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SSRN 2022年

作者： Yang, Jianhua Wang, Ke Li, Ruifeng Perner, Petra State Key Laboratory of Robotics and System Harbin Institute of Technology Harbin150001 China FutureLab Artificial Intelligence IBaI II Kurt-Eisner-Str.81 Leipzig04275 Germany

We present a conceptually simple, flexible, and efficient "Combine-and-Conquer" framework, CC-Det for object detection task. Our approach efficiently detects objects in an image by generating a keypoint heatmap based on a single one-level combined feature map. The proposed method is composed of a very simple single-level detection pipeline. First CC-Det encodes input image by using existing backbone network, then uses neck network to combine multi-scale information into one feature map. Finally, CC-Det uses only one detection head with a heatmap branch and a regression branch to perform detection on this one-level feature map. Both two branches are composed of only two convolutional layers to predict a heatmap and bounding boxes, respectively. Compared with "Divide-and-Conquer" detectors like YOLOv4, RetinaNet and FCOS and other single-level detectors like CornerNet, CenterNet and YOLOF, CC-Det uses these existing components to achieve an excellent trade-off among speed, accuracy and model size without any elaborate special design. Moreover, CC-Det is easy to generalize to other tasks with minor modifications and achieves state-of-the-art performance. Excellent results are presented on COCO, PASCAL VOC, WiderFace and CrowdHuman datasets. © 2022, The Authors. All rights reserved.

关键词： Object detection

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Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase

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中国药理学报（英文版） 2022年第2期43卷 470-482页

作者： Wen Li Li-ping Liao Ning Song Yan-jun Liu Yi-luan Ding Yuan-yuan Zhang Xiao-ru Zhou Zhong-ya Sun Sen-hao Xiao Hong-bo Wang Jing Lu Nai-xia Zhang Hua-liang Jiang Kai-xian Chen Chuan-peng Liu Jie Zheng Ke-hao Zhao Cheng Luo School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University)Ministry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China Center of Immunological Diseases Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Gastroenterology Xinhua HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 201210China Department of Analytical Chemistry Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Life Science and Technology Harbin Institute of TechnologyHarbin 200092China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchSha

Aerobic glycolysis,also known as the Warburg effect,is a hallmark of cancer cell glucose metabolism and plays a crucial role in the activation of various types of immune *** 3-phosphate dehydrogenase(GAPDH)catalyzes the conversion of D-glyceraldehyde 3-phosphate to D-glycerate 1,3-bisphosphate in the 6th critical step in *** exerts metabolic flux control during aerobic glycolysis and therefore is an attractive therapeutic target for cancer and autoimmune ***,GAPDH inhibitors were reported to function through common suicide inactivation by covalent binding to the cysteine catalytic residue of ***,by developing a high-throughput enzymatic screening assay,we discovered that the natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose(PGG)is an inhibitor of GAPDH with Ki=0.5 μ*** blocks GAPDH activity by a reversible and NAD+and Pi competitive mechanism,suggesting that it represents a novel class of GAPDH ***-depth hydrogen deuterium exchange mass spectrometry(HDX-MS)analysis revealed that PGG binds to a region that disrupts NAD+and inorganic phosphate binding,resulting in a distal conformational change at the GAPDH tetramer *** addition,structural modeling analysis indicated that PGG probably reversibly binds to the center pocket of ***,PGG inhibits LPS-stimulated macrophage activation by specific downregulation of GAPDH-dependent glucose consumption and lactate *** summary,PGG represents a novel class of GAPDH inhibitors that probably reversibly binds to the center pocket of *** study sheds new light on factors for designing a more potent and specific inhibitor of GAPDH for future therapeutic applications.

