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Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72

Cellular & Molecular Immunology 2022年第6期19卷 702-714页

作者： Yan Zhao Fengming Huang Zhen Zou Yuhai Bi Yang Yang Cong Zhang Qiang Liu Daozhen Shang Yiwu Yan Xiangwu Ju Song Mei Peng Xie Xiao Li Mingyao Tian Shuguang Tan Huijun Lu Zongsheng Han Kangtai Liu Yuqing Zhang Junbo Liang Zhu Liang Qingchao Zhang Jiahui Chang William JLiu Cong Feng Tanshi Li Michael Q.Zhang Xiaoyue Wang George FGao Yingxia Liu Ningyi Jin Chengyu Jiang State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of BiochemistryPeking Union Medical CollegeBeijing 100005China Shenzhen Key Laboratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseSecond Hospital Affiliated with Southern University of Science and TechnologyShenzhen Third People’s HospitalShenzhenGuangdong 518112China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China School of Life Science University of Science and Technology of ChinaHefeiAnhui 230027China Department of Automation Tsinghua UniversityBeijing 100084China Genetic Engineering Laboratory Institute of Military VeterinaryAcademy of Military Medical SciencesChangchunJilin 130062China State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China HospitalSichuan UniversityChengduSichuan 610000China State Key Laboratory of Medical Molecular Biology Department of Biochemistry and Center for BioinformaticsInstitute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China National Institute for Viral Disease Control and Prevention Chinese Centers for Disease Control and PreventionBeijing 102206China Department of Emergency General Hospital of the PLAHaidian DistrictBeijing 100853China Department of Biological Sciences and Center for Systems Biology The University of Texas at DallasRichardsonTXUSA

Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can betterescape host innate immune responses than the less virulent seasonal H1N1 virus. Here, we report a mechanism by whichtranscriptional readthrough (TRT)-mediated suppression of innate immunity occurs post AIV infection. By using cell lines, mouselungs, and patient PBMCs, we showed that genes on the complementary strand (“trans” genes) influenced by TRT were involved inthe disruption of host antiviral responses during AIV infection. The trans-TRT enhanced viral lethality, and TRT abolishmentincreased cell viability and STAT1/2 expression. The viral NS1 protein directly bound to SSU72, and degradation of SSU72 inducedTRT. SSU72 overexpression reduced TRT and alleviated mouse lung injury. Our results suggest that AIVs infection induce TRT byreducing SSU72 expression, thereby impairing host immune responses, a molecular mechanism acting through the NS1-SSU72-trans-TRT-STAT1/2 axis. Thus, restoration of SSU72 expression might be a potential strategy for preventing AIV pandemics.

关键词： AIV infection TRT SSU72 NS1 Immune escape

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Collision/Obstacle Avoidance Dynamic Formation Reconfiguration of High-Order Nonlinear Multi-Agent Systems

Collision/Obstacle Avoidance Dynamic Formation Reconfigurati...

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第35届中国控制与决策会议

作者： Liwei An Weinan Gao Chao Deng Wei-Wei Che College of Information Science and Engineering Northeastern University State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Institute of Advanced Technology Nanjing University of Posts and Telecommunications Department of Automation Qingdao University

Multi-Agent formation involves the motion conflicts of large numbers of physical systems,which leads to significant safety challenges in terms of collision/obstacle *** paper studies the problem of collision/obstacle avoidance formation tracking for a class of high-order strict-feedback nonlinear multiagent systems and presents a dynamic formation reconfiguration ***,a smooth and analytic reference trajectory is constructed,which consists of a convex combination of preset trajectory and delayed target trajectory with its coefficient adaptively adjusted by two barrier functions to avoid ***,a distributed backstepping control scheme with highorder filtering for barrier functions is ***,all agents adaptively reconfigure their formation shape within the barrier function's coverage to avoid collisions with each other and obstacles,while quickly forming a pre-defined shape of formation following the target trajectory outside the barrier function's *** results are given to illustrate the effectiveness of the proposed scheme.

