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Pickering emulsion transport in skeletal muscle tissue:A dissipative particle dynamics simulation approach

Chinese Journal of Chemical engineering 2024年第4期68卷 65-75页

作者： Xuwei Liu Wei Chen Yufei Xia Guanghui Ma Reiji Noda Wei Ge State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Division of Environmental Engineering Science Graduate School of Science and TechnologyGunma University1-5-1 Tenjin-choKiryuGunma 376-8515Japan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering ***,extensive research on the internal delivery mechanisms of these emulsions,especially the complex intercellular interactions of deformable Pickering emulsions,has been surprisingly *** gap in knowledge holds significant potential for enhancing vaccine *** study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell *** transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case *** factors impacting the transport process are explored,including local cellular tissue environmental factors and the properties of the Pickering emulsion *** simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport ***,larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single *** study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering *** insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug ***,the desired transport efficiency varies depending on the specific *** instance,while a more rapid transport might be crucial for lymph-node-targeted drug delivery,certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.

关键词： Pickering emulsion Skeletal muscular cells Transport phenomena Dissipative particle dynamics Drug delivery

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Facile Fabrication of Core-Shell Structure Fe_(3)O_(4)@C Nanodots for Enhanced Lithium-Sulfur Batteries

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Acta Metallurgica Sinica(English Letters) 2021年第3期34卷 410-416页

作者： Xiang-Rui He Yu-Jiao Zhang Li-Fan Yang Ji-Lu Zhao Hong-Tai Li Yi-Bo Gao Bao Wang Xiao-Dong Guo School of Chemical Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Biochemical Engineering.Instituteof Process Engineering Chinese Academy of SciencesBeijing 100190China School of Chemistry Sun Yat-Sen UniversityGuangzhou 510275China

Lithium sulfur battery(LSB) is widely considered as a next-generation battery system due to its high theoretical energy density of 2567 Wh ***,several inherent issues obstruct the business application of *** address these issues,we assemble core-shell structure Fe_(3)O_(4)@C nanodots with 5 nm diameter as a valid sulfur host via a convenient organic pyrolysis treatment followed by *** nanosized Fe3O4 particles could expose more chemisorption sites and inhibit the polysulfides ***,the carbon layer could not only increase the conductivity but also ensure structural integrity during cyclic ***,the mesoporous channels around Fe_(3)O_(4)@C could supply sufficient space to load sulfur and physically restrict the shuttle of ***,the resultant S/Fe_(3)O_(4)@C cathode shows a highly initial capacity of 1089 mAh g^(-1) at 0.2 C,even retains 655 mAh g^(-1) over 200 cycles at 1 C.

关键词： Fe(3)O_(4) Nanodots Cathode Lithium–sulfur batteries

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Synthesis Chemistry & Performance Enhancement of Critical Inorganic Functional Materials

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Chemical Research in Chinese Universities 2024年第3期40卷 343-345页

作者： WANG Dan YU Ranbo State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and DeliveryInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China Department of Physical Chemistry School of Metallurgical and Ecological EngineeringUniversity of Science&Technology BeijingBeijing 100083P.R.China

The development of human economy and society relies on the advancement of materials,and the research of advanced materials continuously drives industrial changes,giving rise to a new wave of global scientific and technological *** plays a significant role in the field of materials research and industry,however,the increasing prominence of key strategic materials being controlled by external forces has become a bottleneck issue that hinders national economic and social development as well as national security.

关键词： hinder continuously forces

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Separation of chitin from shrimp shells enabled by transition metal salt aqueous solution and ionic liquid

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Chinese Journal of Chemical engineering 2023年第1期53卷 133-141页

作者： Mi Feng Bin He Xinyan Chen Junli Xu Xingmei Lu Cai Jia Jian Sun Key Laboratory of Molecular Medicine and Biotherapy Ministry of Industry and Information TechnologySchool of Life SciencesBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologyAdvanced Research Institute of Multidisciplinary ScienceBeijing Institute of TechnologyBeijing 100081China CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Multiphase Complex SystemsState Key Laboratory of Biochemical EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical and Engineering University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

Chitin is a widely used important industrial polymer mainly from shrimp shells, but its commercial preparation is under the great challenge of serious pollution due to the requirement of HCl and Na ***, we demonstrated that high purity chitin can be obtained from waste shrimp shells(WSSs) by cascade separation with transition metal salt aqueous solution and ionic liquid(IL). Firstly, calcium carbonate of WSSs was effectively removed in the metal salt aqueous solution driven by the ion exchange interaction. Subsequently, 1-butyl-3-methylimidazolium chloride([Bmim]Cl) had bifunctional abilities to remove residual protein and introduced metal salts simultaneously by hydrogen bonding and coordination interactions. The key experimental factors affecting the separation process were systematically studied, including the type of metal salts, temperature, and [Bmim]Cl loading. After sequential treatment with a 20%(mass) Ni SO4aqueous solution at 130 ℃ and [Bmim]Cl at 150 ℃, the purity of a-chitin can be up to 96.5%(mass) that meets commercial requirements. The use of metal salts with higher coordination ability makes the preparation of chitin no longer depend on the commonly acid-base reaction, which is conducive to the preservation of chitin structure.

