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IEEE International Conference on Micro Electro Mechanical systems

作者： K. Naka T. Hashishin Jun Tamaki S. Konishi Graduate School of Science and Engineering Ritsumeikan University Japan Center of Promotion of the COE program Ritsumeikan University Japan Department of Applied Chemistry Ritsumeikan University Japan Department of Micro System Technology Ritsumeikan University Japan

This paper deals with a pyrolyzed polymer as a kind of carbon materials obtained by pyrolysis of polymers. Through the combination of micromachining of polymers and following pyrolysis process, we can obtain pyrolyzed polymer MEMS structures for various applications. This work focuses on pyrolyzed polymer as an absorbent of nitrogen dioxide sensor. The resistance of the developed sensor was dramatically decreased when the sensor was exposed to the NO 2 mixture gas. Through evaluations of dependence on pyrolysis temperature and operating temperature, it is found that higher pyrolysis temperature and higher operating temperature contribute to higher sensitivity against gas mixture of NO 2 .

关键词： Polymers Nitrogen Gas detectors Temperature sensors Organic materials Temperature dependence Raman scattering Electrodes Batteries Gases

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A novel gene carrier responding to intracellular signal protein kinase Cα

A novel gene carrier responding to intracellular signal prot...

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55th Society of Polymer Science Japan Symposium on Macromolecules

作者： Toita, Riki Kang, Jeong-Hun Jiang, Yuhua Mori, Takeshi Niidome, Takuro Ktayama, Yoshiki Graduate School of System Life Sciences Kyushu University 744 Motooka Nishi-ku Fukuoka 819-0395 Japan Department of Applied Chemistry Faculty of Engineering Kyushu University 744 Motooka Nishi-Ku Fukuoka 819-0395 Japan CREST Japan Science and Technology Corporation 4-1-8 Honcho Kawaguchi-shi Saitama 322-0012 Japan Center for Future Chemistry Kyushu University Grant-in-Aid for the 21st Century COE Program

Gene therapy has been expected as a medical approach to treat tumors, inheritable diseases and so on. For gene therapy, effective delivery of gene to the target tissue is vitally important. Previously, we have proposed a novel approach for gene therapy using a drug delivery system responding to cellular signal (D-RECS), especially to protein kinase C (PKC) α. PKCα plays an important role in the differentiation and proliferation of tumor cell. It was known that extraordinary activation of PKCα is seen in many cancers such as breast cancer, melanoma, liver cancer and so on. In this study, PKCα was used as a target protein kinase for D-RECS.

关键词： Genes

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D-RECS (3) development of functional polymers for inflammatory cells specific gene delivery system

D-RECS (3) development of functional polymers for inflammato...

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55th SPSJ Annual Meeting

作者： Asai, Daisuke Shoji, Yoko Kawamura, Kenji Oishi, Jun Kang, Jeong-Hun Sato, Yuko Niidome, Takuro Nakashima, Hideki Katayama, Yoshiki JST-CREST Kyushu University 744 Moto-oka Nishi-ku Fukuoka 819-0395 Japan Dept. of Microbiology St. Marianna University Dept. of Applied Chem. Fac. of Engineering Graduate School of System Life Sci. Center for Future Chemistry Grant-in-Aid for the 21St Century COE Program Kyushu University 744 Moto-oka Nishi-ku Fukuoka 819-0395 Japan

Recently, we have developed and proposed a new system of the intracellular signal-responsive gene regulation as cell specific gene delivery, and termed the new concept D-RECS. In the present study, we focused IκB kinase that regulates NF-κB activation. According to D-RECS strategy, acrylamide polymers containing a substrate peptide for IκB kinase were designed and synthesized. The synthetic polymers were first examined in the gel retardation assay for IκB kinase β (IKKβ) using recombinant IKKβ. A polymer showed the efficient binding activity for plasmid DNA and significant responses to IKKβ. When the polymer-reporter plasmid DNA complex was transfected into living cells, and then the reporter activity was measured under the condition with or without TNFα stimulation, the gene expression with TNFα was stronger than that without TNFα stimulation. The differences in the reporter activity were found to be well-correlated to the TNFα stimulation.

