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Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable,safe and efficient vaccine adjuvant

Frontiers of Chemical Science and engineering 2022年第6期16卷 973-984页

作者： Lili Yuan Xiao-Dong Gao Yufei Xia Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

To increase antibody secretion and dose sparing,squalene-in-water aluminium hydrogel(alun^-stabilised emulsions(ASEs)have been developed,which offer increased surface areas and cellular interactions for higher antigen loading and enhanced immune ***,the squalene(oil)in previous attempts suffered from limited oxidation resistance,thus,safety and stability were *** a clinical translational perspective,it is imperative to screen the optimal oils for enhanced emulsion ***,because of the varying oleic to linoleic acid ratio,soybean oil,peanut oil,and olive oil were utilised as oil phases in the preparation of aluminium hydrogel-stabilised squalene-in-water emulsions,which were then screened for their stability and ***,the underlying mechanisms of oil phases and emulsion stability were unravelled,which showed that a higher oleic to linoleic acid ratio increased anti-oxidative capabilities but reduced the long-term storage stability owing to the relatively low zeta potential of the prepared *** a result,compared with squalene-in-water ASEs,soybean-in-water ASEs exhibited comparable immune responses and enhanced *** optimising the oil phase of the emulsion adjuvants,this work may offer an alternative strategy for safe,stable,and effective emulsion adjuvants.

关键词： pickering emulsion vaccine adjuvant alum-stabilised emulsion oleic to linoleic acid ratio stability

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仿生酶固定化纳米反应器通过级联催化反应实现胆固醇的精确检测

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Science China Materials 2024年第8期67卷 2540-2549页

作者：熊京商灵灵赵德偲王丹 State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and DeliveryInstitute of Process EngineeringChinese Academy of Sciences1 North 2nd StreetZhongguancunBeijing 100190China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing 100049China

基于酶的生化检测方法具有准确性高、检测速度快等优势,但生物酶的不稳定性限制了这一方法的应用.因此,开发一种活性高、稳定性强、反应效率高的酶包封体系是提高胆固醇生化检测的关键.为此,本研究发展了由二棕榈酸磷脂酰胆碱包覆中空... 详细信息

基于酶的生化检测方法具有准确性高、检测速度快等优势,但生物酶的不稳定性限制了这一方法的应用.因此,开发一种活性高、稳定性强、反应效率高的酶包封体系是提高胆固醇生化检测的关键.为此,本研究发展了由二棕榈酸磷脂酰胆碱包覆中空多壳层结构的仿生人造细胞,HoMS的区室化结构和磷脂膜的选择透过性实现了酶的稳定包封和信号的高效传输.本研究通过信号的级联放大实现了胆固醇的快速准确检测.即利用负载胆固醇氧化酶的HoMS@DPPC引发胆固醇氧化反应,产生的中间产物H;2;O;2;作为信号分子,在负载辣根过氧化物酶的HoMS@DPPC催化作用下,促进荧光红染料生成试卤灵,再进行比色检测胆固醇的含量.由级联催化介导的胆固醇信号放大使得该系统可以应用于胆固醇检测,并且该方法表现出高的选择性和准确性,检测范围为0.05~0.3mM,检测限可达4.9μM.该方法可用于动物血清中胆固醇的检测,回收率为90.8%~104.9%,检测值与商业检测方法的结果高度吻合.此外,该系统可与智能设备集成,构建智能比色平台,实现图像分析与胆固醇浓度检测的一体化,为准确、快速的生化检测开辟了新途径.

关键词：图像分析设备集成生化检测胆固醇氧化酶选择透过性信号放大动物血清酶固定化

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Laser-enhanced high-magnification telecentric imaging system for multiphase flow monitoring in membrane fouling

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Chinese Journal of Chemical engineering 2025年 82卷 25-38页

作者： Xu, Haohan Liang, Hu Feng, Xin Zhang, Weipeng Duan, Xiaoxia Chen, Jie Yang, Chao State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing100190 China School of Chemical Engineering University of Chinese Academy of Sciences Beijing100049 China

