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Searching for plant NLR immune receptors conferring resistance to potyviruses

The Crop Journal 2024年第1期12卷 28-44页

作者： Xin Hong Shufen Li Xiaofei Cheng Haijian Zhi Jinlong Yin Kai Xu Jiangsu Key Laboratory for Microbes and Functional Genomics Jiangsu Engineering and Technology Research Center for MicrobiologyCollege of Life SciencesNanjing Normal UniversityNanjing 210023JiangsuChina College of Plant Protection Northeast Agricultural UniversityHarbin 150030HeilongjiangChina National Center for Soybean Improvement National Key Laboratory for Crop Genetics and Germplasm EnhancementKey Laboratory of Biology and Genetic Improvement of Soybean-Ministry of AgricultureNanjing Agricultural UniversityNanjing 210095JiangsuChina

To fight against invasion by pathogens,plants have evolved an elaborate innate immune system,of which the nucleotide-binding domain leucine-rich repeat-containing receptor(NLR)acts as the sensor and immune ***,comprising one of the largest genera of plant viruses,cause severe crop yield losses *** crop resistance to potyviruses can be used in breeding and plant transgenesis to control disease *** review summarizes achievements in mapping and cloning NLR genes conferring dominant resistance against potyvirus in the families Fabaceae,Solanaceae,Brassicaceae,and *** compares mechanisms of potyviral protein recognition and downstream signaling employed by NLRs and discusses strategies for exploiting NLRs to better control diseases caused by potyviruses.

关键词： NLR Potyvirus resistance genetic diversity Mapping Engineer

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Plant-derived natural products improve disease: Focus on gut-brain axis

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Food Science and Human Wellness 2025年

作者： Chen Song Wenjing Lang Li Meng Wenxiang Ping Jingping Ge Engineering Research Center of Agricultural Microbiology Technology， Ministry of Education & Heilongjiang Provincial Key Laboratory of Ecological Restoration and Resource Utilization for Cold Region & School of Life Sciences， Heilongjiang University Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region & Key Laboratory of Microbiology， College of Heilongjiang Province， Heilongjiang University Key Laboratory of Science and Engineering for the Multi-modal Prevention and Control of Major Chronic Diseases， Ministry of Industry and Information Technology

Dysbiosis of the gut microbiota may lead to a wide range of metabolic， neurological， intestinal and cardiovascular disorders and even to tumorigenesis. Evidence suggests that the gut-brain axis (GBA) plays a crucial role in the treatment of these diseases. Many plant-derived natural actives modulate the gut microbiota and its metabolites， gut hormones and neurotransmitters through a variety of mechanisms， and these actions contribute to the alleviation of irritable bowel syndrome， type 2 diabetes mellitus， cancer， and brain disorders. This review focuses on how natural products act through GBA to protect the central nervous system， regulate metabolism and promote apoptosis in cancer cells. The role of gut microbiota metabolites and neurotransmitter release in modulating inflammation-related factors， promoting or reducing oxidative stress， and activating or inhibiting related signaling pathways is also discussed. This comprehensive overview of the complex GBA mechanisms deepens the understanding of how natural products can target GBA to treat disease， providing valuable insights into the development and utilization of these natural interventions.

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Genome-wide association study identifies novel loci associated with feed efficiency traits in Hu lambs

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Journal of Integrative Agriculture 2025年第4期24卷 1259-1269页

作者： Deyin Zhang Xiaolong Li Fadi Li Xiaoxue Zhang Yuan Zhao Yukun Zhang Zongwu Ma Huibin Tian Xiuxiu Weng Weimin Wang State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems Key Laboratory of Grassland Livestock Industry InnovationMinistry of Agriculture and Rural Affairs/Engineering Research Center of Grassland IndustryMinistry of Education/College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou 730020China College of Animal Science and Technology Gansu Agricultural UniversityLanzhou 730070China

