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Bioimplant-on-a-Chip for Facile Investigation of Periodontal Ligament Formation on Biogenic Hydroxyapatite/Ti6Al4 V Implants

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ACS applied materials & interfaces 2025年第21期17卷 2025 May 13页

作者： Sangbae Park Jae Eun Kim Juo Lee Woochan Kim Woobin Choi Myung Chul Lee Jae Woon Lim Kyoung-Je Jang Hoon Seonwoo Jangho Kim Jong Hoon Chung Department of Biosystems Engineering Seoul National University Seoul 08826 Korea. Research Institute of Agriculture and Life Sciences Seoul National University Seoul 08826 Republic of Korea. Integrated Major in Global Smart Farm College of Agriculture and Life Sciences Seoul National University Seoul 08826 Republic of Korea. Department of Convergent Biosystems Engineering College of Life Science and Natural Resources Sunchon National University Suncheon 57922 Republic of Korea. Department of Convergence Biosystems Engineering Chonnam National University Gwangju 61186 Republic of Korea. Department of Rural and Biosystems Engineering Chonnam National University Gwangju 61186 Republic of Korea. Interdisciplinary Program in IT-Bio Convergence System Chonnam National University Gwangju 61186 Republic of Korea. Medicinal Materials Research Center Biomedical Research Division Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of Korea. Department of Bio-Systems Engineering Institute of Smart Farm Gyeongsang National University Jinju 52828 Republic of Korea. Institute of Agriculture & Life Science Gyeongsang National University Jinju 52828 Republic of Korea. Interdisciplinary Program in IT-Bio Convergence System Sunchon National University Suncheon 57922 Republic of Korea. Institute of Nano-Stem Cells Therapeutics NANOBIOSYSTEM Co. Ltd Gwangju 61008 Republic of Korea. ELBIO Inc Seoul 08812 Republic of Korea.

Highly osseointegrative dental implants surrounded by reconstructed periodontal tissues represent a promising strategy for functional tooth replacement, as they mimic the structural and physiological characteristics of natural teeth. However, there is currently a lack of in vitro platforms that can effectively evaluate the integration of engineered periodontal ligament (PDL) tissues with bioimplants. In this study, we developed a bioimplant-on-a-chip (BoC) platform designed to recapitulate the native PDL-cementum interface and assess the early stage biological performance of bioimplants in vitro. The BoC consists of a dental implant, a calcium phosphate cement (CPC) insert, a nanopatterned polydimethylsiloxane (PDMS) substrate, and PDL-like tissue derived from human dental pulp stem cells (DPSCs). To establish viable culture conditions within the platform, surface coatings and cell seeding densities were optimized to support the formation of PDL-like tissue. Nanogrooved substrates were incorporated to guide cellular alignment, which was assessed through orientation analysis. Collagen fiber organization and matrix deposition were further examined as indicators of ligamentous tissue maturation. Cementogenic activity was evaluated by immunofluorescent staining of cementum protein-1 (CEMP-1) in response to varying biogenic hydroxyapatite (bHA) contents in the bioimplants. The results demonstrated successful reproduction of a PDL-like tissue interface and material-dependent differences in CEMP-1 expression. This platform provides a modular and reproducible tool for the comparative evaluation of bioimplants in a physiologically relevant setting and may be useful in advancing regenerative strategies in dental implantology.

关键词： bioimplant-on-a-chip bioimplants in vitro model periodontal ligament tissue engineering

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Some solution strategies for automated highway exit bottleneck problems

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TRANSPORTATION RESEARCH PART C-EMERGING TECHNOLOGIES 1996年第3期4卷 167-179页

作者： Ran, B Huang, WJ Leight, S Intelligent Transportation System Program Department of Civil Environmental Engineering University of Wisconsin at Madison 2256 Engineering Hall 1415 Engineering Drive Madison WI 53706 U.S.A.