Membrane fouling is the primary resistance to the continuous production of stirred membrane reactors. This work presents a laser-enhanced high-magnification telecentric imaging system (LEHTIS), which uses a high-magnification telecentric lens and laser-enhanced illumination to invasively capture the motion of particles on the membrane surface or near the membrane. The problems of working distance and particle interference in the stirred membrane reactor are solved to achieve the purpose of in-situ monitoring of membrane fouling. This method is suitable for high flow rates, high solid holdup, and small particle size systems, and the dynamic motion and accumulation of particles are preliminarily analyzed. It shows that the accumulation and desorption of particles on the membrane surface are related to the physical properties of the membrane surface. There is an intermittent rotational movement in the flow field near the membrane, and it tends to stabilize over time. The filtration process can be assessed by monitoring changes in the overall velocity and acceleration of particles near the membrane. The analysis of forces acting on individual particles is compared and validated with the force balance model to correct and accurately apply it to stirred membrane reactors. The development of LEHTIS provides an effective tool for in-situ monitoring of membrane fouling and optimizing the stirred membrane reactors for industrial applications. © 2025 The Chemical Industry and engineering Society of China, and Chemical Industry Press Co., Ltd.

关键词： Chemical industry

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Large Scale One-Pot Synthesis of Monodispersed Na_(3)(VOPO_(4))_(2)F Cathode for Na-Ion Batteries

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Energy Material Advances 2022年第1期2022卷 309-319页

作者： Qiangqiang Zhang Xing Shen Quan Zhou Kaixuan Li Feixiang Ding Yaxiang Lu Junmei Zhao Liquan Chen Yong-Sheng Hu Key Laboratory for Renewable Energy Beijing Key Laboratory for New Energy Materials and DevicesBeijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Biochemical EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

Na-ion batteries(NIBs)have received significant interest as potential candidates for large-scale energy storage owing to the widespread distribution of sodium and superior low-temperature ***,their commercial application is usually hindered by the high production cost and inadequate performance for electrode materials,particularly for ***_(3)(VOPO_(4))_(2)F(NVOPF)has been recognized as one of the most promising cathodes for high-energy NIBs owing to the high working voltage and energy ***,we report a facile highly efficient room-temperature solution protocol for large-scale synthesis of NVOPF cathode for *** simply regulating pH,NVOPF can be obtained,which delivered a discharge capacity of 120.2 mAh g^(-1) at 0.1 C and 72%capacity retention over 8000 cycles at 25 ***,the kilogram-level NVOPF products have been synthesized,and 26650 cylindrical cells were fabricated,which exhibit excellent cycling stabilities,remarkable lowtemperature performance with comparable safety *** hope our findings could provide insights on the industrial application of NVOPF in NIBs.

关键词： cycling cylindrical Cathode

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Advances in oral peptide drug nanoparticles for diabetes mellitus treatment

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Bioactive Materials 2022年第9期7卷 392-408页

作者： Yan Li Wen Zhang Ruichen Zhao Xin Zhang School of Chemistry and Biological Engineering University of Science and Technology BeijingBeijing100083PR China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190PR China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049PR China

Peptide drugs play an important role in diabetes mellitus *** administration of peptide drugs is a promising strategy for diabetes mellitus because of its convenience and high patient compliance compared to parenteral administration ***,there are a series of formidable unfavorable conditions present in the gastrointestinal(GI)tract after oral administration,which result in the low oral bioavailability of these peptide *** overcome these challenges,various nanoparticles(NPs)have been developed to improve the oral absorption of peptide drugs due to their unique in vivo properties and high design *** review discusses the unfavorable conditions present in the GI tract and provides the corresponding strategies to overcome these *** review provides a comprehensive overview on the NPs that have been constructed for oral peptide drug delivery in diabetes mellitus ***,we will discuss the rational application and give some suggestions that can be utilized for the development of oral peptide drug *** aim is to provide a systemic and comprehensive review of oral peptide drug NPs that can overcome the challenges in GI tract for efficient treatment of diabetes mellitus.

