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A food-grade and senescent cell-targeted fisetin delivery system based on whey protein isolate-galactooligosaccharides Maillard conjugate

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Food Science and Human Wellness 2024年第2期13卷 688-697页

作者： Shuai Hou Chutong Lai Yukun Song Haitao Wang Jialu Ni Mingqian Tan Academy of Food Interdisciplinary Science School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Institute of Cancer Stem Cell Cancer CenterDalian Medical UniversityDalian 116044China National Engineering Research Center of Seafood Dalian Polytechnic UniversityDalian 116034China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

cellular senescence is the results of aging and age-related diseases,and the development of anti-aging methods may improve health and extend *** natural flavonol fisetin has been shown to antagonize senescence in vitro and increases longevity in vivo,but has poor water solubility and limited *** this study,a food-grade and senescent cell-targeted delivery system for fisetin was developed based on whey protein isolate-galactooligosaccharides(WPI-GOS)Maillard conjugate,which could recognize senescence associatedβ-galactosidase in senescent *** fisetin nanoparticles possessed a high encapsulation efficiency,excellent dispersibility in water,good storage stability and well ***,they could effectively accumulate and retain in senescent cells with excellent senescent cell-targeting efficacy,and inhibit the oxidative stress-induced cellular senescence in ***,this novel nanoparticle system based on WPI-GOS Maillard conjugate showed promise to deliver hydrophobic bioactive ingredients like fisetin to senescent cells to improve their bioavailability and anti-senescence effect.

关键词： Fisetin Nanoparticle cellular senescence Targeted delivery

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DROPLET INCUBATOR: A NEW DROPLET-BASED MODEL TO INVESTIGATE LIVING cell-SYNTHETIC cell INTERACTIONS 26

DROPLET INCUBATOR: A NEW DROPLET-BASED MODEL TO INVESTIGATE ...

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26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

作者： Dimitriou, Pantelitsa Li, Jin Tornillo, Giusy Smalley, Matthew J. Barrow, David A. School of Engineering Cardiff University United Kingdom School of Biosciences European Cancer Stem Cell Research Institute Cardiff University United Kingdom

ISBN: (纸本)9781733419048

Building feasible models to enable synthetic cell and living cell interaction is an important step towards developing smart, soft matter materials for pharmaceutical and clinical usage. Herein, we demonstrate for the first time, a new complex emulsion-based model, named as droplet incubator (DI), that is devised to co-culture artificial cell materials and tumour spheroids. © 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Drops

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The association between urinary tract infections and diet: a literature review

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Discover Medicine 2025年第1期2卷 1-17页

作者： Çelik, Haluk Kozan, Esra Caf, Balım Bengisu Çebi, Gizem Koç, Murat Vivosens Inc. San Francisco USA Program of Stem Cell and Tissue Engineering Institute of Graduate Education Istinye University Istanbul Türkiye Department of Health Informatics University of Health Science Hamidiye Institute of Health Sciences Istanbul Türkiye

Urinary tract infections (UTIs) are a significant global health concern, affecting millions worldwide, with particular prevalence among specific vulnerable populations. Women of sexually active age, post-menopausal women, pregnant women, individuals with diabetes, catheterized patients, childs and older indivisuals face heightened risk due to various physiological, hormonal, and anatomical factors. While anatomical abnormalities and behavioral factors contribute to UTI susceptibility, the growing challenge of antibiotic resistance has necessitated exploration of alternative treatment approaches. Non-antibiotic interventions, including probiotics, cranberry products, and natural remedies, are gaining attention for their potential role in UTI prevention and management. Recent studies suggest the efficacy of probiotics and plant extracts in promoting urinary tract health and preventing bacterial colonization. Additionally, research highlights the importance of dietary factors, such as vitamin D and probiotic intake, in reducing UTI susceptibility. This review examines the emerging shift toward non-drug strategies, offering a more comprehensive approach to UTI management while addressing the pressing concern of antibiotic resistance.

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Enhanced angiogenesis in porous poly(ε-caprolactone)scaffolds fortified with methacrylated hyaluronic acid hydrogel after subcutaneous transplantation

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Biomaterials Translational 2024年第1期5卷 59-68页

作者： Huaxin Yang Mengjia Zheng Yuyue Zhang Chaochang Li Joseph Ho Chi Lai Qizheng Zhang Kannie WY Chan Hao Wang Xin Zhao Zijiang Yang Chenjie Xu Department of Biomedical Engineering City University of Hong KongHong Kong Special Administrative RegionChina Center for Pluripotent Stem Cell Research and Engineering Research Institute of TsinghuaGuangzhouGuangdong ProvinceChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