关键词： Formation reconfiguration collision/obstacle avoidance multi-agent systems barrier functions

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Distributed Event-Triggered Bandit Convex Optimization With Time-Varying Constraints

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IEEE Transactions on Control of Network Systems 2025年

作者： Zhang, Kunpeng Yi, Xinlei Wen, Guanghui Cao, Ming Johansson, Karl H. Chai, Tianyou Yang, Tao Northeastern University State Key Laboratory of Synthetical Automation for Process Industries Shenyang110819 China Ministry of Education Shanghai Institute of Intelligent Science and Technology National Key Laboratory of Autonomous Intelligent Unmanned Systems Frontiers Science Center for Intelligent Autonomous Systems Shanghai201210 China Southeast University School of Automation Nanjing210096 China University of Groningen Engineering and Technology Institute Groningen Faculty of Science and Engineering GroningenAG 9747 Netherlands KTH Royal Institute of Technology Division of Decision and Control Systems School of Electrical Engineering and Computer Science Stockholm10044 Sweden KTH Royal Institute of Technology Digital Futures Stockholm10044 Sweden

This paper considers the distributed bandit convex optimization problem with time-varying inequality constraints over a network of agents, where the goal is to minimize network regret and cumulative constraint violation. Existing distributed online algorithms solving this problem require that each agent broadcasts its decision to its neighbors at each iteration. However, communication resources are often limited. To better utilize communication resources, we propose a distributed event-triggered online primal-dual algorithm with two-point bandit feedback. Under several classes of appropriately chosen decreasing parameter sequences and non-increasing event-triggered threshold sequences, we establish dynamic network regret and network cumulative constraint violation bounds. These bounds are comparable to the results achieved by distributed event-triggered online algorithms with full-information feedback. Finally, a numerical example is provided to verify the theoretical results. © 2014 IEEE.

关键词： Optimization algorithms

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In Situ Investigation of Dynamic Silver Crystallization Driven by Chemical Reaction and Diffusion

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Research 2020年第1期2020卷 739-749页

作者： Ting Liu Xiangyu Dou Yonghui Xu Yongjun Chen Yongsheng Han State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of Sciences100190 BeijingChina State Key Laboratory of Marine Resource Utilization in South China Sea Hainan University570228 HaikouChina School of Chemical Engineering University of Chinese Academy of Sciences100049 BeijingChina

Rational synthesis of materials is a long-term challenging issue due to the poor understanding on the formation mechanism of material structure and the limited capability in controlling nanoscale *** emergent in situ electron microscope provides an insight to this *** employing an in situ scanning electron microscope,silver crystallization is investigated in real time,in which a reversible crystallization is *** disclose this reversible crystallization,the radicals generated by the irradiation of electron beam are *** is found that the concentrations of radicals are spatiotemporally variable in the liquid cell due to the diffusion and reaction of *** fluctuation of the reductive hydrated electrons and the oxidative hydroxyl radicals in the cell leads to the alternative dominance of the reduction and oxidation *** reduction leads to the growth of silver crystals while the oxidation leads to their dissolution,which results in the reversible silver crystallization.A regulation of radical distribution by electron dose rates leads to the formation of diverse silver structures,confirming the dominant role of local chemical concentration in the structure evolution of materials.

关键词： silver reversible crystallization

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Carbon Dioxide as a Temporary Protective Agent for Highly Efficient and Selective Access to Diols Via Ki-Catalyzed Hydration of Epoxides

SSRN

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SSRN 2024年

作者： Zhang, Jingshun Wang, Xueke Hu, Hao Wang, Ziyi Wang, Li Zhang, Jinglai Gao, Guohua State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University Institute of Eco-Chongming 3663 North Zhongshan Road Shanghai 200062 20 Cuiniao Road Shanghai202162 China Henan Key Laboratory of Protection and Safety Energy Storage of Light Metal Materials College of Chemistry and Molecular Sciences Henan University Henan Kaifeng475004 China

The CO2 utilization had attracted a great attention in chemical synthesis. Herein, a strategy of CO2 as a temporary protective agent was disclosed and well applied to the KI-catalyzed hydration of epoxides to synthesized diols with high yields (87.8-98.9%) and selectivities (89.5-99.1%) at a low H2O/epoxide ratio of 1.5:1. Isotope labeling experiments using isotope-labeled water (H218O) confirmed that the strategy remained direct hydration of epoxides. Mechanistic experiments and density functional theory (DFT) calculations implied that CO2 as a temporary protective agent, protected the oxygen-negative intermediates formed from the ring opening of epoxides to generate carbonate anion, thereby safeguarding the hydration of epoxides against potential condensation reactions and simultaneously activate H2O for nucleophilic substitution reaction. Finally, CO2 could be automatically released later through the decarboxylation process. The strategy with excellent functional group tolerance, the viability from the gram-scale reaction, and the flue gas reaction will open up new avenues for applications of CO2 in the hydration of epoxides and inspire novel synthetic design by utilizing CO2 as a temporary protective agent. © 2024, The Authors. All rights reserved.

