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Enhanced peroxi-coagulation process for the treatment of anaerobically-treated palm oil mill effluent (POME)

Journal of Industrial and engineering Chemistry 2025年 149卷 859-874页

作者： Ismail, Saiyidah Anisah Ang, Wei Lun Mahmoudi, Ebrahim Mohammad, Abdul Wahab Wong, Wai Yin Department of Chemical and Process Engineering Faculty of Engineering and Built Environment Universiti Kebangsaan Malaysia Selangor Bangi43600 Malaysia Chemical and Water Desalination Engineering Program College of Engineering University of Sharjah Sharjah27272 United Arab Emirates Fuel Cell Institute Universiti Kebangsaan Malaysia Selangor Bangi43600 Malaysia

This study investigated the effectiveness of the peroxi-coagulation (PC) process in removing dissolved organic impurities from palm oil mill effluent (POME). Key experimental parameters assessed in this study included wastewater pH, electrolysis duration, and the dosage of H2O2. After a five-hour treatment period, maximum breakdown of organic contaminants and removal of suspended particles were achieved, with around 86 % of soluble COD (SCOD), 91 % of total COD (TCOD), 99 % of true colour, and 84 % of turbidity were removed under optimal operating conditions (pH 3 and external dosing of 31.09 mM H2O2). These outcomes can be attributed to two removal mechanisms: the predominant Fenton oxidation reaction at low pH which promoted effective •OH generation from the dosed H2O2, and the simultaneous coagulation activity by the electrochemically produced Fe(OH)3 coagulant. This PC process was governed by the pseudo-first-order kinetic model, which achieved a maximum kinetic rate of 0.5321 min−1 under ideal operating conditions. The estimated energy consumption for POME degradation ranged from 0.461 to 1.874 kWh per kg of COD reduced, indicating low electrical energy intake. These findings demonstrate the potential of the PC process as a pre- or post- treatment step that can enhance the removal of COD and pigmentation in integrated POME treatment systems. © 2025 The Korean Society of Industrial and engineering Chemistry

关键词： Coagulation

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Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy-and glycophagy-based energy metabolism

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中国药理学报（英文版） 2022年第6期43卷 1395-1407页

作者： Fan Qiu Yi Yuan Wei Luo Yan-shan Gong Zhong-ming Zhang Zhong-min Liu Ling Gao Translational Medical Center for Stem Cell Therapy&Institute for Regenerative Medicine Shanghai East HospitalTongji University School of MedicineShanghai 200123China Department of Cardiovascular and Thoracic Surgery Shanghai East HospitalTongji University School of MedicineShanghai 200120China Translational Medical Center for Stem Cell Therapy&Institute for Regenerative Medicine Shanghai East HospitalTongji University School of MedicineShanghai 200123China Department of Cardiovascular and Thoracic Surgery Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221006China Translational Medical Center for Stem Cell Therapy&Institute for Regenerative Medicine Shanghai East HospitalTongji University School of MedicineShanghai 200123China Department of Cardiovascular and Thoracic Surgery Shanghai East HospitalTongji University School of MedicineShanghai 200120China Shanghai Institute of Stem Cell Research and Clinical translation Shanghai East HospitalTongji UniversityShanghai 200120China Shanghai Engineering Research Center for Stem Cell Clinical Treatment Shanghai 200123China Translational Medical Center for Stem Cell Therapy&Institute for Regenerative Medicine Shanghai East HospitalTongji University School of MedicineShanghai 200123China Shanghai Institute of Stem Cell Research and Clinical translation Shanghai East HospitalTongji UniversityShanghai 200120China Shanghai Engineering Research Center for Stem Cell Clinical Treatment Shanghai 200123China

