检索结果-内蒙古大学图书馆

Impact of particulate matter 2.5 on placental ultrastructure including mitochondrial damage through oxidative stress

引用

Reproductive Toxicology 2025年 136卷 108973页

作者： Gain Lee Jung Mi Han Young-Ah You Yoon-Young Go Sunwha Park Young Min Hur Soo Min Kim Ki-Hwan Han Young Ju Kim Graduate Program in System Health Science and Engineering Ewha Womans University Republic of Korea Nano Imaging Laboratory in the Ewha Medical Research Institute Ewha Womans University Republic of Korea Department of Obstetrics and Gynecology and Ewha Medical Institute College of Medicine Ewha Womans University Republic of Korea Department of Anatomy College of Medicine Ewha Womans University Republic of Korea

Introduction Particulate matter 2.5 (PM 2.5 ) refers to fine particles with a diameter of less than 2.5μm, associated with adverse pregnancy outcomes. The study aims to determine whether elevated prenatal PM 2.5 levels were associated with alterations in the ultrastructure of the placenta and mitochondria, potentially linked to oxidative stress. Methods The placental samples were collected from the Air Pollution on Pregnancy Outcome (APPO) cohort and were classified into two groups based on PM 2.5 exposure levels: the High group (> 15 μg/m³; n = 9) and the Low group (≤ 15 μg/m³; n = 8). Transmission electron microscopy was used to assess the ultrastructure of the placenta, specifically the syncytiotrophoblast area. The structure of the mitochondria in the fetal capillaries was also analyzed. Malondialdehyde (MDA) and superoxide dismutase 2 (SOD2) were quantified by using enzyme-linked immunosorbent assays (ELISA). Results The High group placenta showed ultrastructural changes including microvilli loss, basement membrane thickening, vacuolation and swollen endoplasmic reticulum (ER). Microvilli were significantly shortened and lost in the High group ( P  < 0.005). Swollen vacuoles, ER stress, and basement membrane thickening were observed in High group syncytiotrophoblast ( P  < 0.005). Mitochondria in fetal capillaries from the High group were also damaged, showing disrupted double membranes and cristae ( P  < 0.05). MDA and SOD2 levels were significantly upregulated in the High group ( P  < 0.05). Conclusion Prenatal exposure to PM 2.5 may be associated with alterations of placental ultrastructure and mitochondrial damage in fetal capillaries, potentially mediated by oxidative stress, as indicated by elevated levels of MDA and SOD2.

关键词： APPO Air Pollution on Pregnancy Outcome BMI Body mass index EDS Energy-dispersive X-ray spectroscopy ELISA Enzyme-linked immunosorbent assay ER Endoplasmic reticulum GDM Gestational diabetes mellitus HCG Human Chorionic gonadotrophin IUGR Intrauterine growth restriction LTE Long-term evolution MDA Malondialdehyde MMP Mitochondrial membrane potential NICU Neonatal intensive care unit OXPHOS Oxidative phosphorylation PlGF Placental growth factor PM 2.5 Particulate matter 2.5 PTB Preterm birth ROS Reactive oxygen species SGA Small gestational age SOD2 Superoxide dismutase 2 TEM Transmission electron microscopy Particulate matter 2.5 Placenta Syncytiotrophoblast Transmission electron microscopy Oxidative stress Mitochondrial damage

来源：评论

学校读者我要写书评

暂无评论

Toward Foundational Model for Sleep Analysis Using a Multimodal Hybrid Self-Supervised Learning Framework

arXiv

引用

arXiv 2025年

作者： Lee, Cheol-Hui Kim, Hakseung Yoon, Byung C. Kim, Dong-Joo Department of Brain and Cognitive Engineering Korea University Seoul Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul Korea Republic of Department of Radiology Stanford University School of Medicine VA Palo Alto Health Care System Palo AltoCA United States Department of Neurology Korea University College of Medicine Seoul Korea Republic of

