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Metallo-supramolecular complexes enantioselectively target monkeypox virus RNA G-quadruplex and bolster immune responses against MPXV

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National Science Review 2025年第1期12卷 167-176页

作者： Jie Yang Geng Qin Baoying Huang Hualong Song Jiewei Sun Miles Postings Peter Scott Chuanqi Zhao Chunyu Wang Wenjie Tan Jinsong Ren Xiaogang Qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) Department of Chemistry University of Warwick School of Pharmacy Xinxiang Medical University State Key Laboratory of Supramolecular Structure and Materials Jilin University

The Mpox virus(MPXV) has emerged as a formidable orthopoxvirus, posing an immense challenge to global public health. An understanding of the regulatory mechanisms of MPXV infection, replication and immune evasion will benefit the development of novel antiviral strategies. Despite the involvement of G-quadruplexes(G4s) in modulating the infection and replication processes of multiple viruses, their roles in the MPXV life cycle remain largely unknown. Here, we found a highly conservative and stable G4 in MPXV that acts as a positive regulatory element for viral immunodominant protein ***, by screening 42 optically pure chiral metal complexes, we identified the Λ enantiomer of a pair of chiral helical compounds that can selectively target m RNA G4 and enhance expression of the 39-k Da core protein encoded by the MPXV A5L gene. Mechanistically, RNA G4-specific helicase DHX36 inhibits A5L protein expression by unwinding G4s. In contrast, MH3 Λ enhanced m RNA stability by specifically targeting G4 structures and subsequently increased protein expression. Furthermore, given the pivotal role of the 39-k Da core protein in activating immune responses and facilitating virion maturation, modulation of MPXV G4 folding by MH3 Λ exhibited inhibitory effects on MPXV replication through enhancing the immune response. Our findings underscore the critical involvement of G4 in the MPXV life cycle and offer potential avenues for developing antiviral drugs that target G4.

关键词： G-quadruplex ligand binding Mpox virus chirality supramolecular chemistry

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Study on damage mechanism and damage distribution of the rear plate under impact of debris cloud

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Defence Technology（防务技术） 2024年第5期35卷 151-167页

作者： Chenyang Wu Xiaowei Chen Qiguang He State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyHaidian DistrictBeijing 100081China School of Mechatronical Engineering Beijing Institute of TechnologyHaidian DistrictBeijing 100081China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621900SichuanChina

The debris cloud generated by the hypervelocity impact(HVI)of orbiting space debris directly threatens the spacecraft.A full understanding of the damage mechanism of rear plate is useful for the optimal design of protective *** this study,the hypervelocity yaw impact of a cylindrical aluminum projectile on a double-layer aluminum plate is simulated by the FE-SPH adaptive method,and the damage process of the rear plate under the impact of the debris cloud is analyzed based on the debris cloud *** damage process can be divided into the main impact stage of the debris cloud and the structural response of the rear *** main impact stage lasts a short time and is the basis of the rear plate *** the stage of structure response,the continuous deformation and inertial motion of the rear plate dominate the perforation of the rear *** further analyze the damage mechanism and damage distribution characteristics of the rear plate in ***,the connection between velocity space and position space of the debris cloud is established,which promotes the general analysis of the damage law of debris *** on the relationship,the features of typical damage areas are identified by the localized fine *** the cumulative effect and structural response cause the perforation of rear plate;in the non-perforated area,cratering by the impact of hazardous fragments is the main damage mode of the rear plate.

