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Measurement of the production cross section for Z+b jets in proton-proton collisions at s=13 TeV

Physical Review D 2022年第9期105卷 092014-092014页

作者： A. Tumasyan W. Adam J. W. Andrejkovic T. Bergauer S. Chatterjee K. Damanakis M. Dragicevic A. Escalante Del Valle R. Frühwirth M. Jeitler N. Krammer L. Lechner D. Liko I. Mikulec P. Paulitsch F. M. Pitters J. Schieck R. Schöfbeck D. Schwarz S. Templ W. Waltenberger C.-E. Wulz V. Chekhovsky A. Litomin V. Makarenko M. R. Darwish E. A. De Wolf T. Janssen T. Kello A. Lelek H. Rejeb Sfar P. Van Mechelen S. Van Putte N. Van Remortel F. Blekman E. S. Bols J. D’Hondt M. Delcourt H. El Faham S. Lowette S. Moortgat A. Morton D. Müller A. R. Sahasransu S. Tavernier W. Van Doninck D. Beghin B. Bilin B. Clerbaux G. De Lentdecker L. Favart A. Grebenyuk A. K. Kalsi K. Lee M. Mahdavikhorrami I. Makarenko L. Moureaux L. Pétré A. Popov N. Postiau E. Starling L. Thomas M. Vanden Bemden C. Vander Velde P. Vanlaer T. Cornelis D. Dobur J. Knolle L. Lambrecht G. Mestdach M. Niedziela C. Roskas A. Samalan K. Skovpen M. Tytgat B. Vermassen L. Wezenbeek A. Benecke A. Bethani G. Bruno F. Bury C. Caputo P. David C. Delaere I. S. Donertas A. Giammanco K. Jaffel Sa. Jain V. Lemaitre K. Mondal J. Prisciandaro A. Taliercio M. Teklishyn T. T. Tran P. Vischia S. Wertz G. A. Alves C. Hensel A. Moraes W. L. Aldá Júnior M. Alves Gallo Pereira M. Barroso Ferreira Filho H. Brandao Malbouisson W. Carvalho J. Chinellato E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza C. Mora Herrera K. Mota Amarilo L. Mundim H. Nogima P. Rebello Teles A. Santoro S. M. Silva Do Amaral A. Sznajder M. Thiel F. Torres Da Silva De Araujo A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores D. S. Lemos P. G. Mercadante S. F. Novaes Sandra S. Padula A. Aleksandrov G. Antchev R. Hadjiiska P. Iaydjiev M. Misheva M. Rodozov M. Shopova G. Sultanov A. Dimitrov T. Ivanov L. Litov B. Pavlov P. Petkov A. Petrov T. Cheng T. Javaid M. Mittal L. Yuan M. Ahmad G. Bauer C. Dozen Z. Hu J. Martins Y. Wang K. Yi E. Chapon G. M. Chen H. S. Chen M. Chen F. Iemmi A. Kapoor D. Leggat H. Liao Z.-A. Liu V. Milosevic F. Monti R. Sharma J. Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Institute for Nuclear Problems Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Korea University Seoul Korea Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China Massachusetts Institute of Technology Cambridge Massachusetts USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Sun Yat-Sen University Guangzhou China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) - Fudan University Shanghai China Rice University Houston Texas USA Zhejiang University Hangzhou China Zhejiang China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt The University of Kansas Lawrence Kansas USA Center for High Energy Physics (CHEP-FU) Fayoum University El-Fayoum Egypt

The measurement of the cross section for the production of a Z boson, decaying to dielectrons or dimuons, in association with at least one bottom quark jet is performed with proton-proton collision data at s=13 TeV. The data sample corresponds to an integrated luminosity of 137 fb−1, collected by the CMS experiment at the LHC during 2016–2018. The integrated cross sections for Z+≥1 b jet and Z+≥2 b jets are reported for the electron, muon, and combined channels. The fiducial cross sections in the combined channel are 6.52±0.04(stat)±0.40(syst)±0.14(theo) pb for Z+≥1 b jet and 0.65±0.03(stat)±0.07(syst)±0.02(theo) pb for Z+≥2 b jets. The differential cross section distributions are measured as functions of various kinematic observables that are useful for precision tests of perturbative quantum chromodynamics predictions. The ratios of integrated and differential cross sections for Z+≥2b jets and Z+≥1 b jet processes are also determined. The value of the integrated cross section ratio measured in the combined channel is 0.100±0.005(stat)±0.007(syst)±0.003(theo). All measurements are compared with predictions from various event generators.

关键词： Bottom quark W & Z bosons Hadron colliders

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Search for top squark production in fully hadronic final states in proton-proton collisions at s=13 TeV

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Physical Review D 2021年第5期104卷 052001-052001页

