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Indentation behavior of a semi-infinite piezoelectric semiconductor under a rigid flat-ended cylindrical indenter

Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 649-662页

作者： Shijing GAO Lele ZHANG Jinxi LIU Guoquan NIE Weiqiu CHEN State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures Shijiazhuang Tiedao UniversityShijiazhuang 050043China School of Mechanical Engineering Shijiazhuang Tiedao UniversityShijiazhuang 050043China Hebei Key Laboratory for Mechanics of Intelligent Materials and Structures Department of Engineering MechanicsShijiazhuang Tiedao UniversityShijiazhuang 050043China State Key Laboratory of Computer Aided Design and Computer Graphics Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceDepartment of Engineering MechanicsZhejiang UniversityHangzhou 310027China

This paper theoretically studies the axisymmetric frictionless indentation of a transversely isotropic piezoelectric semiconductor(PSC)half-space subject to a rigid flatended cylindrical *** contact area and other surface of the PSC half-space are assumed to be electrically *** the Hankel integral transformation,the problem is reduced to the Fredholm integral equation of the second *** equation is solved numerically to obtain the indentation behaviors of the PSC half-space,mainly including the indentation force-depth relation and the electric potential-depth *** results show that the effect of the semiconductor property on the indentation responses is limited within a certain range of variation of the steady carrier *** dependence of indentation behavior on material properties is also analyzed by two different kinds of *** element simulations are conducted to verify the results calculated by the integral equation technique,and good agreement is demonstrated.

关键词： piezoelectric semiconductor(PSC) insulating indenter electromechanical response singular integral equation finite element simulation

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Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and post-transcriptional regulation of heme oxygenase-1 in vascular smooth muscle cells

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Acta Pharmaceutica Sinica B 2025年第3期15卷 1514-1534页

作者： Weile Ye Pinglian Yang Mei Jin Jiami Zou Zhihua Zheng Yuanyuan Li Dongmei Zhang Wencai Ye Zunnan Huang Jiaojiao Wang Zhiping Liu State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchInternational Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education(MOE)College of PharmacyJinan UniversityGuangzhou 511436China Key Laboratory of Big Data Mining and Precision Drug Design of Guangdong Medical University Key Laboratory of Computer-Aided Drug Design of Dongguan CityKey Laboratory for Research and Development of Natural Drugs of Guangdong ProvinceSchool of PharmacyGuangdong Medical UniversityDongguan 523808China

Abdominal aortic aneurysm(AAA)is a deadly condition of the aorta,carrying a significant risk of death upon ***,there is a dearth of efficacious pharmaceutical interventions to impede the advancement of AAA and avert it from ***,we investigated dihydromyricetin(DHM),one of the predominant bioactive flavonoids in Ampelopsis grossedentata(***),as a potential agent for inhibiting *** effectively blocked the formation of AAA in angiotensin II-infused apolipoprotein E-deficient(ApoE^(−/−))mice.A combination of network pharmacology and whole transcriptome sequencing analysis revealed that DHM’s anti-AAA action is linked to heme oxygenase(HO)-1(Hmox-1 for the rodent gene)and hypoxia-inducible factor(HIF)-1αin vascular smooth muscle cells(VSMCs).Remarkably,DHM caused a robust rise(∼10-fold)of HO-1 protein expression in VSMCs,thereby suppressing VSMC inflammation and oxidative stress and preserving the VSMC contractile ***,the therapeutic effect of DHM on AAA was largely abrogated by VSMC-specific Hmox1 knockdown in ***,on one hand,DHM increased the transcription of Hmox-1 by triggering the nuclear translocation and activation of HIF-1α,but not nuclear factor erythroid 2-related factor 2(NRF2).On the other hand,molecular docking,combined with cellular thermal shift assay(CETSA),isothermal titration calorimetry(ITC),drug affinity responsive target stability(DARTS),co-immunoprecipitation(Co-IP),and site mutant experiments revealed that DHM bonded to HO-1 at Lys243 and prevented its degradation,thereby resulting in considerable HO-1 *** summary,our findings suggest that naturally derived DHM has the capacity to markedly enhance HO-1 expression in VSMCs,which may hold promise as a therapeutic strategy for AAA.