Feed efficiency(FE)is a crucial economic trait that significantly impacts profitability in intensive sheep production,and can be evaluated by the residual feed intake(RFI)and feed conversion ratio(FCR).However,the underlying genetic mechanisms that underlie FE-related traits in sheep are not fully ***,we measured the FE-related traits of 1,280 Hu sheep and conducted the phenotype statistics and correlation analysis,the result showcase that there was a large variation for FE-related traits,and RFI was significant positive correlation with average daily feed intake(ADFI)and ***,a genome-wide association study(GWAS)was conducted using whole-genome resequencing data to investigate the genetic associations of ADFI,FCR and *** ADFI and FCR traits,2 and one single nucleotide polymorphisms(SNPs)exceeded the genome-wide significance threshold,whereas ten and 5 SNPs exceeded the suggestive significance *** RFI traits,only 4 SNPs exceeded the suggestive significance ***,a total of 8 genes(LOC101121953,LOC101110202,CTNNA3,IZUMO3,PPM1E,YIPF7,ZSCAN12and LOC105603808)were identified as potential candidate genes for FE-related ***,we further analyzed the effects of 2 candidate SNPs associated with RFI on growth and FE traits in enlarged experimental population,the results demonstrated that these 2 SNPs was not significantly associated with growth traits(P>0.05),but significantly related to RFI traits(P<0.05).These findings will provide valuable reference data and key genetic variants that can be used to effectively select feed-efficient individual in sheep breeding programs.

关键词： sheep feed efficiency GWAS re-sequencing RFI FCR

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Cotton metabolism regulatory network:Unraveling key genes and pathways in fiber development and growth regulation

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Plant Communications 2025年第3期6卷 159-173页

作者： Zhao Liu Liqiang Fan Sheng Shu Ghulam Qanmber Eryong Chen Jinquan Huang Fuguang Li Zuoren Yang Zhengzhou Research Base State Key Laboratory of Cotton Bio-breeding and Integrated UtilizationSchool of Agricultural SciencesZhengzhou UniversityZhengzhou 450001HenanChina State Key Laboratory of Cotton Bio-breeding and Integrated Utilization Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyang 455000HenanChina Xinjiang Key Laboratory of Crop Gene Editing and Germplasm Innovation Institute of Western Agricultural of CAASChangjiXinjiang 831100China Henan Engineering Research Center of Crop Genome Editing School of AgricultureHenan Institute of Science and TechnologyXinxiang 453000HenanChina National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China

Cotton(Gossypium hirsutum L.)is one of the world’s most important commercial ***,the dynamics of metabolite abundance and potential regulatory networks throughout its life cycle remain poorly *** this study,we developed a cotton metabolism regulatory network(CMRN)that spans various developmental stages and encompasses 2138 metabolites and 90309 expressed genesin upland *** integrating high-resolution spatiotemporal metabolome and transcriptome data,we identified 1958 differentially accumulated metabolites and 13597 co-expressed differentially expressed genes between the dwarf mutant pagoda1 and its wild-type counterpart Zhongmiansuo *** metabolites and genes were categorized into seven clusters based on tissue-specific accumulation patterns and gene expression profiles across different developmental *** Encyclopedia of genes and Genomes enrichment analysis revealed significant differential enrichment in the fatty acid elongation pathway,particularly in *** differential involvement of genes and metabolites in very-long-chain fatty acid(VLCFA)synthesis led to the identification of GhKCS1b_Dt as a key *** of GhKCS1b_Dt significantly promoted fiber elongation,while its silencing markedly inhibited cotton fiber growth,affirming its positive regulatory role in fiber *** dataset provides a valuable resource for further research into metabolic pathways and gene regulatory networks,offering novel insights for advancing cotton breeding strategies.

关键词： CMRN cotton metabolome transcriptome pag1 metabolic regulatory network

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A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice

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National Science Review 2023年第12期10卷 98-110页

作者： Guohao Wang Shuhan Jin Jiaqi Liu Xu Li Peng Dai Yuetong Wang Steven X.Hou The Basic Research Laboratory Center for Cancer ResearchNational Cancer Institute at FrederickNational Institutes of Health Department of Cell and Developmental Biology at the School of Life Sciences State Key Laboratory of Genetic EngineeringInstitute of Metabolism and Integrative BiologyHuman Phenome Institute Department of Liver Surgery and Transplantation of Liver Cancer Institute at Zhongshan Hospital Fudan University