作者： A. M. Sirunyan A. Tumasyan W. Adam J. W. Andrejkovic T. Bergauer S. Chatterjee M. Dragicevic A. Escalante Del Valle R. Frühwirth M. Jeitler N. Krammer L. Lechner D. Liko I. Mikulec F. M. Pitters J. Schieck R. Schöfbeck M. Spanring S. Templ W. Waltenberger C.-E. Wulz V. Chekhovsky A. Litomin V. Makarenko M. R. Darwish E. A. De Wolf X. Janssen T. Kello A. Lelek H. Rejeb Sfar P. Van Mechelen S. Van Putte N. Van Remortel F. Blekman E. S. Bols J. D’Hondt J. De Clercq M. Delcourt S. Lowette S. Moortgat A. Morton D. Müller A. R. Sahasransu S. Tavernier W. Van Doninck P. Van Mulders D. Beghin B. Bilin B. Clerbaux G. De Lentdecker L. Favart A. Grebenyuk A. K. Kalsi K. Lee I. Makarenko L. Moureaux L. Pétré A. Popov N. Postiau E. Starling L. Thomas C. Vander Velde P. Vanlaer D. Vannerom L. Wezenbeek T. Cornelis D. Dobur M. Gruchala G. Mestdach M. Niedziela C. Roskas K. Skovpen M. Tytgat W. Verbeke B. Vermassen M. Vit A. Bethani G. Bruno F. Bury C. Caputo P. David C. Delaere I. S. Donertas A. Giammanco V. Lemaitre K. Mondal J. Prisciandaro A. Taliercio M. Teklishyn P. Vischia S. Wertz S. Wuyckens G. A. Alves C. Hensel A. Moraes W. L. Aldá Júnior M. Barroso Ferreira Filho H. Brandao Malbouisson W. Carvalho J. Chinellato E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza J. Martins D. Matos Figueiredo C. Mora Herrera K. Mota Amarilo L. Mundim H. Nogima P. Rebello Teles L. J. Sanchez Rosas A. Santoro S. M. Silva Do Amaral A. Sznajder M. Thiel F. Torres Da Silva De Araujo A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores D. S. Lemos P. G. Mercadante S. F. Novaes Sandra S. Padula A. Aleksandrov G. Antchev I. Atanasov R. Hadjiiska P. Iaydjiev M. Misheva M. Rodozov M. Shopova G. Sultanov A. Dimitrov T. Ivanov L. Litov B. Pavlov P. Petkov A. Petrov T. Cheng W. Fang Q. Guo T. Javaid M. Mittal H. Wang L. Yuan M. Ahmad G. Bauer C. Dozen Z. Hu Y. Wang K. Yi E. Chapon G. M. Chen H. S. Chen M. Chen A. Kapoor D. Leggat H. Liao Z.-A. LIU R. Sharma A. Spiezia J. Tao J. Thomas-Wils Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Wien Austria Institute for Nuclear Problems Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Korea University Seoul Korea Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista São Paulo Brazil Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Beihang University Beijing China Rutgers The State University of New Jersey Piscataway New Jersey 08854 USA Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China The University of Kansas Lawrence Kansas 66045 USA Sun Yat-Sen University Guangzhou China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE)—Fudan University Shanghai China Zhejiang University Hangzhou China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt Center for High Energy Phy

A search for production of the supersymmetric partners of the top quark, top squarks, is presented. The search is based on proton-proton collision events containing multiple jets, no leptons, and large transverse momentum imbalance. The data were collected with the CMS detector at the CERN LHC at a center-of-mass energy of 13 TeV, and correspond to an integrated luminosity of 137 fb−1. The targeted signal production scenarios are direct and gluino-mediated top squark production, including scenarios in which the top squark and neutralino masses are nearly degenerate. The search utilizes novel algorithms based on deep neural networks that identify hadronically decaying top quarks and W bosons, which are expected in many of the targeted signal models. No statistically significant excess of events is observed relative to the expectation from the standard model, and limits on the top squark production cross section are obtained in the context of simplified supersymmetric models for various production and decay modes. Exclusion limits as high as 1310 GeV are established at the 95% confidence level on the mass of the top squark for direct top squark production models, and as high as 2260 GeV on the mass of the gluino for gluino-mediated top squark production models. These results represent a significant improvement over the results of previous searches for supersymmetry by CMS in the same final state.

关键词： Supersymmetry Superpartners Top quark Hadron colliders

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Search for invisible decays of the Higgs boson produced via vector boson fusion in proton-proton collisions at s=13 TeV

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Physical Review D 2022年第9期105卷 092007-092007页

作者： A. Tumasyan W. Adam J. W. Andrejkovic T. Bergauer S. Chatterjee K. Damanakis M. Dragicevic A. Escalante Del Valle R. Frühwirth M. Jeitler N. Krammer L. Lechner D. Liko I. Mikulec P. Paulitsch F. M. Pitters J. Schieck R. Schöfbeck D. Schwarz S. Templ W. Waltenberger C.-E. Wulz V. Chekhovsky A. Litomin V. Makarenko M. R. Darwish E. A. De Wolf T. Janssen T. Kello A. Lelek H. Rejeb Sfar P. Van Mechelen S. Van Putte N. Van Remortel E. S. Bols J. D’Hondt A. De Moor M. Delcourt H. El Faham S. Lowette S. Moortgat A. Morton D. Müller A. R. Sahasransu S. Tavernier W. Van Doninck D. Vannerom D. Beghin B. Bilin B. Clerbaux G. De Lentdecker L. Favart A. K. Kalsi K. Lee M. Mahdavikhorrami I. Makarenko L. Moureaux S. Paredes L. Pétré A. Popov N. Postiau E. Starling L. Thomas M. Vanden Bemden C. Vander Velde P. Vanlaer T. Cornelis D. Dobur J. Knolle L. Lambrecht G. Mestdach M. Niedziela C. Rendón C. Roskas A. Samalan K. Skovpen M. Tytgat N. Van Den Bossche B. Vermassen L. Wezenbeek A. Benecke A. Bethani G. Bruno F. Bury C. Caputo P. David C. Delaere I. S. Donertas A. Giammanco K. Jaffel Sa. Jain V. Lemaitre K. Mondal J. Prisciandaro A. Taliercio M. Teklishyn T. T. Tran P. Vischia S. Wertz G. A. Alves C. Hensel A. Moraes P. Rebello Teles W. L. Aldá Júnior M. Alves Gallo Pereira M. Barroso Ferreira Filho H. Brandao Malbouisson W. Carvalho J. Chinellato E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao V. Dos Santos Sousa S. Fonseca De Souza C. Mora Herrera K. Mota Amarilo L. Mundim H. Nogima A. Santoro S. M. Silva Do Amaral A. Sznajder M. Thiel F. Torres Da Silva De Araujo A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores D. S. Lemos P. G. Mercadante S. F. Novaes Sandra S. Padula A. Aleksandrov G. Antchev R. Hadjiiska P. Iaydjiev M. Misheva M. Rodozov M. Shopova G. Sultanov A. Dimitrov T. Ivanov L. Litov B. Pavlov P. Petkov A. Petrov T. Cheng T. Javaid M. Mittal L. Yuan M. Ahmad G. Bauer C. Dozen Z. Hu J. Martins Y. Wang K. Yi E. Chapon G. M. Chen H. S. Chen M. Chen F. Iemmi A. Kapoor D. Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Institute for Nuclear Problems Minsk Belarus Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Korea University Seoul Korea Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China Massachusetts Institute of Technology Cambridge Massachusetts USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Sun Yat-Sen University Guangzhou China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE)—Fudan University Shanghai China Rice University Houston Texas USA Zhejiang University Hangzhou China Zhejiang China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics Cairo Egypt Center for High Energy Physics (CHEP-FU) Fayoum University El-Fayoum Egypt National Institute of Chemical Physics and Biophy