关键词： Flavonoids Dihydromyricetin Abdominal aortic aneurysm Vascular smooth muscle cells Heme oxygenase-1 HIF-1a Inflammation Oxidative stress

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Alternating optimization for bundle adjustment with closed form solutions

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Science China(Information Sciences) 2025年第6期 286-300页

作者： Chengzhe MENG Yiwen JIANG Weiwei XU State Key Lab of Computer-Aided Design & Computer Graphics Zhejiang University

This study proposes a novel alternating optimization algorithm for bundle adjustment, a critical process in structure from motion methods. We introduce the inverse depth of each three-dimensional(3D) point as an augmented independent variable and develop a low-order polynomial error metric. Theoretically, the error can be adjusted to align closely with the re-projection error since it essentially acts as a re-weighted re-projection error. We decouple the bundle adjustment problem by breaking it down into three separate tasks: estimating the camera's pose, determining the 3D structure, and optionally estimating the camera's intrinsic parameter. Each task can be handled independently, either by camera or by point, allowing for easy distribution of computation. Camera pose estimation is a case of the absolute orientation problem, which can be globally solved in closed form. A linearization scheme is proposed for 3D point estimation, which allows the computation of the update direction and line search in closed form. Our algorithm proves to be efficient, reliable,and accurate, as demonstrated by experimental results that confirm its superiority over recent alternatives.

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Microsnoop: A generalist tool for microscopy image representation

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The Innovation 2024年第1期5卷 109-117页

作者： Dejin Xun Rui Wang Xingcai Zhang Yi Wang Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China State Key Lab of Computer-Aided Design&Computer Graphics Zhejiang UniversityHangzhou 310058China John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University Hangzhou 310018China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China

Accurate profiling of microscopy images from small scale to high throughput is an essential procedure in basic and applied biological ***,we present Microsnoop,a novel deep learning–based representation tool trained on large-scale microscopy images using masked self-supervised *** can process various complex and heterogeneous images,and we classified images into three categories:single-cell,full-field,and batch-experiment *** benchmark study on 10 high-quality evaluation datasets,containing over 2,230,000 images,demonstrated Microsnoop’s robust and state-ofthe-art microscopy image representation ability,surpassing existing generalist and even several custom *** can be integrated with other pipelines to perform tasks such as superresolution histopathology image and multimodal ***,Microsnoop can be adapted to various hardware and can be easily deployed on local or cloud computing *** will regularly retrain and reevaluate the model using communitycontributed data to consistently improve Microsnoop.

关键词： hardware image representation

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Multi-omics Approach Reveals Influenza-A Virus Target Genes Associated Genomic,Clinical and Immunological Characteristics in Cancers

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Biomedical and Environmental Sciences 2024年第7期37卷 698-715页

作者： Jiaojiao Wang Yong Liao Pinglian Yang Weile Ye Yong Liu Chunxia Xiao Weixiong Liao Chunbo Chen Zhiping Liu Zunnan Huang Center of Scientific Research Department of CardiologyMaoming People’s HospitalMaoming 525000GuangdongChina Department of Pharmacy Maoming People’s HospitalMaoming 525000GuangdongChina State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632GuangdongChina Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632GuangdongChina Key Laboratory of Big Data Mining and Precision Drug Design of Guangdong Medical University Key Laboratory of Computer-Aided Drug Design of Dongguan CityKey Laboratory for Research and Development of Natural Drugs of Guangdong ProvinceSchool of PharmacyGuangdong Medical UniversityDongguan 523808GuangdongChina Department of Critical Care Medicine Maoming People’s HospitalMaoming 525000GuangdongChina

Objective To examine the precise function of influenza A virus target genes(IATGs)in *** Using multi-omics data from the TCGA and TCPA datasets,33 tumor types were evaluated for *** expression in cancer cells was analyzed using transcriptome *** number variation(CNV)was assessed using GISTICS ***’s analysis was used to correlate mRNA expression with methylation *** was used for the enrichment ***’s correlation analysis was used to examine the association between IATG mRNA expression and *** ImmuCellAI algorithm was used to calculate the infiltration scores of 24 immune cell *** In 13 solid tumors,IATG mRNA levels were atypically *** for UCS,UVM,KICH,PCPG,THCA,CHOL,LAMI,and MESO,most cancers contained somatic IATG *** main types of CNVs in IATGs are heterozygous amplifications and *** most tumors,IATG mRNA expression is adversely associated with ***-PCR demonstrated that EGFR,ANXA5,CACNA1C,CD209,UVRAG were upregulated and CLEC4M was downregulated in KIRC cell lines,consistent with the TCGA and GTEx *** Genomic changes and clinical characteristics of IATGs were identified,which may offer fresh perspectives linking the influenza A virus to cancer.