关键词： Damage of rear plate Debris cloud Secondary impact Hypervelocity yaw impact FE-SPH adaptive method

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A probe into the acid deposition mitigation path in China over the last four decades and beyond

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National Science Review 2024年第4期11卷 84-92页

作者： Qian Yu Xiaodong Ge Haotian Zheng Jia Xing Lei Duan Dongwei Lv Dian Ding Zhaoxin Dong Yisheng Sun Posch Maximilian Danni Xie Yu Zhao Bin Zhao Shuxiao Wang Jan Mulder Thorj?rn Larssen Jiming Hao State Key Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua University State Key Laboratory of Pollution Control &Resource Reuse and School of the Environment Nanjing University State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex School of EnvironmentTsinghua University International Institute for Applied System Analysis(IIASA) School of Land Engineering Chang'an University Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life Sciences Norwegian Institute for Water Research

China currently has the highest acid deposition globally, yet research on its status, impacts, causes and controls is lacking. Here, we compiled data and calculated critical loads regarding acid deposition. The results showed that the abatement measures in China have achieved a sharp decline in the emissions of acidifying pollutants and a continuous recovery of precipitation p H, despite the drastic growth in the economy and energy consumption. However, the risk of ecological acidification and eutrophication showed no significant decrease. With similar emission reductions, the decline in areas at risk of acidification in China(7.0%) lags behind those in Europe(20%) or the USA(15%). This was because, unlike Europe and the USA, China's abatement strategies primarily target air quality improvement rather than mitigating ecological impacts. Given that the area with the risk of eutrophication induced by nitrogen deposition remained at 13%of the country even under the scenario of achieving the dual targets of air quality and carbon dioxide mitigation in 2035, we explored an enhanced ammonia abatement pathway. With a further 27% reduction in ammonia by 2035, China could largely eliminate the impacts of acid deposition. This research serves as a valuable reference for China's future acid deposition control and for other nations facing similar challenges.

关键词： acid deposition critical loads acidification eutrophication ammonia abatement

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Communication Countermeasure Strategy Decision-Making Based on Incomplete Information Game 27

Communication Countermeasure Strategy Decision-Making Based ...

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27th International Conference on Advanced Communications Technology, ICACT 2025

作者： Liu, Jinyue Gao, Xiang Yang, Haowei Zhang, Jihao Liu, Yuhan Gong, Peng National Key Laboratory of Mechatronic Engineering and Control School of Mechatronical Engineering Beijing Institute of Technology Beijing China Institute of Computer Application Technology Norinco Group Beijing China

ISBN: (纸本)9791188428137

In modern battlefields, the stability of wireless communications is crucial for intelligence transmission, command coordination, and maintaining strategic advantage. However, with the rapid advancement of communication technologies, the electromagnetic environment has become increasingly complex, making intelligent decision-making in communication countermeasures a prominent research focus. However, most existing studies adopt deep learning and reinforcement learning methods, which require extensive data samples and computational resources. To address these limitations, this paper proposes a game-theoretic model for intelligent radio communication countermeasures under incomplete information. It quantitatively evaluates common attack and defense tactcis used in communication countermeasures and explores the mixed-strategy equilibrium of the game when both the attackers and defenders consist of multiple types. Furthermore, simulation-based comparative analyses are conducted to assess the factors influencing the utility of both the attacker and defender. The findings offer theoretical insights and decision-making support for the deployment of communication countermeasure strategies in practical military operations, contributing to significant strategic value. © 2025 Institute of Electrical and Electronics Engineers Inc.. All rights reserved.

关键词： Deep reinforcement learning

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Experimental Study on Impingement Processes of Fuel Sprays on Biomimetic Structured Surfaces

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Journal of Bionic engineering 2024年第1期21卷 362-373页

作者： Yanling Chen Liang Guo Wanchen Sun Yuying Yan Rong Xuan Junfeng Zhang State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130025China Faculty of Engineering University of NottinghamNottingham NG72RDUK

To improve the controllability of the wall-wetting process after the fuel spray-wall impingement in internal combustion engines,the methods of laser etching,chemical etching and surface free energy modification are used to prepare biomimetic structured surfaces with different *** impingement processes of diesel and n-butanol sprays on the walls under different conditions are experimentally *** the surface oleophilicity increases,the spreading radius of wall-impinging sprays *** about 5 s after the fuel injections,the fuel spray droplets hit the walls for the first time,and the secondary breakup and rebound *** mixture concentrations of different fuels hitting the various walls reach the peak *** a higher surface temperature,the peak value of the mixture concentration is mainly related to the heat flux to the fuel droplets in different boiling regimes from the metal *** concentration of the air–fuel mixture in the near wall region increases with increasing surface oleophilicity,increasing wall temperature and decreasing ambient *** with diesel,n-butanol presents a higher air–fuel mixture concentration in the near wall region.

