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Integrated Cross-Scale Manipulation and Modulable Encapsulation of Cell-Laden Hydrogel for Constructing Tissue-Mimicking Microstructures

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Research 2025年第1期2024卷 704-717页

作者： Yanfeng Zhao Xinyi Dong Yang Li Juan Cui Qing Shi Hen-Wei Huang Qiang Huang Huaping Wang Intelligent Robotics Institute School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China Peking University First Hospital Xicheng DistrictBeijing 100034China Key Laboratory of Instrumentation Science and Dynamic Measurement Ministry of EducationNorth University of ChinaTaiyuan 030051China Beijing Advanced Innovation Center for Intelligent Robots and Systems Beijing Institute of TechnologyBeijing 100081China Laboratory for Translational Engineering Harvard Medical SchoolCambridgeMA 02139USA Key Laboratory of Biomimetic Robots and Systems (Beijing Institute of Technology) Ministry of EducationBeijing 100081China

Engineered microstructures that mimic in vivo tissues have demonstrated great potential for applications in regenerative medicine,drug screening,and cell behavior ***,current methods for engineering microstructures that mimic the multi-extracellular matrix and multicellular features of natural tissues to realize tissue-mimicking microstructures in vitro remain ***,we propose a versatile method for constructing tissue-mimicking heterogeneous microstructures by orderly integration of macroscopic hydrogel exchange,microscopic cell manipulation,and encapsulation ***,various cell-laden hydrogel droplets are manipulated at the millimeter scale using electrowetting on dielectric to achieve efficient hydrogel ***,the cells are manipulated at the micrometer scale using dielectrophoresis to adjust their density and arrangement within the hydrogel ***,the photopolymerization of these hydrogel droplets is triggered in designated regions by dynamically modulating the shape and position of the excitation ultraviolet ***,heterogeneous microstructures with different extracellular matrix geometries and components were constructed,including specific cell densities and *** resulting heterogeneous microstructure supported long-term culture of hepatocytes and fibroblasts with high cell viability(over 90%).Moreover,the density and distribution of the 2 cell types had significant effects on the cell proliferation and urea *** propose that our method can lead to the construction of additional biomimetic heterogeneous microstructures with unprecedented potential for use in future tissue engineering applications.

关键词： cell behavior explorationhowevercurrent tissue mimicking microstructures cell laden hydrogel electrowetting dielectric regenerative medicinedrug screeningand heterogeneous microstructures engineered microstructures orderly integration

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A Hierarchical Control Scheme for Active Power-assist Lower-limb Exoskeletons

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Journal of Bionic Engineering 2024年第5期21卷 2184-2198页

作者： Jing Deng Wenzheng Jiang Haibo Gao Yapeng Shi Mantian Li State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin150001HeilongjiangChina Shenzhen Academy of Aerospace Technology Shenzhen518063China Faculty of Computing Harbin Institute of TechnologyHarbin150001HeilongjiangChina Institute of Intelligent Manufacturing Technology Shenzhen Polytechnic UniversityShenzhen518055China

Effectively controlling active power-assist lower-limb exoskeletons in a human-in-the-loop manner poses a substantial chal-lenge,demanding an approach that ensures wearer autonomy while seamlessly adapting to diverse wearer *** paper introduces a novel hierarchical control scheme comprising five integral components:intention recognition layer,dynamics feedforward layer,force distribution layer,feedback compensation layer,as well as sensors and *** intention rec-ognition layer predicts the wearer's movement and enables wearer-dominant movement through integrated force and position *** force distribution layer effectively resolves the statically indeterminate problem in the context of double-foot support,showcasing flexible control *** dynamics feedforward layer mitigates the effect of the exoskeleton itself on ***,the feedback compensation layer provides reliable closed-loop *** approach mitigates abrupt changes in joint torques during frequent transitions between swing and stance phases by decomposed *** this innovative hierarchical control scheme on a hydraulic exoskeleton platform through a series of experiments,the results demonstrate its capability to deliver assistance in various modes such as stepping,squatting,and jumping while adapting seamlessly to different terrains.