A search for invisible decays of the Higgs boson produced via vector boson fusion (VBF) has been performed with 101 fb−1 of proton-proton collisions delivered by the LHC at s=13 TeV and collected by the CMS detector in 2017 and 2018. The sensitivity to the VBF production mechanism is enhanced by constructing two analysis categories, one based on missing transverse momentum and a second based on the properties of jets. In addition to control regions with Z and W boson candidate events, a highly populated control region, based on the production of a photon in association with jets, is used to constrain the dominant irreducible background from the invisible decay of a Z boson produced in association with jets. The results of this search are combined with all previous measurements in the VBF topology, based on data collected in 2012 (at s=8 TeV), 2015, and 2016, corresponding to integrated luminosities of 19.7, 2.3, and 36.3 fb−1, respectively. The observed (expected) upper limit on the invisible branching fraction of the Higgs boson is found to be 0.18 (0.10) at the 95% confidence level, assuming the standard model production cross section. The results are also interpreted in the context of Higgs-portal models.

关键词： Higgs bosons W & Z bosons Hadron colliders

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Nonresonant central exclusive production of charged-hadron pairs in proton-proton collisions at s=13 TeV

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Physical Review D 2024年第11期109卷 112013-112013页

作者： A. Hayrapetyan A. Tumasyan W. Adam J. W. Andrejkovic T. Bergauer S. Chatterjee K. Damanakis M. Dragicevic P. S. Hussain M. Jeitler N. Krammer A. Li D. Liko I. Mikulec J. Schieck R. Schöfbeck D. Schwarz M. Sonawane S. Templ W. Waltenberger C.-E. Wulz M. R. Darwish T. Janssen P. Van Mechelen E. S. Bols J. D’Hondt S. Dansana A. De Moor M. Delcourt H. El Faham S. Lowette I. Makarenko D. Müller A. R. Sahasransu S. Tavernier M. Tytgat G. P. Van Onsem S. Van Putte D. Vannerom B. Clerbaux A. K. Das G. De Lentdecker L. Favart P. Gianneios D. Hohov J. Jaramillo A. Khalilzadeh K. Lee M. Mahdavikhorrami A. Malara S. Paredes L. Pétré N. Postiau L. Thomas M. Vanden Bemden C. Vander Velde P. Vanlaer M. De Coen D. Dobur Y. Hong J. Knolle L. Lambrecht G. Mestdach K. Mota Amarilo C. Rendón A. Samalan K. Skovpen N. Van Den Bossche J. van der Linden L. Wezenbeek A. Benecke A. Bethani G. Bruno C. Caputo C. Delaere I. S. Donertas A. Giammanco K. Jaffel Sa. Jain V. Lemaitre J. Lidrych P. Mastrapasqua K. Mondal T. T. Tran S. Wertz G. A. Alves E. Coelho C. Hensel T. Menezes De Oliveira A. Moraes P. Rebello Teles M. Soeiro W. L. Aldá Júnior M. Alves Gallo Pereira M. Barroso Ferreira Filho H. Brandao Malbouisson W. Carvalho J. Chinellato E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza R. Gomes De Souza J. Martins C. Mora Herrera L. Mundim H. Nogima J. P. Pinheiro A. Santoro A. Sznajder M. Thiel A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores P. G. Mercadante S. F. Novaes B. Orzari Sandra S. Padula A. Aleksandrov R. Hadjiiska P. Iaydjiev M. Misheva M. Shopova G. Sultanov A. Dimitrov L. Litov B. Pavlov P. Petkov A. Petrov E. Shumka S. Keshri S. Thakur T. Cheng Q. Guo T. Javaid L. Yuan Z. Hu J. Liu K. Yi G. M. Chen H. S. Chen M. Chen F. Iemmi C. H. Jiang A. Kapoor H. Liao Z.-A. Liu R. Sharma J. N. Song J. Tao C. Wang J. Wang Z. Wang H. Zhang A. Agapitos Y. Ban A. Levin C. Li Q. Li Y. Mao S. J. Qian X. Sun D. Wang H. Yang L. Zhang C. Zhou Z. You N. Lu G. Bauer X. Gao D. Leggat Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Indian Institute of Technology Madras Madras India Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Korea University Seoul Korea Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Instituto De Alta Investigación Universidad de Tarapacá Casilla 7 D Arica Chile Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China California Institute of Technology Pasadena California USA University of Florida Gainesville Florida USA Massachusetts Institute of Technology Cambridge Massachusetts USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Sun Yat-Sen University Guangzhou China University of Science and Technology of China Hefei China Nanjing Normal University Nanjing China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE)—Fudan University Shanghai China Zhejiang University Hangzhou Zhejiang China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador

