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Lower Reoperation Rate and Superior Patient-Reported Outcome Following Arthroscopic Rotator Cuff Repair With Concomitant Acromioplasty: An Updated Systematic Review of Randomized Controlled Trials

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Arthroscopy - Journal of Arthroscopic and Related Surgery 2025年第5期41卷 1618-1634页

作者： Yang, Songyun Pang, Long Zhang, Chunsen Wang, Jiapeng Yao, Lei Li, Yinghao Huang, Yizhou Tang, Xin Sports Medicine Center West China Hospital Sichuan University Chengdu China Department of Orthopedics Orthopedic Research Institute West China Hospital Sichuan University Chengdu China Department of Orthopedics People's Hospital of Santai County Santai China Laboratory of Stem Cell and Tissue Engineering State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China

Purpose: To systematically assess the postoperative outcomes in patients undergoing arthroscopic rotator cuff repairs with or without concomitant acromioplasty through a rigorous systematic review of randomized controlled trials (RCTs). Methods: This systematic review, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, aimed to identify RCTs comparing clinical outcomes of patients with full-thickness rotator cuff tears undergoing arthroscopic rotator cuff repair with acromioplasty versus those without at a minimum 12-month follow-up. Databases searched included PubMed, Web of Science, Embase, and the Cochrane Library. The risk of bias in the included studies was assessed using the revised Cochrane Risk of Bias 2. Meta-analysis was conducted for outcomes with at least 3 studies reporting, with pooled effect estimates calculated using either fixed-effect or random-effects models based on heterogeneity levels. Results were presented as the weighted mean difference or odds ratio with 95% confidence intervals (CIs). For outcomes with fewer than 3 studies reporting, a Fisher exact test was conducted, with continuity correction applied if necessary. Primary outcomes included rates of retear and reoperation, whereas secondary outcomes included improvement in American Shoulder and Elbow Surgeons (ASES) score, range of motion (ROM), and complication rate. Results: Five high-quality RCTs, with low bias risk, involving 409 patients, revealed demographics of 58.4% males, mean age of 58.4 years, and the following acromion types: 12.2% type I, 70.7% type II, and 17.1% type III. Mean follow-up was 52.2 months. Retear (12.5% vs 16.1%, P = .536) and complication rates (odds ratio, 3.11;95% CI, 0.31-30.73;P = .33) were comparable between the 2 groups. However, reoperation rate (5.3% vs 15.9%, P < .001) and improvement in ASES score (weighted mean difference, 3.99;95% CI, 1.00-6.99;P = .009) favored the acromioplasty group. Both groups showed s

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Update on techniques for cryopreservation of human spermatozoa

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Asian Journal of Andrology 2022年第6期24卷 563-569页

作者： Chuan Huang Yu-Lin Tang Jian-Ling Hu Wen-Jun Zhou Zeng-Hui Huang Xue-Feng Luo Zheng Li Wen-Bing Zhu Institute of Reproductive and Stem Cell Engineering Basic Medicine CollegeCentral South UniversityChangsha 410000China Reproductive and Genetic Hospital of CITIC-Xiangya Changsha 410000China Department of Andrology Center for Men's HealthShanghai General HospitalShanghai Key Lab of Reproductive MedicineShanghai 200025China

In the 1960s,sperm cryopreservation was developed as a method to preserve ***,techniques for the cryopreservation of human spermatozoa have been widely used in assisted ***,although sperm cryobiology has made notable achievements,the optimal method for the recovery of viable spermatozoa after cryopreservation remains *** sperm quality can be affected by cryoprotectants,ice formation,storage conditions,and osmotic stress during the freezing *** review discusses recent advances in different cryopreservation techniques,cryoprotectants,and freezing and thawing methods during cryopreservation and new indications for the use of cryopreserved spermatozoa.