关键词： Functional polymers

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Enhancing Highway Geometric Design: Development of Interactive Virtual Reality Visualization system with Open-Source Technologies

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Transportation Research Record 2006年第1期1980卷 134 - 142页

作者： Kai Han Dan Middleton Alan Clayton Department of Civil Engineering University of Manitoba Room 246A Engineering Building 15 Gillson Street Winnipeg Manitoba R3T 5V6 Canada.TJKM Transportation Consultants 516 West Shaw Avenue Suite 200 Fresno CA 93704-2518. System Monitoring Program Texas Transportation Institute Texas A&M University System Gilchrist Room 142 3135 TAMU College Station TX 77843-3135. Department of Civil Engineering University of Manitoba Room 246A Engineering Building 15 Gillson Street Winnipeg Manitoba R3T 5V6 Canada.

Visualization based on virtual reality (VR) has gained increasingly wider recognition among transportation engineers and researchers because of advances in computer and VR technologies. The benefits of applying VR in transportation are well documented. However, many technical and financial issues hinder wide acceptance of this new technology in highway engineering design. Therefore, the concept of a custom-built, lightweight visualization system aimed at enhancing highway geometric design processes is developed. Capable of supporting the construction of a three-dimensional (3-D) road surface with accurate geometry and providing vehicle-based navigation with controlled driver perspectives, the visualization system is created by applying open-source VR modeling technology with proven key techniques. A systematic approach was taken to integrate data, create 3-D modules, and implement the visualization system as numerous case studies by using real-world data. The successful implementation proves the design concept, shows great potential for supporting the engineering design process, and opens new opportunities for further development.

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07S-SIW-074 Conceptual modeling for the probability of raid annihilation (PRA) testbed

07S-SIW-074 Conceptual modeling for the probability of raid ...

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Spring Simulation Interoperability Workshop 2007, 07 Spring SIW

作者： Reading, Richard Trbovich, Sarah Malone, Shala Systems Engineering Division VisiTech Ltd. 99 Canal Center Plaza Alexandria VA 22314 United States Navy Program Executive Office Integrated Warfare Systems PEO IWS 7D Washington Navy Yard 1333 Isaac Hull Avenue DC 20376 United States HLA Federation Developments U.S. Navy Ship Combat System United States Department of M and S PEO IWS United States NATO Sub-Group 61 United States

ISBN: (纸本)9781604239232

A U.S. Navy enterprise methodology has been established for consistent ship self defense operational test and evaluation (OT&E) across all ship classes. A cornerstone of the Navy T&E Enterprise is the Probability of Raid Annihilation (PRA) Testbed. The Navy PRA Testbed implements HLA federated simulations of ship combat system elements against independent, reactive threat raids in a common environment to formulate an overall combat system assessment. The LPD 17 ship class is the first to implement a PRA Testbed baseline as a formal component of ship class OT&E. Products and lessons from the LPD 17 baseline are being transitioned to multiple ship classes including DDG 1000, LHA 6, LCS, and CVN 21. While the PRA Testbed LPD 17 baseline adheres to the Federation Development and Execution Process (FEDEP), conceptual modeling is a particularly distinctive feature. The systems engineering Concept Model (SECM) is an extension of the 'Conceptual Model' product of FEDEP step 2 that broadens the impact of conceptual modeling in the SE process and specifically supports federation Verification, Validation, and Accreditation (VV&A). Accreditation of the PRA Testbed for LPD 17 operational testing is a challenging proposition. The purpose of the SECM is to provide a central documentation tool for stakeholders to 'view' the Testbed capabilities and limitations from multiple perspectives. The SECM is divided into 3 views, which generally follow sequential stages in Testbed system engineering: system View, Model View, and Federate View. Each view is intended to reveal, address, and resolve a particular class of issues for PRA Testbed accreditation. Explanation of engineering judgments is inclusive to the documentation. The SECM is a not an 'easy button' for making engineering decisions or wishing away limitations. Yet, it does create a framework of deliberate intent for making decisions and accountability for limits in capability. The SECM also establishes a persistent documentation

关键词： Testbeds

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Antarctic Internet Data Distribution (Antarctic-IDD) system