The central exclusive production of charged-hadron pairs in pp collisions at a center-of-mass energy of 13 TeV is examined, based on data collected in a special high-β* run of the LHC. The nonresonant continuum processes are studied with the invariant mass of the centrally produced two-pion system in the resonance-free region, mπ+π−<0.7 or mπ+π−>1.8 GeV. Differential cross sections as functions of the azimuthal angle between the surviving protons, squared exchanged four-momenta, and mπ+π− are measured in a wide region of scattered proton transverse momenta, between 0.2 and 0.8 GeV, and for pion rapidities |y|<2. A rich structure of interactions related to double-pomeron exchange is observed. A parabolic minimum in the distribution of the two-proton azimuthal angle is observed for the first time. It can be interpreted as an effect of additional pomeron exchanges between the protons from the interference between the bare and the rescattered amplitudes. After model tuning, various physical quantities are determined that are related to the pomeron cross section, proton-pomeron and meson-pomeron form factors, pomeron trajectory and intercept, and coefficients of diffractive eigenstates of the proton.

关键词： Particle interactions Hadrons Hadron colliders

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Search for Inelastic Dark Matter in Events with Two Displaced Muons and Missing Transverse Momentum in Proton-Proton Collisions at s=13 TeV

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Physical Review Letters 2024年第4期132卷 041802-041802页

作者： A. Hayrapetyan A. Tumasyan W. Adam J. W. Andrejkovic T. Bergauer S. Chatterjee K. Damanakis M. Dragicevic A. Escalante Del Valle P. S. Hussain M. Jeitler N. Krammer D. Liko I. Mikulec J. Schieck R. Schöfbeck D. Schwarz M. Sonawane S. Templ W. Waltenberger C.-E. Wulz M. R. Darwish T. Janssen P. Van Mechelen E. S. Bols J. D’Hondt S. Dansana A. De Moor M. Delcourt H. El Faham S. Lowette I. Makarenko A. Morton D. Müller A. R. Sahasransu S. Tavernier M. Tytgat S. Van Putte D. Vannerom B. Clerbaux G. De Lentdecker L. Favart D. Hohov J. Jaramillo A. Khalilzadeh K. Lee M. Mahdavikhorrami A. Malara S. Paredes L. Pétré N. Postiau L. Thomas M. Vanden Bemden C. Vander Velde P. Vanlaer M. De Coen D. Dobur J. Knolle L. Lambrecht G. Mestdach C. Rendón A. Samalan K. Skovpen N. Van Den Bossche L. Wezenbeek A. Benecke G. Bruno C. Caputo C. Delaere I. S. Donertas A. Giammanco K. Jaffel Sa. Jain V. Lemaitre J. Lidrych P. Mastrapasqua K. Mondal T. T. Tran S. Wertz G. A. Alves E. Coelho C. Hensel T. Menezes De Oliveira A. Moraes P. Rebello Teles M. Soeiro W. L. Aldá Júnior M. Alves Gallo Pereira M. Barroso Ferreira Filho H. Brandao Malbouisson W. Carvalho J. Chinellato E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza J. Martins C. Mora Herrera K. Mota Amarilo L. Mundim H. Nogima A. Santoro S. M. Silva Do Amaral A. Sznajder M. Thiel A. Vilela Pereira C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores P. G. Mercadante S. F. Novaes B. Orzari Sandra S. Padula A. Aleksandrov G. Antchev R. Hadjiiska P. Iaydjiev M. Misheva M. Shopova G. Sultanov A. Dimitrov T. Ivanov L. Litov B. Pavlov P. Petkov A. Petrov E. Shumka S. Keshri S. Thakur T. Cheng Q. Guo T. Javaid M. Mittal L. Yuan G. Bauer Z. Hu K. Yi G. M. Chen H. S. Chen M. Chen F. Iemmi C. H. Jiang A. Kapoor H. Liao Z.-A. Liu F. Monti R. Sharma J. N. Song J. Tao J. Wang H. Zhang A. Agapitos Y. Ban A. Levin C. Li Q. Li X. Lyu Y. Mao S. J. Qian X. Sun D. Wang H. Yang C. Zhou Z. You N. Lu X. Gao D. Leggat H. Okawa Y. Zhang Z. Lin C. Lu M. Xiao C. Avi Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Indian Institute of Technology Madras Madras India Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Korea University Seoul Korea Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Instituto De Alta Investigación Universidad de Tarapacá Casilla 7 D Arica Chile Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China Massachusetts Institute of Technology Cambridge Massachusetts USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Sun Yat-Sen University Guangzhou China University of Science and Technology of China Hefei China Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE) - Fudan University Shanghai China Rice University Houston Texas USA Zhejiang University Hangzhou Zhejiang China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of Cyprus Nicosia Cyprus Charles University Prague Czech Republic Escuela Politecnica Nacional Quito Ecuador Universidad San Francisco de Quito Quito Ecuador Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Phys

A search for dark matter in events with a displaced nonresonant muon pair and missing transverse momentum is presented. The analysis is performed using an integrated luminosity of 138 fb−1 of proton-proton (pp) collision data at a center-of-mass energy of 13 TeV produced by the LHC in 2016–2018. No significant excess over the predicted backgrounds is observed. Upper limits are set on the product of the inelastic dark matter production cross section σ(pp→A′→χ1χ2) and the decay branching fraction B(χ2→χ1μ+μ−), where A′ is a dark photon and χ1 and χ2 are states in the dark sector with near mass degeneracy. This is the first dedicated collider search for inelastic dark matter.