关键词： cryodamage cryoprotectant dry preservation freezing and thawing sperm cryopreservation

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Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair

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Bioactive Materials 2023年第1期19卷 626-641页

作者： Lan Ma Chider Chen Dawei Liu Zhiqing Huang Jiaqi Li Haixiang Liu Ryan Tsz Kin Kwok Benzhong Tang Bingdong Sui Xiao Zhang Jianxia Tang Xueli Mao Weiying Huang Songtao Shi Xiaoxing Kou Hospital of Stomatology Guanghua School of StomatologySun Yat-sen UniversitySouth China Center of Craniofacial Stem Cell ResearchGuangdong Provincial Key Laboratory of Stomatology510055GuangzhouChina Department of Anatomy and Cell Biology University of PennsylvaniaSchool of Dental MedicinePhiladelphiaPA19104USA Department of Orthodontics Peking University School&Hospital of Stomatology#22 Zhongguancun South AvenueBeijing100081China Department of Chemical and Biological Engineering Department of ChemistryThe Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen2001 Longxiang BoulevardLonggang DistrictShenzhen CityGuangdong518172China Key Laboratory of Stem Cells and Tissue Engineering(Sun Yat-Sen University) Ministry of EducationGuangzhouGuangdong510055China

Over 300 billion of cells die every day in the human body,producing a large number of endogenous apoptotic extracellular vesicles(apoEVs).Also,allogenic stem cell transplantation,a commonly used therapeutic approach in current clinical practice,generates exogenous *** is well known that phagocytic cells engulf and digest apoEVs to maintain the body’s *** this study,we show that a fraction of exogenous apoEVs is metabolized in the integumentary skin and hair ***,apoEVs activate the Wnt/β-catenin pathway to facilitate their metabolism in a wave-like *** migration of apoEVs is enhanced by treadmill exercise and inhibited by tail suspension,which is associated with the mechanical force-regulated expression of DKK1 in ***,we show that exogenous apoEVs promote wound healing and hair growth via activation of Wnt/β-catenin pathway in skin and hair follicle mesenchymal stem *** study reveals a previously unrecognized metabolic pathway of apoEVs and opens a new avenue for exploring apoEV-based therapy for skin and hair disorders.

关键词： Apoptosis Extracellular vesicle Metabolized regulator Integumentary system Mesenchymal stem cells

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Caveolin-1 downregulation promotes the dopaminergic neuron-like differentiation of human adipose-derived mesenchymal stem cells

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Neural Regeneration Research 2021年第4期16卷 714-720页

作者： Chao Han Ya-Jun Wang Ya-Chen Wang Xin Guan Liang Wang Li-Ming Shen Wei Zou Jing Liu Stem Cell Clinical Research Center Regenerative Medicine CenterFirst Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina National Joint Engineering Laboratory First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina College of Life Science Liaoning Normal UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina

Previous studies have shown that caveolin-1 is involved in regulating the differentiation of mesenchymal stem ***,its role in the differentiation of human adipose mesenchymal stem cells into dopaminergic neurons remains *** aim of this study was to investigate whether caveolin-1 regulates the differentiation of human adipose mesenchymal stem cells into dopaminergic-like *** also examined whether the expression of caveolin-1 could be modulated by RNA interference technology to promote the differentiation of human adipose mesenchymal stem cells into dopaminergic-like *** differentiation of human adipose mesenchymal stem cells into dopaminergic neurons was evaluated morphologically and by examining expression of the markers tyrosine hydroxylase,Lmx1a and *** analyses revealed that during the differentiation of human adipose mesenchymal stem cells into dopaminergic neurons,the expression of caveolin-1 is ***,the downregulation of caveolin-1 promoted the differentiation of human adipose mesenchymal stem cells into dopaminergic-like neurons,and it increased the expression of tyrosine hydroxylase,Lmx1a and ***,our findings suggest that caveolin-1 plays a negative regulatory role in the differentiation of dopaminergic-like neurons from stem cells,and it may therefore be a potential molecular target for strategies for regulating the differentiation of these *** study was approved by the Medical Ethics Committee of the First Affiliated Hospital of Dalian Medical University of China(approval ***-KS-KY-2020-54)on March 7,2017.

