检索结果-内蒙古大学图书馆

Punicalagin alleviates hypercholesterolemia in mice through modulating farnesoid X receptor signaling and modulating gut microbiota

引用

Food Science and Human Wellness 2025年第1期14卷 175-189页

作者： Huanhuan Liu Hongli Liu Chunhong Yan Jiaxiu Liu Yu Cao Guopeng Li Xiaodong Xia State Key Laboratory of Marine Food Processing and Safety Control National Engineering Research Center of SeafoodSchool of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Punicalagin has been demonstrated to exhibit anti-oxidant and anti-inflammatory properties,but whether and how it could impact hypercholesterolemia remains not fully *** aim of this study was to investigate the influence of punicalagin on hypercholesterolemia in mice and its related *** 6 weeks'intervention,punicalagin significantly reduced serum total cholesterol and low-density lipoprotein cholesterol(LDL-C)levels in mice fed a high-fat high-cholesterol(HFHC)***,punicalagin supplementation lowered hepatic cholesterol level,which corresponded to the down-regulation of cholesterol synthesis genes(Fdps,Cyp51)and up-regulated bile acid synthesis genes(Cyp7a1,Cyp27a1).In addition,bile acid reabsorption was retarded in punicalagin-fed mice through down-regulating ileal apical sodium-dependent BA transporter(ASBT).Furthermore,intestinal farnesoid X receptor(FXR)-fibroblast growth factor 15(Fgf15)pathway was inhibited while hepatic FXR-small heterodimeric partner(SHP)pathway was activated in punicalagin *** analysis and targeted metabolomics showed that punicalagin decreased the abundance of bile-salt hydrolase(BSH)-producing bacteria(Clostridiaceae and Bifidobacteriaceae)and the ratio of primary BAs to secondary *** conclusion,the cholesterol-lowering effect of punicalagin partly through down-regulating cholesterol synthesis and increasing cholesterol catabolism,which could be achieved by regulating gut microbiota,altering bile acid composition and modulating FXR signaling *** findings indicate the potential application of punicalagin-related products as an alternative strategy for hypercholesterolemia prevention and mitigation.

关键词： Punicalagin Hypercholesterolemia Farnesoid X receptor Bile acid metabolism Gut microbiota

来源：评论

学校读者我要写书评

暂无评论

Phase Formation Mechanism of Al-Si-Ge Filler Metals Based on Thermodynamics Calculation

引用

稀有金属材料与工程 2025年第2期54卷 293-300页

作者： Huang Sen Long Weimin Shan Jiguo Jiang Chao Jing Peiyao Zhang Guanxing School of Mechanical Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory of Advanced Brazing Filler Metals and Technology Zhengzhou Research Institute of Mechanical Engineering Co.LtdZhengzhou 450052China

A series of Al-xSi-yGe filler metals(x=4–12 and y=10–40,wt%)were prepared,and the effect of Si and Ge on microstructure and melting characteristics of filler metals was *** thermodynamic model of Al-Si-Ge ternary alloy was established to analyze the phase formation mechanism of filler metals based on Miedema model,Tanaka model,and Toop *** research provided a basis for the composition optimization of filler metals and the analysis of metallurgical reaction process between filler metals and base *** show that Al-Si-Ge alloy is composed of Al-Ge eutectic phase,Al-Si eutectic phase,and primary *** addition promotes the precipitation of primary *** is the main melting point depressant element of filler *** the increase in Ge content from 10wt%to 40wt%,the solid phase line of filler metals remains unchanged,whereas the liquidus temperature decreases from 567.65°C to 499.96°*** the increase in Ge content of filler metal,Ge content in eutectic Si phase is increased,the endothermic peak of Al-Si eutectic reaction according to thermogravimetry curve becomes smoother,and Al-Si eutectic temperature is *** addition can reduce the free energy of Al-Si alloy *** lowest point of free energy is located on Al-Ge *** eutectic Ge phase with the composition similar to pure Ge composition is the most likely to appear in the microstructure of filler metals,whereas the eutectic Si phase with the composition similar to pure Si composition is the least likely to *** thermodynamic calculation results are consistent with the experiment results.

