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Significant enhancement in local thermal conductivity of erythritol at interface with nanoparticles due to their interaction

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Nano Research 2024年第8期17卷 7726-7736页

作者： Ning Cao Yanhui Feng Kening Yan Zihan Liu Jiawei Wan Lin Qiu School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and DeliveryInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China

When nano-fillers are used to enhance the thermal conductivity of organic phase change materials(PCMs),the naturally formed interface is considered to hinder thermal transport of the composite ***,the effect of the interface on the thermal properties of surrounding PCM has not been fully *** this paper,three composite PCMs(Ery@SiC,Ery@SiO_(2) and Ery@Si_(3)N_(4))were prepared by melt-blending *** local thermal conductivity and reduced Young’s modulus(E^(*))of the erythritol at the interface and far away from the interface in the composite PCMs were simultaneously measured by scanning thermal microscopy(SThM).The results revealed significant enhancement in local thermal conductivity of erythritol at the interface and its obvious positive correlation with E^(*).For different composite PCMs,molecular dynamics(MD)simulations suggested that the increase in intrinsic thermal conductivity and E^(*)of erythritol is attributed to the increase in interaction energy between erythritol and nanoparticles,as more erythritol phonon vibrations transform from localized mode to delocalized mode and erythritol has a higher density at the *** findings will provide new ideas for the design of PCM for energy storage.

关键词： scanning thermal microscopy phase change materials thermal conductivity reduced Young’s modulus interaction energy phonon participation ratio

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Exploring the role of cationic lipids in modulating immunogenicity and vaccine efficacy of mRNA-LNP

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Particuology 2025年第2期97卷 1-11页

作者： Yan Zhou Xiangfei Shan Renji Gu Yufei Xia Xiaonan Huang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100081China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing10090China

The mRNA vaccines have become a transformative platform in medicine,with their success during the COVID-19 pandemic accelerating research in viral prevention and cancer *** nanoparticles(LNPs)enhance the stability and efficacy of mRNA vaccines,but achieving an optimal balance between innate immune activation and mRNA expression is crucial for their *** cationic lipids,although largely replaced by ionizable lipids due to concerns over excessive immunogenicity,have demonstrated potential in cancer immunotherapy by inducing strong immune *** this study,we investigated whether incorporating cationic lipids into mRNA-LNP formulations could enhance immunogenicity without requiring new lipid *** introduced varying proportions of cationic lipids into D-Lin-MC3-DMA and SM-102-based LNPs and evaluated their impact on innate immune activation,along with long-term humoral and cellular immune *** results showed that in MC3-based LNPs,cationic lipids significantly improved anti-tumor efficacy,though slightly diminished long-term humoral and cellular *** contrast,in SM-102-based LNPs,cationic lipids enhanced anti-tumor effects without negatively impacting long-term *** findings suggest that adding cationic lipid as an additional component allows for the fine-tuning of mRNA-LNP immunogenicity,expanding the potential applications of mRNA vaccines and simplifying LNP design.

关键词： Lipid nanoparticle mRNA vaccine Immunogenicity Cationic lipids Immune response

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Synergistic solvent extraction system of bis(pyridin-2-ylmethyl)dodecan-1-amine and dinonylnaphthalene for enhanced selective extraction of nickel and cobalt

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Chinese Journal of Chemical engineering 2025年第1期77卷 10-18页

作者： Bharat Prasad Sharma Tianzhang Wang Yufeng Liang Jinping Xiong Liangrong Yang Zheng Li Beijing Key Laboratory of Electrochemical Process and Technology of Materials Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 101408China CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Key Laboratory of Green and High-end Utilization of Salt Lake Resources Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Simultaneous recovery of Ni and Co from Fe(Ⅲ)and AI is a critical challenge in hydrometallurgical *** solvent extraction systems often struggle with selectivity and effective performance in mixed metal ion ***,a new synergistic solvent extraction(SSX)system comprised of a novel pyridine analog,N,N-bis(pyridin-2-ylmethyl)dodecan-1-amine(BPMDA),and dinonylnaphthalene sulfonic acid(DNNSA)with tributyl phosphate as phase modifier is *** SSX system demonstrates high extraction performance achieving>90%for Ni and>97%for Co in a singlestage extraction process,with high *** optimal conditions,the selectivity sequence is observed as Co^(2+)(>97%)>Ni^(2+)(>90%)>Mn^(2+)(<20%)>Fe^(3+)(<10%)>Mg^(2+)(<5%)>Al^(3+)(<2%)>Ca^(2+)(<1%).Spectroscopic analysis evidences the preferential binding of BPMDA with Ni and Co in the presence of DNNSA,concurrently achieving a significant reduction in the co-extraction of Fe(Ⅲ)and *** selective complexation of Ni and Co using the SSX system offers a highly efficient and selective approach for their extraction,with promising potential for applications in recovery-based processes.

