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7th International Conference on Contemporary Computing and Informatics, IC3I 2024

作者： Arabelli, Rajeshwarrao Boddepalli, Eswararao Yadav, Roobal Kanwer, Budesh Wicaksono, Yudi Krisno Dhanraj, Joshuva Arockia Sr University School of Engineering Telanagana Warangal India Virginia Tech Bradely Department of Ece Blacksburg United States G.L. Bajaj Institute Of Technology And Management Greater Noida India Poornima Institute of Engineering and Technology India Uin Sayyid Ali Rahmatullah Social Science Education Program Tulungagung Indonesia Lovely Professional University Research and Development Cell Jalandhar-Delhi Grand Trunk Road Punjab Phagwara144411 India

ISBN: (纸本)9798350350067

The Internet of Things (IoT) has altered many fields because it combines so entirety. But likely that these instruments are so smooth to hack, it has still created plenty safety worries. To hold Wi-Fi IoT networks cautious, Intrusion Detection and Prevention Systems (IDPS) are very main. They look for and fix safety dents. This research focuses on Machine Learning (ML) systems and looks at the various types of IDPS for Wi-Fi IoT networks. There is plenty research on intrusion detection systems (IDS) over the internet of things (IoT) that is look at in this place study. It displays by virtue of what well differing algorithms, containing neural networks, decision trees, random forests, and Support Vector Machines (SVM), act. It further checks machine learning-based IoT safety models, like Support Vector Clustering (SVC) in addition to convolutional neural networks (CNNs), in consideration of label and stop hacking risks in IoT backgrounds. Reviewing secondary evidence and secondary data is part of the study process. These are used to find the basic IDPS for Wireless IoT Networks styles and questions. This research explains that intrusion detection systems (IDS) are essential for consistency the Internet of Things cautious, what plans established machine learning can help find and stop threats more effectively. This study has plenty useful information for scientists and experts that can help them devise better IDPS remedies for Wireless IoT Networks. © 2024 IEEE.

关键词： Network intrusion

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An innovative and mass-sensitive quartz tuning fork (QTF) biosensor for GFAP detection: A novel approach for traumatic brain injury diagnosis

Biosensors and Bioelectronics: X

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Biosensors and Bioelectronics: X 2025年 24卷

作者： Özcan, Burcu Anıl, İnci Uludağ Ünal, Mehmet Altay Arı, Fikret Sezgintürk, Mustafa Kemal Özkan, Sibel Ayşıl Çanakkale Onsekiz Mart University Faculty of Engineering Bioengineering Department Çanakkale17020 Turkey Ankara University Stem Cell Institute Ankara06520 Turkey Ankara University Faculty of Engineering Electrical and Electronics Engineering Department Ankara06830 Turkey Ankara University Faculty of Pharmacy Analytical Chemistry Ankara06560 Turkey

The early diagnosis and management of traumatic brain injury (TBI) are dependent upon the early and precise detection of glial fibrillary acidic protein (GFAP). In this investigation, a novel biosensor based on quartz tuning forks (QTF) was introduced and functionalized with 11-mercaptoundecanoic acid (11-MUA). This biosensor is designed to facilitate the highly sensitive and selective detection of GFAP in human serum. In contrast to conventional neuroimaging methods, which are resource-intensive and frequently inaccessible in emergency situations, this innovative biosensor offers a portable, cost-effective, and efficient alternative for rapid GFAP measurement. The detection range of the system is 0.05 fg mL−1 to 25 fg mL−1. The Atomic Force Microscopy (AFM) was utilized to visualize the morphology of the QTF surface during the immobilization steps of the sensor. The developed biosensor presented advantages such as ability to determine GFAP concentrations at femtogram level, reproducibility and repeatability (standard deviation: ±0.0935966 Hz, and coefficient of variation: 7.91 %). This study highlights a significant progression in biosensing technology, providing an exceptionally sensitive and scalable platform for diagnosing neurological disorders, with potential uses in point-of-care environments. © 2025 The Authors

关键词： Diagnosis

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Digital light processing (DLP)-based (bio)printing strategies for tissue modeling and regeneration

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Aggregate 2023年第2期4卷 42-61页

作者： Hongbin Li Jiliang Dai Zixuan Wang Heshan Zheng Wanlu Li Mian Wang Feng Cheng MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbinP.R.China College of Light Industry and Textile Qiqihar UniversityQiqiharP.R.China Biomanufacturing Center Department of Mechanical Engineering Tsinghua UniversityBeijingP.R.China School of Biomedical Engineering and Med-X Research Institute Shanghai Jiao Tong UniversityShanghaiP.R.China Institute for Regenerative Medicine Shanghai East HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Science and TechnologyTongji UniversityShanghaiP.R.China

