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Nucleic acid therapy for metabolic-related diseases

Chinese Chemical Letters 2025年第3期36卷 83-94页

作者： Jing Guo Zhi-Guo Lu Rui-Chen Zhao Bao-Ku Li Xin Zhang College of Pharmaceutical Sciences Hebei UniversityBaoding 071002China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Biopharmaceutical Preparation and Delivery Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Metabolism is a general term for a series of ordered chemical reactions in an organism used to maintain life,mainly divided into anabolic and catabolic *** acid therapy can not only precisely up-regulate and down-regulate the expression of target genes but also correct mutated disease-causing genes,which demonstrates irreplaceable and outstanding advantages in the treatment of metabolismrelated diseases and has been applied to the clinical treatment of metabolism-related *** this review,we introduce the structures of several major nucleic acid drugs and the mechanism of nucleic acid ***,we describe the mechanisms of various biomolecular and tissue metabolisms and the etiology of metabolic disorders,classified according to metabolic *** analyze the signal pathways and potential targets affecting the metabolism of each substrate and describe the nucleic acid drugs applied to these targets and their delivery *** review aims to provide new ideas and targets for treating these diseases by investigating the role played by metabolism in developing diseases and providing guidance for the selection and design of nucleic acid drugs.

关键词： Metabolism-related diseases Signal pathways Target genes Nucleic acid therapy Delivery technologies

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MOF-assisted Synthesis of Dual-atom Palladium Catalysts for Acetylene Semi-hydrogenation

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China Petroleum processing & Petrochemical Technology 2024年第3期26卷 42-52页

作者： Chen Jie Xu Yuebing Qi Jian Liu Bing Liu Xiaohao Department of Chemical Engineering School of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

The selective removal of trace acetylene in ethylene feed gas is of great significance in the petrochemicalindustry;however, there are still challenges in designing and developing high-performance catalysts. Here, a MOFassistedencapsulation strategy was adopted for the precise synthesis of diatomic Pd2 sites on a ZnO support. When usedfor the acetylene semi-hydrogenation reaction, the dual-atom Pd2-ZnO catalyst exhibited improved catalytic performance,achieving complete conversion of acetylene at 125 °C with an 89% selectivity to ethene, as compared to Pd single-atom andnanoparticles. This enhancement was mainly attributed to the catalyst’s ability to dissociate H2 and facilitate the desorptionof intermediate C2H4. Moreover, the strong interaction between the support and the diatomic Pd sites was responsible for thecatalyst’s excellent stability during the long-term reaction.

关键词： dual-atom palladium acetylene semi-hydrogenation MOFs hydrogen dissociation intermediate

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Preparation of conductive and transparent dipeptide hydrogels for wearable biosensor

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Bio-Design and Manufacturing 2022年第1期5卷 153-162页

作者： Yafeng Jing Anhe Wang Jieling Li Qi Li Qingquan Han Xuefang Zheng Hongyu Cao Shuo Bai College of Life Science and Biotechnology DalianUniversityDalian 116622China State Key Laboratory of Biochemical Engineering Instituteof Process EngineeringChinese Academy of SciencesBeijing 100190China College of Environmental and Chemical Engineering DalianUniversityDalian 116622China

Conductive and transparent dipeptide hydrogels are desirable building blocks to prepare soft electronic devices and wearable biosensors due to their excellent biocompatibility,multi-functionality,and physiochemical properties similar to those of body ***,the preparation of such hydrogels featuring high conductivity and transparency is a huge challenge because of the hydrophobic feature of conductive additives making the doping process *** overcome this issue,hydrophilic conductive polydopamine(PDA)-doped polypyrrole(PPy)nanoparticles are introduced into the dipeptide hydrogel networks to form conductive nanofibrils in situ to achieve a good level of hydrophilic templating of the hydrogel *** tech-nique creates a complete conductive network and allows visible light to pass *** strategy proposed herein not only endows the dipeptide hydrogel with good conductivity and high transparency,but also provides a great potential application of conductive dipeptide hydrogels for body-adhered signal detection,as evidenced by the experimental data.