关键词： cells factor in vitro neural differentiation Parkinson’s disease plasticity protein stem cells

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Whole-genome sequencing reveals the evolutionary trajectory of HBV-related hepatocellular carcinoma early recurrence

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Signal Transduction and Targeted Therapy 2022年第2期7卷 543-559页

作者： Shao-Lai Zhou Zheng-Jun Zhou Cheng-Li Song Hao-Yang Xin Zhi-Qiang Hu Chu-Bin Luo Yi-Jie Luo Jia Li Zhi Dai Xin-Rong Yang Ying-Hong Shi Zheng Wang Xiao-Wu Huang Jia Fan Jian Zhou Department of Liver Surgery and Transplantation Zhongshan HospitalFudan UniversityShanghai 200032China Liver Cancer Institute Zhongshan HospitalFudan UniversityShanghai 200032China Novogene Bioinformatics Institute Beijing 100083China Institute of Cancer Stem Cell Dalian Medical UniversityDalianLiaoning 116044China State Key Laboratory of Genetic Engineering Fudan UniversityShanghai 200032China

Patients with hepatocellular carcinoma(HCC)have poor long-term survival following curative resection because of the high rate of tumor early *** is known about the trajectory of genomic evolution from primary to early-recurrent *** this study,we performed whole-genome sequencing(WGS)on 40 pairs of primary and early-recurrent hepatitis B virus(HBV)-related HCC tumors from patients who received curative resection,and from four patients whose primary and recurrent tumor were extensively *** identified two recurrence patterns:de novo recurrence(18/40),which developed genetically independently of the primary tumor and carried different HCC drivers,and ancestral recurrence(22/40),which was clonally related to the primary tumor and progressed more rapidly than de novo *** found that the recurrence location was predictive of the recurrence pattern:distant recurrence tended to display the de novo pattern,whereas local recurrence tended to display the ancestral *** then uncovered the evolutionary trajectories based on the subclonal architecture,driver-gene mutations,and mutational processes observed in the primary and recurrent ***-region WGS demonstrated spatiotemporal heterogeneity and polyclonal,monophyletic dissemination in HCC ancestral *** addition,we identified recurrence-specific mutations and copy-number gains in BCL9,leading to WNT/β-catenin signaling activation and an immuneexcluded tumor microenvironment,which suggests that BCL9 might serve as a new therapeutic target for recurrent ***,our results allow us to view with unprecedented clarity the genomic evolution during HBV-related HCC early recurrence,providing an important molecular foundation for enhanced understanding of HCC with implications for personalized therapy to improve patient survival.

关键词： hepatocellular pattern evolutionary

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Microfluidic Separation,Detection,and engineering of Extracellular Vesicles for Cancer Diagnostics and Drug Delivery

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Accounts of Materials Research 2022年第5期3卷 498-510页

作者： Fei Tian Chao Liu Jinqi Deng Jiashu Sun Beijing Engineering Research Center for BioNanotechnology CAS Key Laboratory of Standardization and Measurement for NanotechnologyNational Center for Nanoscience and TechnologyBeijing 100190China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

Extracellular vesicles(EVs)are cell-derived submicron bioparticles composed of lipid bilayer membrane and molecular cargos,acting as important mediators of physiopathological cellular *** analysis and engineering of EVs hold significant therapeutic potential in noninvasive cancer diagnostics and innovative drug delivery *** significant improvements in technologies for EV investigation,the clinical use of EVs has been hampered by several challenges including the requirement of expensive equipment such as ultracentrifuge for EV isolation from clinical samples,laborious and time-consuming procedures for EV analysis,and large batch-to-batch variation for EV *** this respect,microfluidic technologies have attracted increasing attention as promising avenues to accelerate the study of EVs by offering advantages of small-volume capacity,cost effectiveness,precise manipulation of bioparticles,streamlined workflows,high levels of sensitivity and specificity,and good reproducibility and *** this Account,we review the state-of-the-art advances in the development of microfluidic platforms for EV separation,detection,and engineering with key applications in cancer diagnostics and drug *** first elaborate a variety of passive and active microfluidic approaches for label-free,high-resolution separation of EVs from biological matrix based on their physical *** an example of passive method,viscoelastic microfluidics exploits the size-dependent elastic lift force imposed on EVs in a viscoelastic medium,allowing for the high-resolution isolation of EVs from *** active methods leverage the use of externally applied physical fields(e.g.,electric and acoustic fields)to achieve rapid separation of submicron-sized *** then summarize different signal amplification and detection strategies implemented with microfluidic platforms for sensitive and specific characterization of EVs in clinical *** combination of mic