Digital light processing(DLP)-based bioprinting technology has recently aroused considerable concerns as a strategy to deliver biomedical materials and/or specific cells to create sophisticated structures for various tissue modeling and *** this review,we display a concise introduction of DLP bioprinting,and a further discussion on the design and manufacture of DLP(bio)printer with varied bioinks and their biomedical applications toward drug screening,disease modeling,tissue repair,and regenerative ***,the advantages,challenges,and perspectives of the DLP printing platforms are *** is believed that DLP bioprinting will play a decisive role in the field of tissue model and regenerative medicine,mainly due to its time-efficient,higher resolution,and amenability to automation for various tissue needs.

关键词： disease modeling DLP bioprinting drug screening tissue modeling

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A novel homozygous frameshift mutation in MNS1 associated with severe oligoasthenoteratozoospermia in humans

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Asian Journal of Andrology 2021年第2期23卷 197-204页

作者： Yong Li Wei-Li Wang Chao-Feng Tu Lan-Lan Meng Tong-Yao Hu Juan Du Ge Lin Hong-Chuan Nie Yue-Qiu Tan Institute of Reproductive and Stem Cell Engineering School of Basic Medical ScienceCentral South UniversityChangsha 410078China Reproductive and Genetic Hospital of CITIC-Xiangya Changsha 410078China Clinical Research Center for Reproduction and Genetics in Hunan Province Changsha 410078China

Oligoasthenoteratozoospermia(OAT)refers to the combination of various sperm abnormalities,including a decreased sperm count,reduced motility,and abnormal sperm *** a few genetic causes have been shown to be associated with ***,we identified a novel homozygous frameshift mutation in meiosis-specific nuclear structural 1(MNS1;NM_018365:c.603_604insG:***202Glufs*6)by whole-exome sequencing in an OAT proband from a consanguineous Chinese *** variant screening identified four additional heterozygous MNS1 variants in 6/219 infertile individuals with oligoasthenospermia,but no MNS1 variants were observed among 223 fertile *** analysis showed MNS1 to be normally located in the whole-sperm flagella,but was absent in the proband's *** analysis by Western blot also confirmed that MNS1 was absent in the proband's *** flagellum morphology and ultrastructural disturbances in outer doublet microtubules were observed in the proband's sperm.A total of three intracytoplasmic sperm injection cycles were carried out for the proband's wife,but they all failed to lead to a successful ***,this is the first study to report a loss-of-function mutation in MNS1 causing OAT in a Han Chinese patient.

关键词： intracytoplasmic sperm injection male infertility meiosis-specific nuclear structural 1(MNS1) oligoasthenoteratozoospermia whole-exome sequencing

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Endogenous retroviral ERVH48‑1 promotes human urine cell reprogramming

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cell Regeneration 2024年第1期13卷 212-226页

作者： Yuling Peng Jieying Zhu Qi Zhang Ran Zhang Zhenhua Wang Zesen Ye Ning Ma Dajiang Qin Duanqing Pei Dongwei Li Key Laboratory of Biological Targeting Diagnosis Therapy and Rehabilitation of Guangdong Higher Education InstitutesThe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510799China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510005China CAS Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineInstitutes of Biomedicine and HealthGIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research CentreHong Kong Institute of Science&InnovationGuangzhouGuangzhouGuangdong 510530China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoChina Guangzhou National Laboratory GuangzhouChina Laboratory of Cell Fate Control School of Life SciencesWestlake UniversityHangzhou 310024China GuangDong Engineering Technology Research Center of Biological Targeting Diagnosis Therapy and RehabilitationThe Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhouChina Guangdong Engineering Research Center of Early Clinical Trials of Biotechnology Drugs The Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhouChina

Endogenous retroviruses(ERVs),once thought to be mere remnants of ancient viral integrations in the mammalian genome,are now recognized for their critical roles in various physiological processes,including embryonic devel-opment,innate immunity,and *** impact on host organisms is significant driver of evolutionary changes,offering insight into evolutionary *** our study,we explored the functionality of ERVs by exam-ining single-cell transcriptomic profiles from human embryonic stem cells and urine *** led to the discovery of a unique ERVH48-1 expression pattern between these cell ***,somatic cell reprogramming efficacy was enhanced when ERVH48-1 was overexpressed in a urine cell-reprogramming *** pluripotent stem cells(iPSCs)generated with ERVH48-1 overexpression recapitulated the traits of those produced by traditional repro-gramming approaches,and the resulting iPSCs demonstrated the capability to differentiate into all three germ layers in *** research elucidated the role of ERVs in somatic cell reprogramming.