关键词： Conductivity Transparency Peptide hydrogel Polypyrrole-polydopamine nanoparticles Wearable biosensor

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Enzymatically prepared alginate oligosaccharides improve broiler chicken growth performance by modulating the gut microbiota and growth hormone signals

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Journal of Animal Science and Biotechnology 2023年第5期14卷 2107-2127页

作者： A La Teng Zhu La Yuqing Feng Die Hu Yimei Feng Xiaolu Jin Dan Liu Yuming Guo Gong Cheng Yongfei Hu State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Background Alginate oligosaccharide(AOS)holds great potential as a novel feed supplement in farm ***,the effects of AOS on chicken health and the underlying mechanisms are not fully *** study aimed to optimize the enzymatic preparation of AOS by using bacterial alginate lyases expressed in yeast,investigate the effects of the prepared AOS on the growth performance and gut health of broiler chickens,and reveal the underlying *** Five alginate lyases from bacteria were cloned into Pichia pastoris GS115 and the alginate lyase PDE9 was expressed at relatively high yield,activity and stability in *** trials were carried out using 3201-day-old male Arbor Acres broilers(four groups;8 replicates/group×10 chicks/replicate)receiving either a basal diet or the same diet supplemented with 100,200 and 400 mg/kg PDE9-prepared AOS for 42 *** results showed that dietary supplementation of 200 mg/kg AOS displayed the highest activity in promoting the birds’ADG and ADFI(P<0.05).AOS ameliorated the intestinal morphology,absorption function and barrier function,as indicated by the enhanced(P<0.05)intestinal villus height,maltase activity,and the expression of PEPT,SGLT1,ZNT1,and *** also increased serum insulin-like growth factor-1,ghrelin(P<0.05),and growth hormone(P<0.1).Moreover,the concentrations of acetate,isobutyrate,isovalerate,valerate,and total SCFAs in cecum of birds fed AOS were significantly higher than the control birds(P<0.05).Metagenomic analysis indicated that AOS modulated the chicken gut microbiota structure,function,and microbial interactions and promoted the growth of SCFAs-producing bacteria,for example,Dorea sp.002160985;SCFAs,especially acetate,were found positively correlated with the chicken growth performance and growth-related hormone signals(P<0.05).We further verified that AOS can be utilized by Dorea *** grow and to produce acetate in *** We demonstrated that the enzymatically

关键词： Acetate Alginate lyases Alginate oligosaccharides Dorea sp. Gut microbiota

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Co-MOF-derived stalk-flower like NiCo-LDH homostructure towards boosting electrochemical energy storage

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Progress in Natural Science:Materials International 2024年第6期34卷 1236-1248页

作者： Panpan Li Xiaoliang Wang Shaobin Yang Jian Qi College of Mining College of Materials Science and Engineering Geology and Mineral Engineering Special Materials Professional Technology Innovation Center of Liaoning Province Key Laboratory of Mineral High Value Conversion and Energy Storage Materials of Liaoning Province Liaoning Technical University Department of Architecture and Civil Engineering Lyuliang University State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences

The rational design of the heterostructure of multi-component materials acts on electrochemical ***, the effect of structure and component alone on the performance is ignored. Homostructure can reflect the advantages of structural design more directly and fully tap the potential of the material itself. Herein, the homogeneous stereostructure with NiCo-LDH nanostalks（NiCo-LDHS） and NiCo-LDH nanoflowers（NiCo-LDHF）was synthesized through simultaneous Co-MOF in-situ etch and electrodeposition. NiCo-LDHSnot only preserves the shape of MOF rods, but also forms a firm adhesion to nickel foam. The coated NiCo-LDHFon NiCo-LDHS increases the loading of pseudocapacity material. As a result of the high capacity of Ni（OH）2, the high conductivity of Co（OH）2, as well as the stalk-flower stereostructure, the NiCo-LDHS-Felectrode demonstrates a specific capacity of 2058 F g-1(13994 mF cm-2) at 1 A g-1, along with an ultrahigh rate capability, retaining 73.9 % of its capacity at 20 A g-1. Moreover, the assembled NiCo-LDHS-F//AC hybrid supercapacitor（HSC） exhibits striking energy and power densities of 48.44 Wh·kg-1(0.78 m Wh·cm-2) and 800 W kg-1(12.8 mW cm-2), ***, after 10,000 consecutive charging and discharging cycles, the device maintains a capacity retention of85.36 %, demonstrating its good cycling stability. These findings prove the essentiality of designing homogeneous structure for the advancement of energy storage performance.

