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Initiation of dendritic NMDA spikes co-regulated via distance-dependent and dynamic distribution of the spine number and morphology in neuron dendrites

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Science China(Technological Sciences) 2023年第2期66卷 429-438页

作者： CAO YuWei SHEN Chun QIU Hu GUO WanLin State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Mechanics and Control of Mechanical Structure and Key Laboratory for Intelligent Nano Materials and Devices of the Ministry of Education Institute for Frontier Science and Institute of NanoscienceNanjing University of Aeronautics and AstronauticsNanjing 210016China

Dendritic spines are small membranous protrusions that receive synaptic inputs from other neurons,enabling the initiation of dendritic N-methyl-D-aspartic(NMDA)spikes and somatic action *** learning and memory processes,both the number of spines on a dendrite and the morphology of individual spines are constantly *** individual influence of spine number and morphology on dendritic NMDA spikes has already been revealed,but the functional significance of the coregulation of spine number and morphology on NMDA spikes remains ***,we systematically investigated the initiation of local dendritic NMDA spikes by the dynamic distributions of the spine number and morphology on single dendrites in reconstructed neuron *** from the traditional cognition,we found the threshold number of spines required to generate local dendrite NMDA spikes on distal dendrites is fewer than that on proximal ones,because the thinner distal dendrites own higher *** for the spine morphology,the presence of moreα-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid(AMPA)receptors on the spine leads to larger NMDA spikes rather than an increase in the spine dimension ***,we first suggested that a single dendrite containing spines with gradually increasing head diameters away from the soma could generate larger NMDA spikes than that irrational distribution of spine morphology containing spines with decreasing head diameters,which can be compensated by the increasing spine ***,the distance-dependent distribution of spine number and morphology co-regulate the intension of dendritic NMDA *** findings about the threshold for NMDA spikes provide novel insights into the role of the irrational dynamic distribution of the spine number and morphology in senescence and disease processes such as Alzheimer’s disease,schizophrenia,and Parkinson’s disease,which causes abnormal neuron firing.

关键词： dendritic spine spine number spine morphology NMDA spikes memory neurological diseases

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Magnetic and luminescent properties of bifunctional composite Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+)

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Journal of Rare Earths 2024年第8期42卷 1568-1576,I0006页

作者： Zhiqi Liang Zhili Zhang Liu Li Wen Xu Decai Li School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing100044China Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale Beijing100044China State Key Laboratory of Tribology Tsinghua UniversityBeijing100084China

As a kind of non-destructive testing method,magnetic particle inspection is widely used in the fields of aviation and high-speed *** properties of magnetic fluorescent bifunctional composites,such as fluorescence intensity and magnetic properties,have increasing demands in magnetic particle *** earth compounds offer potential as novel materials for fluorescent magnetic bifunctional composites due to their excellent optical properties and extremely narrow emission *** this work,the rare earth fluorescent material Y_(2)O_(2)S:Eu^(3+) was synthesized by solid-state reaction ***_(3)O_(4)nanoparticles prepared by hydrothermal method were uniformly coated on the Y_(2)O_(2)S:Eu^(3+) particles through physical adsorption of *** obtained Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+) exhibits dark red color under the ultraviolet *** additio n,X-ray diffractio n,morphology,photoluminescence and hyste resis loop of Fe_(3)O_(4)@Y_(2)O_(2)S:Cu^(3+) were *** luminescence mechanism of Y_(2)O_(2)S:Eu^(3+) is described in detail Fe_(3)O_(4)@Y_(2)O_(2)S:Cu^(3+) displays good paramagnetism and has a good controllability under a magnetic *** magnetic particle inspection of Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+) was performed using a 4-pole electromagnet and a test piece *** magnetic fluorescent bifunctional composite presented in this work can be applied for non-destructive testing.