关键词： Oral nanoparticles Peptide drugs Gastrointestinal tract Diabetes mellitus Oral bioavailability

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Novel magnetic carbon supported molybdenum disulfide catalyst and its application in residue upgrading

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Green Energy & Environment 2021年第6期6卷 952-960页

作者： Xiangyang Zhu Dong Qiao Liangrong Yang Qinling Bi Huifang Xing Shan Ni Menglei Yuan Huizhou Liu Luhai Wang An Ma CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Biochemical EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China c China University of Petroleum Beijing102249China Petrochemical Research Institute PetrochinaBeijing102206China

A novel hybrid material consisted of carbon covered Fe_(3)O_(4)nanoparticles and MoS_(2)nanoflower(FCM)was designed and prepared by micelle-assisted hydrothermal *** techniques,including X-Ray diffraction(XRD),high-resolution transmission electron microscopy(HRTEM)and X-ray photoelectron spectroscopy(XPS)were employed to characterize *** results show that FCM has a flower-like morphology with a 330 nm Fe_(3)O_(4)core as well as 70 nm highly crystalline MoS_(2)*** is superparamagnetic with a saturation magnetization of 35 emu *** hydrocracking of Canadian bitumen residue(CBR)was applied to estimate its catalytic *** results show that FCM exhibits superior catalytic hydrocracking activity compared to bulk MoS_(2)and commercial oil-dispersed Mo(CO)6 by the same Mo *** measurement by elemental analysis,XPS and XRD reveals that the MoS_(2)nanoflower with abundant catalytic active sites and covered carbon layer with anti-coke ability donate to the superior upgrading ***,the catalysts can be easily recovered by the external magnetic *** work provides a novel kind magnetic nanocatalyst which is potential for slurry-phase hydrocracking applications.■2020,Institute of process engineering,Chinese Academy of *** services by Elsevier *** behalf of KeAi Communications Co.,*** is an open access article under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Magnetic Carbon MoS_(2) Catalyst Heavy oil

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Extraction and characterization of bovine collagen Type V and its effects on cell behaviors

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Regenerative Biomaterials 2022年第1期9卷 460-470页

作者： Jun Xu Xi Luo Yang Zhang Jianping Gao Ching-Cheng Huang Xinpeng Bai Guifeng Zhang College of Food Science and Engineering Engineering Research Center of Utilization of Tropical Polysaccharide ResourcesMinistry of EducationHainan UniversityHaikou 570228China PARSD Biomedical Material Research Center(Changzhou) Changzhou 213176China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringCASBeijing 100190China Department of Biomedical Engineering Ming-Chuan University32033 TaiwanChina

Collagen Type V(Col.V)plays an essential role in cell behaviors and has attracted increasing attention in recent *** Col.V is needed for evaluating its biological *** this research,the enzymatic hydrolysis process was combined with ultrafiltration to purify Col.V from the bovine *** purity of Col.V was determined to be above 90%by both sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE)and high-performance liquid chromatography *** effect of Col.V on cell behaviors was *** circular dichroism spectroscopy results demonstrated that the extracted Col.V exhibited a complete triple helix ***-PAGE suggested that the molecular weight of Col.V was 440 *** self-assembly experiment revealed that the proportion of Col.V in the collagen mixture can affect the Col.I fiber *** cell culture results implied that Col.V can inhibit fibroblasts(L929)*** L929 showed maximum mobility when the addition of Col.V was 30%.Thus,Col.V has the effect of inhibiting L929 proliferation and promoting *** high-purity Col.V provides useful information for further understanding its biological implications.

关键词： collagen Type V bovine cornea fiber diameter cell migration

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An Integrated process Coupling Biooxidation and Fenton Oxidation for Treatment of Arsenic-Containing Acid Mine Drainage

SSRN

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SSRN 2024年

作者： Shen, Cailong Chen, Yanzhen Yang, Li Zhang, Guangji Yang, Chao State Key Laboratory of Biochemical Engineering CAS Key Laboratory of Green Process and Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing100190 China School of Chemical Engineering University of Chinese Academy of Sciences Beijing100049 China