Transportation planners are exploring methods to ease congestion on urban freeways. The Automated Highway system(AHS) is a potential solution that could triple current freeway capacity. A three-fold increase in freeway capacity would translate into a significant increase in peak freeway traffic how. The corresponding increase of flow on urban roads due to exiting AHS vehicles could quickly overwhelm the capacity of urban streets and lead to critical bottlenecking of AHS flow. If exiting AHS vehicles cannot sufficiently clear AHS exits because the local streets are jammed, traffic will spill onto the AHS mainline and reduce AHS capacity. The loss of AHS capacity due to congestion in urban destinations and the resulting back spill of traffic onto the AHS wilt greatly detract from the AHS system. The following Non-Intermodal Interface (NII) and Intermodal Interface (II) strategies are proposed as solutions to this critical problem: (1) the dispersion of flow through AHS networks;(2) the dispersion of flow at commuter destinations;and (3) the consolidation of flow at central locations. Specifically, smart street signals and prioritized street design, intermodal terminals, and automated garages are identified as potential solutions. This paper qualitatively discusses the advantages and disadvantages of each of the three general strategies, and quantitatively discusses the advantages and disadvantages of each of the four specific solutions through Simulated scenarios which account for varying ramp volumes, trip attraction patterns, and urban structures. Our investigation shows that creative combinations of these methods can be useful to integrate future AHS with local road networks. Without such integration, the AHS cannot succeed. Copyright (C) 1996 Elsevier Science Ltd

关键词： Highway systems

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Survival Analysis of Kasturi Tobacco Plants in Jember District using the Stratified Cox and Extended Cox Models

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MethodsX 2025年

作者： Angga Iryanto Pratama Dwi Rantini Ratih Ardiati Ningrum Arip Ramadan Fazidah Othman Data Science Technology Study Program Faculty of Advanced Technology and Multidiscipline Universitas Airlangga Surabaya 60115 Indonesia Research Group of Data-Driven Decision Support System Faculty of Advanced Technology and Multidiscipline Universitas Airlangga Surabaya 60115 Indonesia Information System Study Program School of Industrial and System Engineering Telkom University Surabaya Campus Surabaya 60231 Indonesia Department of Computer System and Technology Faculty of Computer Science and Information Technology University of Malaya Malaysia

In 2022, tobacco was the top export commodity, generating $106.3 million in sales. East Java Province contributes significantly to Indonesia's tobacco production, with an annual output of 188.6 thousand tons. Jember Regency is the area in East Java Province which is a Kasturi tobacco cultivation area. The productivity of Kasturi tobacco continues to decrease due to several factors that can affect the survival of the tobacco. This study aims to analyze the survival of Kasturi tobacco by creating stratified Cox and extended Cox models in order to handle factors that cannot fulfill the proportional hazard assumption. Based on the results of the analysis, the stratified Cox model is the best model with AIC and BIC values of 798.108 and 805.5748 respectively, while the extended Cox has AIC and BIC values of 840.2186 and 850.1732 respectively. Variables that can significantly affect the survival of Kasturi tobacco are the variable concentration of ZA fertilizer, pesticide concentration. The addition of ZA fertilizer must be appropriate, because if excessive it can cause poisoning of tobacco plants. Likewise with pesticides, if excessive it will cause damage to the leaves. This policy can increase the productivity of Kasturi tobacco. Then, Jember Regency contributes greater export capacity. • This paper aims to determine the factors that affect the survival of Kasturi tobacco plants in Jember • By using the extended Cox model, the best one is obtained using the Heaviside function with AIC and BIC values of 840.2186 and 850.1732, respectively • The stratified Cox model is better than the extended Cox model, which has AIC and BIC values of 798.108 and 805.5748, respectively

关键词： Productive Agriculture Cox Proportional Hazard Stratified Cox Extended Cox Kasturi Tobacco

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A constant revenue model for telecommunication networks

A constant revenue model for telecommunication networks

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International Conference on Networking, International Conference on systems andInternational Conference on Mobile Communications and Learning Technologies, ICN/ICONS/MCL'06

作者： Sukasdadi, Hapsara R. Verma, Pramode K. Graduate Program in Telecommunication System Department of Electrical and Computer Engineering

ISBN: (纸本)0769525520

It is well known that the quality of service provided by a telecommunication network as measured by the probability of blocking decreases rapidly when the incident traffic exceeds the design limits of the network. A higher probability of blocking results in reduced throughput and loss of revenue for the service provider. This paper presents a mechanism that introduces priority in a telephone system with the objective of providing a defined grade of service to priority traffic carrying a higher price tag. The non-priority traffic carries a lower price tag and a lower grade of service. The proposed pricing scheme maintains the overall revenue associated with the network at a constant level over a wide range of incident traffic. © 2006 IEEE.