关键词： batch separation utilize

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Novel use of acitretin for posttransplant Grover's disease and cutaneous graft versus host disease

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JAAD Case Reports 2023年 33卷 67-69页

作者： Gupta, Neha Virgen, Cesar A. Goyal, Amrita Lane, Andrew A. Antin, Joseph H. Divito, Sherrie J. Larocca, Cecilia Center for Cutaneous Oncology Dana-Farber Cancer Institute Boston Massachusetts United States Department of Dermatology Brigham and Women's Hospital Boston Massachusetts United States Case Western Reserve University School of Medicine Cleveland Ohio United States Harvard Medical School Boston Massachusetts United States Blastic Plasmacytoid Dendritic Cell Neoplasm Center Dana-Farber Cancer Institute Boston Massachusetts United States Department of Medical Oncology Stem Cell Transplantation Program Dana-Farber Cancer Institute Boston Massachusetts United States

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FOXO-regulated DEAF1 controls muscle regeneration through autophagy

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Autophagy 2024年第12期20卷 2632-2654页

作者： Goh, Kah Yong Lee, Wen Xing Choy, Sze Mun Priyadarshini, Gopal Krishnan Chua, Kenon Tan, Qian Hui Low, Shin Yi Chin, Hui San Wong, Chee Seng Huang, Shu-Yi Fu, Nai Yang Nishiyama, Jun Harmston, Nathan Tang, Hong-Wen Program in Cancer and Stem Cell Biology Duke-NUS Medical School Department of Orthopaedic Surgery Singapore General Hospital Programme in Musculoskeletal Sciences Academic Clinical Program SingHealth/Duke-NUS Division of Science Yale-NUS College Program in Neuroscience and Behavioral Disorders Duke-NUS Medical School Department of Medical Research National Taiwan University Hospital Molecular Biosciences Division Cardiff School of Biosciences Cardiff University Division of Cellular & Molecular Research Humphrey Oei Institute of Cancer Research National Cancer Centre Singapore

The commonality between various muscle diseases is the loss of muscle mass, function, and regeneration, which severely restricts mobility and impairs the quality of life. With muscle stem cells (MuSCs) playing a key role in facilitating muscle repair, targeting regulators of muscle regeneration has been shown to be a promising therapeutic approach to repair muscles. However, the underlying molecular mechanisms driving muscle regeneration are complex and poorly understood. Here, we identified a new regulator of muscle regeneration, Deaf1 (Deformed epidermal autoregulatory factor-1)–a transcriptional factor downstream of foxo signaling. We showed that Deaf1 is transcriptionally repressed by FOXOs and that DEAF1 targets to Pik3c3 and Atg16l1 promoter regions and suppresses their expression. Deaf1 depletion therefore induces macroautophagy/autophagy, which in turn blocks MuSC survival and differentiation. In contrast, Deaf1 overexpression inactivates autophagy in MuSCs, leading to increased protein aggregation and cell death. The fact that Deaf1 depletion and its overexpression both lead to defects in muscle regeneration highlights the importance of fine tuning DEAF1-regulated autophagy during muscle regeneration. We further showed that Deaf1 expression is altered in aging and cachectic MuSCs. Manipulation of Deaf1 expression can attenuate muscle atrophy and restore muscle regeneration in aged mice or mice with cachectic cancers. Together, our findings unveil an evolutionarily conserved role for DEAF1 in muscle regeneration, providing insights into the development of new therapeutic strategies against muscle atrophy. Abbreviations: DEAF1: Deformed epidermal autoregulatory factor-1;FOXO: Forkhead box O;MuSC: Muscle stem cell;PAX7: Paired box 7;PIK3C3: Phosphatidylinositol 3-kinase catalytic subunit type 3. © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

