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arXiv 2022年

作者： Ghojogh, Benyamin Ghodsi, Ali Karray, Fakhri Crowley, Mark Department of Electrical and Computer Engineering Machine Learning Laboratory University of Waterloo WaterlooON Canada Department of Statistics and Actuarial Science David R. Cheriton School of Computer Science Data Analytics Laboratory University of Waterloo WaterlooON Canada Department of Electrical and Computer Engineering Centre for Pattern Analysis and Machine Intelligence University of Waterloo WaterlooON Canada

This is a tutorial and survey paper on metric learning. Algorithms are divided into spectral, probabilistic, and deep metric learning. We first start with the definition of distance metric, Mahalanobis distance, and generalized Mahalanobis distance. In spectral methods, we start with methods using scatters of data, including the first spectral metric learning, relevant methods to Fisher discriminant analysis, Relevant Component Analysis (RCA), Discriminant Component Analysis (DCA), and the Fisher-HSIC method. Then, large-margin metric learning, imbalanced metric learning, locally linear metric adaptation, and adversarial metric learning are covered. We also explain several kernel spectral methods for metric learning in the feature space. We also introduce geometric metric learning methods on the Riemannian manifolds. In probabilistic methods, we start with collapsing classes in both input and feature spaces and then explain the neighborhood component analysis methods, Bayesian metric learning, information theoretic methods, and empirical risk minimization in metric learning. In deep learning methods, we first introduce reconstruction autoencoders and supervised loss functions for metric learning. Then, Siamese networks and its various loss functions, triplet mining, and triplet sampling are explained. Deep discriminant analysis methods, based on Fisher discriminant analysis, are also reviewed. Finally, we introduce multi-modal deep metric learning, geometric metric learning by neural networks, and few-shot metric learning. Copyright © 2022, The Authors. All rights reserved.

关键词： Surveys

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VulnerVAN: A Vulnerable Network Generation Tool

VulnerVAN: A Vulnerable Network Generation Tool

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MILCOM, Military Communications Conference

作者： Sridhar Venkatesan Jason A. Youzwak Shridatt Sugrim Cho-Yu J. Chiang Alexander Poylisher Matthew Witkowski Gary Walther Michelle Wolberg Ritu Chadha E. Allison Newcomb Blaine Hoffman Norbou Buchler Machine Learning and Data Analytics Research Perspecta Labs Inc. Basking Ridge NJ USA Computational and Information Science Directorate U.S. CCDC Army Research Laboratory Aberdeen MD USA Human Research and Engineering Directorate U.S. CCDC Army Research Laboratory

ISBN: (数字)9781728142807

ISBN: (纸本)9781728142814

Cyber training, security testing, and research and development activities are vital to improve the security posture of a network. Currently, many institutions use cyber security testbeds to conduct these activities in an isolated virtual environment. One of the important requirements for such an environment is to provide organizers (or experimenters) with a library of vulnerable network scenarios and capabilities to mount attacks against them. However, the task of preparing a vulnerable network scenario in current testbed environments is costly in time and labor, requires significant support from the testbed staff. To this end, we present a toolset called VulnerVAN that creates a vulnerable network scenario to realize an attack sequence. In this paper, we discuss the design of VulnerVAn - our proof-of-concept implementation on CyberVAN - and present a new high-level attack specification language that enables users to chain attack steps into an attack sequence. For a given attack sequence and network scenario, VulnerVAN identifies all possible attack paths through the network that can realize the attack sequence, and provides instructions to configure machines on an attack path selected by the user. VulnerVAn also provides an attack blueprint that can guide a Red team or an automated attacker to execute the attack sequence. To demonstrate VulnerVAN's capability, we consider the use-case of a typical data exfiltration attack sequence conducted by APTs and study the performance of VulnerVAn in mapping the attack sequence to different networks.