Sleep is essential for maintaining human health and quality of life. Analyzing physiological signals during sleep is critical in assessing sleep quality and diagnosing sleep disorders. However, manual diagnoses by clinicians are time-intensive and subjective. Despite advances in deep learning that have enhanced automation, these approaches remain heavily dependent on large-scale labeled datasets. This study introduces SynthSleepNet, a multimodal hybrid self-supervised learning framework designed for analyzing polysomnography (PSG) data. SynthSleepNet effectively integrates masked prediction and contrastive learning to leverage complementary features across multiple modalities, including electroencephalogram (EEG), electrooculography (EOG), electromyography (EMG), and electrocardiogram (ECG). This approach enables the model to learn highly expressive representations of PSG data. Furthermore, a temporal context module based on Mamba was developed to efficiently capture contextual information across signals. SynthSleepNet achieved superior performance compared to state-of-the-art methods across three downstream tasks: sleep-stage classification, apnea detection, and hypopnea detection, with accuracies of 89.89%, 99.75%, and 89.60%, respectively. The model demonstrated robust performance in a semi-supervised learning environment with limited labels, achieving accuracies of 87.98%, 99.37%, and 77.52% in the same tasks. These results underscore the potential of the model as a foundational tool for the comprehensive analysis of PSG data. SynthSleepNet demonstrates comprehensively superior performance across multiple downstream tasks compared to other methodologies, making it expected to set a new standard for sleep disorder monitoring and diagnostic systems. The source code is available at https://***/dlcjfgmlnasa/SynthSleepNet. Copyright © 2025, The Authors. All rights reserved.

关键词： Self-supervised learning

来源：评论

学校读者我要写书评

暂无评论

Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment of drinking water: A mini review

引用

Frontiers of Environmental Science & engineering 2019年第3期13卷 3-11页

作者： Virender K.Sharma Xin Yu Thomas J.McDonald Chetan Jinadatha Dionysios D.Dionysiou Mingbao Feng Department of Environmental and Occupational Health School of Public Health Texas A&M University College Station TX 77843 USA Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China Central Texas Veterans Health Care System Temple TX 76504 USA College of Medicine Texas A&M Health Science Center Bryan TX 77807 USA Environmental Engineering and Science Program Department of Chemical and Environmental Engineering (DChEE) 705 Engineering Research Center University of Cincinnati Cincinnati OH 45221 USA

Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) have been recognized as one of the biggest public health issues of the 21 st century. Both ARB and ARGs have been determined in water after treatment with conventional disinfectants. Ultraviolet (UV) technology has been seen growth in application to disinfect the water. However, UV method alone is not adequate to degrade ARGs in water. Researchers are investigating the combination of UV with other oxidants (chlorine, hydrogen peroxide (H2O2), peroxymonosulfate (PMS), and photocatalysts) to harness the high reactivity of produced reactive species (C1-, C1O -, Cl2-,-OH, and SO4-_) in such processes with constituents of cell (e.g., deoxyribonucleic acid (DNA) and its components) in order to increase the degradation efficiency of ARGs. This paper briefly reviews the current status of different UV-based treatments (UV/chlorination, UV/H2O2, UV/PMS, and UV-photocatalysis) to degrade ARGs and to control horizontal gene transfer (HGT) in water. The review also provides discussion on the mechanism of degradation of ARGs and application of q-PCR and gel electrophoresis to obtain insights of the fate of ARGs during UV-based treatment processes.

关键词： Antibiotic resistance bacteria Advanced oxidation processes Disinfection Reactive chlorine species Sulfate radicals Reactive oxygen species

来源：评论

学校读者我要写书评

暂无评论

Association of paternal cadmium and other heavy metal exposure to birth outcomes using propensity score matching.

引用

Chemosphere 2023年第Pt 1期311卷 136792页

作者： Lee, Yu Min Kim, Yangho Park, Hyesook Hong, Yun-Chul Ha, Mina Kim, Young Ju Ha, Eun Hee Department of Occupational and Environmental Medicine Severance Hospital Seoul Korea Republic of Department of Occupational and Environmental Medicine Ulsan University Hospital University of Ulsan College of Medicine Ulsan Korea Republic of Department of Preventive Medicine College of Medicine Ewha Medical Research Center Ewha Womans University Seoul Korea Republic of Graduate Program in System Health Science and Engineering Ewha Womans University Korea Republic of Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea Republic of Department of Preventive Medicine College of Medicine Dankook University Cheonan Korea Republic of Department of Obstetrics and Gynecology College of Medicine Ewha Womans University Seoul Korea Republic of Department of Environmental Medicine College of Medicine Ewha Womans University Seoul Korea Republic of