关键词： Genomic changes Immune microenvironment Prognosis Drug resistance Experimental validation

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EC-SfM: Efficient Covisibility-based Structure-from-Motion for Both Sequential and Unordered Images

arXiv

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arXiv 2023年

作者： Ye, Zhichao Bao, Chong Zhou, Xin Liu, Haomin Bao, Hujun Zhang, Guofeng State Key Laboratory of Computer Aided Design and Computer Graphics Zhejiang University Hangzhou310058 China SenseTime Research Hangzhou311215 China ZJU-SenseTime Joint Lab of 3D Vision China

Structure-from-Motion is a technology used to obtain scene structure through image collection, which is a fundamental problem in computer vision. For unordered Internet images, SfM is very slow due to the lack of prior knowledge about image overlap. For sequential images, knowing the large overlap between adjacent frames, SfM can adopt a variety of acceleration strategies, which are only applicable to sequential data. To further improve the reconstruction efficiency and break the gap of strategies between these two kinds of data, this paper presents an efficient covisibility-based incremental SfM. Different from previous methods, we exploit covisibility and registration dependency to describe the image connection which is suitable to any kind of data. Based on this general image connection, we propose a unified framework to efficiently reconstruct sequential images, unordered images, and the mixture of these two. Experiments on the unordered images and mixed data verify the effectiveness of the proposed method, which is three times faster than the state-of-the-art on feature matching, and an order of magnitude faster on reconstruction without sacrificing the accuracy. The source code is publicly available at https://***/openxrlab/xrsfm. © 2023, CC BY.

关键词： HTTP

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Robust computation of subcortical functional connectivity guided by quantitative susceptibility mapping: An application in Parkinson's disease diagnosis

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NeuroImage 2025年 314卷 121256-121256页

作者： Qin, Jianmei Wu, Haoting Wu, Chenqing Guo, Tao Zhou, Cheng Duanmu, Xiaojie Tan, Sijia Wen, Jiaqi Zheng, Qianshi Yuan, Weijin Zhu, Zihao Chen, Jingwen Wu, Jingjing He, Chenyu Ma, Yiran Liu, Chunlei Xu, Xiaojun Guan, Xiaojun Zhang, Minming Department of Radiology the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Joint Laboratory of Clinical Radiology the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China State Key Laboratory of Computer-aided Design & Computer Graphics Zhejiang University College of Computer Science and technology Hangzhou China State Key Laboratory of Industrial Control Technology Zhejiang University College of Control Science and Engineering Hangzhou China Department of Electrical Engineering and Computer Sciences University of California Berkeley CA United States Helen Wills Neuroscience Institute University of California Berkeley CA United States

Previous resting state functional MRI (rs-fMRI) analyses of the basal ganglia in Parkinson's disease heavily relied on T1-weighted imaging (T1WI) atlases. However, subcortical structures are characterized by subtle contrast differences, making their accurate delineation challenging on T1WI. In this study, we aimed to introduce and validate a method that incorporates quantitative susceptibility mapping (QSM) into the rs-fMRI analytical pipeline to achieve precise subcortical nuclei segmentation and improve the stability of RSFC measurements in Parkinson's disease. A total of 321 participants (148 patients with Parkinson's Disease and 173 normal controls) were enrolled. We performed cross-modal registration at the individual level for rs-fMRI to QSM (FUNC2QSM) and T1WI (FUNC2T1), *** consistency and accuracy of resting state functional connectivity (RSFC) measurements in two registration approaches were assessed by intraclass correlation coefficient and mutual information. Bootstrap analysis was performed to validate the stability of the RSFC differences between Parkinson's disease and normal controls. RSFC-based machine learning models were constructed for Parkinson's disease classification, using optimized hyperparameters (RandomizedSearchCV with 5-fold cross-validation). The consistency of RSFC measurements between the two registration methods was poor, whereas the QSM-guided approach showed better mutual information values, suggesting higher registration accuracy. The disruptions of RSFC identified with the QSM-guided approach were more stable and reliable, as confirmed by bootstrap analysis. In classification models, the QSM-guided method consistently outperformed the T1WI-guided method, achieving higher test-set ROC-AUC values (FUNC2QSM: 0.87–0.90, FUNC2T1: 0.67–0.70). The QSM-guided approach effectively enhanced the accuracy of subcortical segmentation and the stability of RSFC measurement, thus facilitating future biomarker development in Parkinso

关键词： Parkinson's disease Quantitative susceptibility mapping Resting-state functional connectivity Subcortical nuclei

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Protective effect of 4-methyl-2-{[4-(toluene-4-sulfonyl)-thiomorpholine-3-carbonyl]-amino}-pentanoic acid isopropyl ester against cerebral ischemia

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Asian Journal of Traditional Medicines 2021年第3期16卷 139-152页

作者： Tinghui Zhang Yihan Wang Xin Li Jinwei Dai Quankun Zhuang Xirui Song Junhai Xiao Lili Wang Yuyang Zhang School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China Laboratory of Computer-Aided Drug Design&Discovery State Key Laboratory of Toxicology and Medical CountermeasuresInstitute of Pharmacology and ToxicologyAcademy of Military Medial SciencesBeijing 100850China Laboratory of the drug screening Institute of Pharmacology and ToxicologyAcademy of Military Medial SciencesBeijing 100850China