关键词： glyceraldehyde 3-phosphate dehydrogenase 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose hydrogen deuterium exchange mass spectrometry reversible inhibitor glycolysis

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Giant Tunneling Magnetoresistance Based on Spin-Valley-Mismatched Ferromagnetic Metals

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Physical Review Letters 2025年第3期134卷 036302-036302页

作者： Kun Yan Li Cheng Yizhi Hu Junjie Gao Xiaolong Zou Xiaobin Chen School of Science State Key Laboratory on Tunable Laser Technology and Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System Harbin Institute of Technology Shenzhen Shenzhen 518055 China Shenzhen Geim Graphene Center and Shenzhen Key Laboratory of Advanced Layered Materials for Value-added Applications Institute of Materials Research Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen 518055 China Collaborative Innovation Center of Extreme Optics Shanxi University Taiyuan 030006 China

Half metals, which are amenable to perfect spin filtering, can be utilized for high-magnetoresistive devices. However, available half metals are very limited. Here, we demonstrate that materials with intrinsic spin-valley-mismatched (SVM) states can be used to block charge transport, resembling half metals and leading to giant tunneling magnetoresistance. As an example, by using first-principles transport calculations, we show that ferromagnetic 1T−VSe2, 1T−VS2, and 2H−VS2 are such spin-valley-mismatched metals, and giant magnetoresistance of more than 99% can be realized in spin-valve van der Waals (vdW) junctions using these metals as electrodes. Owing to the intrinsic mismatch of spin states, the central-layer materials for the vdW junctions can be arbitrary nonmagnetic materials, in principle. Our research provides clear physical insights into the mechanism for high magnetoresistance and opens new avenues for the search and design of high-magnetoresistance devices.

关键词： Van der Waals forces

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First Demonstration of Wafer-Level Arrayed β-Ga2O3 Thin Films and MOSFETs on Diamond by Transfer Printing technology

First Demonstration of Wafer-Level Arrayed β-Ga2O3 Thin Fil...

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International Electron Devices Meeting (IEDM)

作者： Tiancheng Zhao Xinxin Yu Wenhui Xu Yang He Zhenyu Qu Rui Shen Ruize Wang Huaixin Guo Huarui Sun Zhonghui Li Min Zhou Tiangui You Xin Ou State Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai China CETC Key Laboratory of Carbon-based Electronics Nanjing Electronic Devices Institute Nanjing China School of Science and Ministry of Industry and Information Technology Key Laboratory of Micro-Nano Optoelectronic Information System Harbin Institute of Technology Shenzhen China National Key Laboratory of Solid-State Microwave Devices and Circuits Nanjing China

ISBN: (数字)9798350365429

ISBN: (纸本)9798350365436

We, for the first time, fabricated wafer-level arrayed β-Ga 2 O 3 single crystal thin films on diamond substrate using transfer printing technology. The transfer-printed β-Ga 2 O 3 thin film possesses a thickness of 260 nm, a XRD rocking curve FWHM of ∼78 arcsec, and a surface roughness of 0.36 nm. The amorphous interface layer after post-annealing is less than 2 nm. The thermal boundary resistance is extracted to 21.7 m 2 .K/GW, which is the lowest value reported for single-crystal β-Ga 2 O 3 integrated with diamond. Thanks to the high thermal conductivity of diamond and the high-quality hetero-interface, the performance of β-Ga 2 O 3 -on-diamond RF MOSFETs is significantly enhanced. The maximum on-state current is 810 mA/mm, and the $f_{\max}$ before de-embedding reaches 61 GHz, which is the highest recorded value to date. Infrared thermal imaging shows that integrating with diamond significantly reduces the junction temperature of β-Ga 2 O 3 devices. The $\mathrm{R}_{\text{th}}$ of β-Ga 2 O 3 -on-diamond devices is merely 5.52 K·mm/W, setting a new record for β-Ga 2 O 3 -based devices. These results demonstrate that hetero-integration with diamond via wafer-level transfer printing technology provides an effective thermal management platform for β-Ga 2 O 3 , facilitating its advancement in high-power and RF devices.

关键词： Radio frequency Printing Temperature measurement MOSFET X-ray scattering Voltage measurement Thermal resistance Logic gates Diamond Substrates

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Lensless camera: Unraveling the breakthroughs and prospects

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Fundamental Research 2024年

作者： Li, Shuowen Gao, Yunhui Wu, Jiachen Wang, Mingjie Huang, Zhangcheng Chen, Shumei Cao, Liangcai Department of Precision Instruments Tsinghua University Beijing 100084 China Key Laboratory of Micro-Nano Optoelectronic Information System of Ministry of Industry and Information Technology Harbin Institute of Technology Shenzhen 518055 China State Key Laboratory of ASIC and System Frontier Institute of Chip and System Fudan University Shanghai 200438 China