关键词： Chitin Ionic liquids Transition metal salts Separation Sustainability

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Apoferritin nanoparticle based dual-antigen influenza conjugate vaccine with potential cross-protective efficacy against heterosubtypic influenza virus

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Particuology 2022年第5期20卷 56-64页

作者： Yanan Sheng Jiangxue Wei Zhengjun Li Zhiguo Su Guanghui Ma Songping Zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Ferritin nanoparticles with self-assembling properties have been widely explored as vaccine carrier by displaying foreign antigens through genetic fusion *** the present work,an apoferritin(AFt)nanoparticle was tested as influenza vaccine carrier by chemically conjugating a matrix protein 2 ectodomain(M2e)antigen peptide or/and the full-length hemagglutinin(HA)antigen on the outer surface of the AFt,with heterobifunctional sSMCC or SM(PEG)_(24) containing PEG chain as *** each AFt nanoparticle,about 30-32 M2e or 1.8 HA antigen could be *** AFt-(PEG)24-M2e,in which the M2e was coupled through SM(PEG)_(24) containing PEG chain,conferred higher protective efficacy in immunized mice than AFt-M2e did,but was less effective than AFt-(PEG)_(24)-*** both M2e and HA were coupled,the synthesized dual-antigen vaccine candidate AFt-(PEG)_(24)-M2e/HA elicited high level of M2e and HA antigen-specific antibodies and conferred 100%protection against lethal infection of homologous PR8 HI N1 virus strain and 70%protection against a heterologous A/FM/1/47(FM1,H1N1)strain,which was more effective than the M2e or HA single antigen vaccine *** potential cross-protective effect of the dual-antigen vaccine was further demonstrated by significant specific hemagglutination inhibition(HAI)titers in serum of the immunized mice against three other heterologous viral strains including A/Singapore/GPl908/2015(IVR-180)H1N1,A/Anhui/1/2005 H5N1,and A/Hong Kong H3N2.

关键词： Influenza vaccine Apoferritin nanoparticle Hemagglutinin M2e Conjugate vaccine

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The development of hollow multishelled structure: from the innovation of synthetic method to the discovery of new characteristics

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Science China Chemistry 2022年第1期65卷 7-19页

作者： Jiangyan Wang Zumin Wang Dan Mao Dan Wang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Hollow multishelled structure(HoMS)is one of the most promising multifunctional *** high complexity of its structure makes the general and controllable synthesis of HoMS rather *** integration of multidisciplinary knowledge,a great achievement in HoMSs has been obtained in the past ***,the developed sequential templating approach has significantly boomed the progress of HoMS in composition and structure diversity and application *** implementation of the temporal-spatial ordering in HoMS makes it indispensable in solving the key scientific problems in energy conversion,catalysis and drug delivery *** development in HoMSs with novel intricate structures will bring new *** this review,we systematically introduce the development history of HoMSs,summarize the inspiration inherited from the previous research on hollow structures,and discuss the milestones in the development of HoMSs,with a focus on the sequential templating approach for HoMS fabrication,attractive temporal-spatial ordering property and dynamic smart behavior for advanced *** hope to reveal the inherent relationship between the precise synthesis of HoMS and its highly tunable compositional and structural characteristics,and point out its future direction to boost HoMS area further.

关键词： hollow multishelled structure sequential templating approach temporal-spatial ordering smart dynamic behavior

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Mesenchymal Stem Cells Proliferation on Konjac Glucomannan Microcarriers:Effect of Rigidity

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Chinese Journal of Polymer Science 2022年第9期40卷 1080-1089页

作者： Xing-Ran Yan Juan Li Xiang-Ming Na Tong Li Yu-Fei Xia Wei-Qing Zhou Guang-Hui Ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Mesenchymal stem cells(MSCs)have attracted great attention as a source of cells for regenerative medicine owing to their self-renewal ability and multiple differentiation ***,the serious shortage of MSCs and the difficulty of maintaining the differentiation potential during culture in vitro limit their *** culture technology is an effective method to realize large-scale culture of MSCs,whereas the effect of microcarriers properties on MSCs proliferation and differentiation potential maintenance should be *** this study,Konjac glucomannan(KGM)microcarriers with a wide range of rigidity from 0.2 MPa to 10 MPa were prepared using water-in-oil emulsion *** was found that the microcarriers rigidity had great influence on MSCs by regulating cell spreading *** proliferation and good differentiation potential maintenance of MSCs were achieved on the intermediate rigidity about 2.51±0.65 MPa with the faster spreading rate of *** a result,MSCs on 2.51±0.65 MPa KGM microcarriers proliferated about 27 times,which was 1.7 times as much as MSCs cultured on the commercial microcarriers *** differentiation potential was also improved about 3.2 times compared to ***,it is indispensable to regulate microcarriers rigidity,especially for application of MSCs.