关键词： Hierarchical control Active power-assist Exoskeleton robots Dynamics feedforward Force distribution Feedback compensation

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CO_(2)emission evaluation and cost analysis of oxygen blast furnace process with sintering flue gas injection

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Journal of Iron and Steel Research International 2024年第9期31卷 2101-2109页

作者： Wei Zhang Jia-meng Lei Jing-qi Li Guo-jun Ma Henrik Saxén The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina Process and Systems Engineering Laboratory Faculty of Science and EngineeringÅbo Akademi UniversityÅbo20500Finland

In order to achieve ultra-low emissions of SO_(2)and NO_(x),the oxygen blast furnace with sintering flue gas injection is presented as a promising novel *** CO_(2)emission was examined,and a cost analysis of the process was *** results show that in the cases when the top gas is not circulated(Cases 1–3),and the volume of injected sintering flue gas per ton of hot metal is below about 1250 m^(3),the total CO_(2)emissions decrease first and then increase as the oxygen content of the blast *** the volume of injected sintering flue gas per ton of hot metal exceeds approximately 1250 m^(3),the total CO_(2)emissions gradually *** the recirculating top gas and the vacuum pressure swing adsorption are considered,the benefits of recovered gas can make the ironmaking cost close to or even lower than that of the ordinary blast ***,the implementation of this approach leads to a substantial reduction in total CO_(2)emissions,with reductions of 69.13%(Case 4),70.60%(Case 5),and 71.07%(Case 6),*** integrating previous research and current findings,the reasonable oxygen blast furnace with sintering flue gas injection can not only realize desulfurization and denitrification,but also achieve the goal of reducing CO_(2)emissions and ironmaking cost.

关键词： Oxygen blast furnace Sintering flue gas CO_(2)emission Ironmaking cost

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Spherical robot: A novel robot for exploration in harsh unknown environments

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IET Cyber-systems and robotics 2023年第4期5卷 1-15页

作者： Wei Ren You Wang Haoxiang Liu Song Jin Yixu Wang Yifan Liu Ziang Zhang Tao Hu Guang Li State Key Laboratory of Industrial Control Technology Institute of Cyber Systems and ControlZhejiang UniversityHangzhouChina

The authors propose a complete software and hardware framework for a novel spherical robot to cope with exploration in harsh and unknown *** proposed robot is driven by a heavy pendulum covered by a fully enclosed spherical shell,which is strongly protected,amphibious,anti-overturn and has a *** for location and perception,planning and motion control are comprehensively *** the one hand,the authors fully consider the kinematic model of a spherical robot,propose a positioning algorithm that fuses data from inertial measurement units,motor encoder and Global Navigation Satellite System,improve global path planning algorithm based on Hybrid A*and design an instruction planning controller based on model predictive control(MPC).On the other hand,the dynamic model is built,linear MPC and robust servo linear quadratic regulator algorithm is improved,and a speed controller and a direction controller are *** addition,based on the pose and motion charac-teristics of a spherical robot,a visual obstacle perception algorithm and an electronic image stabilisation algorithm are ***,the authors build physical systems to verify the effectiveness of the above algorithms through experiments.

关键词： mobile robots robot control robot perception robot planning

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A bio-inspired spider-like structure isolator for low-frequency vibration

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Applied Mathematics and Mechanics(English Edition) 2023年第8期44卷 1263-1286页

作者： Guangdong SUI Shuai HOU Xiaofan ZHANG Xiaobiao SHAN Chengwei HOU Henan SONG Weijie HOU Jianming LI State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Yangtze River Delta HIT Robot Technology Research Institute Wuhu 241000Anhui ProvinceChina Tianjin Key Laboratory of Microgravity and Hypogravity Environment Simulation Technology Tianjin 300301China

This paper proposes a quasi-zero stiffness(QZS)isolator composed of a curved beam(as spider foot)and a linear spring(as spider muscle)inspired by the precise capturing ability of spiders in vibrating *** curved beam is simplified as an inclined horizontal spring,and a static analysis is carried out to explore the effects of different structural parameters on the stiffness performance of the QZS *** finite element simulation analysis verifies that the QZS isolator can significantly reduce the first-order natural frequency under the load in the QZS *** harmonic balance method(HBM)is used to explore the effects of the excitation amplitude,damping ratio,and stiffness coefficient on the system’s amplitude-frequency response and transmissibility performance,and the accuracy of the analytical results is verified by the fourth-order Runge-Kutta integral method(RK-4).The experimental data of the QZS isolator prototype are fitted to a ninth-degree polynomial,and the RK-4 can theoretically predict the experimental *** experimental results show that the QZS isolator has a lower initial isolation frequency and a wider isolation frequency bandwidth than the equivalent linear *** frequency sweep test of prototypes with different harmonic excitation amplitudes shows that the initial isolation frequency of the QZS isolator is 3 Hz,and it can isolate 90%of the excitation signal at 7 *** proposed biomimetic spider-like QZS isolator has high application prospects and can provide a reference for optimizing low-frequency or ultra-low-frequency isolators.