Myocardial infarction(MI)causes disturbances in myocardial energy metabolism,ultimately leading to a poor *** glycogen autophagy(glycophagy)and mitochondrial autophagy(mitophagy)are upregulated in Ml to optimize energy metabolism but to a limited *** acid(AA),a pentacyclic triterpene derived from the traditional Chinese herb Centella asiatica,displays anti-inflammatory,antioxidant,and antiapoptotic *** has been found to alleviate focal cerebral and liver ischemic injury by reversing mitochondrial *** this study,we investigated whether AA exerted cardioprotective effects against Ml by activating glycophagy and mitophagy to improve the energy *** vitro cardioprotective effects were examined in neonatal mouse cardiomyocytes subjected to oxygen-glucose deprivation for 12 *** with AA(2-50 μM)significantly increased cell viability and improved the energy metabolism evidenced by increased ATP level and phosphocreatine/ATP *** vivo cardioprotective effects were studied in a mouse model of *** of AA(5-125 mg·kg-1·d-1,ig)significantly reduced infarct size and ischemic myocardial injury,and improved cardiac *** treatment also promoted mitophagy and relieved mitochondrial edema evidenced by increased number of mitophagosomes in ischemic myocardium in vivo and increased mitochondria-light chain 3(LC3)-Ⅱ colocalization in ODG-treated cardiomyocytes in *** activation was accompanied by activation of the AMPK signaling *** of AMPK abolished AA-activated ***,we showed that glycophagy was upregulated in OGD cardiomyocytes evidenced by increased starch binding domain protein 1(STBD1)-GABA type A receptor-associated protein-like 1(GABARAPL1)interaction and extracellular acidification rate,whereas AA treatment further promoted glycophagy accompanied by PI3K/Akt ***3K inhibitor LY294002 or Akt inhibitor GSK690693 blocked the effects of AA on glyc

关键词： myocardial infarction asiatic acid glycophagy mitophagy energy metabolism AMPK signaling

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Gene-knockout by iSTOP enables rapid reproductive disease modeling and phenotyping in germ cells of the founder generation

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Science China(Life Sciences) 2024年第5期67卷 1035-1050页

作者： Yaling Wang Jingwen Chen Xueying Huang Bangguo Wu Peng Dai Feng Zhang Jinsong Li Lingbo Wang State Key Laboratory of Genetic Engineering Shanghai Key Laboratory of Metabolic Remodeling and HealthInstitute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Institute of Reproduction and Development Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China NHC Key Lab of Reproduction Regulation(Shanghai Institute for Biomedical and Pharmaceutical Technologies) School of PharmacyFudan UniversityShanghai 200433China Shanghai Key Laboratoryof Maternal and Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchoolof Life Sciences and TechnologyTongji UniversityShanghai 200092China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

Cytosine base editing achieves C·G-to-T·A substitutions and can convert four codons(CAA/CAG/CGA/TGG)into STOP-codons(induction of STOP-codons,iSTOP)to knock out genes with reduced *** enables direct phenotyping in founders’somatic cells,but it remains unknown whether this works in founders’germ cells so as to rapidly reveal novel genes for ***,we initially establish that iSTOP in mouse zygotes enables functional characterization of known genes in founders’germ cells:Cfap43-iSTOP male founders manifest expected sperm features resembling human“multiple morphological abnormalities of the flagella”syndrome(i.e.,MMAF-like features),while oocytes of Zp3-iSTOP female founders have no zona *** further illustrate iSTOP’s utility for dissecting the functions of unknown genes with Ccdc183,observing MMAF-like features and male infertility in Ccdc183-iSTOP founders,phenotypes concordant with those of Ccdc183-KO *** ultimately establish that CCDC183 is essential for sperm morphogenesis through regulating the assembly of outer dynein arms and participating in the intra-flagellar *** study demonstrates iSTOP as an efficient tool for direct reproductive disease modeling and phenotyping in germ cells of the founder generation,and rapidly reveals the essentiality of Ccdc183 in fertility,thus providing a time-saving approach for validating genetic defects(like nonsense mutations)for human infertility.

关键词： disease modeling infertility multiple morphological abnormalities of the flagella(MMAF) induction of STOP-codons(iSTOP CRISPR-STOP) sperm motility

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Microcarriers promote the through interface movement of mouse trophoblast stem cells by regulating stiffness

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Bioactive Materials 2023年第10期28卷 196-205页

作者： Zili Gao Jia Guo Bo Gou Zhen Gu Tan Jia Sinan Ma Liyuan Jiang Wenli Liu Lixun Zhou Qi Gu State Key Laboratory of Membrane Biology The State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyChinese Academy of SciencesBeijing100101PR China Beijing Institute for Stem Cell and Regenerative Medicine Beijing100101PR China University of Chinese Academy of Sciences Beijing100049PR China Department of Chemistry and Biological Engineering University of Science and TechnologyBeijing100083PR China School of Life Sciences Northeast Agricultural UniversityHarbin150030PR China