Lensless imaging is an innovative and swiftly advancing technology at the intersection of optics, imaging technology, and computational science. It captures scene by directly recording the interference or diffraction patterns of light, subsequently utilizing algorithms to reconstruct the original image from these patterns. Lensless imaging transforms traditional imaging paradigms, offering newfound design flexibility and the capacity to seamlessly integrate within diverse imaging ecosystems. This paper aims to provide an overview of significant developments in optical modulation elements, image sensors, and reconstruction algorithms. The novel application scenarios that benefit from lensless computational imaging are presented. The opportunities and challenges associated with lensless camera are discussed for further improving its performance. © 2024

关键词： Coded aperture imaging Compressive sensing Deep learning Lensless camera Metasurface

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Corrigendum to “An alternate drive method for improving the carrying load capacity and displacement smoothness of a vertical piezoelectric platform” [Mechatronics, 2023, 92: 102983]

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Mechatronics 2024年 99卷

作者： Qingbing Chang Jie Deng Weishan Chen Yingxiang Liu State Key Laboratory of Robotics and System Harbin Institute of Technology Harbin 150001 Heilongjiang Province China

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Research on applicability of containment test data for HPR1000 based on phenomena scaling

International Journal of Advanced Nuclear Reactor Design and...

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International Journal of Advanced Nuclear Reactor Design and technology 2025年第2期7卷 120-127页

作者： Yusheng, Liu Xuedong, Qiao Sichao, Tan Jianping, Jing Ting, Wang Yuanbing, Zhu State Environmental Protection Key Laboratory of Nuclear and Radiation Safety Regulatory Simulation and Validation Nuclear and Radiation Safety Center MEE Beijing100086 China Guangdong Provincial Key Laboratory of Nuclear Power Safety Shenzhen518026 China Heilongjiang Provincial Key Laboratory of Nuclear Power System & Equipment Harbin Engineering University Harbin150001 China China Nuclear Power Technology Research Institute Co. Ltd. Shenzhen518026 China

The volume of the nuclear power plant containment is huge, making it difficult to conduct equal-scale or large-scale thermal-hydraulic tests. Currently the test data mainly come from small-scale tests. To address the applicability of small-scale containment test data in validation process of the containment performance analysis code, the analysis method for applicability of experimental data is proposed and developed on the basis of similarity analysis of the pressure response process in the containment. The applicability study of the test data, which are produced by some scaled containment facilities such as the HDR, Battelle and CVTR, is carried out in combination with the test parameters. The applicability of each test case isobtained respectively when they are applied to validate the containment code in case of the Large Break Loss of Coolant Accident (LBLOCA) and Main Steam Line Break Accident (MSLB) of HPR1000 nuclear power plant. The results show that the similarity criteria for pressure response process and key phenomena within the containment vessel under accident conditions can be employed to analyze the applicability of different containment tests to specified power plant. The test dataoriginating fromHDR ISP-16 and HDR ISP-23can represent the pressure transient process, results of coupling phenomena such as mass and energy release at the break, condensation near the containment shell and internals, within the HPR1000 containment in case of LBLOCA or MSLB. The distortion is either within the acceptable range or conservative for design limits of containment pressure, so that the small-scale containment test data could be suitable for verification and validation of the HPR1000 containment thermal hydraulic response analysis code. © 2025 Xi'an Jiaotong University

关键词： Loss of coolant accidents

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Design of Six-Wheeled Planetary Rover with a Novel Hybrid Suspension

Design of Six-Wheeled Planetary Rover with a Novel Hybrid Su...

