prediction results on a penicillin fermentation process indicate that, using the proposed method, the knowledge gained from the data aligns with existing prior knowledge. This approach shows promise in filling the gap between data-driven and physics-based modeling in chemical processes. © 2024 Elsevier B.V.

关键词： Graphic methods

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Efficient Separation of Co2/ch4 By Covering Ultrathin Ionic Liquid Film on Cof Membrane

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SSRN 2024年

作者： Wang, Qixin Guo, Yandong Long, Yan Liu, Yawei Wang, Zhenlei Liu, Yiming Zhang, Xiaochun College of Mathematics Science Bohai University Liaoning Jinzhou121013 China Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of Education East China University of Science and Technology Shanghai200237 China Beijing Key Laboratory of Ionic Liquids Clean Process CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Mesoscience and Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing100190 China Henan Institute of Advanced Technology Zhengzhou University Zhengzhou450000 China Qingdao University China

Covalent organic framework (COF) membranes show great potential for gas separation, but their large pore size make it hard to effectively separate gases with similar kinetic diameters. A promising strategy is to cover the surface of COF membranes with an ultrathin film of ionic liquids (ILs) to improve the selectivity of gas permeation. Here, we investigated the CO2/CH4 separation performance of composite membranes composed of COF (CTF-1) and 20 kinds of ILs, respectively, using molecular simulations. The [BMIM][PF6]/COF membrane is found to exhibit the best separation performance, with CO2 permeability up to 7.93×104 GPU and CO2/CH4 selectivity of 12.33 when the IL thickness is 8 Å. By studying the microstructure of the composite membrane, it was found that there is a relatively dispersed distribution of cations and anions on the COF surface, which is beneficial to the diffusion of gas molecules. The gas permeation process results reveal that CO2 rapidly achieves equilibrium in both the adsorption and dissolution layers simultaneously, thereby enhancing the permeation rate of gas molecules. The analysis of interaction energy and PMF indicates that the improved selectivity is due to the stronger interaction between IL and CO2 than that for CH4 © 2024, The Authors. All rights reserved.

关键词： Carbon dioxide

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