Mechanical force is crucial in the whole process of embryonic ***,the role of trophoblast mechanics during embryo implantation has rarely been *** this study,we constructed a model to explore the effect of stiffness changes in mouse trophoblast stem cells(mTSCs)on implantation:microcarrier was prepared by sodium alginate using a droplet microfluidics system,and mTSCs were attached to the microcarrier surface with laminin modifications,called T(micro).Compared with the spheroid,formed by the self-assembly of mTSCs(T(sph)),we could regulate the stiffness of the microcarrier,making the Young’s modulus of mTSCs(367.70±79.81 Pa)similar to that of the blastocyst trophoblast ectoderm(432.49±151.90 Pa).Moreover,T(micro)contributes to improve the adhesion rate,expansion area and invasion depth of ***,T(micro)was highly expressed in tissue migration-related genes due to the activation of the Rho-associated coiled-coil containing protein kinase(ROCK)pathway at relatively similar modulus of ***,our study explores the embryo implantation process with a new perspective,and provides theoretical support for understanding the effect of mechanics on embryo implantation.

关键词： Biomechanics Microcarriers Embryo implantation cell migration

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PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality

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Zoological Research 2024年第5期45卷 1037-1047页

作者： Chun-Xue Niu Jia-Wei Li Xiao-Li Li Lin-Lin Zhang Yan Lang Zhen-Bo Song Chun-Lei Yu Xiao-Guang Yang Hai-Feng Zhao Jia-Ling Sun Li-Hua Zheng Xue Wang Ying Sun Xiao-Hong Han Guan-Nan Wang Yong-Li Bao National Engineering Laboratory for Druggable Gene and Protein Screening Northeast Normal UniversityChangchunJilin 130117China China International Joint Research Center for Human Stem Cell Bank Northeast Normal UniversityChangchunJilin 130117China Jilin Institute for Drug Control ChangchunJilin 130022China

Serine protease 50(PRSS50/TSP50)is highly expressed in *** study investigated its role in testicular development and ***,PRSS50 knockdown was observed to impair DNA synthesis in *** further explore this,we generated PRSS50 knockout(Prss50^(−/−))mice(Mus musculus),which exhibited abnormal spermatid nuclear compression and reduced male ***,dysplastic seminiferous tubules and decreased sex hormones were observed in 4-week-old Prss50^(−/−)mice,accompanied by meiotic progression defects and increased apoptosis of spermatogenic *** analysis indicated that PRSS50 deletion resulted in increased phosphorylation of extracellular signal-regulated protein kinases 1 and 2(ERK1/2)and elevated levels of MAP kinase phosphatase 3(MKP3),a specific ERK antagonist,potentially accounting for testicular dysplasia in adolescent Prss50−/−*** together,these findings suggest that PRSS50 plays an important role in testicular development and spermatogenesis,with the MKP3/ERK signaling pathway playing a significant role in this process.

关键词： PRSS50(TSP50) Meiotic progression Sperm quality MKP3 ERK

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Inhibiting scar formation via wearable multilayer stacked electret patch:Self-creation of persistent and customizable DC electric field for fibrogenic activity restriction

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InfoMat 2024年第3期6卷 66-80页

作者： Sung-Won Kim Sumin Cho Donghan Lee Jiyu Hyun Sunmin Jang Inwoo Seo Hyun Su Park Hee Jae Hwang Hyung-Seop Han Dae Hyeok Yang Heung Jae Chun Suk Ho Bhang Dongwhi Choi School of Chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee UniversityYonginGyeonggiRepublic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)SeoulRepublic of Korea Department of Medical Life Sciences College of MedicineInstitute of Cell and Tissue EngineeringThe Catholic University of KoreaSeoulRepublic of Korea

Electrical stimulation has recently received attention as noninvasive treatment in skin wound healing with its outstanding biological property for clinical ***,the complexity of equipment for applying appropriate electrical stimulation remains an ongoing ***,we proposed a strategy for skin scar inhibition by providing electrical stimulation via a multilayer stacked electret(MS-electret),which can generate direct current(DC)electric field(EF)without any power supply *** addition,the MS-electret can easily control the intensity of EFs by simply stacking electret layers and maintain stable EF with the surface potential of 3400 V over 5 days owing to the injected charges on the electret *** confirmed inhibition of type 1 collagen andα-SMA expression of human dermal fibroblasts(hDFs)by 90%and 44%in vitro,indicating that the transition of hDFs to myofibroblasts was restricted by applying stable electrical *** further revealed a 20%significant decrease in the ratio of myofibroblasts caused by the MS-electret in *** findings present that the MS-electret is an outstanding candidate for effective skin scar inhibition with a battery-free,physiological electrical microenvironment,and noninvasive treatment that allows it to prevent external infection.