关键词： Spray-wall impingement Morphological development Air-fuel mixture concentration Surface wettability Wall temperature:Ambient pressure

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Temperature-Dependent Tearing Behavior of Rubber Materials:Characterization and Modeling

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Acta Mechanica Solida Sinica 2024年第2期37卷 316-326页

作者： Qinyuan Yao Feilong Zhang Pan Dong Ziyuan Zhao Yi He Weiguo Li Liming Chen State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400044China College of Aerospace Engineering Chongqing UniversityChongqing400044China

With the increasingly widespread application of rubber in many fields,there is a growing demand for quantitative characterization of temperature-dependent mechanical properties in high-temperature service *** critical tearing energy is an important criterion for determining whether rubber materials will experience tearing instability,while tear strength is a key parameter for rubber materials to resist *** is necessary to quantitatively characterize their evolution with *** theoretical research mainly relies on fitting a large amount of experimental data,which is not convenient for engineering ***,in this work,a temperature-dependent critical tearing energy model is firstly developed based on the force-heat equivalence energy density *** model considers the equivalent relationship between the critical tearing energy required for crack instability propagation and the thermal energy stored in the rubber *** is demonstrated that our model has higher prediction accuracy when compared to other ***,combining with the Griffith fracture theory,temperature-dependent tear strength models applicable to three different crack modes are separately *** models are validated using experimental data for Mode I opening cracks and ModeⅢtearing cracks,and good consistency is ***,a quantitative analysis of the influence of elastic modulus on tear strength at different temperatures is *** work provides a reliable way for predicting temperature-dependent tearing instability behavior and offers beneficial suggestions for improving the tear strength of rubber materials at different temperatures.

关键词： Temperature-dependent Critical tearing energy Tear strength Rubber Theoretical model

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Ultralow friction of ion-containing water nanodroplets

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Nano Research 2023年第1期16卷 1792-1797页

作者： Jie Tan Yufeng Guo Wanlin Guo State Key Laboratory of Mechanics and Control of Mechanical Structures MOE Key Laboratory for Intelligent Nano Materials and DevicesCollege of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China

We reveal the ultralow friction or superlubricity of water nanodroplets containing cations and anions on graphene substrates at high ion concentration by molecular dynamics *** the ion concentration is higher than 7 wt.%and the nanodroplet diameter is larger than 10 nm,the friction coefficients of water nanodroplets are lower than 10−2,and can decrease to the order of 10−3 with increasing the ion concentration *** a certain ion concentration,the optimal nanodroplet diameter of 17–20 nm exists at which the friction coefficient is the *** ultralow friction behaviors of water nanodroplets containing cations and anions are mainly attributed to the opposite variation trends between the interfacial adhesion energy and surface energy of water nanodroplet with ion concentration,and the interfacial hydrophobicity sustained by high ion *** results unveil the essential role of ions in achieving the superlubricity of water nanodroplets.