关键词： Telecommunication networks

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Initiation of ice jam in front of bridge piers-An experimental study

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Journal of Hydrodynamics 2019年第1期31卷 117-123页

作者： Jun Wang Jian Hua Pang-pang Chen Jueyi Sui Peng Wu Todd Whitcombe College of Civil and Hydraulic Engineering Hefei University of TechnologyHefei 230009China Modern Green Development Co.LTD Beijing 100028China Environmental Sciences and Engineering Program University of Northern British ColumbiaPrince GeorgeBCCanada Environmental System Engineering Program University of ReginaReginaCanada

The presence of bridge piers in natural rivers significantly changes the flow and boundary *** a consequence,ice jams can often be initiated in front of bridge *** the changes in flow conditions,two types of ice jam formation may appear:surface accumulation of ice blocks (surface ice blockage) and thickened accumulation of ice blocks (vertical ice blockage).In the present study,the initiation process of ice jam was studied based on *** is found that the critical ice concentration for ice jam blockage depends on the ice block dimension,channel opening and flow *** surface blockage conditions,a larger ratio of ice cube dimension to channel opening (between piers) can result in a smaller critical ice concentration for ice jam blockage,which has no obvious relation with flow *** vertical blockage conditions,the critical ice concentration for ice jam blockage increases with flow Froude number and decreases with the ratio of ice dimension to channel opening (between piers).Based on experiments conducted in laboratory,equations for determining critical ice concentration for these two types of ice jam blockage have been developed.

关键词： Bridge piers surface ice blockage vertical ice blockage critical ice concentrations

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IMS to PSTN/CS interworking 7

IMS to PSTN/CS interworking

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7th International Conference on Telecommunications, ConTEL 2003

作者： Maršić, Bruno Boroša, Tomislav Počuča, Sergej Program and System Engineering Siemens d.d. Zagreb Croatia

ISBN: (纸本)9531840520

Internet Protocol (IP) Multimedia Subsystem (IMS) has been added to the Universal Mobile Telecommunications system (UMTS) core network starting from 3GPP UMTS Release 5 (see [13]). Now, UMTS network consists of the following three domains: Circuit Switched (CS), Packet Switched (PS) and IP Multimedia Subsystem (IMS). IMS needs connectivity to old networks like CS networks and Public Switching Telephone Networks (PSTN). For that purposes, some interworking must be done. The IMS provides services for any type of IP communication whether it is voice or video telephony, video streaming, instant and multimedia messaging, multimedia gaming or virtual-reality. This paper describes connectivity between user in the IMS network and user in the PSTN/CS network. © 2003, Institute of Electrical and Electronics Engineers Inc. All rights reserved.

关键词： Packet switching

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Autonomous Quadcopter Trajectory Tracking and Stabilization Using Control system Based on Sliding Mode Control and Kalman Filter 24

Autonomous Quadcopter Trajectory Tracking and Stabilization ...

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24th International Seminar on Intelligent Technology and Its Applications, ISITIA 2023

作者： Agustina, Nilla Perdana Darwito, Purwadi Agus Physics Engineering Master Program Faculty of Industrial Technology and System Engineering Surabaya Indonesia Physics Engineering Department Faculty of Industrial Technology and System Engineering Surabaya Indonesia

ISBN: (纸本)9798350313956

In this paper, a control system based on Sliding Mode Control (SMC) and Kalman Filter has been designed to stabilize the quadcopter in the takeoff and hover phases as well as at the expected altitude. The control system is needed to support the performance of the quadcopter in carrying out the mission that has been given. The designed control system begins with the creation of a system model equation and is implemented in a real quadcopter simulation. The resulting response in terms of the results of the resulting control signal is stable, meets the trajectory as expected, and can produce a real quadcopter simulation taking off vertically and flying stably. Even though there was an unstable response for about 15 to 20 seconds at the beginning of the resulting response, after that the system showed stability. Tracking the resulting trajectory in accordance with the desired trajectory. Real quadcopter simulation results show that the takeoff phase can be carried out vertically and that the resulting trajectory stability can be stable during takeoff and flight. The height of the quadcopter has reached 100%, namely with a height of 1.5 meters as expected, and the average error value obtained at the x position is 2.93e^-07, the y position is 2.96e^-07, and the z position is 1.80e^-03. The proposed SMC-Kalman filter control system is expected to be implemented in a conventional quadcopter that has been developed. © 2023 IEEE.