关键词： DC electric field dermal fibroblasts electret scar formation restriction self-creation of electrical stimulation

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MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB

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Signal Transduction and Targeted Therapy 2024年第11期9卷 5267-5285页

作者： Xiujian Wang Xiao Tao Pengjie Chen Penglei Jiang Wenxiao Li Hefeng Chang Cong Wei Xinyi Lai Hao Zhang Yihan Pan Lijuan Ding Zuyu Liang Jiazhen Cui Mi Shao Xinyi Teng Tianning Gu Jieping Wei Delin Kong Xiaohui Si Yingli Han Huarui Fu Yu Lin Jian Yu Xia Li Dongrui Wang Yongxian Hu Pengxu Qian He Huang Bone Marrow Transplantation Center The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Liangzhu Laboratory Zhejiang University Medical Center1369 West Wenyi RoadHangzhou 311121China Institute of Hematology Zhejiang UniversityHangzhou 310003China Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy Hangzhou 310003China Center of Stem Cell and Regenerative Medicine Zhejiang University School of MedicineHangzhou 310058China Department of Hematology The Third Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325200China

Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T(CAR-T)***1/2 inhibitors(MEKIs),widely used in cancer treatment due to their ability to inhibit aberrant MAPK signaling,have shown potential synergistic effects when combined with ***,the impact and mechanisms of MEKIs on CAR-T cells remain uncertain and *** address this,we conducted a comprehensive investigation to determine whether MEKIs enhance or impair the efficacy of CAR-T *** findings revealed that MEKIs attenuated CAR-T cell exhaustion and terminal differentiation induced by tonic signaling and antigen stimulation,thereby improving CAR-T cell efficacy against hematological and solid ***,these effects were independent of the specific scFvs and costimulatory domains utilized in ***,analysis of bulk and single-cell transcriptional profiles demonstrates that the effect of MEK inhibition was related to diminish anabolic metabolism and downregulation of c-Fos and ***,the overexpression of c-Fos or JunB in CAR-T cells counteracted the effects of MEK ***,our Cut-and-Tag assay revealed that MEK inhibition downregulated the JunB-driven gene profiles associated with exhaustion,differentiation,anergy,glycolysis,and *** summary,our research unveil the critical role of the MAPK-c-Fos-JunB axis in driving CAR-T cell exhaustion and terminal *** mechanistic insights significantly broaden the potential application of MEKIs to enhance the effectiveness of CAR-T therapy.

关键词： JunB metabolism stimulation

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Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron Ji Hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

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Techniques for increasing the yield of stem cell-derived exosomes:what factors may be involved?

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Science China(Life Sciences) 2022年第7期65卷 1325-1341页

作者： Zi-Yuan Feng Qing-Yi Zhang Jie Tan Hui-Qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Exosomes are nano-scale extracellular vesicles secreted by cells and constitute an important part in the cell-cell *** main contents of the exosomes include proteins,micro RNAs,and *** mechanism and safety of stem cell-derived exosomes have rendered them a promising therapeutic strategy for regenerative ***,limited yield has restrained full explication of their functions and clinical *** address this,various attempts have been made to explore the up-and down-stream manipulations in a bid to increase the production of *** review has recapitulated factors which may influence the yield of stem cell-derived exosomes,including selection and culture of stem cells,isolation and preservation of the exosomes,and development of artificial exosomes.

关键词： exosome stem cell yield therapy

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Peripheral actions and direct central-local communications of melanocortin 4 receptor signaling

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Journal of Sport and Health Science 2023年第1期12卷 45-51页

作者： Lei Li Jinye Liang Cong Zhang Tiemin Liu Chao Zhang Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Department of Biology University of IowaIowa CityIA 52242USA State Key Laboratory of Genetic Engineering Department of Endocrinology and Metabolismand School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200032China

Melanocortin 4 receptor(MC4R),the most important monogenetic cause of human metabolic disorders,has been of great interest to many researchers in the field of energy homeostasis and public *** MC4R is a vital pharmaceutical target for maintaining controllable appetite and body weight for professional athletes,previous studies have mainly focused on the central,rather than the peripheral,roles of ***,the local expression of MC4R and its behavioral regulation remain *** an attempt to shed light on different directions for future studies of MC4R signaling,we review a series of recent and important studies exploring the peripheral functions of MC4R and the direct physiological interaction between peripheral organs and central MC4R neurons in this article.

关键词： Body weight Energy homeostasis GPCR Melanocortin-4 receptor

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