关键词： data security Training Specification languages Virtual environments

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Analyzing the Structure of Attention in a Transformer Language Model

arXiv

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arXiv 2019年

作者： Vig, Jesse Belinkov, Yonatan Palo Alto Research Center Machine Learning and Data Science Group Interaction and Analytics Lab Palo AltoCA United States Harvard John A. Paulson School of Engineering and Applied Sciences MIT Computer Science and Artificial Intelligence Laboratory CambridgeMA United States

The Transformer is a fully attention-based alternative to recurrent networks that has achieved state-of-the-art results across a range of NLP tasks. In this paper, we analyze the structure of attention in a Transformer language model, the GPT-2 small pretrained model. We visualize attention for individual instances and analyze the interaction between attention and syntax over a large corpus. We find that attention targets different parts of speech at different layer depths within the model, and that attention aligns with dependency relations most strongly in the middle layers. We also find that the deepest layers of the model capture the most distant relationships. Finally, we extract exemplar sentences that reveal highly specific patterns targeted by particular attention heads. Copyright © 2019, The Authors. All rights reserved.

关键词： Recurrent neural networks

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ICDAR 2021 competition on on-line signature verification

arXiv

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arXiv 2021年

作者： Tolosana, Ruben Vera-Rodriguez, Ruben Gonzalez-Garcia, Carlos Fierrez, Julian Rengifo, Santiago Morales, Aythami Ortega-Garcia, Javier Ruiz-Garcia, Juan Carlos Romero-Tapiador, Sergio Jiang, Jiajia Lai, Songxuan Jin, Lianwen Zhu, Yecheng Galbally, Javier Diaz, Moises Ferrer, Miguel Angel Gomez-Barrero, Marta Hodashinsky, Ilya Sarin, Konstantin Slezkin, Artem Bardamova, Marina Svetlakov, Mikhail Saleem, Mohammad Szücs, Cintia Lia Kovari, Bence Pulsmeyer, Falk Wehbi, Mohamad Zanca, Dario Ahmad, Sumaiya Mishra, Sarthak Jabin, Suraiya Biometrics and Data Pattern Analytics Lab UAM Spain South China University of Technology China Guangdong Artificial Intelligence and Digital Economy Laboratory China European Commission Joint Research Centre Italy Universidad del Atlantico Medio Spain Universidad de las Palmas de Gran Canaria Spain Hochschule Ansbach Germany Tomsk State University of Control Systems and Radioelectronics Russia Budapest University of Technology and Economics Hungary Machine Learning and Data Analytics Lab FAU Germany Jamia Millia Islamia India

This paper describes the experimental framework and results of the ICDAR 2021 Competition on On-Line Signature Verification (SVC 2021). The goal of SVC 2021 is to evaluate the limits of on-line signature verification systems on popular scenarios (office/mobile) and writing inputs (stylus/finger) through large-scale public databases. Three different tasks are considered in the competition, simulating realistic scenarios as both random and skilled forgeries are simultaneously considered on each task. The results obtained in SVC 2021 prove the high potential of deep learning methods. In particular, the best on-line signature verification system of SVC 2021 obtained Equal Error Rate (EER) values of 3.33% (Task 1), 7.41% (Task 2), and 6.04% (Task 3). SVC 2021 will be established as an on-going competition12, where researchers can easily benchmark their systems against the state of the art in an open common platform using large-scale public databases such as DeepSignDB13 and SVC2021_EvalDB14, and standard experimental protocols. © 2021, CC BY-NC-ND.