关键词： Bifunctional material Fe_(3)O_(4) Y_(2)O_(2)S:Eu^(3+) Luminescence Solid-state reaction Rare earths

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Integrated Motion control of Interaction Safety, Stability, and Path-Tracking for Front-and-Rear-Independent-Drive Electric Vehicle

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IEEE Transactions on Transportation Electrification 2025年第3期11卷 8573-8583页

作者： Zeng, X.H. Duan, C.S. Song, D.F. Qian, Q.F. Yang, D.P. Zhang, X.M. Jilin University State Key Laboratory of Automotive Simulation and Control Changchun130022 China Jiangsu University School of Automotive and Transportation Engineering Zhenjiang212000 China

Under two vehicle interaction scenarios, the uncertain motion states of traffic participants pose significant challenges to the safety of autonomous vehicles (AVs), and AVs are susceptible to instability with emergency avoidance constraints. To address this issue, an integrated motion control of interaction safety, stability, and path-tracking is proposed for front-and-rear-independent-drive electric vehicles (FRIDEV). First, a control-oriented longitudinal-lateral coupled dynamic model is established. Then, a variable step model predictive control (MPC) is designed to solve multiobjective optimization problems, which mainly include two parts: 1) adaptive adjustment of stability weight by an improved phase plane method and 2) adding an interactive safety constraint to motion control by backward reachability analysis. Finally, simulation results show that the proposed controller can effectively utilize the longitudinal and lateral tire forces and achieve a balance between stability and tracking accuracy, and reduce collision risk in the interactive scenario with milder control actions. Moreover, the hardware-in-the-loop (HIL) test demonstrates that the proposed controller is effective in the real-time environment. © 2015 IEEE.

关键词： Predictive control systems

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Detector-grade perovskite single-crystal wafers via stress-free gel-confined solution growth targeting high-resolution ionizing radiation

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Light(Science & Applications) 2023年第5期12卷 754-765页

作者： Yilong Song Lixiang Wang Yongqiang Shi Weihui Bi Jianwu Chen Mingwei Hao Anran Wang Xueying Yang Yuan Sun Fan Yu Liansheng Li Yanjun Fang Deren Yang Qingfeng Dong State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China State Key Laboratory of Silicon Materials and School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China Beijing Institute of Control Engineering Beijing 100190China Science and Technology on Space Intelligent Control Laboratory Beijing 100190China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China

Solution-processed organic‒inorganic halide perovskite(OIHP)single crystals(SCs)have demonstrated great potential in ionizing radiation detection due to their outstanding charge transport properties and low-cost ***,the energy resolution(ER)and stability of OIHP detectors still lag far behind those of melt-grown inorganic perovskite and commercial CdZnTe counterparts due to the absence of detector-grade high-quality OIHP ***,we reveal that the crystallinity and uniformity of OIHP SCs are drastically improved by relieving interfacial stress with a facial gel-confined solution growth strategy,thus enabling the direct preparation of large-area detector-grade SC wafers up to 4 cm with drastically suppressed electronic and ionic *** resultant radiation detectors show both a small dark current below 1 nA and excellent baseline stability of 4.0×10^(-8) nA cm^(-1) s^(-1) V^(-1),which are rarely realized in OIHP ***,a record high ER of 4.9% at 59.5 keV is achieved under a standard 241Am gamma-ray source with an ultralow operating bias of 5 V,representing the best gamma-ray spectroscopy performance among all solution-processed semiconductor radiation detectors ever reported.

关键词： resolution confined stress

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A Method for Scattering Removal in Three-Dimensional Fluorescence Spectra Based on Physics-Informed Neural Networks

A Method for Scattering Removal in Three-Dimensional Fluores...

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2024 China Automation Congress, CAC 2024

作者： Zhang, Lingke Yu, Jie Fan, Xingyu Cao, Shuai Zhang, Qiuhao Zhang, Guangxin State Key Laboratory of Industrial Control Technology College of Control Science and Engineering Zhejiang University Hangzhou China

ISBN: (纸本)9798350368604

Three-dimensional fluorescence spectroscopy offers high-dimensional information and rapid sensitivity, making it advantageous in fields such as environmental monitoring and food testing. However, scattering effects can hinder analysis accuracy, and traditional de-scattering methods often lead to signal loss and distortion. To overcome these issues, a denoising method based on a physics-informed neural network is proposed. This method includes a physical information reconstruction module that generates theoretical values approximating actual scattering values. Integrated into a GAN framework, this module uses physical quantities to guide the generator in producing physically consistent images, thus preserving material integrity after scattering removal. Tests on a self-built dataset show that this method achieves higher physical consistency compared to traditional methods. © 2024 IEEE.

