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Single and Repeated Supplementation of SOD Differently Improve Antioxidant Capacity Against Exercise Challenges

Current Developments in Nutrition 2022年 6卷 6009322-6009322页

作者： Nam, Yea-eun Kim, Yunsoo Kim, Hye Jin Jung, Minji Kwon, Oran Ewha Womans University Department of Nutritional Science and Food Management Graduate Program in System Health Science and Engineering Ewha Womans University Department of Nutritional Science and Food Management The Research Institute for Veterinary Science College of Veterinary Medicine Seoul National University

AbstractObjectivesOxidative stress, commonly exposed in our daily life, produces free radicals. Excessively produced free radicals damage body components and eventually promote degenerative diseases. It has been reported that the reinforcement of superoxide dismutase (SOD), the first barrier of the antioxidant system, protects our body from oxidative stress by enhancing the subsequent redox cycle. The use of SOD, an enzymatic antioxidant rather than a simple antioxidant, is still insufficient to evaluate its safety and efficacy. Therefore, the purpose of this study is to evaluate the long-term consumption safety for enzymatic antioxidants and the effect of SOD supplementation on exercise-induced oxidative stress. MethodsThis study was designed as a randomized, double-blind, placebo-controlled in 80 healthy adults. The subjects consumed SOD (250 IU/capsule) daily for 8 weeks and induced oxidative stress via acute aerobic exercise at the beginning and end of the experimental period. The exercise challenge was performed on a treadmill for 30 minutes at an intensity of 60% of each subject’s maximal oxygen consumption (VO 2 max). Blood and urine samples have collected a total of three times, after overnight fasting, immediately after exercise, and after a 30-minute rest, which was used to evaluate the safety of long-term enzymatic antioxidant supplementation, as well as functional indicators of antioxidant systems and oxidative stress. ResultsEndogenous antioxidant defense systems, oxidative damage, and even antioxidant balance indicators were compared by considering the interaction between the group and status over time. A single intake of SOD significantly reduced the level of oxidative damage and inflammation indicators ( P < 0.05) as it sequentially activated antioxidant enzymes ( P < 0.10). Furthermore, long-term intake of SOD showed a stabilized defense response against the same oxidative stress load and improved balance between antioxidant enzymes immediately afte

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Design and Implementation Study of 3.12 kWp On – Grid Rooftop Solar PV system

Design and Implementation Study of 3.12 kWp On – Grid Rooft...

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International Conference on Electrical engineering and Informatics, ICEEI

作者： Ariyq Naufal Mizard Dwi Riana Aryani Ariono Verdianto Chairul Hudaya Faculty of Engineering Universitas Indonesia Energy System Engineering Master Study Program Faculty of Engineering Universitas Indonesia Kampus Baru UI Depok Republic of Indonesia

Conversion of fossil fuels as an energy source can be achieved by optimizing the use of renewable energy. One of the most used renewable energy is solar photovoltaics (PV). At present, solar power plant is an electrification support system for certain buildings because the abundant availability of solar radiation. On this research, Power and energy observations are carried out to determine measure the load power trend, the amount of energy flow from PV to the load, as well as import or export power from or to utility grid by direct measurement on Mosque of Faculty of engineering, Universitas Indonesia. According to the study, the highest power generated by solar power plant mostly occurs at 12:00 - 13:00 with the highest power generated by PV is 2,344 W and the exported power is 939 W, and 32.19% - 55.67% electricity energy savings consumption from utility grid.

关键词： Power generation Inverters Power measurement Current measurement Power cables Renewable energy sources Energy measurement

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Transferable individual brain regional atrophy progression prediction model using structural connectome

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Alzheimer's & Dementia 2023年第S14期19卷

作者： Yu Xiao Joanna Su Xian Chong Bing Cai Kok Kwun Kei Ng Christopher Li-Hsian Chen Juan Helen Zhou Quantitative Biology and Medicine Program Duke-NUS Medical School Singapore Singapore Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Correspondece Department of Pharmacology Clinical Research Centre National University Health System National University of Singapore Singapore Singapore Memory Ageing and Cognition Centre National University Health System Singapore Singapore Electrical and Computer Engineering National University of Singapore Singapore Singapore Integrative Sciences and Engineering Programme (ISEP) NUS Graduate School National University of Singapore Singapore Singapore