关键词： MSCs Proliferation Differentiation potential Rigidity Spreading

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Multi-functional Hollow Structures for Intelligent Drug Delivery

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Chemical Research in Chinese Universities 2024年第3期40卷 394-412页

作者： HOU Ping YANG Nailiang WANG Dan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049P.R.China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100049P.R.China

Multi-fountional hollow structures have emerged as promising platforms for intelligent drug delivery due to their unique properties,such as high loading capacities and programmed drug *** particular,hollow multishell structures(HoMSs)with multilevel shell and space can regulate the molecular-level interaction between drugs and materials,so as to achieve the temporal-spatial order and sequential release of *** anisotropic hollow structures can control the drug diffusion process by inducing the macroscopic interface flow through autonomous movement,realizing the targeted drug transport and *** this paper,a key focus will be HoMSs with their temporal-ordered architectures and anisotropic hollow carriers with directional *** synthesis mechanisms,structure-property relationships,smartly programmed drug delivery and biomedical applications will be discussed,providing insights into designing next-generation intelligent drug carriers.

关键词： Hollow multishell structure Anisotropic hollow structure Intelligent drug carrier Temporal-spatial order Directional movement

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Nucleic acid drug vectors for diagnosis and treatment of brain diseases

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Signal Transduction and Targeted Therapy 2023年第2期8卷 604-656页

作者： Zhi-Guo Lu Jie Shen Jun Yang Jing-Wen Wang Rui-Chen Zhao Tian-Lu Zhang Jing Guo Xin Zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190P.R.China University of Chinese Academy of Sciences Beijing100049P.R.China

Nucleic acid drugs have the advantages of rich target selection,simple in design,good and enduring *** have been demonstrated to have irreplaceable superiority in brain disease treatment,while vectors are a decisive factor in therapeutic *** physiological barriers,such as degradation and clearance in circulation,blood-brain barrier,cellular uptake,endosome/lysosome barriers,release,obstruct the delivery of nucleic acid drugs to the brain by the *** acid drugs against a single target are inefficient in treating brain diseases of complex *** between individual patients lead to severe uncertainties in brain disease treatment with nucleic acid *** this Review,we briefly summarize the classification of nucleic acid ***,we discuss physiological barriers during drug delivery and universal coping strategies and introduce the application methods of these universal strategies to nucleic acid drug ***,we explore nucleic acid drug-based multidrug regimens for the combination treatment of brain diseases and the construction of the corresponding *** the following,we address the feasibility of patient stratification and personalized therapy through diagnostic information from medical imaging and the manner of introducing contrast agents into ***,we take a perspective on the future feasibility and remaining challenges of vector-based integrated diagnosis and gene therapy for brain diseases.

关键词： treatment diagnosis replace

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Constructing BaTiO_(3)/TiO_(2)@polypyrrole composites with hollow multishelled structure for enhanced electromagnetic wave absorbing properties

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International Journal of Minerals,Metallurgy and Materials 2023年第3期30卷 581-590页

作者： Dan Mao Zhen Zhang Mei Yang Zumin Wang Ranbo Yu Dan Wang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Department of Energy Storage Science and Engineering School of Metallurgical and Ecological EngineeringUniversity of Science and Technology BeijingBeijing 100083China University of Chinese Academy of Sciences Beijing 100049China

BaTiO_(3)/TiO_(2)@polypyrrole(PPy)composites with hollow multishelled structure(HoMS)were constructed to enhance the electromagnetic wave absorbing properties of BaTiO_(3)-based absorbing ***_(3)/TiO_(2)HoMSs were prepared by hydrothermal crystallization using TiO_(2)Ho MSs as ***,FeCl3 was introduced to initiate the oxidative polymerization of pyrrole monomer,forming BaTiO_(3)/TiO_(2)@PPy HoMSs *** electromagnetic wave absorbing properties of BaTiO_(3)/TiO_(2)HoMSs and BaTiO_(3)/TiO_(2)@PPy Ho MSs with different shell number were investigated using a vector network *** results indicate that BaTiO_(3)/TiO_(2)@PPy HoMSs exhibit improved microwave absorption compared with BaTiO_(3)/TiO_(2)*** particular,tripled-shelled BaTiO_(3)/TiO_(2)@PPy HoMS has the most excellent absorbing *** best reflection loss can reach up to-21.80 dB at 13.34 GHz with a corresponding absorber thickness of only 1.3 mm,and the qualified absorption bandwidth of tripled-shelled BaTiO_(3)/TiO_(2)@PPy HoMS is up to 4.2 *** work paves a new way for the development of high-performance composite microwave absorbing materials.

关键词： BaTiO_(3)/TiO_(2)@polypyrrole composites hollow multishelled structure electromagnetic wave absorbing

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