关键词： III-V semiconductors

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Collaborative Improvement of Structure Shape and Surface Integrity in Titanium Alloy Hole Burnishing

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Chinese Journal of Mechanical engineering 2025年第1期38卷 186-205页

作者： Jiahui Liu Pingfa Feng Zibiao Wang Jianfu Zhang Feng Feng Xiangyu Zhang Beijing Key Laboratory of Precision/Ultra-precision Manufacturing Equipments and Control Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Division of Advanced Manufacturing Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

In the aerospace field,hole burnishing enhancement plays an essential role in improving the service performance of load-bearing *** satisfy the assembly accuracy and strength requirements,the structure shape and surface integrity must be considered simultaneously during the enhancement *** current manufacturing process of hole burnishing has a relatively weak balance between the structure shape and surface integrity;therefore,it is necessary to analyze the mechanism and optimize the parameters to improve the strengthening effect of the *** this study,a two-dimensional longitudinal simplified model for the hole burnishing process was established,and the reasons for the surface roughness improvement of the hole wall and material accumulation on the upper surface were *** were conducted to determine the influence of the burnishing parameters on the structure shape(material accumulation,shape contour,and roundness)and surface integrity(surface roughness,residual stress,and surface hardness),based on the opposite requirements of improving the structure shape and surface integrity for the burnishing depth(BD).The results showed that with an increase in the BD,the structure shape deteriorated,whereas the surface integrity *** behavior verification experiments were conducted,and parameter selection schemes for the collaborative improvement of the structure shape and surface integrity were *** the holes of titanium alloy TB6(Ti-10V-2Fe-3Al),the fatigue life can be increased by 162%when the BD,spindle speed,and feed rate were 0.20 mm,200 r/min,and 0.2 mm/r,respectively.

关键词： Hole burnishing Surface roughness Material accumulation Structure shape Titanium alloy Fatigue life

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Strain engineering of Pt-based electrocatalysts for oxygen reaction reduction

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Frontiers in Energy 2024年第2期18卷 241-262页

作者： Zeyu WANG Yanru LIU Shun CHEN Yun ZHENG Xiaogang FU Yan ZHANG Wanglei WANG State Key Laboratory of Solidification Processing Atomic Control and Catalysis Engineering LaboratorySchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyDepartment of Dental MaterialsSchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China Institute of New Energy Materials and Engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Key Laboratory of Marine Chemistry Theory and Technology(Ministry of Education) College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao 266100China

Proton exchange membrane fuel cells(PEMFCs)are playing irreplaceable roles in the construction of the future sustainable energy ***,the insufficient performance of platinum(Pt)-based electrocatalysts for oxygen reduction reaction(ORR)hinders the overall efficiency of *** the surface strain of catalysts is considered an effective way to tune their electronic structures and therefore optimize catalytic *** this paper,insights into strain engineering for improving Pt-based catalysts toward ORR are elaborated in ***,recent advances in understanding the strain effects on ORR catalysts are comprehensively ***,strain engineering methodologies for adjusting Ptbased catalysts are comprehensively ***,further information on the various challenges and potential prospects for strain modulation of Pt-based catalysts is provided.

关键词： strain engineering Pt-based catalysts oxygen reduction reaction(ORR) catalytic performance proton exchange membrane fuel cells(PEMFCs)

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Continued evolution of H10N3 influenza virus with adaptive mutations poses an increased threat to mammals

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Virologica Sinica 2024年第4期39卷 546-555页

作者： Shiping Ding Jiangtao Zhou Junlong Xiong Xiaowen Du Wenzhuo Yang Jinyu Huang Yi Liu Lihong Huang Ming Liao Jiahao Zhang Wenbao Qi State Key Laboratory for Animal Disease Control and Prevention South China Agricultural UniversityGuangzhou510642China National Avian Influenza Para-Reference Laboratory Guangzhou510642China Key Laboratory of Zoonoses Ministry of Agriculture and Rural AffairsGuangzhou510642China National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control Guangzhou510642China Key Laboratory of Zoonoses Prevention and Control of Guangdong Province Guangzhou510642China State Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China College of Animal Science and Technology Zhongkai University of Agriculture and EngineeringGuangzhou510550China