关键词： Al-Si-Ge filler metals microstructure thermodynamics phase formation mechanism

来源：评论

学校读者我要写书评

暂无评论

Platinum modification of metallic cobalt defect sites for efficient electrocatalytic oxidation of 5-hydroxymethylfurfural

引用

Journal of Energy Chemistry 2025年第2期101卷 463-473,I0010页

作者： Haoyu Zhan Baixue Cheng Yankun Lu Danning Xing Xingshuai Lv Huining Huang Thomas Frauenheim Tao Wang Peng Zhou State Key Laboratory of Bio-fibers and Eco-textiles College of Materials Science and EngineeringCollaborative Innovation Center of Shandong Marine Biobased Fibers and Ecological TextilesInstitute of Marine Biobased MaterialsQingdao UniversityQingdao 266071ShandongChina Shandong Institute of Advanced Technology Jinan 250100ShandongChina College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100ShandongChina Tianjin Key Laboratory of Advanced Functional Porous Materials Institute for New Energy Materials & Low-Carbon TechnologiesSchoolof Materials Science and Engineering Tianjin University of TechnologyTianjin 300384China School of Science Constructor UniversityBremen 28759Germany Beijing Computational Science Research Center Beijing 100193China College of Chemistry and Molecular Engineering Qingdao University of Science and TechnologyQingdao 266042ShandongChina

Co_(3)O_(4)possesses both direct and indirect oxidation effects and is considered as a promising catalyst for the oxidation of 5-hydroxymethylfurfural(HMF).However,the enrichment and activation effects of Co_(3)O_(4)on OH-and HMF are weak,which limits its further *** defect engineering can regulate the electronic structure,optimize the adsorption of intermediates,and improve the catalytic activity by breaking the symmetry of the material,which is rarely involved in the upgrading of *** this work,we prepare Co_(3)O_(4)with metal defects and load the precious metal platinum at the defect sites(PtVco).The results of in-situ characterizatio ns,electrochemical measurements,and theoretical calculations indicate that the reduction of Co-Co coordination number and the formation of Pt-Co bond induce the decrease of electron filling in the antibonding orbitals of Co *** resulting upward shift of the d-band center of Co combined with the characteristic adsorption of Pt species synergically enhances the enrichment and activation of organic molecules and OH species,thus exhibiting excellent HMF oxidation activity(including a lower onset potential(1.14 V)and 19 times higher current density than pure Co_(3)O_(4)at 1.35 V).In summary,this work explores the adsorption enhancement mechanism of metal defect sites modified by precious metal in detail,provides a new option for improving the HMF oxidation activity of cobalt-based materials,broadens the application field of metal defect based materials,and gives an innovative guidance for the functional utilization of metal defect sites in biomass conversion.

关键词： Electrocatalysis Biomass upgrading Metallic defect Coordination environment Adsorption enhancement

来源：评论

学校读者我要写书评

暂无评论

Passive activity enhances residual control ability in patients with complete spinal cord injury

引用

Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

来源：评论

学校读者我要写书评

暂无评论

Mode-locked cylindrical vector vortex beam unlocked the generation of a 2 µm multidimensional ultrafast laser

引用

Optics Express 2025年第6期33卷 13001-13009页

作者： Kang, Hui Xu, Tong Miao, Kairui Zhu, Qiang Yao, Tianchen Song, Xiaozhao Ma, Jiacheng Zhou, Wei Qian, Zhisheng Xie, Zhengpin Gong, Yue Wang, Haotian Xu, Xiaodong Jia, Baohua Wang, Yishan Wang, Fei Shen, Deyuan Jiangsu Key Laboratory of Advanced Laser Materials and Devices School of Physics and Electronic Engineering Jiangsu Normal University Xuzhou221116 China Jiangsu Institute of Mid Infrared Laser Technology & Applications Xuzhou221000 China RMIT University MelbourneVIC3000 Australia State Key Laboratory of Ultrafast Optical Science and Technology Xi’an Institute of Optics and Precision Mechanics Chinese Academy of Sciences Xi’an710119 China