A composite scaffold composed of a porous scaffold and hydrogel filling can facilitate engraftment,survival,and retention in cell transplantation *** study presents a composite scaffold made of poly(ε-caprolactone)(PCL)and methacrylated hyaluronic acid(MeHA)hydrogel and describes the corresponding physical properties(surface area,porosity,and mechanical strength)and host response(angiogenesis and fibrosis)after subcutaneous ***,we synthesise MeHA with different degrees of substitution and fabricate a PCL scaffold with different ***,we construct a series of PCL/MeHA composite scaffolds by combining these hydrogels and *** experiments with mice,the scaffold composed of 3%PCL and 10-100 kDa,degree of substitution 70%MeHA results in the least fibrosis and a higher degree of *** study highlights the potential of PCL/MeHA composite scaffolds for subcutaneous cell transplantation,given their desirable physical properties and host response.

关键词： angiogenesis cell transplantation hyaluronic acid poly(ε-caprolactone) scaffold

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Structural Characterization, in Vitro Bioactivity, and Cytotoxicity Evaluation of Sol-Gel Derived Sio2- Cao- Na2o- P2o5 Based Glass- Ceramics in the Presence of Manganese

SSRN

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SSRN 2024年

作者： Gogajeh, Narges Nasehi Yekta, Bijan Eftekhari Javadpour, Jafar Eslaminejad, Mohamadreza Baghaban School of Metallurgy and Materials Engineering Iran University of Science and Technology Tehran Iran Department of Stem Cells and Developmental Biology Cell Science Research Center Royan Institute for Stem Cell Biology and Technology Tehran Iran

Bioactive glasses (BGs) have garnered significant interest in bone regeneration due to their capacity to bond with bone. One area of particular focus within the scientific community is the development of metal ion-containing BGs with enhanced biological properties. To address this, the current study aims to synthesize manganese-containing bioactive glass (MnBG) in the SiO2-CaO-Na2O-P2O5 system by the sol-gel method. The study will also analyze the structural and textural properties of the Mn-bearing BGs. The synthesized powders were characterized and assessed by X-ray diffractometer (XRD), thermogravimetric analysis (TGA), differential thermal analysis (DTA), and Fourier transform infrared (FTIR) techniques. According to the results, Mn ions showed different valances in the glass network, which led to distinct colors ranging from pinkish brown to dark brown in powders. Mn also decreased the crystallization temperature of the glass and inhibited silicorhenanite crystallization, while combeite and silicorhenanite crystallized simultaneously in the manganese-free glass during calcination at 650°C for 1 h. The impact of MnO content on the resulting glass-ceramics structure, bioactivity, and cytotoxicity was also investigated. The XRD and EDS techniques were used to verify the formation of hydroxyapatite (HA) on the samples after 14 days of immersion in simulated body fluid (SBF). Results indicated a slight decrease in the HA precipitation kinetics by increasing the MnO content beyond 2 mol.%. The cellular test confirmed the non-cytotoxicity of the samples on hBMSCs for up to 7 days, and mitochondrial activity increased considerably over this period. © 2024, The Authors. All rights reserved.

关键词： Bioactive glass

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Supra-and sub-threshold intracellular-like recording of 2D and 3D neuronal networks using nanopillar electrode arrays

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Microsystems & Nanoengineering 2024年第6期10卷 351-361页

作者： Shivani Shukla Joshua L.Schwartz Callum Walsh Wen Mai Wong Vrund Patel Yu-Peng Hsieh Chichi Onwuasoanya Shaoming Chen Andreas Offenhäusser Gert Cauwenberghs Francesca Santoro Alysson R.Muotri Gene W.Yeo Sreekanth H.Chalasani Zeinab Jahed Shu Chien-Gene Lay Department of Bioengineering University of California San DiegoLa JollaCA 92093USA Aiiso Yufeng Li Family Department of Chemical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Department of Cellular and Molecular Medicine University of California San DiegoLa JollaCA 92093USA Institute for Genomic Medicine University of California San DiegoLa JollaCA 92093USA Molecular Neurobiology Laboratory The Salk Institute for Biological StudiesLa JollaCA 92037USA Institute of Biological Information Processing—Bioelectronics IBI-3Forschungszentrum JülichJülich 52428Germany Neuroelectronic Interfaces Faculty of Electrical Engineering and ITRWTH AachenAachen 52074Germany Department of Pediatrics University of California San DiegoSan DiegoCAUSA Center for Academic Research and Training in Anthropogeny(CARTA)and Archealization(ArchC) University of California San DiegoLa JollaCA 92093USA Sanford Stem Cell Education and Integrated Space Stem Cell Orbital Research(ISSCOR)Center University of California San Diego La JollaCA 92093USA Sanford Stem Cell Institute Innovation Center University of California San DiegoLa JollaCA 92093USA Center for RNA Technologies and Therapeutics University of California San DiegoLa JollaCA 92093USA