关键词： Deep learning

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Monitoring medication optimization in patients with Parkinson’s disease

Monitoring medication optimization in patients with Parkinso...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Hamid Moradi Julius Hannink Sabine Stallforth Till Gladow Stefan Ringbauer Martin Mayr Jürgen Winkler Jochen Klucken Bjoern M. Eskofier Department of Artificial Intelligence in Biomedical Engineering Machine Learning and Data Analytics Laboratory (MaD Lab) Friedrich Alexander University Erlangen Nuremberg Erlangen-Nuremberg Germany Portabiles HealthCare Technologies GmbH Erlangen Germany Department of Molecular-Neurology University Hospital Erlangen Erlangen Germany Medical Valley Digital Health Application Center Bamberg Germany NeuroSys GmbH Ulm Germany Luxembourg Institute of Health Centre Hospitalier du Luxembourg University of Luxembourg

Medication optimization is a common component of the treatment strategy in patients with Parkinson’s disease. As the disease progresses, it is essential to compensate for the movement deterioration in patients. Conventionally, examining motor deterioration and prescribing medication requires the patient’s onsite presence in hospitals or practices. Home-monitoring technologies can remotely deliver essential information to physicians and help them devise a treatment decision according to the patient’s need. Additionally, they help to observe the patient’s response to these changes. In this regard, we conducted a longitudinal study to collect gait data of patients with Parkinson’s disease while they received medication changes. Using logistic regression classifier, we could detect the annotated motor deterioration during medication optimization with an accuracy of 92%. Moreover, an in-depth examination of the best features illustrated a decline in gait speed and swing phase duration in the deterioration phases due to suboptimal *** relevance— Our proposed gait analysis method in this study provides objective, detailed, and punctual information to physicians. Revealing clinically relevant time points related to the patient’s need for medical adaption alleviates therapy optimization for physicians and reduces the duration of suboptimal treatment for patients. As the home-monitoring system acts remotely, embedding it in the medical care pathways could improve patients’ quality of life.

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learning with Group Noise

arXiv

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arXiv 2021年

作者： Wang, Qizhou Yao, Jiangchao Gong, Chen Liu, Tongliang Gong, Mingming Yang, Hongxia Han, Bo Department of Computer Science Hong Kong Baptist University Hong Kong Key Laboratory of Intelligent Perception and Systems for High-Dimensional Information of MoE School of Computer Science and Engineering Nanjing University of Science and Technology China Data Analytics and Intelligence Lab Alibaba Group China Department of Computing Hong Kong Polytechnic University Hong Kong Trustworthy Machine Learning Lab School of Computer Science University of Sydney Australia School of Mathematics and Statistics University of Melbourne Australia

machine learning in the context of noise is a challenging but practical setting to plenty of real-world applications. Most of the previous approaches in this area focus on the pairwise relation (casual or correlational relationship) with noise, such as learning with noisy labels. However, the group noise, which is parasitic on the coarse-grained accurate relation with the fine-grained uncertainty, is also universal and has not been well investigated. The challenge under this setting is how to discover true pairwise connections concealed by the group relation with its fine-grained noise. To overcome this issue, we propose a novel Max-Matching method for learning with group noise. Specifically, it utilizes a matching mechanism to evaluate the relation confidence of each object (cf. Figure 1) w.r.t. the target, meanwhile considering the Non-IID characteristics among objects in the group. Only the most confident object is considered to learn the model, so that the fine-grained noise is mostly dropped. The performance on a range of real-world datasets in the area of several learning paradigms demonstrates the effectiveness of Max-Matching. Copyright © 2021, The Authors. All rights reserved.

关键词： machine learning

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Hierarchical Bayesian approach for adaptive integration of Bragg peaks in time-of-flight neutron scattering data

arXiv

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arXiv 2024年

作者： Reshniak, Viktor Wang, Xiaoping Zhang, Guannan Liu, Siyan Yin, Junqi Data Analysis and Machine Learning Group Oak Ridge National Laboratory 1 Bethel Valley Rd Oak RidgeTN37830 United States Single Crystal Diffraction Oak Ridge National Laboratory 1 Bethel Valley Rd Oak RidgeTN37830 United States Computational Earth Sciences Group Oak Ridge National Laboratory 1 Bethel Valley Rd Oak RidgeTN37830 United States Analytics and AI Methods at Scale Oak Ridge National Laboratory 1 Bethel Valley Rd Oak RidgeTN37830 United States