Neuroimmune connections have been revealed to play a central role in neurodegenerative diseases(NDs).However, the mechanisms that link the central nervous system(CNS) and peripheral immune cells are still mostly unknown. We recently found that specific ablation of the Arf1 gene in hindbrain and spinal cord neurons promoted NDs through activating the NLRP3 inflammasome in microglia via peroxided lipids and adenosine triphosphate(ATP) releasing. Here, we demonstrate that IL-1β with elevated chemokines in the neuronal Arf1-ablated mouse hindbrain and spinal cord recruited and activated γ δ T cells in meninges. The activated γ δ T cells then secreted IFN-γ that entered into parenchyma to activate the microglia-A1astrocyte-C3-neuronal C3a R neurotoxic pathway. Remarkably, the neurodegenerative phenotypes of the neuronal Arf1-ablated mice were strongly ameliorated by IFN-γ or C3 knockout. Finally, we show that the Arf1-reduction-induced neuroimmune-IFN-γ-gliosis pathway exists in human NDs, particularly in amyotrophic lateral sclerosis and multiple sclerosis. Together, our results uncover a previously unknown mechanism that links the CNS and peripheral immune cells to promote neurodegeneration.

关键词： neurodegenerative diseases disease-associated microglia γδ T cells reactive astrocyte IFN-γ C3

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Diverse nucleotide substitutions in rice base editing mediated by novel TadA variants

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Plant Communications 2024年第8期5卷 104-112页

作者： Man Yu Yongjie Kuang Chenyang Wang Xuemei Wu Shaofang Li Dawei Zhang Wenxian Sun Xueping Zhou Bin Ren Huanbin Zhou State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Department of Plant Pathology China Agricultural UniversityBeijing 100193China Scientific Observing and Experimental Station of Crop Pests in Guilin Ministry of Agriculture and Rural AffairsGuilin 541399China Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment College of Life ScienceState Key Laboratory of Hydraulics and Mountain River EngineeringSichuan UniversityChengdu 610064China State Key Laboratory of Vegetable Biobreeding National Engineering Research Center for VegetablesBeijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry ScienceBeijing 100097China State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058China Key Laboratory of Gene Editing Technologies(Hainan) Ministry of Agricultural and Rural AffairsSanya 572024China

CRISPR-mediated base editors have been widely used to correct defective alleles and create novel alleles by artificial evolution for the rapid genetic improvement of *** editing capabilities of base editors strictly rely on the performance of various nucleotide modification *** with the welldeveloped adenine base editors(ABEs),cytosine base editors(CBEs)and dual base editors suffer from unstable editing efficiency and patterns at different genomic loci in rice,significantly limiting their ***,we comprehensively examined the base editing activities of multiple evolved TadA8e variants in *** found that both TadA-CDd and TadA-E27R/N46L achieved more robust C-to-T editing than previously reported hyperactive hAID*D,and TadA-CDd outperformed TadA-E27R/N46L.A C-to-G base editor(CGBE)engineered with TadA-CDd and OsUNG performed highly efficient C-to-G editing in rice compared with that of *** addition,a dual base editor constructed with a single protein,TadDE,enabled simultaneous,highly efficient C-to-T and A-to-G editing in ***,our results demonstrate that TadA8e derivatives improve both CBEs and dual base editors in rice,providing a powerful way to induce diverse nucleotide substitutions for plant genome editing.

关键词： CRISPR TadA variants cytosine base editing dual base editor rice

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Overexpression of a transcription factor MdWRKY126 altered soluble sugar accumulation in apple and tomato fruit

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Horticultural Plant Journal 2025年第3期11卷 989-998页

作者： Lihua Zhang Yu Xu Zhexing Luo Long Lyu Changzhi Wang Lingcheng Zhu Fengwang Ma Mingjun Li Deguo Han The Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(Northeast Region) Ministry of Agriculture and Rural Affairs/National-Local Joint Engineering Research Center for Development and Utilization of Small Fruits in Cold RegionsCollege of Horticulture&Landscape ArchitectureNortheast Agricultural UniversityHarbinHeilongjiang 150030China State Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple College of HorticultureNorthwest A&F UniversityYanglingShaanxi 712100China