关键词： Endogenous retroviruses ERVH48-1 Human embryonic stem cells Induced pluripotent stem cells Urine cell integration-free reprogramming system

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DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice

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Signal Transduction and Targeted Therapy 2023年第2期8卷 351-354页

作者： Shushu Zhou Shimin Yuan Jintao Zhang Lanlan Meng Xin Zhang Siyu Liu Guangxiu Lu Ge Lin Mingxi Liu Yue-Qiu Tan State Key Laboratory of Reproductive Medicine Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing211166China Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefei230022China Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITIC-XIANGYAChangsha410008China Institute of Reproductive and Stem Cell Engineering NHC Key Laboratory of Human Stem Cell and Reproductive EngineeringSchool of Basic Medical SciencesCentral South UniversityChangsha410008China Hunan International Scientific and Technological Cooperation base of Development and carcinogenesis Changsha410008China State Key Laboratory of Reproductive Medicine The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou School of Clinical MedicineNanjing Medical UniversityNanjing211166China

Dear Editor,Male subfertility,a multifactorial disease affecting~7%of the global male population,is usually caused by abnormalities in sperm *** flagella and motile cilia have similar“9+2”axonemes and are evolutionarily conserved,being widely distributed in bacteria,archaea and *** defects also lead to primary ciliary dyskinesia(PCD),which affects approximately 1/10,000 individuals worldwide.

关键词： fertility functional assembly

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Liposome of a synergistic combination of HDP-mimicking polymer and rifampicin for treating bacterial infections in aquaculture via oral administration

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Science China Materials 2025年第4期68卷 1259-1270页

作者： Haowen Yu Luhang Chen Yueming Wu Wenhui Dai Minzhang Chen Yuan Chen Longqiang Liu Jiangzhou Wang Xinqi Huang Kang Chen Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Key Laboratory for Ultrafine Materials of Ministry of EducationFrontiers Science Center for Materiobiology and Dynamic ChemistryEngineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Biomaterials and Stem Cells Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China

The extensive use of antibiotics in high-density aquaculture has accelerated the emergence of antibiotic-resistant *** presence of antibiotics in water and soil,and their transmission through the food chain exacerbate the pressures associated with antibiotic resistance,posing a significant threat to human *** this challenge and serious issue,effective alternatives to antibiotics remain *** this study,we report a potent synergistic effect between an HDP-mimicking polymer,DLLys90-BLG10,and rifampicin against Vibrio *** synergistic combination substantially reduces the required dosage of rifampicin,thereby mitigating the risk of antibiotic resistance development and the release of rifampicin into water and ***,we developed a cell-penetrating peptide-modified liposome system that can co-encapsulate DLLys90-BLG10 and rifampicin,which exerts potent antibacterial activity against Vibrio both in vitro and in vivo,while maintaining ***,oral administration of CPP-Lip@Syn showed effective control of Vibrio *** strategy opens new avenues in exploring antibiotic alternatives in aquaculture and implies potential applications in aquaculture.

关键词： liposomes oral administration aquaculture synergistic combinations Vibrio infections

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Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways

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Science China(Life Sciences) 2023年第8期66卷 1915-1929页

作者： Chao Li Li Tao Guobo Guan Zhangyue Guan Austin M.Perry Tianren Hu Jian Bing Ming Xu Clarissa J.Nobile Guanghua Huang Department of Infectious Diseases Huashan HospitalShanghai Institute of Infectious Disease and Biosecurity and State Key Laboratory of Genetic EngineeringSchool of Life SciencesFudan UniversityShanghai 200438China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Department of Molecular and Cell Biology University of CaliforniaMercedMerced CA 95343USA Quantitative and Systems Biology Graduate Program University of CaliforniaMercedMerced CA 95343USA Health Sciences Research Institute University of CaliforniaMercedMerced CA 95343USA Shanghai Engineering Research Center of Industrial Microorganisms Shanghai 200438China Shanghai Huashen Institute of Microbes and Infections Shanghai 200052China

Sexual reproduction is prevalent in eukaryotic organisms and plays a critical role in the evolution of new traits and in the generation of genetic *** factors often have a direct impact on the occurrence and frequency of sexual reproduction in *** regulatory effects of atmospheric relative humidity(RH)on sexual reproduction and pathogenesis in plant fungal pathogens and in soil fungi have been extensively ***,the knowledge of how RH regulates the lifecycles of human fungal pathogens is *** this study,we report that low atmospheric RH promotes the development of mating projections and same-sex(homothallic)mating in the human fungal pathogen Candida *** RH causes water loss in *** cells,which results in osmotic stress and the generation of intracellular reactive oxygen species(ROS)and *** water transporting aquaporin Aqy1,and the G-protein coupled receptor Gpr1 function as cell surface sensors of changes in atmospheric *** of the trehalose metabolic pathway by inactivating trehalose synthase or trehalase promotes same-sex mating in *** by increasing osmotic or ROS stresses,*** trehalose and ROS signal the Hog1-osmotic and Hsf1-Hsp90 signaling pathways to regulate the mating ***,therefore,propose that the cell surface sensors Aqy1 and Gpr1,intracellular trehalose and ROS,and the Hog1-osmotic and Hsf1-Hsp90 signaling pathways function coordinately to regulate sexual mating in response to low atmospheric RH conditions in ***.