关键词： Autophagy cancer cachexia Deaf1 FOXO muscle sarcopenia

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Extracellular vesicles derived from mesenchymal stem cells:the wine in Hebe's hands to treat skin aging

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Precision Clinical Medicine 2024年第2期7卷 170-189页

作者： Qixiang Gui Neng Ding Zuochao Yao Minjuan Wu Ruifeng Fu Yue Wang Yunpeng Zhao Lie Zhu Department of Plastic and Reconstructive Surgery Second Affliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)Shanghai 20o001China Department of Plastic and Reconstructive Surgery of Shanghai East Hospital School of MedicineTongji UniversityShanghai 200120China Department of Histology and Embryology Naval Medical UniversityShanghai 200433China Shanghai Key Laboratory of Cell Engineering Translational Medical Research CenterNaval Medical UniversityShanghai 200433China hanghai Institute of Stem Cell Research and Clinical Translation Shanghai 200092China

Owing to its constant exposure to the external environment and various stimuli,skin ranks among the organs most vulnerable to manifestations of *** and delaying skin aging has become one of the prominent research subjects in recent *** stem celis(MsCs)are multipotent stem cells derived from mesoderm with high self-renewal ability and multilineage differentiation ***-derived extracellular vesicles(MSC-EVs)are nanoscale biological vesicles that facilitate intercellular communication and regulate biological *** studies have shown that MSC-EVs have potential applications in anti-aging therapy due to their anti-inflammatory,anti-oxidative stress,and wound healing promoting *** review presents the latest progress of MSC-EVs in delaying skin *** mainly includes the MSC-EVs promoting the proliferation and migration of keratinocytes and fibroblasts,reducing the expression of matrix metalloproteinases,resisting oxidative stress,and regulating *** then briefly discuss the recently discovered treatment methods of MSc-EVs in the field of skin ***,the advantages and limitations of EV-based treatments are also presented.

关键词： mesenchymal stem cell extracellular vesicles exosomes skin aging anti-aging photoaging

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Hif1α and Wnt are required for posterior gene expression during Xenopus tropicalis tail regeneration

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Developmental Biology 2022年第0期483卷 157-168页

作者： Patel, Jeet H. Schattinger, Preston A. Takayoshi, Evan E. Wills, Andrea E. Department of Biochemistry University of Washington Seattle WA United States Program in Molecular and Cellular Biology University of Washington School of Medicine Seattle WA United States Institute for Stem Cell and Regenerative Medicine University of Washington Seattle WA United States

Regeneration of complex tissues is initiated by an injury-induced stress response, eventually leading to activation of developmental signaling pathways such as Wnt signaling. How early injury cues are interpreted and coupled to activation of these developmental signals and their targets is not well understood. Here, we show that Hif1α, a stress induced transcription factor, is required for tail regeneration in Xenopus tropicalis. We find that Hif1α is required for regeneration of differentiated axial tissues, including axons and muscle. Using RNA-sequencing, we find that Hif1α and Wnt converge on a broad set of genes required for posterior specification and differentiation, including the posterior hox genes. We further show that Hif1α is required for transcription via a Wnt-responsive element, a function that is conserved in both regeneration and early neural patterning. Our findings indicate that Hif1α has regulatory roles in Wnt target gene expression across multiple tissue contexts. © 2022

关键词： Anteroposterior patterning Hif1α Hox genes Regeneration Wnt signaling Xenopus

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