The compositions and contents of soluble sugars highly determine the flavor and quality of fleshy *** the present study,we found that the overexpression of transcription factor MdWRKY126 localized on the nucleus enhanced sucrose concentration while decreased fructose and glucose concentration in transgenic apple calli and ripening tomato *** comprehensively understand the effects of the MdWRKY126 on the content of various soluble sugars in apple and tomato fruits,enzyme activities and related essential genes associated with the sugar metabolism and transportation pathway in MdWRKY126-overrexpressed apple and tomato lines were *** results indicated that the overexpression of MdWRKY126 upregulated sucrose phosphate synthase(SPS)activity and the gene expression levels of SPS and sucrose transporter SUT,which was conducive to a large accumulation of sucrose in fruit ***,MdWRKY126 overexpression downregulated the activity of enzymes involved in sucrose decomposition including cell wall invertase(CWINV),sucrose synthase(SUSY)and the corresponding gene expressions,as well as inhibited the expression levels of hexose transporter(HTs)and tonoplast sugar transporter(TSTs)that transport hexose into vacuoles,resulting in a reduced hexose level in apple calli and tomato *** findings enrich our understanding of the metabolism and regulation of soluble sugars in apple fruits.

关键词： Malus WRKY126 Soluble sugar Transcriptional regulation Fruit quality

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HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation

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细胞研究（英文版） 2023年第11期33卷 851-866页

作者： Erpeng Wu Wenyan He Chenlu Wu Zhangcheng Chen Shijie Zhou Xialian Wu Zhiheng Hu Kelong Jia Jiasong Pan Limin Wang Jie Qin Dan Liu Junxia Lu Huayi Wang Jixi Li Sheng Wang Liming Sun State Key Laboratory of Cell Biology Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghaiChina State Key Laboratory of Molecular Biology Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghaiChina Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouChina School of Life Science and Technology ShanghaiTech UniversityShanghaiChina State Key Laboratory of Genetic Engineering School of Life Sciences and Huashan HospitalShanghai Engineering Research Center of Industrial MicroorganismsFudan UniversityShanghaiChina

Ultra-stable fibrous structure is a hallmark of *** contrast to canonical disease-related amyloids,emerging research indicates that a significant number of cellular amyloids,termed'functional amyloids',contribute to signal transduction as temporal signaling hubs in ***,it is unclear how these functional amyloids are effectively disassembled to terminate signal *** motif-containing amyloids,the largest functional amyloid family discovered thus far,play an important role in mediating necroptosis signal transduction in mammalian ***,we identify heat shock protein family A member 8(HSPA8)as a new type of enzyme—which we name as'amyloidase'—that directly disassembles RHIM-amyloids to inhibit necroptosis signaling in cells and *** from its role in chaperone-mediated autophagy where it selects substrates containing a KFERQ-like motif,HSPA8 specifically recognizes RHIM-containing proteins through a hydrophobic hexapeptide motif N(X1)φ(X3).The SBD domain of HSPA8 interacts with RHIM-containing proteins,preventing proximate RHIM monomers from stacking into functional fibrils;furthermore,with the NBD domain supplying energy via ATP hydrolysis,HSPA8 breaks down pre-formed RHIM-amyloids into non-functional ***,HSPA8's amyloidase activity in disassembling functional RHIM-amyloids does not require its co-chaperone *** this amyloidase activity,HSPA8 reverses the initiator RHIM-amyloids(formed by RIP1,ZBP1,and TRIF)to prevent necroptosis initiation,and reverses RIP3-amyloid to prevent necroptosis execution,thus eliminating multi-level RHIM-amyloids to effectively prevent spontaneous necroptosis *** discovery that HSPA8 acts as an amyloidase dismantling functional amyloids provides a fundamental understanding of the reversibility nature of functional amyloids,a property distinguishing them from disease-related amyloids that are unbreakable in vivo.