关键词： bionic isolation structure curved beam nonlinear stiffness quasi-zero stiffness(QzS) low-frequency vibration isolator

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Thermal analysis of lubricated three-dimensional contact bodies considering interface roughness

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Frontiers of Mechanical Engineering 2022年第2期17卷 177-191页

作者： Jiqiang WU Liqin WANG Zhen LI Peng LIU Chuanwei ZHANG MIIT Key Laboratory of Aerospace Bearing Technology and Equipment Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150080China

Surface roughness and thermal action are of remarkable importance in the lubrication performance of mechanical components,especially in extreme ***,available studies mainly focus on the full-film lubrication conditions without considering temperature rise and real 3D surface roughness due to the complexity of surface topography and temperature ***,studies on the interfacial thermal behaviors of 3D rough surface lubricated contact in an extended range of working conditions remain *** this paper,a deterministic mixed thermal elastohydrodynamic lubrication model considering real 3D surface roughness and thermal effects is *** this model,pressure and temperature are coupled with each other,the computation of elastic deformation is accelerated through the discrete convolution and fast Fourier transform method,the temperature field is calculated with the column sweeping technique,and the semi-system method is introduced to improve convergence and numerical stability under severe *** model is validated by comparing its results with available published numerical and experimental *** thermal behaviors of the contact interface are studied in a wide range of working *** influences of surface roughness and thermal effect on lubrication performance are *** results show that the proposed model can be used as a powerful analysis tool for lubrication performance and temperature prediction in various heavy-load,high-speed lubricated components over a wide range of lubrication conditions.

关键词： thermal elastohydrodynamic lubrication surface roughness effect thermal effect temperature characteristics severe conditions

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Hybrid Models for Forecasting Allocative Localization Error in Wireless Sensor Networks

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International Journal of Cognitive Computing in Engineering 2025年 6卷 333-350页

作者： Li, Guo Sheng, Hongyu State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Chengdu610054 China College of Robotics Beijing Union University Beijing 100101 China

This study presents a machine learning-based approach to forecast Allocative Localization Error (ALE) in Wireless Sensor Networks (WSNs), addressing challenges such as dynamic network topologies and resource constraints. The approach utilizes Radial Basis Function (RBF) models enhanced with advanced optimization algorithms, including Coot Optimization Algorithm (COA), Smell Agent Optimization (SAO), and Northern Goshawk Optimization (NGO) to improve ALE prediction accuracy. Hybrid models (RBCO, RBSO, and RFNG) are developed by integrating these optimization techniques, which refine critical RBF parameters, such as spread and center selection, through iterative optimization. Furthermore, an ensemble framework (RSNC) combines all three optimizers with RBF to achieve superior performance. The proposed methods are validated using R2 and RMSE metrics, demonstrating their ability to minimize ALE, optimize resource allocation, and extend network lifespans. The study highlights the practical applicability of these models in real-world scenarios, such as environmental monitoring and industrial automation, offering enhanced efficiency and economic benefits. The RFNG model, in particular, achieved the lowest Mean Absolute Relative Error (MARE) of 0.049, demonstrating superior performance compared to other approaches in the test section. Moreover, RBNG obtained 0.069 and 0.978 values for the RMSE and R2, respectively, which were the most suitable values compared to other models, namely RBGO, RBSO, RSNC, and RBF. The results indicate that the proposed hybrid models significantly improve the prediction of ALE, leading to more efficient node deployment and better network management. This research provides valuable insights into leveraging machine learning for WSN optimization, benefiting researchers, network engineers, and industries relying on sensor networks for applications such as environmental monitoring, smart cities, and asset tracking. © 2025

关键词： Radial basis function networks

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Hierarchical Sponge-Hydrogel Hybrid Structures with Robust Interfaces

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Chinese Journal of Chemistry 2023年第20期41卷 2635-2640页

作者： Pei Zhang Guangda Chen Xingmei Chen Junfei Xing Yue Tao Ji Liu Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhenGuangdong518055 China Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Department of Mechanical and Energy EngineeringSouthern University of Science and TechnologyShenzhenGuangdong518055 China Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities Southern University of Science and TechnologyShenzhenGuangdong518055 China

Soft materials including elastomers and hydrogels are playing critical roles in a variety of fields,including bioelectrodes,batteries,supercapacitors,biomedical scaffolds,and solar vapor *** hydrophobic sponges(i.e.,mechanical robustness,elasticity and macroscopic porous structure)and hydrophilic hydrogels(i.e.,autonomous water absorption and transportation,biocompatibility)within one unit could readily combine the complementary characters from each component,making a number of future research directions and applications *** propose a simple yet effective strategy to construct sponge-hydrogel hybrid structures with robust hydrophobic-hydrophilic *** sponge scaffold imparts the sponges-hydrogel hybrids with desirable mechanical robustness,elasticity and macroscopic *** the other hand,the incorporated hydrogel component endows the hybrids with high water content(98 wt%hydrogel and 2 wt%sponge),superior compatibility,and nanoscale pores allowing for storage and transportation of various chemical and biological *** further demonstrate that the introduction of hydrophilic hydrogel components could effectively improve the liquid absorption capability,blood coagulation rate,hemostatic capacity and hemocompatibility,thus promising as hemostatic agents.