关键词： water nanodroplet ion ultralow friction molecular dynamics

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Ion-Induced Friction Reduction in Water Nanoflow over Graphene

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Acta Mechanica Solida Sinica 2023年第2期36卷 214-220页

作者： Yue Wang Yufeng Guo Wanlin Guo State Key Laboratory of Mechanics and Control of Mechanical Structures MOE Key Laboratory for Intelligent Nano Materials and DevicesCollege of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China

Our extensive nonequilibrium and equilibrium molecular dynamics simulations reveal the ion-induced interfacial friction reduction of NaCl-containing water nanoflow over *** under a normal pressure,with the increase in ion concentration,the friction coefficients of water nanoflow at the water/graphene interfaces decrease,and the slip lengths and shear viscosities of water nanoflow *** interfacial friction reduction with the increase in ion concentration is mainly attributed to the decrease in interfacial hydrated ions and the weaker binding of water molecules with graphene at a higher ion *** presence of ions changes the hydrogen bond networks and structural configuration of water molecules close to the underlying graphene sheets and plays a key role in reducing the interfacial friction between water nanoflow and graphene.

关键词： Water nanoflow Ion Friction reduction Molecular dynamics

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Influence of nanosized magnesia on the hydration of borehole-sealing cements prepared using different methods

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International Journal of Coal Science & Technology 2023年第4期10卷 343-360页

作者： Quanle Zou Jinfei Zhan Xin Wang Zhen Huang State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing 400044China

Gas drainage is an efective technology for gas control in coal mines.A high borehole-sealing quality is the fundamental precondition for efcient gas *** expansibilities of cement pastes used in borehole-sealing processes are critical for the borehole-sealing *** magnesia expansive agents are used to improve the expansibilities of cement pastes and improve the borehole-sealing *** magnetic resonance spectrometry and scanning electron microscopy were adopted to study the efects of nanosized magnesia on the hydration of borehole-sealing cements used with diferent preparation *** results showed that an increase in the mass fraction of the nanosized magnesia promoted cement hydration,and the mass fraction was positively correlated with the promotion *** use of diferent preparation methods did not change the water-phase distribution in the *** using the wet-mixing preparation method,nanosized magnesia promoted the induction,acceleration,and deceleration periods of hydration;when using the dry-mixing preparation method,the nanosized magnesia promoted the induction period of cement hydration,and the promotion efect was less obvious than that seen when using the wet-mixing *** using the wet-mixing preparation method,the nanosized magnesia was uniformly dispersed,thus enlarging the surface area of the reaction,which provided more nucleation sites for the hydration products of the cement and therefore accelerated the hydration *** using the dry-mixing preparation method,the nanosized magnesia powders were dispersed nonuniformly and *** these conditions,only a few nanosized magnesia particles on the surfaces of the aggregated clusters took part in hydration,so only a small number of nucleation sites were provided for the hydration products of *** led to inconsistent hydration of cement pastes prepared using the dry-mixing *** surface porosity of the cement prepared with the wet-mi

关键词： Borehole-sealing cement Nanosized magnesia Preparation method Hydration Morphological analysis Nuclear magnetic resonance relaxation analysis

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Formal management-specifying approach for model-based safety assessment

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Journal of Systems engineering and Electronics 2023年第6期34卷 1589-1601页

作者： XU Changyi DUAN Yiman ZHANG Chao School of Control Science and Engineering Key Laboratory of Intelligent Control and Optimization for Industrial Equipment of Ministry of EducationDalian University of TechnologyDalian 116024China State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China

In the field of model-based system assessment,mathematical models are used to interpret the system ***,the industrial systems in this intelligent era will be more *** management operations will be dynamically set,and the system will be no longer static as it is initially ***,the static model generated by the traditional model-based safety assessment(MBSA)approach cannot be used to accurately assess the *** mainly exists three ***:huge and complex behaviors make the modeling to be trivial manual;Dynamic:though there are thousands of states and transitions,the previous model must be resubmitted to assess whenever new management arrives;Unreusable:as for different systems,the model must be resubmitted by reconsidering both the management and the system itself at the same time though the management is the *** by solving the above problems,this research studies a formal management specifying approach with the advantages of agility modeling,dynamic modeling,and specification design that can be ***,three typical managements are specified in a series-parallel system as a demonstration to show the potential.

关键词： model-based safety assessment(MBSA) management availability reliability maintainability continuous time Markov chain.

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