Arsenic-containing acid mine drainage (AMD) is a serious water pollution problem worldwide. In present study, an integrated process coupling biooxidation and Fenton oxidation was proposed for treatment of simulated AMD with high As(III) concentration. The biooxidation experiments showed that Acidithiobacillus ferrooxidans was resistant to at least additional H2O2 of 90 mM when cultured in 100 mL Leathen medium with 5 g FeSO4·7H2O. The XRD and SEM confirmed the formation of crystalline jarosite and amorphous schwertmannite. The AMD treatment was carried out with 300 mg/L As(III) in shaking flasks, and finally 73.15% arsenic was removed in 96 h. The formed precipitates exhibited 2.117 mg/L arsenic in leachate in the toxicity characteristic leaching procedure (TCLP) test, which was below the United states Environmental Protection Agency’s limit of 5 mg/L. However, the precipitates formed in the treatment experiments without additional H2O2 exhibited leached arsenic of 6.492 mg/L in the TCLP test. The results suggested a better stability of the formed precipitates in the integrated arsenic removal process. The XPS suggested that the improved stability was attributed to that the formed precipitates mainly contained As(V) instead of As(III). Meanwhile, the ICP-OES and ASV showed a rapid As(III) oxidation in the solution immediately after the addition of H2O2. The arsenic removal process was carried out in a 5 L stirred tank reactor to evaluate the feasibility on a larger scale. The results confirmed that biooxidation was not inhibited by additional H2O2 from the point of view of the metabolic activity of bacteria. About 85% arsenic settled down in 120 h, and the formed precipitates exhibited a good stability of 0.534 mg/L arsenic leaching concentration in the TCLP test, indicating the potential of the arsenic removal process for further application. © 2024, The Authors. All rights reserved.

关键词： Iron compounds

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engineering single atomic ruthenium on defective nickel vanadium layered double hydroxide for highly efficient hydrogen evolution

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Nano Research 2023年第4期16卷 4612-4619页

作者： Xiaoyu Chen Jiawei Wan Meng Zheng Jin Wang Qinghua Zhang Lin Gu Lirong Zheng Xianzhu Fu Ranbo Yu College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Department of Physical Chemistry School of Metallurgical and Ecological EngineeringUniversity of Science and Technology Beijing InstitutionBeijing 100083China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Beijing National Center for Electron Microscopy and Laboratory of Advanced Materials Department of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Advanced Material Processing&Mold Ministry of EducationZhengzhou UniversityZhengzhou 450002China

Fabricating single-atom catalysts(SACs)with high catalytic activity as well as great stability is a big ***,we propose a precise synthesis strategy to stabilize single atomic ruthenium through regulating vanadium defects of nickel vanadium layered double hydroxides(NiV-LDH)ultrathin nanoribbons ***,the isolated atomically Ru doped NiV-LDH ultrathin nanoribbons(NiVRu-R)were successfully fabricated with a super-high Ru load of 12.8 wt.%.X-ray absorption spectrum(XAS)characterization further confirmed atomic dispersion of *** catalysts for electrocatalytic hydrogen evolution reaction(HER)in alkaline media,the NiVRu-R demonstrated superior catalytic properties to the commercial Pt/***,it maintained exceptional stability even after 5,000 cyclic voltammetry ***-situ XAS and density functional theory(DFT)calculations prove that the Ru atomic sites are stabilized on supports through forming the Ru-O-V structure,which also help promote the catalytic properties through reducing the energy barrier on atomic Ru catalytic sites.

关键词： hydrogen evolution reaction layered double hydroxide ruthenium atomic site ultrathin nanoribbons

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生物启发和生物工程核酸药物载体

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Science China Materials 2024年第8期67卷 2393-2413页

作者：左嘉敏卢治国郭京赵睿琛张田露王朝霞袁云邓健文袁俊亮张欣 State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Neurology Peking University Sixth HospitalPeking University Institute of Mental HealthBeijing 100191China Department of Neurology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Neurovascular Disease Discovery Beijing 100034China Key Laboratory of Biopharmaceutical Preparation and Delivery Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

核酸药物具有直接作用于致病基因的优势,在治疗各种疾病方面具有巨大潜力.然而,由于核酸药物需要克服多重生理障碍才能到达靶点,因此在实际应用中面临诸多困难和挑战.为了提高核酸药物的稳定性和递送效率,研究人员开始利用生物工程化和... 详细信息

核酸药物具有直接作用于致病基因的优势,在治疗各种疾病方面具有巨大潜力.然而,由于核酸药物需要克服多重生理障碍才能到达靶点,因此在实际应用中面临诸多困难和挑战.为了提高核酸药物的稳定性和递送效率,研究人员开始利用生物工程化和生物启发材料所具有的内源性递送生物大分子的能力来递送核酸药物.本文重点介绍核酸药物递送过程中需要克服的生物障碍,以及生物工程和生物启发材料在核酸药物递送中的优势和应用.通过利用这些先进的生物材料,研究人员有望提高核酸药物的疗效,为疾病治疗提供新的解决方案.

关键词：生物工程药物递送生理障碍生物启发致病基因生物大分子工程化疾病治疗

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