Background Brain microstructure, as measured by diffusion MR imaging (dMRI), is an early biomarker of Alzheimer’s disease (AD) and has been previously demonstrated to predict whole brain atrophy and cognition. The network-based neurodegeneration hypothesis posits that the onset of AD occurs within key vulnerable regions, whose network connectivity guides the spread of atrophy into new regions. Graph convolutional network (GCN) models can mimic this spread through its convolution process. Here we present a GCN-based model to predict future individual nodal atrophy and disease progression across the AD spectrum using structural connectome. Method We analyzed 371 participants with baseline dMRI scans (154 cognitively normal (CN), 161 mild cognitive impairment (MCI), 56 AD) and longitudinal T1 scans (2.7±1.2 years) from the ADNI study. To predict annual nodal atrophy rates (126 nodes) from baseline structural connectivity (SC), we constructed a two-layer GCN followed by multilayer perceptron (GCN-MLP). Five-fold nested cross-validation and Optuna were used for hyperparameter tuning. We applied the trained GCN-MLP model to predict future disease progression via transfer learning. GNNExplainer was used to identify the predictive SC features for atrophy or cognition. The GCN-MLP model was validated in another independent dataset from Singapore (MACC) with 226 participants (61 CN, 112 MCI, 53 AD, follow-up period of T1 scans (3.1±1.3 years)) using transfer learning. Result The proposed GCN-MLP model predicted the annual rate of regional atrophy at the individual level in the main (R = 0.5407±0.0480; MAE = 0.0013±0.0001; EV = 0.2930±0.0516) and validation (R = 0.5323±0.0564; MAE = 0.0009±0.0001; EV = 0.2808±0.0559) datasets (Table 1; Figure 1). Graph edge SC of the target network contributed most to the atrophy prediction of its own network (Figure 2A&C). Nodal feature SC in hippocampus, striatum, and temporal network were major predictors of atrophy progression across all 1

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Biomedical data and AI

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Science China Life Sciences 2025年第5期68卷 1536-1540页

作者： Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I

The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integrating biological knowledge into models and even accelerating the development of new AI based on biological discoveries, the boundaries of both are constantly expanding, and their connections are becoming closer.

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Protein and lipid expansion microscopy with trypsin and tyramide signal amplification for 3D imaging

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Scientific reports 2023年第1期13卷 21922页

作者： Ueh-Ting Tim Wang Xuejiao Tian Yae-Huei Liou Sue-Ping Lee Hsiao-Tang Hu Chieh-Han Lu Po-Ting Lin Ya-Jen Cheng Peilin Chen Bi-Chang Chen Affiliated Senior High School of National Taiwan Normal University Taipei 106348 Taiwan. Research Center for Applied Sciences Academia Sinica Taipei 11529 Taiwan. Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Tsing Hua University Taipei 11529 Taiwan. Department of Engineering and System Science National Tsing Hua University Hsinchu 300 Taiwan. Institute of Molecular Biology Academia Sinica Taipei 11529 Taiwan. Institute and Undergraduate Program of Electro-Optical Engineering National Taiwan Normal University Taipei 116 Taiwan. Neuroscience Program NPAS Academia Sinica Taipei 11529 Taiwan ROC. Research Center for Applied Sciences Academia Sinica Taipei 11529 Taiwan. chenb10@gate.sinica.edu.tw.

Expansion microscopy, whereby the relative positions of biomolecules are physically increased via hydrogel expansion, can be used to reveal ultrafine structures of cells under a conventional microscope. Despite its utility for achieving super-resolution imaging, expansion microscopy suffers a major drawback, namely reduced fluorescence signals caused by excessive proteolysis and swelling effects. This caveat results in a lower photon budget and disfavors fluorescence imaging over a large field of view that can cover an entire expanded cell, especially in 3D. In addition, the complex procedures and specialized reagents of expansion microscopy hinder its popularization. Here, we modify expansion microscopy by deploying trypsin digestion to reduce protein loss and tyramide signal amplification to enhance fluorescence signal for point-scanning-based imaging. We name our new methodology TT-ExM to indicate dual trypsin and tyramide treatments. TT-ExM may be applied for both antibody and lipid staining. TT-ExM displayed enhanced protein retention for endoplasmic reticulum and mitochondrial markers in COS-7 cell cultures. Importantly, TT-ExM-based lipid staining clearly revealed the complex 3D membrane structures in entire expanded cells. Through combined lipid and DNA staining, our TT-ExM methodology highlighted mitochondria by revealing their DNA and membrane structures in cytoplasm, as well as the lipid-rich structures formed via phase separation in nuclei at interphase. We also observed lipid-rich chromosome matrices in the mitotic cells. These high-quality 3D images demonstrate the practicality of TT-ExM. Thus, readily available reagents can be deployed in TT-ExM to significantly enhance fluorescence signals and generate high-quality and ultrafine-resolution images under confocal microscopy.