关键词： Dark matter Hypothetical particles Hadron colliders

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Combined Measurement of the Higgs Boson Mass in pp Collisions at s=7 and 8 TeV with the ATLAS and CMS Experiments

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Physical Review Letters 2015年第19期114卷 191803-191803页

作者： G. Aad B. Abbott J. Abdallah O. Abdinov R. Aben M. Abolins O. S. AbouZeid H. Abramowicz H. Abreu R. Abreu Y. Abulaiti B. S. Acharya L. Adamczyk D. L. Adams J. Adelman S. Adomeit T. Adye A. A. Affolder T. Agatonovic-Jovin J. A. Aguilar-Saavedra S. P. Ahlen F. Ahmadov G. Aielli H. Akerstedt T. P. A. Åkesson G. Akimoto A. V. Akimov G. L. Alberghi J. Albert S. Albrand M. J. Alconada Verzini M. Aleksa I. N. Aleksandrov C. Alexa G. Alexander T. Alexopoulos M. Alhroob G. Alimonti L. Alio J. Alison S. P. Alkire B. M. M. Allbrooke P. P. Allport A. Aloisio A. Alonso F. Alonso C. Alpigiani A. Altheimer B. Alvarez Gonzalez D. Álvarez Piqueras M. G. Alviggi B. T. Amadio K. Amako Y. Amaral Coutinho C. Amelung D. Amidei S. P. Amor Dos Santos A. Amorim S. Amoroso N. Amram G. Amundsen C. Anastopoulos L. S. Ancu N. Andari T. Andeen C. F. Anders G. Anders J. K. Anders K. J. Anderson A. Andreazza V. Andrei S. Angelidakis I. Angelozzi P. Anger A. Angerami F. Anghinolfi A. V. Anisenkov N. Anjos A. Annovi M. Antonelli A. Antonov J. Antos F. Anulli M. Aoki L. Aperio Bella G. Arabidze Y. Arai J. P. Araque A. T. H. Arce F. A. Arduh J-F. Arguin S. Argyropoulos M. Arik A. J. Armbruster O. Arnaez V. Arnal H. Arnold M. Arratia O. Arslan A. Artamonov G. Artoni S. Asai N. Asbah A. Ashkenazi B. Åsman L. Asquith K. Assamagan R. Astalos M. Atkinson N. B. Atlay B. Auerbach K. Augsten M. Aurousseau G. Avolio B. Axen M. K. Ayoub G. Azuelos M. A. Baak A. E. Baas C. Bacci H. Bachacou K. Bachas M. Backes M. Backhaus E. Badescu P. Bagiacchi P. Bagnaia Y. Bai T. Bain J. T. Baines O. K. Baker P. Balek T. Balestri F. Balli E. Banas Sw. Banerjee A. A. E. Bannoura H. S. Bansil L. Barak S. P. Baranov E. L. Barberio D. Barberis M. Barbero T. Barillari M. Barisonzi T. Barklow N. Barlow S. L. Barnes B. M. Barnett R. M. Barnett Z. Barnovska A. Baroncelli G. Barone A. J. Barr F. Barreiro J. Barreiro Guimarães da Costa R. Bartoldus A. E. Barton P. Bartos A. Bassalat A. Basye R. L. Bates S. J. Batista J. R. Batley M. Battaglia M. Bauce F. Bauer H. S. Bawa J. B. Beach CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Institute of Physics Academia Sinica Taipei Taiwan Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan Nikhef National Institute for Subatomic Physics and University of Amsterdam Amsterdam Netherlands Department of Physics and Astronomy Michigan State University East Lansing Michigan USA Department of Physics University of Toronto Toronto Ontario Canada Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion: Israel Institute of Technology Haifa Israel CERN Geneva Switzerland Department of Physics Stockholm University Sweden The Oskar Klein Centre Stockholm Sweden INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Physics Department Brookhaven National Laboratory Upton New York USA Department of Physics Northern Illinois University DeKalb Illinois USA Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Oliver Lodge Laboratory University of Liverpool Liverpool United Kingdom Institute of Physics University of Belgrade Belgrade Serbia Laboratorio de Instrumentacao e Fisica Experimental de Particulas-LIP Lisboa Portugal Departamento de Fisica Teorica y del Cosmos and CAFPE Universidad de Granada Granada (Spain) Portugal Department of Physics Boston University Boston Massachusetts USA Joint Institute for Nuclear Research JINR Dubna Dubna Russia INFN Sezione di Roma Tor Vergata Roma Italy Dipartimento di Fisica Università di Roma Tor Vergata Roma Italy Fysiska institutionen Lunds universitet Lund Sweden International Center for Elementary Particle Physics and Depart

A measurement of the Higgs boson mass is presented based on the combined data samples of the ATLAS and CMS experiments at the CERN LHC in the H→γγ and H→ZZ→4ℓ decay channels. The results are obtained from a simultaneous fit to the reconstructed invariant mass peaks in the two channels and for the two experiments. The measured masses from the individual channels and the two experiments are found to be consistent among themselves. The combined measured mass of the Higgs boson is mH=125.09±0.21 (stat)±0.11 (syst) GeV.