Antarctic Internet Data Distribution (Antarctic-IDD) system

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86th AMS Annual Meeting

作者： Lazzara, Matthew A. Langbauer, Gabe Manning, Kevin W. Redinger, Robert Seefeldt, Mark W. Vehorn, Robert Yoksas, Tom Antarctic Meteorological Research Center Space Science and Engineering Center University of Wisconsin-Madison 1225 West Dayton Street Madison WI 53706 United States Byrd Polar Research Center Ohio State University Columbus OH United States Mesoscale and Microscale Meteorology Division National Center for Atmospheric Research Boulder CO United States National Scientific Balloon Facility Palestine TX United States Program in Atmospheric and Oceanic Sciences University of Colorado - Boulder Boulder CO United States SPAWAR System Center Charleston Aviation Technical Services Charleston SC United States Unidata Program Center National Center for Atmospheric Research Boulder CO United States

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Medical equipment management strategies

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Biomedical Instrumentation and Technology 2006年第3期40卷 233-237页

作者： Wang, Binseng Furst, Emanuel Cohen, Ted Keil, Ode R. Ridgway, Malcolm Stiefel, Robert JCAHO Clinical Engineering Standards Study Group Program Support and Quality Assurance ARAMARK Healthcare's Clinical Technology Services Charlotte NC United States LLC Tucson AZ United States Clinical Engineering University of California Davis Health System Sacramento CA United States Ode Keil Consulting Group Kildeer IL United States MasterPlan Inc. Chatsworth CA United States Clinical Engineering Department University of Maryland Medical Center Baltimore MD United States ARAMARK Healthcare's Clinical Technology Services 10510 Twin Lakes Pkwy Charlotte NC 28269 United States

Clinical engineering professionals need to continually review and improve their management strategies in order to keep up with improvements in equipment technology, as well as with increasing expectations of health care organizations. In the last 20 years, management strategies have evolved from the initial obsession with electrical safety to flexible criteria that fit the individual institution's needs. Few hospitals, however, are taking full advantage of the paradigm shift offered by the evolution of Joint Commission standards. The focus should be on risks caused by equipment failure, rather than on equipment with highest maintenance demands. Furthermore, it is not enough to consider risks posed by individual pieces of equipment to individual patients. It is critical to anticipate the impact of an equipment failure on larger groups of patients, especially when dealing with one of a kind, sophisticated pieces of equipment that are required to provide timely and accurate diagnoses for immediate therapeutic decisions or surgical interventions. A strategy for incorporating multiple criteria to formulate appropriate management strategies is provided in this article.

关键词： Biomedical engineering

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engineering capacity building in Latin America

Engineering capacity building in Latin America

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113th Annual ASEE Conference and Exposition, 2006

作者： Morell, Lueny Abreu, Alice Cehelsky, Marta Jones, Russel Marcek, Dan Ramos, Teofilo Scavarda Do Carmo, Luiz Spencer, John Yutronic, Jorge Hewlett-Packard United States Hewlett Packard Company United States OAS Office of Science Technology and Education United States Inter American Development Bank United States Department of Sustainable Development InterAmerican Development Bank United States World Expertise LLC United States MIT United States Department of Engineering Ohio State University United States Department of Engineering University of Massachusetts United States Boston University United States University of Delaware United States HP University Relations Instituto Tecnologico de Monterrey Mexico Institute of Technology System Monterrey Mexico Pontifical Catholic University of Rio de Janeiro Brazil Microsoft Corp. United States Microsoft Research External Research and Programs Chile Directive Council of Fundación Chile Chile Executive Committee of the EXPLORA Program CONICYT for the Diffusion of Science and Technology Chile Development and Programs of CONICYT Chile KYBER Movilmaster

The widening, intensifying, speeding up, and growing impact of worldwide interconnectedness, better known as globalization is forcing countries and regions develop strategies to enhance their economies to better compete worldwide. Science, technology, engineering and innovation play a fundamental role in the creation of wealth, economic development and in the improvement of the quality of life for all citizens. This paper addresses the role of capacity building and engineering education as foundations to develop national/regional economic development strategies in Latin America. Contributors from various sectors (academia, non-governmental organizations, industry and government) share their roles, viewpoints and perspectives. © American Society for engineering Education, 2006.

关键词： engineering education

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MBOC: The New Optimized Spreading Modulation Recommended for GALILEO L1 OS and GPS L1C

MBOC: The New Optimized Spreading Modulation Recommended for...