Background: Human exposure to cadmium has various effects on health, especially on male reproductive organs. Although it is widely known that prenatal maternal cadmium exposure can affect birth outcomes, the effect of paternal exposure to cadmium remains unclear. Objectives: This study aimed to evaluate the effect of paternal cadmium exposure on fetal growth by considering maternal cadmium exposure and exposure to other heavy metals, namely mercury and lead. Methods: The Mothers and Children's Environmental Health (MOCEH) study is a prospective birth cohort study in Korea. Overall, 1313 families (father-mother-child triple) without child abnormalities and who completed paternal whole blood cadmium assessments were included in this study. Families were divided into two subgroups based on the blood sampling periods, namely early and late pregnancy. Subjects were selected as follows: one family triple with a high level of paternal cadmium and two triples with low levels of paternal cadmium, using the method of propensity score matching. And linear regression analyses were performed. Results: The group with high paternal cadmium exposure (80% or more;1.93 μg/L) had lower birth weight infants compared to the group with low cadmium concentrations (β(se) = −0.21(0.10);p-value = 0.0283). After stratification by infant sex, prenatal paternal cadmium exposure significantly reduced the birth weight of females in subgroups of different sampling times, namely early pregnancy (β(se) = −0.52 (0.22);p-value = 0.0170) and late pregnancy (β(se) = −0.43 (0.18);p-value = 0.0160). Finally, after performing propensity score matching in the early pregnancy measurement group, it was found that the prenatal exposure of father to cadmium significantly reduced birth weight in females (β(se) = −0.72(0.25);p-value = 0.0047). Conclusion: This study assessed the effect of paternal cadmium exposure on birth outcomes in family units consisting of a father, mother, and child. Prenatal paternal cadmi

关键词： Cadmium

来源：评论

学校读者我要写书评

暂无评论

Plug-and-Play Stability for Intracortical Brain-Computer Interfaces: A One-Year Demonstration of Seamless Brain-to-Text Communication

arXiv

引用

arXiv 2023年

作者： Fan, Chaofei Hahn, Nick Kamdar, Foram Avansino, Donald Wilson, Guy H. Hochberg, Leigh Shenoy, Krishna V. Henderson, Jaimie M. Willett, Francis R. Bio-X Program Stanford University United States Department of Neuroscience Stanford University United States Department of Neurosurgery Stanford University United States Department of Neurobiology Stanford University United States Department of Bioengineering Stanford University United States Department of Computer Science Stanford University United States Wu Tsai Neurosciences Institute Stanford University United States Howard Hughes Medical Institute Stanford University United States Department of Electrical Engineering Stanford University United States School of Engineering Carney Institute for Brain Science Brown University United States VA RR&D Center for Neurorestoration and Neurotechnology VA Providence Healthcare System United States Center for Neurotechnology and Neurorecovery Department of Neurology Massachusetts General Hospital Harvard Medical School United States

Intracortical brain-computer interfaces (iBCIs) have shown promise for restoring rapid communication to people with neurological disorders such as amyotrophic lateral sclerosis (ALS). However, to maintain high performance over time, iBCIs typically need frequent recalibration to combat changes in the neural recordings that accrue over days. This requires iBCI users to stop using the iBCI and engage in supervised data collection, making the iBCI system hard to use. In this paper, we propose a method that enables self-recalibration of communication iBCIs without interrupting the user. Our method leverages large language models (LMs) to automatically correct errors in iBCI outputs. The self-recalibration process uses these corrected outputs ("pseudo-labels") to continually update the iBCI decoder online. Over a period of more than one year (403 days), we evaluated our Continual Online Recalibration with Pseudo-labels (CORP) framework with one clinical trial participant. CORP achieved a stable decoding accuracy of 93.84% in an online handwriting iBCI task, significantly outperforming other baseline methods. Notably, this is the longest-running iBCI stability demonstration involving a human participant. Our results provide the first evidence for long-term stabilization of a plug-and-play, high-performance communication iBCI, addressing a major barrier for the clinical translation of iBCIs. Copyright © 2023, The Authors. All rights reserved.