关键词： Sponge-hydrogel hybrid Interface Hierarchical Robustness Liquid absorption Gels Polymer Composites Materials Science

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DAU-Net: A medical image segmentation network combining the Hadamard product and dual scale attention gate

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Mathematical Biosciences and Engineering 2024年第2期21卷 2753-2767页

作者： Zhang, Xiaoyan He, Mengmeng Li, Hongan School of Computer Science and Technology Xi’an University of Science and Technology Xi’an710054 China State Key Laboratory of Virtual Reality Technology and Systems Beihang University Beijing100191 China

Medical image segmentation has an important application value in the modern medical field, it can help doctors accurately locate and analyze the tissue structure, lesion areas, and organ boundaries in the image, which provides key information support for clinical diagnosis and treatment, but there are still a large number of problems in the accuracy of the segmentation, so in this paper, we propose a medical image segmentation network combining the Hadamard product and dual-scale attention gate (DAU-Net). First, the Hadamard product is introduced in the structure of the fifth layer of the codec for element-by-element multiplication, which can generate feature representations with more representational capabilities. Second, in the jump connection module, we propose a dual scale attention gating (DSAG), which can highlight more valuable features and achieve more efficient jump connections. Finally, in the decoder feature structure, the final segmentation result is obtained by aggregating the feature information provided by each part, and decoding is achieved by up-sampling operation. Through experiments on two public datasets, Luna and Isic2017, DAU-Net is able to extract feature information more efficiently using different modules and has better segmentation results compared to classical segmentation models such as U-Net and U-Net++, and also verifies the effectiveness of the model. © 2024 American Institute of Mathematical Sciences. All rights reserved.

关键词： Image segmentation

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Dynamic Blockchain-Empowered Trustworthy End-Edge Collaborative Computing via Rotating Multi-Agent DRL

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IEEE Transactions on Wireless Communications 2025年第6期24卷 4864-4878页

作者： Xu, Chi Zhang, Peifeng Yu, Haibin Li, Yonghui Chinese Academy of Sciences State Key Laboratory of Robotics Shenyang Institute of Automation Shenyang China Chinese Academy of Sciences Key Laboratory of Networked Control Systems Shenyang China University of Chinese Academy of Sciences Beijing China University of Sydney School of Electrical and Information Engineering Sydney Australia

Blockchain-empowered end-edge collaborative computing is a promising technology for enhancing the timeliness and trustworthiness of Industrial Internet of Things (IIoT). However, integrating task offloading with blockchain consensus inevitably escalates resource consumption across communication, computation, and energy domains. Thus, the joint optimization of task offloading, resource allocation and blockchain consensus is very important for IIoT. This paper studies a general end-edge collaborative computing scenario with multiple end devices and multiple edge servers. We first propose a novel dynamic blockchain (DBC) scheme by developing a dynamic leader election mechanism and designing a dynamic consensus waiting time window. Then, by fully considering the constraints of multi-task size and deadline, communication bandwidth, computing frequency, battery capacity, Byzantine fault tolerant and trustworthiness, we formulate the trustworthy processing efficiency (TPE) maximization problem with respect to end-edge task division, communication and computation resource allocation, leader election and consensus waiting window. To address this problem, we transform it into a Markov decision process and design a compound reward by fully considering the penalty for computing timeout and consensus failure. After that, we propose a rotating multi-agent deep reinforcement learning (R-MADRL) algorithm tailored to the proposed DBC scheme, where an entropy-based dual-critic DRL algorithm is proposed for rotating multi-agent training and decentralized execution. Extensive experiments validate the effectiveness and superiority of the proposed DBC with R-MADRL, where three benchmark DRL algorithms and three blockchain consensus schemes are compared. The results demonstrate that R-MADRL achieves stable convergence with more than 60.32% TPE reward than other algorithms while the task timeout ratio of DBC is reduced by more than 66.49% compared with other schemes. © 2025 Institute of El

关键词： Markov processes

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