关键词： HIGGS bosons RESEARCH COLLISIONS (Nuclear physics) ATLAS (computer program language) REST mass (Relativity) BOSONS

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Observation of the J/ψ→μ+μ−μ+μ− decay in proton-proton collisions at s=13 TeV

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Physical Review D 2024年第11期109卷 L111101-L111101页

作者： A. Hayrapetyan A. Tumasyan W. Adam J. W. Andrejkovic T. Bergauer S. Chatterjee K. Damanakis M. Dragicevic P. S. Hussain M. Jeitler N. Krammer A. Li D. Liko I. Mikulec J. Schieck R. Schöfbeck D. Schwarz M. Sonawane S. Templ W. Waltenberger C.-E. Wulz M. R. Darwish T. Janssen P. Van Mechelen N. Breugelmans J. D’Hondt S. Dansana A. De Moor M. Delcourt F. Heyen S. Lowette I. Makarenko D. Müller S. Tavernier M. Tytgat G. P. Van Onsem S. Van Putte D. Vannerom B. Clerbaux A. K. Das G. De Lentdecker H. Evard L. Favart P. Gianneios D. Hohov J. Jaramillo A. Khalilzadeh F. A. Khan K. Lee M. Mahdavikhorrami A. Malara S. Paredes M. A. Shahzad L. Thomas M. Vanden Bemden C. Vander Velde P. Vanlaer M. De Coen D. Dobur G. Gokbulut Y. Hong J. Knolle L. Lambrecht D. Marckx G. Mestdach K. Mota Amarilo A. Samalan K. Skovpen N. Van Den Bossche J. van der Linden L. Wezenbeek A. Benecke A. Bethani G. Bruno C. Caputo J. De Favereau De Jeneret C. Delaere I. S. Donertas A. Giammanco A. O. Guzel Sa. Jain V. Lemaitre J. Lidrych P. Mastrapasqua T. T. Tran S. Wertz G. A. Alves M. Alves Gallo Pereira E. Coelho G. Correia Silva C. Hensel T. Menezes De Oliveira A. Moraes P. Rebello Teles M. Soeiro A. Vilela Pereira W. L. Aldá Júnior M. Barroso Ferreira Filho H. Brandao Malbouisson W. Carvalho J. Chinellato E. M. Da Costa G. G. Da Silveira D. De Jesus Damiao S. Fonseca De Souza R. Gomes De Souza M. Macedo J. Martins C. Mora Herrera L. Mundim H. Nogima J. P. Pinheiro A. Santoro A. Sznajder M. Thiel C. A. Bernardes L. Calligaris T. R. Fernandez Perez Tomei E. M. Gregores I. Maietto Silverio P. G. Mercadante S. F. Novaes B. Orzari Sandra S. Padula A. Aleksandrov G. Antchev R. Hadjiiska P. Iaydjiev M. Misheva M. Shopova G. Sultanov A. Dimitrov L. Litov B. Pavlov P. Petkov A. Petrov E. Shumka S. Keshri S. Thakur T. Cheng T. Javaid L. Yuan Z. Hu Z. Liang J. Liu K. Yi G. M. Chen H. S. Chen M. Chen F. Iemmi C. H. Jiang A. Kapoor H. Liao Z.-A. Liu R. Sharma J. N. Song J. Tao C. Wang J. Wang Z. Wang H. Zhang J. Zhao A. Agapitos Y. Ban S. Deng B. Guo C. Jian Yerevan Physics Institute Yerevan Armenia Institut für Hochenergiephysik Vienna Austria Indian Institute of Technology Madras Madras India Universiteit Antwerpen Antwerpen Belgium Vrije Universiteit Brussel Brussel Belgium Université Libre de Bruxelles Bruxelles Belgium Korea University Seoul Korea Ghent University Ghent Belgium Université Catholique de Louvain Louvain-la-Neuve Belgium Centro Brasileiro de Pesquisas Fisicas Rio de Janeiro Brazil Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Universidade Estadual Paulista Universidade Federal do ABC São Paulo Brazil Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences Sofia Bulgaria University of Sofia Sofia Bulgaria Instituto De Alta Investigación Universidad de Tarapacá Casilla 7 D Arica Chile Beihang University Beijing China Department of Physics Tsinghua University Beijing China Institute of High Energy Physics Beijing China California Institute of Technology Pasadena California USA University of Florida Gainesville Florida USA Massachusetts Institute of Technology Cambridge Massachusetts USA State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China Deutsches Elektronen-Synchrotron Hamburg Germany Kyung Hee University Department of Physics Seoul Korea Sun Yat-Sen University Guangzhou China University of Science and Technology of China Hefei China Nanjing Normal University Nanjing China Florida State University Tallahassee Florida USA Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application (MOE)—Fudan University Shanghai China Zhejiang University Hangzhou Zhejiang China Universidad de Los Andes Bogota Colombia Universidad de Antioquia Medellin Colombia University of Split Faculty of Electrical Engineering Mechanical Engineering and Naval Architecture Split Croatia University of Split Faculty of Science Split Croatia Institute Rudjer Boskovic Zagreb Croatia University of C

The J/ψ→μ+μ−μ+μ− decay has been observed with a statistical significance in excess of five standard deviations. The analysis is based on an event sample of proton-proton collisions at a center-of-mass energy of 13 TeV, collected by the CMS experiment in 2018 and corresponding to an integrated luminosity of 33.6 fb−1. Normalizing to the J/ψ→μ+μ− decay mode leads to a branching fraction of [10.1−2.7+3.3(stat)±0.4(syst)]×10−7, a value that is consistent with the standard model prediction.