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IEEE Symposium on Position Location and Navigation (PLANS)

作者： G.W. Hein J.-A. Avila-Rodriguez S. Wallner A.R. Pratt J. Owen J. Issler J.W. Betz C.J. Hegarty S. Lenahan J.J. Rushanan A.L. Kraay T.A. Stansell University FAF Munich University of the Federal Armed Forces Munich Institute of Geodesy and Navigation University of the Federal Armed Forces Munich Germany University of Nottingham IESSG UK Air Systems Department Navigation Systems DSTL Transmission Techniques and signal processing department CNES The MITRE Corporation Center for Advanced Aviation System Development The MITRE Corporation Engineering and Advanced Technology Branch GPS Joint Program Office MITRE Corporation Signal Processing Group MITRE Corporation Bedford MA Stansell Consulting

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Reésumés des présentations

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Basic and Clinical Andrology 2007年第2期17卷 154-173页

作者： Russell C. jones Jean-Louis Dacheux Brett Nixon Heath W. Ecroyd Susan H. Hall Yashwanth Radhakrishnan Peter Petrusz Frank S. French Suresh Yenugu W. Avellar Hiroko Takano R. Jones S. Vijayaraghavan Robert Sullivan Julie Girouard Gilles Frenette Sylvie Breton Daniel G. Cyr Gail A. Cornwall Matti Poutanen Kichiya Suzuk Xiuping Yu Marie-Claire Orgebin-Crist Robert J. Matusik K. P. Roberts M. A. Nolan K. M. Ensrud L. B. Piehl J. L. Wooters D. S. Johnston D. W. Hamilton B. Robaire S. Seenundun H. Hamzeh S. A. Lamour B. T. Hinton M. M. Galdamez D. Bomgardner W. Bushman C. Cook J. Gipp M. F. Wilkinson A. Bhardwaj H. W. Song S. Shanker J. Maclean T. T. Turner F. Saez E. Chabory R. Cadet P. Vernet J. M. A. Lobaccaro J. R. Drevet S. A. Jelinsky Terry T. Turner Jose L. Tomsig Daniel S. Johnston Joshua N. Finger Scott A. Jelinsky R. John Aitken Mark Baker Yun Hwa Lee Minjie Lin U. Gottwald G. Langer P. S. Cuasnicu D. J. Cohen V. Da Ros D. Busso J. Maldera N. Goldweic T. G. Cooper J. L. Dacheux F. Dacheux M. Belghaz Y. Lanson M. Jacob K. Barteczko Åke Lundwall U. F. Habenicht DAVID W. Hamilton Kenneth P. Roberts Discipline of Biological Sciences University of Newcastle NSW Australia 2308 Physiologie de la Reproduction et des Comportements UMR INRA-CNRS 6073 37380 Nouzilly France Department of Chemistry University of Adelaide SA Australia 5005 Discipline of Biological Sciences Faculty of Science and it University of Newcastle NSW Australia Laboratories for Reproductive Biology University of North Carolina at Chapel Hill 27599-7505 USA Department of Biochemistry and Molecular Biology Pondicherry Central University 605014 Pondicherry India Section of Experimental Endocrinology Department of Pharmacology Universidade Federal de São Paulo 04044-020 SP Brazil Department of Functional Morphology Hokkaido University Graduate School of Medicine 060-8638 Sapporo Japan The Babraham Institute CB2 4AT Cambridge UK Ce travail est financé par le BBSRC UK Department of Biological Sciences Kent State University 44242 Kent OH USA Centre de Recherche en Biologie de la Reproduction and Département d’Obstétrique-Gynécologie Université Laval Québec Canada Etudes financées par ’Canadian Institutes for Health Research et « Natural Science and Engineering Research Council of Canada » Canada Program in Membrane Biology Massachusetts General Hospital Harvard Medical School Boston MA USA INRS-Institut Armand-Frappier Université du Québec 245 Hymus Bvd. H9R 1G6 Pointe-Claire QC Canada Texas Tech University Health Sciences Center USA Department of Physiology Institute of Biomedicine University of Turku Finland Tohoku University Sendai JAPAN Vanderbilt University Medical Center Nashville Tennessee USA Depts of Urologic Surgery and Integrative Biology & Physiology 6-125 Jackson Hall 321 Church St. SE 55455 Minneapolis MN USA Contraception Women’s Health & Musculoskeletal Biology Wyeth Research 500 Arcola Rd 19426 Collegeville PA Department of Pharmacology and Therapeutics and of Obstetrics and Gynecology McGill University Montreal QC Canada Department of Cell Biology Univer

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