The Spallation Neutron Source (SNS) at Oak Ridge National laboratory (ORNL) operates in the event mode. Time-of-flight (TOF) information about each detected neutron is collected separately and saved as a descriptive entry in a database enabling unprecedented accuracy of the collected experimental data. Nevertheless, the common data processing pipeline still involves the binning of data to perform analysis and feature extraction. For weak reflections, improper binning leads to sparse histograms with low signal-to-noise ratios, rendering them uninformative. In this study, we propose the Bayesian approach for the identification of Bragg peaks in TOF diffraction data. The method is capable of adaptively handling the varying sampling rates found in different regions of the reciprocal space. Unlike histogram fitting methods, our approach focuses on estimating the true neutron flux function. We accomplish this by employing a profile fitting algorithm based on the event-level likelihood, along with a multiresolution histogram-level prior. By using this approach, we ensure that there is no loss of information due to data reduction in strong reflections and that the search space is appropriately restricted for weak reflections. To demonstrate the effectiveness of our proposed model, we apply it to real experimental data collected at the TOPAZ single crystal diffractometer at SNS. Copyright © 2024, The Authors. All rights reserved.

关键词： Diffraction

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Metadata Concepts for Advancing the Use of Digital Health Technologies in Clinical Research

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Digital Biomarkers 2019年第3期3卷 116-132页

作者： Badawy, Reham Hameed, Farhan Bataille, Lauren Little, Max A. Claes, Kasper Saria, Suchi Cedarbaum, Jesse M. Stephenson, Diane Neville, Jon Maetzler, Walter Espay, Alberto J. Bloem, Bastiaan R. Simuni, Tanya Karlin, Daniel R. School of Computer Science University of Birmingham Birmingham United Kingdom Digital Medicine and Pfizer Innovation Research Lab Early Clinical Development Pfizer Inc. CambridgeMA United States College of Computer and Information Science Northeastern University BostonMA United States Analytics Informatics and Business Intelligence Chief Digital Office Pfizer Inc. New YorkNY United States Michael J. Fox Foundation for Parkinson's Research New YorkNY United States Media Lab Massachusetts Institute of Technology CambridgeMA United States UCB Biopharma Brussels Belgium Machine Learning and Healthcare Laboratory Departments of Computer Science Statistics and Health Policy Malone Center for Engineering in Healthcare Armstrong Institute for Patient Safety and Quality Johns Hopkins University BaltimoreMD United States Biogen CambridgeMA United States Critical Path Institute TucsonAZ United States Clinical Data Interchange Standards Consortium AustinTX United States Department of Neurology Christian Albrecht University Kiel Germany James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders University of Cincinnati CincinnatiOH United States Department of Neurology Donders Institute for Brain Cognition and Behavior Radboud University Medical Center Nijmegen Netherlands Department of Neurology Gardner Center for Parkinson's Disease and Movement Disorders UC Gardner Neuroscience Institute University of Cincinnati CincinnatiOH United States Tufts University School of Medicine BostonMA United States HealthMode New YorkNY United States School of Engineering and Applied Science Aston University BirminghamB47ET United Kingdom

Digital health technologies (smartphones, smartwatches, and other body-worn sensors) can act as novel tools to aid in the diagnosis and remote objective monitoring of an individual's disease symptoms, both in clinical care and in research. Nonetheless, such digital health technologies have yet to widely demonstrate value in clinical research due to insufficient data interpretability and lack of regulatory acceptance. Metadata, i.e., data that accompany and describe the primary data, can be utilized to better understand the context of the sensor data and can assist in data management, data sharing, and subsequent data analysis. The need for data and metadata standards for digital health technologies has been raised in academic and industry research communities and has also been noted by regulatory authorities. Therefore, to address this unmet need, we here propose a metadata set that reflects regulatory guidelines and that can serve as a conceptual map to (1) inform researchers on the metadata they should collect in digital health studies, aiming to increase the interpretability and exchangeability of their data, and (2) direct standard development organizations on how to extend their existing standards to incorporate digital health technologies. The proposed metadata set is informed by existing standards pertaining to clinical trials and medical devices, in addition to existing schemas that have supported digital health technology studies. We illustrate this specifically in the context of Parkinson's disease, as a model for a wide range of other chronic conditions for which remote monitoring would be useful in both care and science. We invite the scientific and clinical research communities to apply the proposed metadata set to ongoing and planned research. Where the proposed metadata fall short, we ask users to contribute to its ongoing revision so that an adequate degree of consensus can be maintained in a rapidly evolving technology landscape. © 2019 The Author(s