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IEEE International Conference on robotics and Biomimetics

作者： Sanfeng Hu Guoxing Wang Jianguo Tao State Key Laboratory of Robotics and System Harbin Institute of Technology Harbin China Beijing Spacecraft Beijing China

ISBN: (纸本)9781665405362

A novel hybrid suspension of six-wheeled planetary rover based on serial multi-articulated suspension is proposed. The differential balance support mechanism that is important component of the hybrid suspension and solves the problem of weak carrying capacity of serial suspension, is synthesized by using the constraint synthesis method based on screw theory and mechanism combination method. Taking the envelope volume and the maximum height of obstacles that can be overcome of the hybrid suspension rover as objective functions, the geometric parameters of the hybrid suspension structure are optimized through the elitist nondominated sorting genetic algorithm. The proposed hybrid suspension not only can conform passively to very rugged terrain, but also provides active mobility to cross obstacles and ditches, as well as passes soft terrain and steep slopes in wheel-legged locomotion. The established 3D and simulation models are used to simulate and verily the mobile performance of the hybrid suspension rover. The novel hybrid suspension has important reference significance for the design of the future lunar south pole rover.

关键词： Space vehicles Solid modeling Three-dimensional displays Simulation Moon Prototypes Fasteners

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Force-controlled Compensation Scheme for P-Q Valve-controlled Asymmetric Cylinder used on Hydraulic Quadruped Robots

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Journal of Bionic Engineering 2020年第6期17卷 1139-1151页

作者： Yapeng Shi Mantian Li Fusheng Zha Lining Sun Wei Guo Cong Ma Zhibin Li State Key Laboratory of Robotics and System Harbin Institue of TechnologyHarbin 150001China Shenzhen Academy of Aerospace Technology China Aerospace ScienceShenzhen 518057China School of Informatics The University of EdinburghEdinburgh EH89ABUnited Kingdom

Under the requirement of the force controller of hydraulic quadruped robots,the goal of this work is to accurately track the force commands at the level of the hydraulic drive *** main contribution focuses on the development of a force-controlled compensation scheme,which is specifically aimed at the key issues affecting the hydraulic quadrupedal *** this idea,based on a P-Q valve-controlled asymmetric cylinder,we first establish a mathematical model for the hydraulic drive unit force control *** the desired force commands,a force feed-forward algorithm is presented to improve the dynamic performance of the ***,we propose a disturbance compensation algorithm to reduce the influence induced by external disturbances due to foot-ground ***,combining with a variable gain PI controller,a series of experiments are implemented on a force control performance test platform to verify the proposed *** results demonstrate that the force-controlled compensation scheme has the ability to notably improve the force tracking accuracy,reduce the response time and redundant force.

关键词： hydraulic drive unit force tracking P-Q valve-controlled asymmetric cylinder hydraulic quadruped robot

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A Novel Hybrid Method for Fault Diagnosis of Industrial Equipment Based on Vibration Signals 14

A Novel Hybrid Method for Fault Diagnosis of Industrial Equi...

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14th IEEE Global Reliability and Prognostics and Health Management Conference, PHM-Hangzhou 2023

作者： Tao, Sen Wang, Kai Zeng, Peng Yu, Tianda Wu, Hao Key Laboratory of Networked Control Systems Chinese Academy of Sciences Shenyang110169 China Shenyang Institute of Automation Chinese Academy of Sciences Shenyang110169 China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences Shenyang110169 China University of Chinese Academy of Sciences Beijing100049 China Nuclear Power Institute of China Chengdu610213 China State Key Laboratory of Power Transmission Equipment & System Security and New Technology Chongqing University Chongqing400044 China

ISBN: (纸本)9798350301359

Industrial equipment reliability is a critical issue that smart manufacturing systems must address. Implementation of online fault diagnosis for industrial equipment is a promising technology that can improve equipment reliability. Vibration analysis is a popular technique for equipment condition monitoring. For the non-linear and non-stationary features of industrial vibration signals, a hybrid model based on wavelet transform (WT), support vector machine (SVM), and grey wolf optimization algorithm (GWO) is proposed. The time-frequency domain features of fault signals are extracted by wavelet transform to solve the non-linearity of signals, and the obtained feature vectors are input into SVM for classification. Aiming at the problem of setting penalty coefficient and kernel function parameters, GWO is introduced to seek hyperparameters by using the hunting principle of wolves. In the experimental part, firstly, the comparison of the GWO-WT-SVM, GWO-SVM and SVM models was carried out. Secondly, Comparison with classical classification algorithms is made. Apparently, the GWO-WT-SVM model achieves higher accuracy than other models in bearing fault diagnosis. © 2023 IEEE.

关键词： component Fault diagnosis GWO PHM SVM

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