Shared control schemes allow a human driver to work with an automated driving agent in driver-vehicle systems while retaining the driver’s abilities to control. The human driver, as an essential agent in the driver-v...
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We investigate the basin of attraction properties and its boundaries for chimera states in a circulant network of Hénon maps. It is known that coexisting basins of attraction lead to a hysteretic behaviour in the...
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We investigate the basin of attraction properties and its boundaries for chimera states in a circulant network of Hénon maps. It is known that coexisting basins of attraction lead to a hysteretic behaviour in the diagrams of the density of states as a function of a varying parameter. Chimera states, for which coherent and incoherent domains occur simultaneously, emerge as a consequence of the coexistence of basin of attractions for each state. Consequently, the distribution of chimera states can remain invariant by a parameter change, as well as it can suffer subtle changes when one of the basins ceases to exist. A similar phenomenon is observed when perturbations are applied in the initial conditions. By means of the uncertainty exponent, we characterise the basin boundaries between the coherent and chimera states, and between the incoherent and chimera states, respectively. This way, we show that the density of chimera states can be not only moderately sensitive but also highly sensitive to initial conditions. This chimera's dilemma is a consequence of the fractal and riddled nature of the basins boundaries. Coupled dynamical systems have been used to describe the behaviour of real complexsystems, such as power grids, neuronal networks, economics, and chemical reactions. Furthermore, these systems can exhibit various kinds of interesting nonlinear dynamics, e.g. synchronisation, chaotic oscillations, and chimera states. The chimera state is a spatio-temporal pattern characterised by the coexistence of coherent and incoherent dynamics. It has been observed in a great variety of systems, ranging from theoretical and experimental arrays of oscillators, to in phenomena such as the unihemispheric sleep of cetaceans. We study the chimera state in a circulant network of Hénon maps, seeking to determine how the density of states in the network depends on the system parameters and the initial conditions. We have found that, as expected, the density of states might be inva
Data-driven artificial intelligence technologies have made much progress in medical image analysis in the last decades. However, it still remains challenging due to its distinctive complexity of acquiring and annotati...
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Immune checkpoint blockade has become a paradigm-shifting treatment modality to combat cancer, while conventional administration of immune checkpoint inhibitors, such as anti-PD-L1 antibody (α-PD-L1), often shows uns...
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Immune checkpoint blockade has become a paradigm-shifting treatment modality to combat cancer, while conventional administration of immune checkpoint inhibitors, such as anti-PD-L1 antibody (α-PD-L1), often shows unsatisfactory immune responses and lead to severe immune-related adverse effects (irAEs). Herein, we develop a PD-L1 aptamer-based spherical nucleic acids (SNAs), which consists of oxaliplatin (OXA) encapsulated in a metal–organic framework nanoparticle core and a dense shell of aptPD-L1 (denoted as M@O-A). Upon light irradiation, this nanosystem enables concurrent photodynamic therapy (PDT), chemotherapy, and enhanced immunotherapy in one shot to inhibit both primary colorectal tumors and untreated distant tumors in mice. Notably, M@O-A shows scarcely any systemic immunotoxicity in a clinical irAEs-mimic transgenic mouse model. Collectively, this study presents a novel strategy for priming robust photo-immunotherapy against cancer with enhanced safety.
In a measurement system,new representation methods are necessary to maintain the uncertainty and to supply more powerful ability for reasoning and transformation between numerical system and symbolic system.A grey mea...
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In a measurement system,new representation methods are necessary to maintain the uncertainty and to supply more powerful ability for reasoning and transformation between numerical system and symbolic system.A grey measurement system is discussed from the point of view of intelligent sensors and incomplete information processing compared with a numerical and symbolized mea8urement *** methods of grey representation and information processing are proposed for data collection and *** a case study,multi-ultrasonic sensor systems are demonstrated to verify the effectiveness of the proposed methods.
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