关键词： Co-MOF Sacrificial template Electrodeposition NiCo-LDH Homostructure Supercapacitor

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Dendrimer-induced synthesis of porous organosilica capsules for enzyme encapsulation

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Frontiers of Chemical Science and engineering 2024年第4期18卷 41-48页

作者： Ziyi Chu Boyu Zhang Zhenhua Wu Jiaxu Zhang Yiran Cheng Xueying Wang Jiafu Shi Zhongyi Jiang School of Environmental Science&Engineering Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Organic matter-induced mineralization is a green and versatile method for synthesizing hybrid nanostructured materials,where the material properties are mainly influenced by the species of natural biomolecules,linear synthetic polymer,or small molecules,limiting their ***,we adopted dendrimer poly(amidoamine)(PAMAM)as the inducer to synthesize organosilica-PAMAM network(OSPN)capsules for mannose isomerase(MIase)encapsulation based on a hard-templating *** structure of OSPN capsules can be precisely regulated by adjusting the molecular weight and concentration of PAMAM,thereby demonstrating a substantial impact on the kinetic behavior of the MIase@OSPN *** MIase@OSPN system was used for catalytic production of mannose from Dfructose.A mannose yield of 22.24% was obtained,which is higher than that of MIase in organosilica network capsules and similar to that of the free *** overall catalytic efficiency(kcat/Km)of the MIase@OSPN system for the substrate D-fructose was up to 0.556 s^(-1)·mmol^(-1)·***,the MIase@OSPN system showed excellent stability and recyclability,maintaining more than 50% of the yield even after 12 cycles.

关键词： enzyme immobilization enzyme catalysis organosilica networks capsules sugar biosynthesis

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Ionic liquids inhibit the dynamic transition fromα-helices toβ-sheets in peptides

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Fundamental Research 2024年第4期4卷 777-784页

作者： Ju Liu Yanlei Wang Feng Huo Hongyan He Beijing Key Laboratory of Ionic Liquids Clean Process State Key Laboratory of Mesoscience and EngineeringCAS Key Laboratory of Green Process and EngineeringInstituteof Process EngineeringChineseAcademyof SciencesBeijing100190China Longzihu New Energy Laboratory Zhengzhou Institute of Emerging Industrial TechnologyHenan UniversityZhengzhou 450000China University of Chinese Academyof Sciences Beijing100049China

Abnormalities in the transition betweenα-helices andβ-sheets(α-βtransition)may lead to devastating neurodegenerative diseases,such as Parkinson's syndrome and Alzheimer's *** liquids(ILs)are potential drugs for targeted therapies against these diseases because of their excellent bioactivity and designability of ***,the mechanism through which ILs regulate the aα-βtransition remains ***,a combination of GPU-accelerated microsecond molecular dynamics simulations,correlation analysis,and machine learning was used to probe the dynamicalα-βtransition process induced by ILs of 1-alkyl-3-methylimidazolium chloride([C_(n)mim]cl)and its molecular ***,the cation of [C_(n)mim]+in ILs can spontaneously insert into the peptides as free ions(n≤10)and clusters(n≥11).Such insertion can significantly inhibit theα-β,transition and the inhibiting ability for the clusters is more significant than that of free ions,where[Ciomim]+and[C_(12)mim]+can reduce the maximumβ-sheet content of the peptide by 18.5% and 44.9%,***,the correlation analysis and machine learning method were used to develop a predictive model accounting for the influencing factors on theα-βtransition,which could accurately predict the effect of ILs on theα-β***,these quantitative results may not only deepen the understanding of the role of ILs in theα-βtransition but also guide the development of the IL-based treatments for related diseases.