The brain integrates activity across networks of interconnected neurons to generate behavioral *** physiological and imaging-based approaches have been previously used to monitor responses of individual *** these techniques can identify cellular responses greater than the neuron’s action potential threshold,less is known about the events that are smaller than this threshold or are localized to subcellular *** we use NEAs to obtain temporary intracellular access to neurons allowing us to record information-rich data that indicates action potentials,and sub-threshold electrical *** demonstrate these recordings from primary hippocampal neurons,induced pluripotent stem cell-derived(iPSC)neurons,and iPSC-derived brain ***,our results show that our arrays can record activity from subcellular compartments of the *** suggest that these data might enable us to correlate activity changes in individual neurons with network behavior,a key goal of systems neuroscience.

关键词： recording networks record

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Ca2+ homeostasis: a potential target for cancer therapies

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Biophysics Reports 2024年第5期10卷 283-292页

作者： Min Su Shanliang Zheng Hao Liu Tie-Shan Tang Ying Hu School of Life Science and Technology Harbin Institute of Technology Key Laboratory of Science and Engineering for the Multi-modal Prevention and Control of Major Chronic Diseases Ministry of Industry and Information Technology Department of Medicine and Health Zhengzhou Research Institute of Harbin Institute of Technology State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Beijing Institute for Stem Cell and Regenerative Medicine University of Chinese Academy of Sciences Chinese Academy of Sciences

Calcium ions(Ca2+) play a crucial role as secondary messengers in both excitable and non-excitable cells.A complex system of proteins and molecules involved in calcium handling allows Ca2+signals to be *** cancer cells,mutations,aberrant expression,and dysregulation of these calcium handling toolkit proteins disrupt the normal Ca2+flux between extracellular space,cytosol,endoplasmic reticulum and mitochondria,as well as the spatio-temporal patterns of Ca2+*** leads to the dysregulation of calcium-dependent effectors that control key signaling pathways involved in cancer cell proliferation,survival and *** there has been progressing in understanding the remodelling of calcium homeostasis in cancer cells and identifying key calcium transport molecules that promote malignant phenotypes,much work remains to be done to translate these fundamental findings into new tools for diagnosing and treating cancer by targeting Ca2+homeostasis.

关键词： Calcium homeostasis Cancer Therapy

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Liver cell therapies:cellular sources and grafting strategies

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Frontiers of Medicine 2023年第3期17卷 432-457页

作者： Wencheng Zhang Yangyang Cui Yuan Du Yong Yang Ting Fang Fengfeng Lu Weixia Kong Canjun Xiao Jun Shi Lola M.Reid Zhiying He Institute for Regenerative Medicine Ji’an HospitalShanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai 200123China Shanghai Engineering Research Center of Stem Cells Translational Medicine Shanghai 200335China Shanghai Institute of Stem Cell Research and Clinical Translation Shanghai 200120China Postgraduate Training Base of Shanghai East Hospital Jinzhou Medical UniversityJinzhou 121001China The First Affiliated Hospital of Nanchang University Nanchang 330006China Graduate School of Frontier Biosciences Osaka UniversitySuitaOsaka565-0871Japan Department of General Surgery Ji’an HospitalShanghai East HospitalSchool of MedicineTongji UniversityJi’an 343006China Department of Cell Biology and Physiology and Program in Molecular Biology and Biotechnology/UNC School of Medicine Chapel HillNC 27599USA

The liver has a complex cellular composition and a remarkable regenerative *** primary cell types in the liver are two parenchymal cell populations,hepatocytes and cholangiocytes,that perform most of the functions of the liver and that are helped through interactions with non-parenchymal cell types comprising stellate cells,endothelia and various hemopoietic cell *** regulation of the cells in the liver is mediated by an insoluble complex of proteins and carbohydrates,the extracellular matrix,working synergistically with soluble paracrine and systemic *** recent years,with the rapid development of genetic sequencing technologies,research on the liver’s cellular composition and its regulatory mechanisms during various conditions has been extensively *** breakthroughs in strategies for cell transplantation are enabling a future in which there can be a rescue of patients with end-stage liver diseases,offering potential solutions to the chronic shortage of livers and alternatives to liver *** review will focus on the cellular mechanisms of liver homeostasis and how to select ideal sources of cells to be transplanted to achieve liver regeneration and *** advances are summarized for promoting the treatment of end-stage liver diseases by forms of cell transplantation that now include grafting strategies.

关键词： liver regeneration hepatocytes cholangiocytes stem cells organoids regulatory mechanisms transplantation/grafting strategies

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3D Printed cell and Fiber Guiding Scaffold Mimicking Periodontal Architecture

3D Printed Cell and Fiber Guiding Scaffold Mimicking Periodo...