The H10 subtype avian influenza virus(AIV)poses an ongoing threat to both birds and ***,fatal human cases of H10N3 and H10N8 infections have drawn public *** 2022,we isolated two H10N3 viruses(A/chicken/Shandong/0101/2022 and A/chicken/Shandong/0603/2022)from diseased chickens in *** analysis revealed that these viruses were genetically associated with human-origin H10N3 virus,with internal genes originating from local H9N2 *** to the H10N8 virus(A/chicken/Jiangxi/102/2013),the H10N3 viruses exhibited enhanced thermostability,increased viral release from erythrocytes,and accumulation of hemagglutinin(HA)***,we evaluated the pathogenicity of both H10N3 and H10N8 viruses in *** found that viral titers could be detected in the lungs and nasal turbinates of mice infected with the two H10N3 viruses,whereas H10N8 virus titers were detectable in the lungs and brains of ***,the proportion of double HA Q222R and G228S mutations in H10N3 viruses has increased since ***,the functional roles of the Q222R and G228S double mutations in the HA gene of H10N3 viruses remain unknown and warrant further *** study highlights the potential public health risk posed by the H10N3 virus.A spillover event of AIV to humans could be a foretaste of a looming ***,it is imperative to continuously monitor the evolution of the H10N3 influenza virus to ensure targeted prevention and control measures against influenza outbreaks.

关键词： Avian influenza virus(AIV) H10N3 Evolution Pathogenicity

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Development of a Compact Optical Layout for a Miniature Fluorescence Spectrometer: In-Situ Detection of Organic Pollutants in Aquatic Environment

Development of a Compact Optical Layout for a Miniature Fluo...

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2024 China Automation Congress, CAC 2024

作者： Fan, Xingyu Yu, Jie Zhang, Qiuhao Cao, Shuai Zhang, Lingke Xue, Fangjia State Key Laboratory of Industrial Control Technology College of Control Science and Engineering Zhejiang University Hangzhou China

ISBN: (纸本)9798350368604

In recent years, the increasing presence of emerging organic pollutants in rivers, lakes, and other aquatic environments has posed significant threats to human health and ecological safety. Current monitoring technologies for these pollutants face several challenges, including the high cost of equipment and the scarcity of trained professionals. Furthermore, existing portable fluorescence sensors are limited by inadequate data, unsuitability for in-situ water environments, and the ability to detect only specific pollutants. This paper proposes a novel design for an in-situ miniature fluorescence spectrometer, utilizing a compact optical layout to monitor organic pollutants in water. The design features a high-power UV LED combined with a lens group to enhance the fluorescence excitation effect of low-concentration organic pollutants. The system components are integrated into a compact layout centered around a flow cell, significantly reducing the device's size. In experimental validation, vitamin B was used as a model organic pollutant to test the prototype's detection capabilities. Within the concentration range of 1 - 100 μg/L, the fluorescence intensity exhibited a strong linear correlation with the vitamin B concentration, achieving an R2 value of 0.9945, comparable to that of commercial spectrometers. This portable device demonstrates excellent performance in detecting organic matter and offers significant advantages for in-situ monitoring applications, making it well-suited for real-time pollutant detection in rivers, lakes, and other aquatic environments. © 2024 IEEE.

关键词： Lake pollution

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Relabeling Abnormal Videos via Intra-Video Label Propagation for Weakly Supervised Video Anomaly Detection 14

Relabeling Abnormal Videos via Intra-Video Label Propagation...

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14th Asian control Conference, ASCC 2024

作者： Zhou, Wenhao Li, Yingxuan Zhao, Jiancheng Zhao, Chunhui College of Control Science and Engineering Zhejiang University State Key Laboratory of Industrial Control Technology Hangzhou China

ISBN: (纸本)9789887581598

Weakly supervised video anomaly detection is chal-lenging due to the lack of frame-level labels in abnormal videos. Previous work generally formulates it as a multiple instance learning (MIL) problem, in which abundant snippets especially including hard snippets in abnormal videos are underutilized, causing the training process to be dominated by redundant easy snippets. In this work, we introduce a semi-supervised learning perspective and aim to provide reliable snippet-level labels for abnormal videos to fully leverage them. Specifically, we propose a relabeling strategy by utilizing the Label Propagation Network (LPN) to propagate labels from confident snippets to hard snippets. Considering label propagation tends to be fragile and inaccurate in this case due to incorrect pseudo labels, we develop a feature relation module to enhance the intra-class compactness and inter-class dispersion, as well as a label separation module to enlarge the discrepancy of propagated labels. The overall model is designed to be concise and universal, which can be applied to existing weakly supervised methods to improve performance. Extensive experiments demonstrate that our method achieves state-of-the-art results on three benchmark datasets. © 2024 Asian control Association.

关键词： Self-supervised learning

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