关键词： Sliding mode control

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Reporting system design for family planning field officers in DPPKB using business process improvement (BPI) 6

Reporting system design for family planning field officers i...

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6th Information Technology International Seminar, ITIS 2020

作者： Alifah, Fakhirah Nur Triwibisono, Christanto Suwarsono, Litasari Widyastuti Industrial Engineering Study Program School of Industrial and System Engineering Telkom University Bandung Indonesia

ISBN: (纸本)9781728177267

Family Planning (FP) field officers are the people actively working in the field to encourage people to get involved in the family planning program that supports the government in controlling the population of the country. However, many of the officers have stated that their recruits often make mistakes during the process of inputting data along, added with the long manual validation process. The available digital reporting application called Sistem Informasi Keluarga (SIGA) is also not used at its maximum capability, causing the decrease of data validity collected through the process. Using business process improvement (BPI), valueadded analysis, and gap analysis are performed to find the issues in the system that will become the base of the reporting system redesign. This research was done to provide a proper business process design that is needed to ensure maximum comprehension and reduction of data invalidity with the help of the existing application. The result of this research shows that the new business process design required the digitalization of the data input process using an information system and the reduction of the use of offline forms to increase the validity of data in the reporting system. © 2020 IEEE.

关键词： Design

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Performance based irrigation planning under water shortage

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Irrigation and Drainage systems 1995年第2期9卷 143-162页

作者： Onta, P.R. Loff, R. Banskota, M. Irrigation Engineering and Management Program Asian Institute of Technology Bangkok Thailand Department of Irrigation System Management and Training Branch Kathmandu Nepal

A linear programming (LP) based optimization model and a simulation model are developed and applied in a typical diversion type irrigation system for land and water allocation during the dry season. Optimum cropping patterns for different management strategies are obtained by the LP model for different irrigation efficiencies and water availability scenarios. The simulation model yields the risk-related irrigation system performance measures (i.e. reliability, resiliency and vulnerability) for the management policies defined by the optimization model. The alternative strategies are evaluated in terms of all performance criteria (i.e. net economic benefit, equity and reliability) simultaneously through a trade-off analysis using a multi-criteria decision making method (compromise programming). For the case study of the Kankai irrigation system in Nepal, with equal preference to the objectives, a management strategy with equal share of water among the project subareas appears to be the most satisfactory alternative under water shortage conditions. The existing water allocation policy is not economically efficient. Deficit irrigation in Early paddy appears attractive under favorable hydrologic scenario, particularly if accompanied by measures to improve existing irrigation system efficiency.

关键词： allocation economic efficiency equity irrigation management models performance reliability

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Negative Stiffness Mechanism on An Asymmetric Wave Energy Converter by Using A Weakly Nonlinear Potential Model

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China Ocean engineering 2024年第4期38卷 689-700页

作者： Sunny Kumar POGULURI Dongeun KIM Yoon Hyeok BAE Department of Ocean Engineering IIT MadrasChennaiIndia Multidisciplinary Graduate School Program for Wind Energy Jeju National UniversityJejuRepublic of Korea Mechanical and System Design Engineering Hongik UniversitySeoulRepublic of Korea

Salter's duck,an asymmetrical wave energy converter(WEC)device,showed high efficiency in extracting energy from 2D regular waves in the past;yet,challenges remain for fluctuating wave *** can potentially be addressed by adopting a negative stiffness mechanism(NSM)in WEC devices to enhance system efficiency,even in highly nonlinear and steep 3D waves.A weakly nonlinear model was developed which incorporated a nonlinear restoring moment and NSM into the linear formulations and was applied to an asymmetric WEC using a time domain potential flow *** model was initially validated by comparing it with published experimental and numerical computational fluid dynamics *** current results were in good agreement with the published *** was found that the energy extraction increased in the range of 6%to 17%during the evaluation of the effectiveness of the NSM in regular *** irregular wave conditions,specifically at the design wave conditions for the selected test site,the energy extraction increased by 2.4%,with annual energy production increments of approximately *** findings highlight the potential of NSM in enhancing the performance of asymmetric WEC devices,indicating more efficient energy extraction under various wave conditions.

关键词： asymmetric wave energy converter negative stiffness mechanism weakly nonlinear potential flow power

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