关键词： Metadata

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Accurately predicting anticancer peptide using an ensemble of heterogeneously trained classifiers

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Informatics in Medicine Unlocked 2023年 42卷

作者： Azim, Sayed Mehedi Sabab, Noor Hossain Nuri Noshadi, Iman Alinejad-Rokny, Hamid Sharma, Alok Shatabda, Swakkhar Dehzangi, Iman Center for Computational and Integrative Biology Rutgers University Camden 08102 NJ United States Department of Computer Science and Engineering United International University Plot 2 United City Madani Avenue BaddaDhaka 1212 Bangladesh Department of Bioengineering University of California Riverside 92507 CA United States BioMedical Machine Learning Lab The Graduate School of Biomedical Engineering The University of New South Wales (UNSW Sydney) Sydney NSW 2052 Australia UNSW Data Science Hub UNSW Sydney Sydney NSW 2052 Australia Health Data Analytics Program AI-enabled Processes Research Centre Macquarie University Sydney 2109 Australia Institute for Integrated and Intelligent Systems Griffith University Brisbane Australia Laboratory for Medical Science Mathematics RIKEN Center for Integrative Medical Sciences Yokohama 230-0045 Japan Department of Computer Science Rutgers University Camden 08102 NJ United States

The use of therapeutic peptides for the treatment of cancer has received tremendous attention in recent years. Anticancer peptides (ACPs) are considered new anticancer drugs which have several advantages over chemistry-based drugs including high specificity, strong tumor penetration capacity, and low toxicity level for normal cells. Due to the rise of experimentally verified bioactive peptides, several in silico approaches became imperative for the investigation of the characteristics of ACPs. In this paper, we proposed a new machine learning tool named iACP-RF that uses a combination of several sequence-based features and an ensemble of three heterogeneously trained Random Forest classifiers to accurately predict anticancer peptides. Experimental results show that our proposed model achieves an accuracy of 75.9% which outperforms other state-of-the-art methods by a significant margin. We also achieve 0.52, 75.6%, and 76.2% in terms of Matthews Correlation Coefficient (MCC), Sensitivity, and Specificity, respectively. iACP-RF as a standalone tool and its source code are publicly available at: https://***/MLBC-lab/iACP-RF. © 2023 The Authors

关键词： Anticancer peptides Ensemble learning Feature extraction Heterogeneous classifiers machine learning Random Forest

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Evaluating the Accuracy and Reliability of Real-World Digital Mobility Outcomes in Older Adults After Hip Fracture: Cross-Sectional Observational Study

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JMIR formative research 2025年 9卷 e67792页