To investigate the effects of 4-methyl-2-{[4-(toluene-4-sulfonyl)-thiomorpholine-3-carbonyl]-amino}-pentanoic acid isopropyl ester(HD5-6)against cerebral ischemia in rodents,the models with global and focal ischemia were induced by bilateral common carotid artery occlusion plus hypotension(BCAOH)and permanent cerebral artery occlusion(p-MCAO)in mice(n=10–12 per group in BCAOH;n=8 per group in p-MCAO)and rats(n=10-11 in each group).HD5-6 prolonged lifetime and improved neurological *** deficits score in HD5-6(30 mg/kg)decreased ***(MDA)in HD5-6-treated mice with ischemia considerably *** infarction volume of the HD5-6-treated rats with MCAO-induced ischemia decreased significantly in the high dose group(P<0.05,*** P<0.01,i.v.).Immunohistochemistry showed that Brain derived neurotrophic factor(BDNF)in the ipsilateral hemisphere increased and Vascular endothelial growth factor(VEGF)decreased with HD5-6 ***5-6 has protective effects against experimental cerebral ischemia in rodents and the action mechanism may involve anti-oxidation and neurogenesis.

关键词： HD5-6 global ischemia focal ischemia MDA BDNF VEGF

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Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays

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Genomics, Proteomics & Bioinformatics 2018年第6期16卷 416-427页

作者： Wenfang Zhou Mojie Duan Weitao Fu Jinping Pang Qin Tang Huiyong Sun Lei Xu Shan Chang Dan Li Tingjun Hou College of Pharmaceutical Sciences Zhejiang University State Key Laboratory of Computer Aided Design and Computer Graphics (CAD&GC) Zhejiang University State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsChinese Academy of Sciences Institute of Bioinformatics and Medical Engineering School of Electrical and Information EngineeringJiangsu University of Technology

Androgen receptor(AR) is a ligand-activated transcription factor that plays a pivotal role in the development and progression of many severe diseases such as prostate cancer, muscle atrophy, and osteoporosis. Binding of ligands to AR triggers the conformational changes in AR that may affect the recruitment of coactivators and downstream response of AR signaling ***, AR ligands have great potential to treat these diseases. In this study, we searched for novel AR ligands by performing a docking-based virtual screening(VS) on the basis of the crystal structure of the AR ligand binding domain(LBD) in complex with its agonist. A total of 58 structurally diverse compounds were selected and subjected to LBD affinity assay, with five of them(HBP1-3, HBP1-17, HBP1-38, HBP1-51, and HBP1-58) exhibiting strong binding to AR-LBD. The IC50 values of HBP1-51 and HBP1-58 are 3.96 m M and 4.92 m M, respectively, which are even lower than that of enzalutamide(Enz, IC50= 13.87 m M), a marketed second-generation AR antagonist. Further bioactivity assays suggest that HBP1-51 is an AR agonist, whereas HBP1-58 is an AR antagonist. In addition, molecular dynamics(MD) simulations and principal components analysis(PCA) were carried out to reveal the binding principle of the newlyidentified AR ligands toward AR. Our modeling results indicate that the conformational changes of helix 12 induced by the bindings of antagonist and agonist are visibly different. In summary,the current study provides a highly efficient way to discover novel AR ligands, which could serve as the starting point for development of new therapeutics for AR-related diseases.

关键词： Androgen receptor AR ligand Virtual screening AR agonist AR antagonist

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Mechanical Assembly Packing Problem Using Joint Constraints

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Journal of computer Science & Technology 2017年第6期32卷 1162-1171页

作者： Ming-Liang Xu Ning-Bo Gu Wei-Wei Xu Ming-Yuan Li Jun-Xiao Xue Bing Zhou School of Information Engineering Zhengzhou University Zhengzhou 450000 China State Key Laboratory of Computer Aided Design and Computer Graphics Zhejiang University Hangzhou 310058 China School of Software Zhengzhou University Zhengzhou 450000 China

The three-dimensional packing problem is generally on how to pack a set of models into a given bounding box using the smallest packaging volume. It is known as an NP-hard problem. When discussing the packing problem in mechanical field, the space utilization of a mechanism is low due to the constraint of mechanical joints between different mechanical parts. Although such a situation can be improved by breaking the mechanism into components at every joint, it burdens the user when reassembling the mechanism and may also reduce the service life of mechanical parts. In this paper, we propose a novel mechanism packing algorithm that deliberately considers the DOFs （degrees of freedom） of mechanical joints. With this algorithm, we construct the solution space according to each joint. While building the search tree of the splitting scheme, we do not break the joint, but move the joint. Therefore, the algorithm proposed in this paper just requires the minimal number of splits to meet the goal of space utilization. Numerical examples show that the proposed method is convenient and efficient to pack three-dimensional models into a given bounding box with high space utilization.

关键词： NP-hard problem packing problem search tree

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