关键词： Nickel and cobalt extraction Synergistic solvent extraction DNNSA Pyridine Hydrometallurgy

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PEGylated graphene oxide-mediated stimulation of vascular endothelial cells and responsive release of PD-1/PD-L1 inhibitor for efficient chemo-immunotherapy against cancer Author links open overlay panel

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Particuology 2024年第8期91卷 280-290页

作者： Yan Wang Feng Li Shuang Wang Jiaqi Meng Xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Immune checkpoint blockade(ICB)has emerged as a promising immunotherapeutic modality against cancer in the ***,only 10-30%of patients respond to ICB,primarily due to poor immunogenicity and insufficient T cell infiltration in solid ***,we presented an approach for high-performance cancer treatment using the programmed cell death protein-1 and programmed cell death ligand-1(PD-1/PD-L1)inhibitor(BMS-202)-loaded PEGylated graphene oxide(GPi).On the one hand,GPi dissociated tight junctions of vascular endothelial cells(VECs)in tumor,thus promoting the extravasation and intratumoral accumulation of liposomal doxorubicin(LipDox),which then effectively induced immunogenic cell death of tumor *** the other hand,GPi also stimulated VECs to upregulate the expression of cell-cell interaction molecules,such as intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1,which facilitated the infiltration of T cells in *** acting as a stimulator of VECs,GPi could exert responsive release of BMS-202 under the acidic tumor microenvironment and blockade PD-1/PD-L1 axis in ***,the alternating administration of GPi and LipDox effectively inhibited tumor growth in a 4T1 tumor model,providing a novel treatment mode for chemo-immunotherapy.

关键词： PEGylated graphene oxide Vascular endothelial cells Immune checkpoint blockade Immunogenic cell death Chemo-immunotherapy

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Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： Feng Li Yuan Yang Hua Yue Shuang Wang Xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

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Unlocking the Therapeutic Applicability of LNP-mRNA:Chemistry,Formulation,and Clinical Strategies

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Research 2025年第1期7卷 450-476页

作者： Xiaonan Huang Yishan Ma Guanghui Ma Yufei Xia Sinovac Biotech Ltd. BeijingPR China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijingPR China School of Chemical Engineering University of Chinese Academy of SciencesBeijingPR China

Messenger RNA(mRNA)has emerged as an innovative therapeutic modality,offering promising avenues for the prevention and treatment of a variety of *** tremendous success of mRNA vaccines in effectively combatting coronavirus disease 2019(COVID-19)evidences the unlimited medical and therapeutic potential of mRNA *** challenges related to mRNA stability,immunogenicity,and precision targeting has been made possible by recent advancements in lipid nanoparticles(LNPs).This review summarizes state-of-the-art LNP-mRNA-based therapeutics,including their structure,material compositions,design guidelines,and screening ***,we highlight current preclinical and clinical trends in LNP-mRNA therapeutics in a broad range of treatments in ophthalmological conditions,cancer immunotherapy,gene editing,and rare-disease *** attention is given to the translation and evolution of LNP-mRNA vaccines into a broader spectrum of *** explore concerns in the aspects of inadequate extrahepatic targeting efficacy,elevated doses,safety concerns,and challenges of large-scale production *** discussion may offer insights and perspectives on near-and long-term clinical development prospects for LNP-mRNA therapeutics.

关键词： therapeutic applicability lipid nanoparticles lnps clinical strategies messenger rna mrna

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Enhanced light harvesting ability in hollow Pt/TiO2 nanoreactor for boosting tetracycline photodegradation

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Progress in Natural Science:Materials International 2024年第4期34卷 767-775页

作者： Danyang Li Yongqi Li Dagui Liao Mengqing Cao Lulu Zhang Shasha Zhang Ling Chen Yawen Chen Huan Wang Jian Qi Feifei You College of Textile and Clothing Yancheng Institute of Technology Hebei Key Laboratory of Flexible Functionals Materials School of Materials Science and Engineering Hebei University of Science and Technology State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences School of Chemical Engineering University of Chinese Academy of Sciences

Utilizing solar energy to decompose tetracycline（TC） is a green strategy to treat wastewater. Herein, a heterogeneous hollow structured TiO2decorated Pt nanoparticles were successfully designed and synthesized via hardtemplate approach and photo-deposition process toward TC photodegradation. The Pt nanoparticles loaded on the surface of hollow structured TiO2can increase the visible light absorption due to the local surface plasmon resonance（LSPR） effect. Furthermore, owing to the tough electron oscillation of the LSPR excitation, the plasmonic hot holes on the surface of Pt nanoparticles can capture the electrons of TiO2, effectively facilitating the separation of photo-excited charge carriers because of the formation of Schottky junction constructed between Pt and TiO2. Combined the natural merits of shorten conveying path of charge carriers and physical structural stability for hollow structure, the optimal Pt/TiO2hetero-junction hybrid showed superior photocatalytic activity and durability for TC photodegradation with the degradation efficiency of 93.8 % after 30 min and the rate constant of 0.09196 min-1under 300 W Xe lamp irradiation. This work displays a heterogeneous hybrids catalyst based on eco-friendly metal and semiconductor materials which can be used in the fields including without limitation TC photodegradation.