The development of multidimensional lasers, particularly 2 µm vector vortex pulsed beams, has garnered significant interest for applications in laser medicine and optical communication. This paper reports the successful achievement of mode-locked azimuthally polarized vector beams (APVB) and radially polarized vector beams (RPVB) in a c-cut Tm:CaYAlO4 crystal cavity. Utilizing a semiconductor saturable absorber mirror (SESAM), the laser produced output powers of 110 mW (APVB) and 98 mW (RPVB), with pulse durations of 41.2 ps and 49.7 ps, and vortex topological charges of -1 and +1, respectively. This represents the first stable mode-locked states of the cylindrical vector vortex beam in a 2 µm solid-state laser. © 2025 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

关键词： Solid state lasers

来源：评论

学校读者我要写书评

暂无评论

Micro-convex structure-assisted laser-induced backside dry etching for high-efficiency fabrication of micro-groove array on fused silica toward manipulation of wetting characteristics

引用

Journal of Manufacturing Processes 2025年 145卷 236-251页

作者： Huang, Hu An, Hong Qian, Yongfeng Zhang, Zhiyu Jiang, Minqiang Yan, Jiwang Key Laboratory of CNC Equipment Reliability Ministry of Education School of Mechanical and Aerospace Engineering Electron Microscopy Center Jilin University Changchun130022 China Key Laboratory of Optical System Advanced Manufacturing Technology Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun130033 China State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences Beijing100190 China School of Engineering Science University of Chinese Academy of Sciences Beijing101408 China Department of Mechanical Engineering Faculty of Science and Technology Keio University Yokohama223-8522 Japan

Fused silica has garnered significant attention in various industrial applications. The creation of surface micro/nanostructures on fused silica can impart specialized functional properties, such as extreme wettability, ultra-high transmittance, and excellent antimicrobial characteristics. Nonetheless, existing technologies for achieving surface micro/nanopatterning of fused silica, including wire electrical discharge machining, chemical etching, and electrochemical deposition, generally suffer from long processing cycles and high energy consumption, which are inconsistent with the development concept of the low-carbon economy. In this study, a novel approach termed micro-convex structure-assisted laser-induced backside dry etching (MCSALIBDE) is proposed for high-efficiency fabrication of micro-groove array on fused silica surfaces. The synergistic effect of enhanced heat conduction and plasma explosion in a confined space facilitates material ablation. The impact of processing parameters including scanning pitch and peak laser power intensity on the morphological and topographical features of the MCSALIBDE-processed fused silica surfaces is studied. Notably, the micro-groove structures with a depth-to-width ratio of 1.19 is fabricated. Furthermore, the wetting behaviors of the MCSALIBDE-processed fused silica surfaces before and after annealing treatment are studied. Experimental findings reveal that the MCSALIBDE-processed fused silica surfaces exhibit enhanced hydrophilicity compared to the untreated one. After annealing treatment, a transformation from hydrophilicity to superhydrophobicity is observed. The superhydrophobic surfaces produced under different laser parameters exhibit distinct adhesion and droplet bouncing behaviors. This work offers an in-depth understanding of the high-efficiency fabrication of micro/nanostructures on fused silica surfaces and as well the modulation of their wetting characteristics, heralding innovations in surface engineering fo

关键词： Wetting

来源：评论

学校读者我要写书评

暂无评论

Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke

引用

Acta Pharmaceutica Sinica B 2025年第1期15卷 239-255页

作者： Kangrui Hu Zhihao Zhou Haofeng Li Jijun Xiao Yun Shen Ke Ding Tingting Zhang Guangji Wang Haiping Hao Yan Liang Key Lab of Drug Metabolism&Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Ministry of Education Key Laboratory of Protein Science Beijing Advanced Innovation Center for Structural BiologyBeijing Frontier Research Center for Biological StructureTsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China School of Materials Science and Engineering Hebei University of Science and TechnologyShijiazhuang 050023China