关键词： α-βtransition Moleculardynamics simulation lonic liquids Machine learning Membrane channel protein

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Insight into leaching rare earth from ion-adsorption type rare earth ores with citric acid:Performance,kinetic analysis and differentiation leaching

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Journal of Rare Earths 2025年第3期43卷 591-602,I0007页

作者： Mengfei Zhao Zedong Teng Xingyu Ma Xiaoliang Jiang Hualin Zhang Youming Yang Tinggang Li Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou341000China Key Laboratory of Rare Earths Jiangxi Institute of Rare EarthsGanjiang Innovation AcademyChinese Academy of SciencesGanzhou341119China CAS Key Laboratory of Green Process and Engineering Innovation Academy for Green ManufactureNational Engineering Research Center of Green Recycling for Strategic Metal ResourcesBeijing Engineering Research Centre of Process Pollution ControlInstitute of Process EngineeringChinese Academy ofSciencesBeijing100190China State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and DeliveryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

The rare earth elements(REEs)extraction by chemical leaching from ion-adsorption type rare earth ores(IAREO)has led to serious ecological and environmental ***,demand for bioleaching is on the rise with the advantage of being *** one of the organic acids produced by biological metabolism,citric acid was used to leach REEs and explore the performance and *** results demonstrate that citric acid exhibits higher leaching efficiency(96.00%)for REEs at a relatively low concentration of 0.01 mol/L compared with(NH_(4))_(2)SO_(4)(84.29%,0.1 mol/L)and MgSO_(4)(83.99%,0.1 mol/L).Citric acid shows a preference for leaching heavy rare earth elements,with 99%leaching efficiency in IAREO,which shows higher capacity than(NH_(4))_(2)SO_(4)and MgSO_(4)(as inorganic leaching agents).Kinetic analysis indicates that the leaching process of REEs with citric acid is controlled by both the internal diffusion kinetics and chemical reaction kinetics,which is different from inorganic leaching *** Minteq calculations confirm that RE-Citrate is the main constituent of the extract solution in the leaching process of the IAREO,thereby enhancing the leaching efficiency of REEs from the *** suggests that citric acid may be used as a promising organic leaching agent for the environmentalfriendly extraction of REEs from IAREO.

关键词： Ion-adsorption type rare earth ores Rare earths Citric acid Complexation Organic acid Differential leaching

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Metal Ion-Coordinated Biomolecular Noncovalent Glass with Ceramic-like Mechanics

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CCS Chemistry 2024年第11期6卷 2814-2824页

作者： Shuai Cao Wei Fan Rui Chang Chengqian Yuan Xuehai Yan State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and DeliveryInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190 School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049 Center for Mesoscience Institute of Process EngineeringChinese Academy of SciencesBeijing 100190

Glass materials play a vital role in scientific research and engineering *** noncovalent glasses(BNG),based on amino acids and peptides,have been proposed as the next-generation glass materials to meet the demand of a sustainability and circular ***,bulk BNG with remarkable mechanics and tunable photoluminescence are still rare due to the nature of weak noncovalent interactions and oversimplified molecular ***,we report the design and creation of metal ion-coordinated BNG(MIBNG)based on a simple amino acid derivative and metal *** obtained MIBNG exhibit ceramic-like mechanics,including the hardness,elasticity,and wear resistance,that are unattainable by the pure BNG *** remarkable mechanics can be attributed to the enhanced noncovalent crosslinking network connectivity of biomolecules within MIBNG resulting from the incorporation of strong metal coordination interaction with hydrogen bonding and aromatic ***,fluorescence emission of MIBNG can be tuned feasibly through precisely modulating the types of metal ions *** study sheds light on the crucial role of multiple noncovalent interactions in the construction of BNG and advances the exploration and potential applications of BNG-based functional materials with tunable mechanical and optical properties in such fields as electronics and optics.

关键词： biomolecular glass metal ions amino acids noncovalent interactions mechanical properties

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Celebrating 40 Years of Chemical Research in Chinese Universities

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Chemical Research in Chinese Universities 2024年第4期40卷 561-563页

作者： YU Jihong WANG Dan State Key Laboratory of Inorganic Synthesis and Preparative Chemistry International Center of Future ScienceJilin UniversityChangchun 130012P.R.China State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and DeliveryInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China

Chemical Research in Chinese Universities was founded in 1984 as a comprehensive academic journal in the field of *** has since become a repository of intellectual treasures,documenting the evolving landscape of chemical science within the academic *** the past 40 years,Chemical Research in Chinese Universities has witnessed the rapid development of chemical research in universities.

关键词： chemistry. landscape journal

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