关键词： Brain computer interface

来源：评论

学校读者我要写书评

暂无评论

Harnessing enhanced stability and high-rate capability in lithium-ion batteries using synergistic SnS 2 /MoS 2 2D nanostructures with optimized conversion/alloying reactions

引用

Journal of Alloys and Compounds 2024年 984卷

作者： Boya Venugopal Ravi Mudike Ranjith Ravi Prasanta Kumar Sahoo Abhishek Tripathi Indrajit Shown Institute of Atomic and Molecular Sciences Academia Sinica Taipei 10617 Taiwan Nanoscience and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 11529 Taiwan Department of Engineering and System Science National Tsing Hua University Hsinchu 30013 Taiwan School of Science Minzu University of China Beijing 100081 China Department of Chemistry Hindustan Institute of Technology and Science Chennai 603103 India National Institute of Hydrology Jalvigyan Bhawan Roorkee 247667 India Department of Metallurgical and Material Engineering Malaviya National Institute of Technology Jaipur 302017 India

Recently, there has been a significant interest in the application of SnS 2 /MoS 2 2D nanostructure composites in lithium-ion batteries (LIBs) due to their advantageous conversion, intercalation, and alloying reactions, leading to high capacity during charge and discharge cycles. In this study, we successfully synthesized SnS 2 /MoS 2 composites with a 2D-nanoplate morphology using a single-step hydrothermal method. Specifically, the optimized SnS 2 /MoS 2 -3:1 composite was tested as anodes in coin cell LIBs, demonstrating an impressive capacity of 710 mAh/g at a current density of 500 mA/g, along with outstanding stability (800 cycles) and remarkable rate capability compared to other composites. The excellent electrochemical performance of the SnS 2 /MoS 2 -3:1 composite can be attributed to the moderately coupled SnS 2 and MoS 2 2D-nanosheets, which provide short lithium-ion transportation lengths, low charge transfer resistance, and dominant capacitive behavior.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Hospital Admission Risks and Excess Costs for Neurological Symptoms Attributable to Long-Term Exposure to Fine Particulate Matter in New York State, USA

SSRN

引用

SSRN 2023年

作者： Min, Jieun Lee, Whanhee Bell, Michelle L. Kim, Yijun Heo, Seulkee Kim, Ga Eun Kim, Jee Hyun Yun, Ji Young Kim, Soo In Schwartz, Joel Ha, Eunhee Department of Environmental Medicine School of Medicine Ewha Womans University Seoul Korea Republic of Graduate Program in System Health Science and Engineering College of Medicine Ewha Womans University Seoul Korea Republic of Ewha Womans University College of Medicine Seoul Korea Republic of School of Biomedical Convergence Engineering College of Information and Biomedical Engineering Pusan National University Yangsan Korea Republic of Yale School of the Environment Yale University New HavenCT United States Department of Psychiatry Ewha Womans University Mokdong Hospital Ewha Womans University College of Medicine Seoul Korea Republic of Department of Neurology Ewha Womans University Seoul Hospital Ewha Womans University College of Medicine Seoul Korea Republic of Department of Environmental Health Harvard T H Chan School of Public Health BostonMA United States Department of Medical Science Ewha Womans University School of Medicine Ewha Medical Research Institute Seoul Korea Republic of

Background: Although emerging evidence suggests that PM2.5 is linked to neurological symptoms (NSs) via neuroinflammation, relevant studies are scarce. This study aimed to investigate the risks and excess costs of hospital admission for five NSs—fatigue, headache, dizziness, convulsion, and paralysis—attributable to long-term exposure to PM2.5 in New York State, ***: We analyzed the New York Statewide Planning and Research Cooperative system (SPARCS) from 2010 to 2016. A Bayesian hierarchical model with integrated nested Laplace approximations was performed to estimate the risks and excess costs of hospital admission for NSs due to long-term exposure to PM2.5 at the county ***: A 1 µg/m3 increase in lag 0–1 years PM2.5 was associated with an increased risk of headache and convulsion by 1.06 (1.01, 1.11) and 1.04 (1.01, 1.06), respectively. The excess hospital admission cost for five NSs attributable to lag 0–1 years PM2.5 above the new World Health Organization guideline (annual standard: 5 µg/m3) was $200.24 (95% CI: 6.00, 376.96) million during 2011–2016, recording the highest for convulsion ($153.73 [95% CI: 63.61, 244.19] million).Conclusions: This study provides quantitative estimates of risks and excess costs for NSs attributable to long-term PM2.5 and suggests that policies that reduce long-term PM2.5 concentration in accordance with the new WHO air quality guidelines can yield substantial health and economic benefits related to NSs in the New York State population. © 2023, The Authors. All rights reserved.