Increasing evidence has underscored the significance of post-stroke alterations along gutebrain axis,while its role in pathogenesis and treatment of ischemic stroke(IS)remains largely *** study aimed to elucidate the therapeutic effects and action targets of Panax notoginseng saponins(PNS)on IS and explore a novel pathogenesis and treatment strategy of IS via profiling the microbial community and metabolic characteristics along gutebrain *** findings revealed for the first time that the therapeutic effect of PNS on IS was ***/reperfusion(I/R)modeling significantly downregulated Lactobacilli in rats,and PNS markedly recovered Lactobacilli,particularly Lactobacillus reuteri(***).Metabolomics showed a significant reduction in serum histidine(HIS)in clinical obsolete IS patients and rehabilitation period I/R ***,the *** colonization in I/R rats exhibited significant neuroprotective activity and greatly increased HIS in serum,gut microbiota,and ***,exogenous HIS demonstrated indirect neuroprotective effects through metabolizing to ***,vagus nerve severance in I/R rats was performed to investigate HIS’s neuroprotective *** results innovatively revealed that PNS could promote HIS synthesis in gut by enhancing *** proportion,thereby increasing intracerebral HIS through peripheral ***,our data provided novel insights into HIS metabolism mediated by *** in the pathogenesis and treatment of IS.

关键词： Ischemic stroke Inflammation Gut-brain axis Panaxnotoginseng saponins Lactobacillus reuteri Metabolomics Histidine Histamine

来源：评论

学校读者我要写书评

暂无评论

Differential Protection for Distribution Grids Based on Dual Compressed Sensing Theory

Differential Protection for Distribution Grids Based on Dual...

引用

2024 International Conference Optoelectronic Information and Optical engineering, OIOE 2024

作者： Duan, Yahui Wu, Tonghua Chen, Wei Dai, Wei Cao, Yuhan Cao, Wenjun School of China EU Institute for Clean and Renewable Energy Huazhong University of Science and Technology Wuhan430074 China The State Key Laboratory of Technology and Equipment for Defense against Power System Operational Risks Nari Technology Co. Ltd. Jiangsu211106 China The State Key Laboratory of Advanced Electromagnetic Technology Huazhong University of Science and Technology Wuhan430074 China State Grid Hebei Electronic Power Research Institute Hebei250002 China State Grid Shandong Electronic Power Research Institute Shandong050011 China

ISBN: (数字)9781510688209

ISBN: (纸本)9781510688193

With the increasing integration of distributed renewable energy sources into distribution networks, the characteristics of fault currents in distribution networks have undergone significant changes. Traditional three-stage current protection is no longer sufficient to meet the protection requirements. In theory, a differential protection scheme can better fulfill the requirements of rapid and accurate fault detection and clearance in distribution networks. Differential protection relies on real-time communication for information exchange between devices, and many researchers have incorporated wireless networks such as 5G into distribution network differential protection. Given the exponential growth of data in distribution networks and the security considerations of wireless communication like 5G, this paper proposes a secure protection technique for distribution network differential protection based on dual compressed sensing theory. This technique employs two compressed sensing schemes to compress the data before transmission, reducing the amount of data transferred while enhancing security. Subsequently, secure determinations are made based on the data at both ends processed through the compressed sensing algorithm, ensuring the security of communication in distribution network differential protection while achieving the same level of protection performance as traditional differential protection schemes. © 2025 SPIE.