作者： Martin A Berge Anisoara Paraschiv-Ionescu Cameron Kirk Arne Küderle Encarna Micó-Amigo Clemens Becker Andrea Cereatti Silvia Del Din Monika Engdal Judith Garcia-Aymerich Karoline B Grønvik Clint Hansen Jeffrey M Hausdorff Jorunn L Helbostad Carl-Philipp Jansen Lars Gunnar Johnsen Jochen Klenk Sarah Koch Walter Maetzler Dimitrios Megaritis Arne Müller Lynn Rochester Lars Schwickert Kristin Taraldsen Beatrix Vereijken Department of Neuromedicine and Movement Science Norwegian University of Science and Technology Trondheim Norway. Laboratory of Movement Analysis and Measurement Ecole Polytechnique Federale de Lausanne Lausanne Switzerland. Translational and Clinical Research Institute Faculty of Medical Sciences Newcastle University Newcastle Upon Tyne United Kingdom. Machine Learning and Data Analytics Lab Department Artificial Intelligence in Biomedical Engineering Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Germany. Geriatric Center Medical Faculty Heidelberg Heidelberg University Heidelberg Germany. Department of Geriatrics and Rehabilitation Robert Bosch Hospital Stuttgart Germany. Department of Electronics and Telecommunications Politecnico di Torino Turin Italy. National Institute for Health and Care Research Newcastle Biomedical Research Centre Newcastle University and the Newcastle Upon Tyne Hospitals NHS Foundation Trust Newcastle Upon Tyne United Kingdom. Barcelona Institute for Global Health Barcelona Spain. Department of Medicine and Life Sciences Universitat Pompeu Fabra Barcelona Catalonia Spain. CIBER Epidemiología y Salud Pública Madrid Spain. Department of Neurology University Hospital Schleswig-Holstein and Kiel University Kiel Germany. Center for the Study of Movement Cognition and Mobility Neurological Institute Tel Aviv Medical Center Tel Aviv Israel. Department of Physical Therapy Faculty of Medical & Health Sciences Tel Aviv University Tel Aviv Israel. Sagol School of Neuroscience Tel Aviv University Tel Aviv Israel. Rush Alzheimer's Disease Center Rush University Medical Center Chicago IL United States. Department of Orthopedic Surgery Rush Medical College Rush University Chicago IL United States. Department of Orthopaedic Surgery St. Olav's Hospital Trondheim Norway. Institute of Epidemiology and Medical Biometry Ulm University Ulm Germany. IB University of Health and Social Sciences Study Centre Stuttgart Stuttgart Ger

BACKGROUND:Algorithms estimating real-world digital mobility outcomes (DMOs) are increasingly validated in healthy adults and various disease cohorts. However, their accuracy and reliability in older adults after hip fracture, who often walk slowly for short durations, is underexplored. OBJECTIVE:This study examined DMO accuracy and reliability in a hip fracture cohort considering walking bout (WB) duration, physical function, days since surgery, and walking aid use. METHODS:In total, 19 community-dwelling participants were real-world monitored for 2.5 hours using a lower back wearable device and a reference system combining inertial modules, distance sensors, and pressure insoles. A total of 6 DMO estimates from 164 WBs from 58% (11/19) of the participants (aged 71-90 years; assessed 32-390 days after surgery; Short Physical Performance Battery [SPPB] scores of 3-12; gait speed range 0.39-1.34 m/s) were assessed against the reference system at the WB and participant level. We stratified by WB duration (all WBs, WBs of >10 seconds, WBs of 10-30 seconds, and WBs of >30 seconds) and lower versus higher SPPB scores and observed whether days since surgery and walking aid use affected DMO accuracy and reliability. RESULTS:Across WBs, walking speed and distance ranged from 0.25 to 1.29 m/s and from 1.7 to 436.5 m, respectively. Estimation of walking speed, cadence, stride duration, number of steps, and distance stratified by WB duration showed intraclass correlation coefficients (ICCs) ranging from 0.50 to 0.99 and mean relative errors (MREs) from -6.9% to 12.8%. Stride length estimation showed poor reliability, with ICCs ranging from 0.30 to 0.49 and MREs from 6.1% to 13.2%. Walking speed and distance ICCs in the higher-SPPB score group ranged from 0.85 to 0.99, and MREs ranged from -10.1% to -1.7%. In the lower-SPPB score group, walking speed and distance ICCs ranged from 0.17 to 0.99, and MREs ranged from 13.5% to 32.6%. There was no discernible effect of time since su

关键词： active aging cadence digital mobility assessment distance free living gait walking speed wearable device

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