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IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

作者： Sarin Abraham Pallavi Gupta Kavitha Govarthanan Suresh Rao Tuhin Subhra Santra Department of Engineering Design Indian Institute of Technology Madras Chennai India Institute for Stem Cell Sciences and Regenerative Medicine Bengaluru India

ISBN: (数字)9798350359831

ISBN: (纸本)9798350359848

Periodontal tissue regeneration is the most practical method for reconstructing intricate periodontal tissues. Identifying an appropriate multilayered three-dimensional scaffold that provides the required architecture and promotes cell proliferation and differentiation is essential in periodontal tissue engineering. This work aimed to assess the mechanical properties, biocompatibility, and surface properties of a new design for three-dimensional, trilayered periodontal tissue scaffolds intended for use in vitro investigations. Polylactic acid (PLA) was used for rapidly prototyping the scaffolds in this study, and they were then surface-altered for optimal regeneration. Scanning electron microscope and atomic force microscopy were used for structural and tribological characterization. Compression testing was carried out to investigate the capability of the scaffold to withstand the masticatory forces. All the surface-altered scaffolds showed improved surface qualities, enhanced cell viability, and improved compression modulus in vitro. Using a fluorescent microscope, the morphology, attachment, and proliferation of all the cells on the scaffold's surface were observed. This demonstrated that the cells multiplied over time and could grow on all of the scaffolds. This investigation demonstrated the acceptable compression modulus and good biocompatibility of the PLA scaffold coated with 5% Gelatin Methacryloyl (PLA/5G) and hence these findings confirm that PLA/5G is a prospective scaffold for the regeneration of periodontal tissue to gain ideal architecture

关键词： Scanning electron microscopy Atomic force microscopy Three-dimensional displays Microprocessors Tissue engineering Surface morphology Computer architecture

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Hormonally and chemically defined expansion conditions for organoids of biliary tree stem cells

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Bioactive Materials 2024年第11期41卷 672-695页

作者： Wencheng Zhang Yangyang Cui Mengqi Lu Mingyang Xu Yuting Li Haimeng Song Yi Luo Jinjia Song Yong Yang Xicheng Wang Lijun Liao Yunfang Wang Lola Reid Zhiying He Institute for Regenerative Medicine Medical Innovation Center and State Key Laboratory of CardiologyShanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai200123China Shanghai Engineering Research Center of Stem Cells Translational Medicine Shanghai200335China Shanghai Institute of Stem Cell Research and Clinical Translation Shanghai200120China Postgraduate Training Base of Shanghai East Hospital Jinzhou Medical UniversityJinzhouLiaoning121001China Department of General Surgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi330006China Department of Anesthesiology and Pain Management Shanghai East HospitalTongji University School of MedicineShanghai200123China Hepatobiliary and Pancreatic Center Medical Research CenterBeijing Tsinghua Changgung HospitalBeijing102218China Departments of Cell Biology and Physiology Program in Molecular Biology and BiotechnologyUNC School of MedicineChapel HillNC27599United States

Wholly defined ex vivo expansion conditions for biliary tree stem cell(BTSC)organoids were established,consisting of a defined proliferative medium(DPM)used in combination with soft hyaluronan *** DPM consisted of commercially available Kubota's Medium(KM),to which a set of small molecules,particular paracrine signals,and heparan sulfate(HS)were *** small molecules used were DNA methyltransferase inhibitor(RG108),TGF-βType I receptor inhibitor(A83-01),adenylate cyclase activator(Forskolin),and L-type Ca2+channel agonist(Bay K8644).A key paracrine signal proved to be R-spondin 1(RSPO1),a secreted protein that activates *** hyaluronans,0.05%sodium hyaluronate,were used with DPM to expand monolayer *** of organoids was achieved by using DPM in combination with embedding organoids in Matrigel that was replaced with a defined thiol-hyaluronan triggered with PEGDA to form a hydrogel with a rheology[G*]of less than 100 *** combination is called the BTSC-Expansion-Glycogel-System(BEX-gel system)for expanding BTSCs as a monolayer or as *** BTSC organoids were expanded more than 3000-fold ex vivo in the BEX-gel system within 70 days while maintaining phenotypic traits indicative of stem/***-cell-patch grafting of expanded BTSC organoids was performed on the livers of Fah-/-mice with tyrosinemia and resulted in the rescue of the mice and restoration of their normal liver *** BEX-gel system for BTSC organoid expansion provides a strategy to generate sufficient numbers of organoids for the therapeutic treatments of liver diseases.

关键词： Biliary tree stem cells(BTSCs) Organoids Paracrine signals Defined Proliferative Medium(DPM) BTSC-Expansion-Glycogel(BEX-gel)

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