关键词： Compressed sensing Data transmission Matrices Data communications Wireless communications Network security Reconstruction algorithms Computer security Signal processing Signal to noise ratio

来源：评论

学校读者我要写书评

暂无评论

Energy routing strategy of laser power transmission network based on two-layer optimization

引用

Kongzhi Lilun Yu Yingyong/Control Theory and Applications 2025年第4期42卷 703-712页

作者： Yuan, Ao-Te Cai, Tao Lan, Jian-Yu State Key Laboratory of Advanced Electromagnetic Technology Huazhong University of Science and Technology Hubei Wuhan430074 China Key Laboratory of Power Electronics and Energy Management for Ministry of Education of China School of Electrical and Electronic Engineering Huazhong University of Science and Technology Hubei Wuhan430074 China Shanghai Space Power Research Institute Shanghai200245 China

The low transfer efficiency and poor robustness are important obstacles restricting the development of laser power transmission. The routing strategy of the network has been studied for efficient and reliable energy transfer. The paper analyzed the architecture of the laser power transmission network, modified the calculation formula of laser transmission efficiency in the atmosphere, and abstracted the network into a weight graph. Considering the multidimensional coupling characteristics in the laser power transmission network, a two-layer optimization strategy with spatio-temporal decoupling is proposed. The first layer optimization realizes path planning based on Dijkstra algorithm to find the most efficient energy transmission path. The second layer optimization is based on the optimal paths, takes the total loss as the objective function, builds mathematical models and solves it with inner iterative PSO algorithm. Through the simulation of a unmanned aerial vehicle (UAV) cruise system under different control strategies, the effectiveness and feasibility of the two-layer optimization strategy are verified. © 2025 South China University of technology. All rights reserved.

关键词： Particle swarm optimization (PSO)

来源：评论

学校读者我要写书评

暂无评论

In situ expansion capacity evaluation of terminal alveoli in chronic obstructive pulmonary disease using an ultrathin optical coherence tomography catheter

引用

Biomedical Optics Express 2025年第5期16卷 2156-2170页

作者： Fang, Bingyan Cai, Yigen Zhang, Zhuopan Liang, Jiaxi Chen, Jiarui Chen, Xiaowei Huang, Xiangdi Zhang, Jian Wen, Xue Yang, Sihua Xiong, Kedi College of Biophotonics School of Optoelectronic Science and Engineering South China Normal University Guangzhou510631 China MOE Key Laboratory of Laser Life Science Institute of Laser Life Science South China Normal University Guangzhou510631 China The Key Laboratory of Advanced Interdisciplinary Studies The First Affiliated Hospital of Guangzhou Medical University School of Biomedical Engineering Guangzhou Medical University Guangzhou511436 China Shenzhen Photonstream Limited Shenzhen518117 China State Key Laboratory of Precision Electronics Manufacturing Technology and Equipment Guangdong University of Technology Guangzhou510006 China

Morphological structural changes in the peripheral alveoli serve as critical indicators for the early pathological features of chronic obstructive pulmonary disease (COPD). Endoscopic optical coherence tomography (OCT) has emerged as a valuable diagnostic tool for COPD, enabling the assessment of airway mucosa, smooth muscle thickness, lumen diameter, lumen area, and airway wall area. However, conventional transbronchial OCT imaging catheters are limited in size, restricting their access to terminal bronchioles and thereby impeding the morphological and structural analysis of peripheral alveoli. In this study, we present a bronchial ultrathin OCT (Bronchial-uOCT) imaging catheter with an outer diameter of 380 µm, an axial resolution of 8.4 µm, and a lateral resolution of 9.3 µm. Using New Zealand rabbit COPD models, we achieved real-time in situ 3D volumetric imaging of terminal alveoli. Statistical analysis revealed a difference of 5 times in the alveolar area between normal and COPD pathological groups (P = 0.00018). Quantitative analysis of expansion compliance revealed significant differences in the growth rate and trend of the alveolar area between the normal group and the COPD pathology group. Furthermore, the opening direction of the curve obtained through power law fitting may help diagnose COPD. These findings highlight bronchial-uOCT as a clinically significant approach capable of in situ visualization of alveolar structures in the terminal bronchioles, offering a promising approach for the early diagnosis and assessment of COPD. © 2025 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

关键词： Catheters

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：