关键词： atmospheric relative humidity sexual reproduction same-sex mating Candida albicans trehalose metabolism osmotic stress

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Smart design in biopolymer-based hemostatic sponges:From hemostasis to multiple functions

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Bioactive Materials 2025年第3期45卷 459-478页

作者： Chen-Yu Zou Chen Han Fei Xing Yan-Lin Jiang Ming Xiong Jesse Li-Ling Hui-Qi Xie Department of Orthopedic Surgery and Orthopedic Research Institute Stem Cell and Tissue Engineering Research CenterState Key Laboratory of BiotherapyWest China HospitalSichuan University610041ChengduSichuanPR China Frontier Medical Center Tianfu Jincheng Laboratory610212ChengduSichuanPR China Department of Pediatric Surgery West China HospitalSichuan University610041ChengduSichuanPR China Department of Otolaryngology Head and Neck SurgeryWest China HospitalSichuan University610041ChengduSichuanPR China Department of Medical Genetics West China Second HospitalSichuan University610041ChengduSichuanPR China

Uncontrolled hemorrhage remains the leading cause of death in clinical and emergency care,posing a major threat to human *** achieve effective bleeding control,many hemostatic materials have *** them,nature-derived biopolymers occupy an important position due to the excellent inherent biocompatibility,biodegradability and ***,sponges have been widely used in clinical and daily life because of their rapid blood ***,we provide the overview focusing on the latest advances and smart designs of biopolymer-based hemostatic *** from the component,the applications of polysaccharide and polypeptide in hemostasis are systematically introduced,and the unique bioactivities such as antibacterial,antioxidant and immunomodulation are also *** the perspective of sponge structure,different preparation processes can obtain unique physical properties and structures,which will affect the material properties such as hemostasis,antibacterial and tissue ***,as development frontier,the multifunctions of hemostatic materials is summarized,mainly including enhanced coagulation,antibacterial,avoiding tumor recurrence,promoting tissue repair,and hemorrhage ***,the challenges facing the development of biopolymer-based hemostatic sponges are emphasized,and future directions for in vivo biosafety,emerging materials,multiple application scenarios and translational research are proposed.

关键词： Biopolymer Hemostatic sponges Hemostasis Multiple functions Component Structure

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Mesenchymal stem cell-derived exosomes: A novel and potential remedy for cutaneous wound healing and regeneration

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World Journal of stem cells 2022年第5期14卷 318-329页

作者： Jia-Chen Hu Chen-Xi Zheng Bing-Dong Sui Wen-Jia Liu Yan Jin Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases Center for Tissue EngineeringSchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy Precision Medicine InstituteInstitute for Stem Cell and Regenerative MedicineThe Second Affiliated HospitalXi’an Jiaotong UniversityXi’an 710032Shaanxi ProvinceChina

Poor healing of cutaneous wounds is a common medical problem in the field of *** to the intricate pathophysiological processes of wound healing,the use of conventional treatment methods,such as chemical molecule drugs and traditional dressings,have been unable to achieve satisfactory *** recent years,explicit evidence suggests that mesenchymal stem cells(MSCs)have great therapeutic potentials on skin wound healing and ***,the direct application of MSCs still faces many challenges and ***,exosomes as cell-secreted granular vesicles with a lipid bilayer membrane structure and containing specific components from the source cells may emerge to be excellent substitutes for *** derived from MSCs(MSC-exosomes)have been demonstrated to be beneficial for cutaneous wound healing and accelerate the process through a variety of *** mechanisms include alleviating inflammation,promoting vascularization,and promoting proliferation and migration of epithelial cells and ***,the application of MSC-exosomes may be a promising alternative to cell therapy in the treatment of cutaneous wounds and could promote wound healing through multiple mechanisms *** review will provide an overview of the role and the mechanisms of MSC-derived exosomes in cutaneous wound healing,and elaborate the potentials and future perspectives of MSC-exosomes application in clinical practice.

关键词： Mesenchymal stem cells Extracellular vesicles Exosomes Wound healing Skin regeneration

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