关键词： Hierarchical systems

来源：评论

学校读者我要写书评

暂无评论

Publisher’s Note: “Ultraviolet nanosecond laser ablation of polyimide with thermal and nonthermal effects near threshold fluence” [J. Laser Appl. 34, 032004 (2022)]

引用

Journal of Laser Applications 2022年第3期34卷

作者： ChangSoon Han Muhammad Aleem Zahid Byungwoo Lee Jae-Yong Oh Youngkuk Kim Junsin Yi 1Laser Advanced System Industrialization Center Jeonnam Technopark Stiftung Jeollanam-do Jangseong-gun 57248 Republic of Korea 2Interdisciplinary Program in Photovoltaic System Engineering Sungkyunkwan University Suwon Gyeonggi-Do Suwon 16419 Republic of Korea 3Department of Electrical and Computer Engineering Sungkyunkwan University Suwon Gyeonggi-Do 16419 South Korea

This article was published online on 17 June 2022 with an error in the affiliations and corresponding author information. The affiliations and footnote appear c

关键词：

来源：评论

学校读者我要写书评

暂无评论

Corrigendum to “Synthesis and characterization of eco-friendly chitosan-based waterborne polyurethanes and their ultraviolet degradation properties” [Polymer Degradation and Stability, 233 (2025) 111169]

引用

Polymer Degradation and Stability 2025年 236卷

作者： Chun-Ta Wei Jhu-Lin You Kai-Yen Chin Shu Mei Chang Shun-Yi Jian An-Yu Cheng Department of Chemical & Materials Engineering Chung Cheng Institute of Technology National Defense University Taoyuan 335 Taiwan System Engineering and Technology Program National Chiao Tung University Hsinchu 300 Taiwan Institute of Organic and Polymeric Materials Research and Development Centre for Smart Textile Technology National Taipei University of Technology Taipei 10608 Taiwan Department of Material Engineering Ming Chi University of Technology New Taipei 24301 Taiwan Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei 243303 Taiwan

来源：评论

学校读者我要写书评

暂无评论

Visible light-driven selective redirection of phenolic carbon in heterogeneous Fenton-like reaction

引用

Water Research 2025年

作者： Youn-Jun Lee Prakash Govindaraj Yoo Jae Jeong Runfa Tan In Sun Cho Seong-Jik Park Hern Kim Chang-Gu Lee Pedro J.J. Alvarez Department of Energy Systems Research Ajou University Suwon 16499 Republic of Korea Department of Energy Science and Technology Environmental Waste Recycle Institute Myongji University Yongin Gyeonggi-do 17058 Republic of Korea Materials Science and Engineering Program University of Colorado Boulder Boulder 80303 USA Department of Materials Science & Engineering Ajou University Suwon 16499 Republic of Korea Department of Bioresources & Rural System Engineering Hankyong National University Anseong South Korea Department of Environmental and Safety Engineering Ajou University Suwon 16499 Republic of Korea Department of Civil and Environmental Engineering and Rice WaTER Institute Rice University Houston TX 77005 USA

Oxidative polymerization of phenolic pollutants by the heterogeneous Fenton-like reaction is a sustainable strategy for wastewater decontamination and recovery of carbonaceous resources. However, controlling the reaction pathway to selectively polymerize the phenolic pollutants is challenging. Herein, we used visible light to shift the reaction pathway from phenolic pollutants degradation (which often results in incomplete mineralization) to polymerization over a g–C₃N₄ catalyst deposited on a Cu₂O nanowire. In peroxymonosulfate (PMS) activation, visible light illumination facilitates electron transfer from Cu₂O to g–C₃N₄, shifting the dominant reactive species on the Cu₂O surface from radical species to catalyst–PMS* complex. Experimental results and theoretical calculations verified the increased adsorption of PMS and the reduced energy barrier for phenol (PhOH) polymerization under visible light illumination. Compared to dark control conditions, visible light-assisted Fenton-like process resulted in a 9-fold faster PhOH oxidation (0.029 min⁻¹), significantly higher PMS utilization efficiency for total organic carbon removal, and enhanced robustness in real water matrices. This study provides fundamental insights into the regulation of reaction pathway over light-responsive semiconductor catalysts and highlights the potential for efficient treatment of phenolic water pollutants via oxidative polymerization.

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：