关键词： Pt/TiO2 Hollow structure Photodegradation Tetracycline Hetero-junction

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A two-pronged strategy utilizing exosomes extracted from antigenpresenting cells to combat hepatitis B

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Nano Research 2024年第10期17卷 9084-9094页

作者： Fumin Hu Dangyang Wang Ting Lu Guanghui Ma Hua Yue State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100190China

Chronic hepatitis B(CHB)is consistently challenging to conquer with numerous complications and *** the effectiveness of antiviral therapies in suppressing hepatitis B virus(HBV)replication,there is an urgent need for novel and more effective treatment *** strategies predominantly emphasize immune activation but still face challenges in sufficiently eliciting T cell *** into account the targeted delivery of nanoparticles to the liver and spleen via intravenous injection,we have proposed a dual-pronged therapeutic strategy based on antigen-presenting cells(APCs)-derived ***,exosomes targeted to the spleen can activate specific immune responses,while those targeted to the liver can modulate or reverse the liver’s immunosuppressive *** immunization,exosome formulations exhibit the remarkable ability to effectively activate APCs,thereby triggering the proliferation of CD8^(+)T ***,they also play an immunoregulatory role by converting M2 macrophages into M1 *** two-pronged therapeutic strategy precisely addresses the issues of T cell dysfunction and immune suppression,both characteristic features of CHB *** combined with Aluminum(Alum)-adjuvanted vaccine,these exosome formulations not only demonstrate a high level of cellular immune response but also secrete specific antibodies comparable to those induced by Alum *** combined approach effectively enhances both cellular and humoral immunity,offering a promising avenue for the development of therapeutic hepatitis B vaccines based on exosome formulations.

关键词： chronic hepatitis B antigen-presenting cells(APCs)-derived exosomes immunoregulatory role two-pronged therapeutic strategy

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A STIR nucleic acid drug delivery system for stirring phenotypic switch of microglia in Parkinson’s disease treatments

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Nano Research 2023年第5期16卷 7216-7226页

作者： Yanyue Wu Wenli Wang Xinyu Qiu Zhiguo Lu Weihong Ji Jie Shen Huan Peng Ruichen Zhao Jingwen Wang Tianlu Zhang Jun Yang Xin Zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Neuroinflammation is one of the three important pathological features in neurodegenerative diseases including Parkinson’s disease(PD).The regulation of neuroinflammation can reduce the severity of neurological damage to alleviate *** studies have shown that the phenotype switch of microglia is tightly associated with the nuclear factorκB(NF-κB)-mediated inflammatory ***,the small interfering RNA(siRNA)therapy for downregulating the expression of NF-κB,provides a promising therapeutic strategy for Parkinson’s disease *** the brain delivery challenges of siRNA,a sequential targeting inflammation regulation(STIR)delivery system based on poly(amino acid)s is developed to improve the therapeutic effects of Parkinson’s disease *** STIR system sequentially targets the blood–brain barrier and the microglia to enhance the effective concentration of siRNA in the targeted *** results demonstrate that the STIR nanoparticles can transform microglial phenotypes and regulate brain inflammation,thus achieving neuronal recovery and abnormal aggregation ofα-synuclein protein(α-syn)reduction in the treatment of Parkinson’s ***,this STIR delivery system provides a promising therapeutic platform in PD treatments and has great potential for other neurodegenerative diseases’therapies.

关键词： sequential targeting inflammation regulation phenotypic switch of microglia targeted drug delivery siRNA-based gene therapy responsive release Parkinson’s disease

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Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors

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Nano Research 2024年第2期17卷 836-847页

作者： Shuping Li Xin Li Jiaqi Meng Weier Bao Shuang Wang Peng Ye Xiao-Dong Gao Wei Wei Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education School of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Bacterial outer membrane vesicles(OMVs)are potent immunostimulants of regulating the tumor microenvironment(TME)for immunotherapy,and can be used to deliver ***,the severe systemic inflammatory response triggered by OMVs upon intravenous(i.v.)injection has limited their ***,we developed a safe and effective strategy by conjugating doxorubicin-loaded serum albumin(SA-DOX,AD)onto the surface of OMVs using a matrix metalloproteinase(MMP)-cleavable peptide linker(cL).This approach enabled the dynamic shielding of OMVs to reduce the systemic side effects while simultaneously enhancing the anti-tumor effects through ***,the resulting OMV-cL-AD formulation exhibited significantly enhanced accumulation at the tumor site after ***,facilitated by the SA decoration on the OMVs ***,the shield on the OMV-cL-AD was cleaved by the over-expressed MMP in the TME,leading to the release of both OMVs and *** process provided OMV-induced immunotherapy and DOX-induced chemotherapy,resulting in synergistic tumor *** conclusion,our work demonstrated the potential of OMV-cL-AD as an effective immunochemotherapy strategy that can prolong the survival time of mice without inducing side effects.

关键词： outer membrane vesicles doxorubicin tumor microenvironment immunotherapy chemotherapy

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