关键词： Carbon dioxide

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A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis

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Protein & Cell 2023年第12期14卷 888-907页

作者： Daoyuan Huang Yuesheng Zuo Chen Zhang Guoqiang Sun Ying Jing Jinghui Lei Shuai Ma Shuhui Sun Huifen Lu Yusheng Cai Weiqi Zhang Fei Gao Andy Peng Xiang Juan Carlos Izpisua Belmonte Guang-Hui Liu Jing Qu Si Wang Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stemcell and Regeneration CAsBeijing100101China China National Center for Bioinformation Beijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China 11Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhou510000China Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510000China Altos Labs Inc.San DiegoCA 92121USA and Aging Biomarker Consortium China

The testis is pivotal for male reproduction,and its progressive functional decline in aging is associated with ***,the regulatory mechanism underlying primate testicular aging remains largely ***,we resolve the aging-related cellular and molecular alterations of primate testicular aging by establishing a single-nucleus transcriptomic ***-expression patterns along the spermatogenesis trajectory revealed molecular programs associated with attrition of spermatogonial stem cell reservoir,disturbed meiosis and impaired spermiogenesis along the sequential ***,Sertoli cell was identified as the cell type most susceptible to aging,given its deeply perturbed age-associated transcriptional ***,downregulation of the transcription factor Wilms'Tumor 1(WTi),essential for Sertoli cell homeostasis,was associated with accelerated cellular senescence,disrupted tight junctions,and a compromised cell identity signature,which altogether may help create a hostile microenvironment for ***,our study depicts in-depth transcriptomic traits of non-human primate(NHP)testicular aging at single-cell resolution,providing potential diagnostic biomarkers and targets for therapeutic interventions against testicular aging and age-related male reproductive diseases.

关键词： single-nucleus RNA sequencing primate testis aging WT1

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A parametric study on unbalanced moment of piston type valve core

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Journal of Zhejiang University-Science A(Applied Physics & engineering) 2021年第4期22卷 265-276页

作者： Jin-yuan QIAN Juan MU Cong-wei HOU Zhi-jiang JIN Institute of Process Equipment College of Energy EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

In this paper,the piston type valve core and the unbalanced moment on its bottom are *** decrease the influence of non-common geometrical factors,a simplified model of the piston type globe valve is proposed in this *** on the computational fluid dynamics(CFD)method,the effects of different geometrical parameters on the unbalanced moment existing on the bottom of the valve core,which include the bending radius of the inlet flow channel,the diameter of the special-shaped pipe,and the height of the valve core,are ***,the effects of geometrical parameters on the unbalanced moment on the bottom of the valve core are clarified by correction and variation classification and provide a basis for further optimizing the structure of the piston type *** results show that the unbalanced moment decreases with the increase of the bending radius of the inlet flow channel,but increases with the increase of the diameter of the special-shaped pipe and the height of the valve ***,the relation between the unbalanced moment and flow rate is proposed.

关键词： Piston type valve core Unbalanced moment Geometrical parameters Computational fluid dynamics(CFD)

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Cross-sectional deformation of H96 brass double-ridged rectangular tube in rotary draw bending process with different yield criteria

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Chinese Journal of Aeronautics 2020年第6期33卷 1788-1798页

作者： Yangyang XIA Yuli LIU Mengmeng LIU Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China State Key Laboratory Solidification Process School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710072China

Different yield criterion has great difference in predicting the deformation of tube with different *** order to improve the prediction accuracy of the cross-sectional deformation of the double-ridged rectangular tube(DRRT)during rotary draw bending(RDB)process,Mises isotropic yield criterion,Hill’48 and Barlat/Lian anisotropic yield criteria commonly used in practical engineering are introduced to simulate RDB of *** inverse method combining uniaxial tensile test of whole tube and response surface methodology was proposed to identify the parameters of Hill’48 and Barlat/Lian yield criteria of small-sized H96 brass extrusion DRRT as *** based on ABAQUS/Explicit platform,the FE models of RDB process of DRRT considering Mises,Hill’48 and Barlat/Lian yield criteria were *** results show that:The variation trend of cross-sectional deformation ratio is same when using different yield *** cross-sectional deformation ratio by using Mises yield criterion is close to that by using Hill’48 yield ***,there is a quite difference between by using Barlat/Lian yield criterion and by using Mises or Hill’48 yield *** prediction values of cross-sectional height deformation by using three yield criteria all underestimate the experiment ones,and the prediction values of cross-sectional width deformation overestimate the experiment *** comparing the simulation results of cross-sectional deformation of the DRRT with different yield criteria and experiment ones,Barlat/Lian yield criterion is found to be suitable for describing the RDB process of DRRT.