关键词： Cell signalling Necroptosis

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FBXL4 mutation-caused mitochondrial DNA depletion syndrome is driven by BNIP3/BNIP3L-dependent excessive mitophagy

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Trends in molecular medicine 2024年第2期30卷 113-116页

作者： Kun Gao Xiayun Xu Chenji Wang Department of Clinical Laboratory Shanghai First Maternity and Infant Hospital School of Medicine Tongji University Shanghai China. Electronic address: kungao@***. State Key Laboratory of Genetic Engineering MOE Engineering Research Center of Gene Technology Shanghai Engineering Research Center of Industrial Microorganisms School of Life Sciences Fudan University Shanghai China. State Key Laboratory of Genetic Engineering MOE Engineering Research Center of Gene Technology Shanghai Engineering Research Center of Industrial Microorganisms School of Life Sciences Fudan University Shanghai China. Electronic address: chenjiwang@***.

Encephalomyopathic mitochondrial DNA (mtDNA) depletion syndrome 13 (MTDPS13) is an autosomal recessive disorder arising from biallelic F-box and leucine-rich repeat (LRR) protein 4 (FBXL4) gene mutations. Recent advances have shown that excessive BCL2 interacting protein 3 (BNIP3)/ BCL2 interacting protein 3 like (BNIP3L)-dependent mitophagy underlies the molecular pathogenesis of MTDPS13. Here, we provide an overview of these groundbreaking findings and discuss potential therapeutic strategies for this fatal disease.

关键词： BNIP3/BNIP3L FBXL4 MTDPS13 mitochondria mitophagy ubiquitination

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Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1199-1208页

作者： Xinyi Yang Xu Zheng Yuqi Zhu Xiaying Zhao Jun Liu Jiangna Xun Songhua Yuan Jun Chen Hanyu Pan Jinlong Yang Jing Wang Zhimin Liang Xiaoting Shen Yue Liang Qinru Lin Huitong Liang Min Li Fei Peng Daru Lu Jianqing Xu Hongzhou Lu Shibo Jiang Ping Zhao Huanzhang Zhu State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology Ministry of EducationInstitute of GeneticsSchool of Life SciencesYiwu Research InstituteFudan UniversityShanghaiChina Department of Microbiology Faculty of Naval MedicineNaval Medical UniversityShanghai 200433China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Changzheng Hospital Naval Medical UniversityShanghaiChina Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecuritySchool of Basic Medical SciencesFudan UniversityShanghaiChina Department of Infectious Diseases and Nursing Research Institution National Clinical Research Center for Infectious DiseasesThe Third People’s Hospital of ShenzhenShenzhenGuangdongChina

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes multi-organ damage,which includes hepatic dysfunction,as observed in over 50%of COVID-19 *** I converting enzyme(peptidyl-dipeptidase A)2(ACE2)is the primary receptor for SARS-CoV-2 entry into host cells,and studies have shown the presence of intracellular virus particles in human hepatocytes that express ACE2,but at extremely low ***,we asked if hepatocytes might express receptors other than ACE2 capable of promoting the entry of SARS-CoV-2 into *** address this question,we performed a genome-wide CRISPR-Cas9 activation library screening and found that Asialoglycoprotein receptor 1(ASGR1)promoted SARS-CoV-2 pseudovirus infection of HeLa *** Huh-7 cells,simultaneous knockout of ACE2 and ASGR1 prevented SARS-CoV-2 pseudovirus *** the immortalized THLE-2 hepatocyte cell line and primary hepatic parenchymal cells,both of which barely expressed ACE2,SARSCoV-2 pseudovirus could successfully establish an ***,after treatment with ASGR1 antibody or siRNA targeting ASGR1,the infection rate significantly dropped,suggesting that SARS-CoV-2 pseudovirus infects hepatic parenchymal cells mainly through an ASGR1-dependent *** confirmed that ASGR1 could interact with Spike protein,which depends on receptor binding domain(RBD)and N-terminal domain(NTD).Finally,we also used Immunohistochemistry and electron microscopy to verify that SARS-CoV-2 could infect primary hepatic parenchymal *** inhibiting ASGR1 in primary hepatic parenchymal cells by siRNA,the infection efficiency of the live virus decreased ***,these findings indicate that ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of hepatic parenchymal cells.

关键词： ACE2 infection glycoprotein

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