关键词： Muons Quarkonia Hadron colliders

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Author Correction: Wireless multilateral devices for optogenetic studies of individual and social behaviors

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Nature neuroscience 2022年第10期25卷 1394页

作者： Yiyuan Yang Mingzheng Wu Abraham Vázquez-Guardado Amy J Wegener Jose G Grajales-Reyes Yujun Deng Taoyi Wang Raudel Avila Justin A Moreno Samuel Minkowicz Vasin Dumrongprechachan Jungyup Lee Shuangyang Zhang Alex A Legaria Yuhang Ma Sunita Mehta Daniel Franklin Layne Hartman Wubin Bai Mengdi Han Hangbo Zhao Wei Lu Yongjoon Yu Xing Sheng Anthony Banks Xinge Yu Zoe R Donaldson Robert W Gereau Cameron H Good Zhaoqian Xie Yonggang Huang Yevgenia Kozorovitskiy John A Rogers Department of Mechanical Engineering Northwestern University Evanston IL USA. Department of Neurobiology Northwestern University Evanston IL USA. Center for Bio-Integrated Electronics Northwestern University Evanston IL USA. US Army Research Laboratory Aberdeen Proving Ground MD USA. US Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground MD USA. Washington University Pain Center and Department of Anesthesiology Washington University St. Louis MO USA. State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University Shanghai China. Department of Civil and Environmental Engineering Northwestern University Evanston IL USA. Department of Materials Science and Engineering Northwestern University Evanston IL USA. Department of Physics Tsinghua University Beijing China. SURVICE Engineering Belcamp MD USA. Chemistry of Life Processes Institutes Northwestern University Evanston IL USA. Neurolux Inc Evanston IL USA. School of Civil Engineering Southwest JiaoTong University Chengdu China. School of Chemical Engineering and Technology Tianjin University Tianjin People's Republic of China. CSIR-Central Scientific Instruments Organization Ministry of Science & Technology Sector 30-C Chandigarh India. Department of Biomedical Engineering Northwestern University Evanston IL USA. Department of Electronic Engineering Tsinghua University Beijing China. Simpson Querrey Institute & Feinberg Medical School Northwestern University Evanston IL USA. Department of Biomedical Engineering City University of Hong Kong Kowloong Tong Hong Kong. Psychology and Neuroscience Molecular Cellular and Developmental Biology University of Colorado Boulder Boulder CO USA. State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology Dalian P.R. China. zxie@***. Department of Mechanical Engineering Northwestern University Evanston IL USA. y-huang@northwest

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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries (vol 55, pg 89, 2023)

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NATURE GENETICS 2023年第3期55卷 519-520页

作者： Fernandez-Rozadilla, Ceres Timofeeva, Maria Chen, Zhishan Law, Philip Thomas, Minta Schmit, Stephanie Diez-Obrero, Virginia Hsu, Li Fernandez-Tajes, Juan Palles, Claire Sherwood, Kitty Briggs, Sarah Svinti, Victoria Donnelly, Kevin Farrington, Susan Blackmur, James Vaughan-Shaw, Peter Shu, Xiao-ou Long, Jirong Cai, Qiuyin Guo, Xingyi Lu, Yingchang Broderick, Peter Studd, James Huyghe, Jeroen Harrison, Tabitha Conti, David Dampier, Christopher Devall, Mathew Schumacher, Fredrick Melas, Marilena Rennert, Gad Obon-Santacana, Mireia Martin-Sanchez, Vicente Moratalla-Navarro, Ferran Oh, Jae Hwan Kim, Jeongseon Jee, Sun Ha Jung, Keum Ji Kweon, Sun-Seog Shin, Min-Ho Shin, Aesun Ahn, Yoon-Ok Kim, Dong-Hyun Oze, Isao Wen, Wanqing Matsuo, Keitaro Matsuda, Koichi Tanikawa, Chizu Ren, Zefang Gao, Yu-Tang Jia, Wei-Hua Hopper, John Jenkins, Mark Win, Aung Ko Pai, Rish Figueiredo, Jane Haile, Robert Gallinger, Steven Woods, Michael Newcomb, Polly Duggan, David Cheadle, Jeremy Kaplan, Richard Maughan, Timothy Kerr, Rachel Kerr, David Kirac, Iva Bohm, Jan Mecklin, Lukka-Pekka Jousilahti, Pekka Knekt, Paul Aaltonen, Lauri Rissanen, Harri Pukkala, Eero Eriksson, Johan Cajuso, Tatiana Hanninen, Ulrika Kondelin, Johanna Palin, Kimmo Tanskanen, Tomas Renkonen-Sinisalo, Laura Zanke, Brent Mannisto, Satu Albanes, Demetrius Weinstein, Stephanie Ruiz-Narvaez, Edward Palmer, Julie Buchanan, Daniel Platz, Elizabeth Visvanathan, Kala Ulrich, Cornelia Siegel, Erin Brezina, Stefanie Gsur, Andrea Campbell, Peter Chang-Claude, Jenny Hoffmeister, Michael Brenner, Hermann Slattery, Martha Potter, John Tsilidis, Konstantinos Schulze, Matthias Gunter, Marc Murphy, Neil Castells, Antoni Castellvi-Bel, Sergi Moreira, Leticia Arndt, Volker Shcherbina, Anna Stern, Mariana Pardamean, Bens Bishop, Timothy Giles, Graham Southey, Melissa Idos, Gregory McDonnell, Kevin Abu-Ful, Zomoroda Greenson, Joel Shulman, Katerina Lejbkowicz, Flavio Offit, Kenneth Su, Yu-Ru Steinfelder, Robert Keku, Temitope van Guelpen, Bethany Hudson, Thomas Hampel, Heather Pearlman, Edinburgh Cancer Research Centre Institute of Genomics and Cancer University of Edinburgh Edinburgh UK Genomic Medicine Group Instituto de Investigacion Sanitaria de Santiago Santiago de Compostela Spain Colon Cancer Genetics Group Medical Research Council Human Genetics Unit Institute of Genetics and Cancer University of Edinburgh Edinburgh UK Danish Institute for Advanced Study Department of Public Health University of Southern Denmark Odense Denmark Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University Medical Center Nashville TN USA Division of Genetics and Epidemiology Institute of Cancer Research London UK Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle WA USA Genomic Medicine Institute Cleveland Clinic Cleveland OH USA Population and Cancer Prevention Program Case Comprehensive Cancer Center Cleveland OH USA Colorectal Cancer Group ONCOBELL Program Bellvitge Biomedical Research Institute Barcelona Spain Oncology Data Analytics Program Catalan Institute of Oncology Barcelona Spain Consortium for Biomedical Research in Epidemiology and Public Health Madrid Madrid Spain Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain Department of Biostatistics School of Public Health University of Washington Seattle WA USA Institute of Cancer and Genomic Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK Department of Public Health Richard Doll Building University of Oxford Oxford UK Department of Biomedical Informatics Vanderbilt University School of Medicine Nashville TN USA Department of Preventive Medicine USC Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California Los Angeles CA USA Center for Public Health Genomics Department of Public Health Sciences University of Virginia Charlottesville VA USA Department of Populat

Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.

关键词： Colorectal cancer Epigenomics Genome-wide association studies Transcriptomics

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Author Correction: BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

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Nature methods 2024年第10期21卷 1959页

作者： Linus Manubens-Gil Zhi Zhou Hanbo Chen Arvind Ramanathan Xiaoxiao Liu Yufeng Liu Alessandro Bria Todd Gillette Zongcai Ruan Jian Yang Miroslav Radojević Ting Zhao Li Cheng Lei Qu Siqi Liu Kristofer E Bouchard Lin Gu Weidong Cai Shuiwang Ji Badrinath Roysam Ching-Wei Wang Hongchuan Yu Amos Sironi Daniel Maxim Iascone Jie Zhou Erhan Bas Eduardo Conde-Sousa Paulo Aguiar Xiang Li Yujie Li Sumit Nanda Yuan Wang Leila Muresan Pascal Fua Bing Ye Hai-Yan He Jochen F Staiger Manuel Peter Daniel N Cox Michel Simonneau Marcel Oberlaender Gregory Jefferis Kei Ito Paloma Gonzalez-Bellido Jinhyun Kim Edwin Rubel Hollis T Cline Hongkui Zeng Aljoscha Nern Ann-Shyn Chiang Jianhua Yao Jane Roskams Rick Livesey Janine Stevens Tianming Liu Chinh Dang Yike Guo Ning Zhong Georgia Tourassi Sean Hill Michael Hawrylycz Christof Koch Erik Meijering Giorgio A Ascoli Hanchuan Peng Institute for Brain and Intelligence Southeast University Nanjing China. Microsoft Corporation Redmond WA USA. Tencent AI Lab Bellevue WA USA. Computing Environment and Life Sciences Directorate Argonne National Laboratory Lemont IL USA. Kaya Medical Seattle WA USA. University of Cassino and Southern Lazio Cassino Italy. Center for Neural Informatics Structures and Plasticity Krasnow Institute for Advanced Study George Mason University Fairfax VA USA. Faculty of Information Technology Beijing University of Technology Beijing China. Beijing International Collaboration Base on Brain Informatics and Wisdom Services Beijing China. Nuctech Netherlands Rotterdam the Netherlands. Janelia Research Campus Howard Hughes Medical Institute Ashburn VA USA. Department of Electrical and Computer Engineering University of Alberta Edmonton Alberta Canada. Ministry of Education Key Laboratory of Intelligent Computation and Signal Processing Anhui University Hefei China. Paige AI New York NY USA. Scientific Data Division and Biological Systems and Engineering Division Lawrence Berkeley National Lab Berkeley CA USA. Helen Wills Neuroscience Institute and Redwood Center for Theoretical Neuroscience UC Berkeley Berkeley CA USA. RIKEN AIP Tokyo Japan. Research Center for Advanced Science and Technology (RCAST) The University of Tokyo Tokyo Japan. School of Computer Science University of Sydney Sydney New South Wales Australia. Texas A&M University College Station TX USA. Cullen College of Engineering University of Houston Houston TX USA. Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan. National Centre for Computer Animation Bournemouth University Poole UK. PROPHESEE Paris France. Department of Neuroscience Columbia University New York NY USA. Mortimer B. Zuckerman Mind Brain Behavior Institute Columbia University New York NY USA. Department of Computer Science Northern Illinois Universit

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