关键词： Anisotropy yield criterion Cross-sectional deformation H96 double-ridged rectangular tube H-type rotary draw bending Inverse method

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Design and Construction of 3D Porous Na3V2(PO4)3/C as High Performance Cathode for Sodium Ion Batteries

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Chemical Research in Chinese Universities 2021年第2期37卷 265-273页

作者： HoU Baoxiu MA Linlin ZANG Xiaohuan SHANG Ningzhao SONG Jianmin ZHAO Xiaoxian WANG Chun QI Jian WANG Jiangyan YU Ranbo Department of Chemistry College of ScienceHebei Agricultural UniversityBaoding071001P.R.China Department of Physical Chemistry School of Metallurgical and Ecological EngineeringUniversity of Science and Technology BeijingBeijing100083P.R.China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190P.R.China University of Chinese Academy of Sciences Beijing100049P.R.China

An easy and delicate approach using cheap carbon source as conductive materials to construct 3D sequential porous structural Na3V2(PO4)3/C(NVP/C)with high performance for cathode materials of sodium ion battery is highly *** this paper,the NVP/C with 3D sequential porous structure is constructed by a delicate approach named as“cooking porridge”including evaporation and calcination ***,during evaporation,the viscosity of NVP/C precursor is optimized by controlling the adding quantity of citric acid,thus leading to a 3D sequential porous structure with a high specific surface ***,the NVP/C with a 3D sequential porous structure enables the electrolyte to interior easily,providing more active sites for redox reaction and shortening the diffusion path of electron and sodium ***,benefited from its unique structure,as cathode material of sodium ion batteries,the 3D sequential porous structural NVP/C exhibits high specific capacities(115.7,88.9 and 74.4 mA·h/g at current rates of 1,20 and 50 C,respectively)and excellent cycling stability(107.5 and 80.4 mA·h/g are remained at a current density of 1 C after 500 cycles and at a current density of 20 C after 2200 cycles,respectively).

关键词： Porous structure Na3V2(PO4)3@C Sodium ion battery Cathode material Energy storage

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Halogen atom-induced local asymmetric electron in covalent organic frameworks boosts photosynthesis of hydrogen peroxide from water and air

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Matter 2025年第5期8卷

作者： Liu, Youxing Guo, Yaru Sathishkumar, Nadaraj Liu, Minghui Li, Lu Sang, Zhiyuan Feng, Rongjuan Sun, Zongqiang Sun, Chenglong Luo, Mingchuan Deng, Xuliang Lu, Gang Guo, Shaojun School of Materials Science and Engineering Peking University Beijing100871 China Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical Technology Beijing100029 China Department of Geriatric Dentistry NMPA Key Laboratory for Dental Materials National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Laboratory of Biomedical Materials Peking University School and Hospital of Stomatology Beijing100081 China Department of Physics and Astronomy California State University NorthridgeCA91330 United States Institute of Chemistry Chinese Academy of Sciences Beijing100049 China

The solar-to-chemical conversion (SCC) efficiency of hydrogen peroxide (H2O2) photosynthesis is governed by the O2 adsorption model and energy level, which are experimentally challenging to be tuned. Herein, we report a new strategy for tuning of the O2 adsorption and electron potential energy level of covalent organic frameworks (COFs) using halogen atom (F, Cl, Br, and I) as a regulatory reagent, and demonstrate that I-COFs exhibit the maximum thermodynamic driving force for 2e– oxygen reduction reaction (ORR). The introduction of I atom inhibits the O–O bond breakage for enhancing the selectivity of 2e– ORR from 56.5% to 87.0%, thus promoting the continuous natural sunlight-driven photosynthesis of H2O2 directly from water and air, showing a high SCC efficiency of 1.88% and the operational stability of over 200 h. Meanwhile, I-COFs also show 100% antibacterial performance and efficient wound healing ability, which is significantly better than that of H-COFs with symmetric electron distribution. © 2025 Elsevier Inc.

关键词： Electrolytic reduction

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