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Reutilization and upcycling of spent graphite for sustainable lithium-ion batteries: progress and perspectives

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eScience 2025年

作者： Xueqian Li Chenglong Deng Mengyao Liu Jiawei Xiong Xiaodong Zhang Qiaoyi Yan Jiao Lin Cen Chen Feng Wu Yi Zhao Renjie Chen Li Li Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and Engineering Beijing Institute of Technology Beijing 100081 China Innovative Research Team in High-Safety Energy Storage System and Smart Microgrids of Guangdong Province Beijing Institute of Technology (Zhuhai) Zhuhai 519088 China Shandong Key Laboratory of Advanced Chemical Energy Storage and Intelligent Safety Advanced Technology Research Institute Beijing Institute of Technology Jinan 250300 China State Key Laboratory of Chemical Engineering College of Chemistry Beijing University of Chemical Technology Beijing 100029 China Quantitative Methodology Program The University of Georgia Athens GA 30605 United States

In the development of sustainable lithium-ion batteries, achieving the efficient and cost-effective recycling of all components, particularly spent graphite (SG) anodes, has become a critical requirement. While considerable efforts have been devoted to recovering and reusing SG materials under conventional conditions, limited attention has been given to recycling under extreme conditions. This review systematically elucidates the main failure mechanisms of graphite anodes, including lithium plating and dendrite formation, solid electrolyte interface film failure, structural degradation, and current collector corrosion, with a particular focus on low-temperature and fast-charging conditions. As a contribution toward optimizing resource utilization, this review comprehensively summarizes the industrial perspective on strategies for recycling SG anodes, which aim to produce high-purity regenerated graphite (RG) powders. We also analyze current methods for modifying RG, such as structural reconstruction and surface reconditioning, to bring added value to modified RG materials. A detailed examination of the technical challenges in SG recycling and RG upgrading is presented, offering guidance for the future development of graphite upcycling technologies. This review also provides valuable insights into achieving high efficiency, intelligence, and sustainability in graphite utilization.

关键词： Spent lithium-ion batteries Graphite anode Degradation mechanism Recycling Regeneration

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Evaluation of a highly dexterous robotic manipulator for utilization of on-orbit servicing 70

Evaluation of a highly dexterous robotic manipulator for uti...

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70th International Astronautical Congress, IAC 2019

作者： King, Caitlin Griffin, Brand Low, Thomas Ortiz, Antonio Stephens, Matthew Troll, John Single-Person Spacecraft Genesis Engineering Solutions Inc. 4501 Boston Way LanhamMD20706 United States Robotics Program Taurus Robotic System SRI International 333 Ravenswood Avenue Menlo ParkCA94025 United States

The Single-Person Spacecraft (SPS) is being developed by Genesis engineering Solutions (GES) to provide the space industry with a new piloted, or remotely operated, EVA solution. The SPS provides a free-flyer inspection, repair, and servicing solution for host vehicles and stations, such as the lunar Gateway. This represents a new technology that will enhance human mobility and work efficiency during EVAs, as well as be operable through a locally commanded tele-operated mode. Hardware is being designed and built for a fully robotic demonstration mission, as a precursor to human operations, which will test and validate several key SPS systems in LEO. An effort is currently underway to develop an on-orbit dexterous manipulation capability. This will be achieved by combining the Taurus robotic system, developed by SRI International, with a custom positioning robotic platform that will operate in a seamless end-to-end control system. The commercially available Taurus robotic system is being validated as a highly skilled manipulator platform for spacecraft related tasks and is being evaluated for space-worthiness. A developmental task board has been built and will be used to perform activities such as MLI repair, hook and loop access, wire manipulation, optical performance, and harness connector removal/installation. The capabilities of the Taurus robotic system will be evaluated to complete the activities in a tele-operated mode particularly as compared to the capabilities of a spacesuit glove. The control program will also be evaluated for adapting to pre-routined scripts to perform the activities. Quantitative and qualitative results of the task board evaluations will be discussed and an assessment on how the results relate to the system requirements of the positioning robotic platform. In addition, significant robotic efforts of the program will be discussed including key trades related to the design and ground testing of the robotic system, a virtual environment zer

关键词： Repair

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Improving power scooter in systematic innovative thinking

International Journal of Systematic Innovation

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International Journal of systematic Innovation 2018年第2期5卷 35-44页

作者： Pai, Po-Han Shaw, Heiu-Jou Engineering Management Graduate Program College of Engineering National Cheng Kung University Taiwan Department of System and Naval Mechatronic Engineering National Cheng Kung University Taiwan

With the improvement of medicine and health care, the elderly are facing the dilemma of independent mobility Because the life expectancy of people in Taiwan has greatly increased. And the population structure of this society has been ageing rapidly . At this time, the power scooter is the most important action aids in life, so the design of safety of power scooters is a vital factor, especially in the initial launch, out of c ontrol scooters likely to sudden unintended acceleration (SUA). In order to prevent all possible accidents, it is essential to ensure that the scooter is in a safe state when traveling along a route. In order to deal with these problems above, our study proposes a Triz-based theory by redesigning the speed controller system. Firstly, use the method of The systematic Innovative Thinking defines the potential problems and key disadvantage. Then, take use of Contradiction matrix and 40 Inventive principles to target solution. Finally, by using Trimming tool to delete unnecessary elements. These methods can maintain functional integrity of power scooters and increase the safety of people who take the vehicle. The study improve speed controller system of power scooters and add PWM and Soft-starter to correct the problem of sudden unintended acceleration. Power scooters traffic accidents caused by improper handing have declined greatly. Provide the elderly a kind of safe assistive devices for independent mobility. © 2018 Society of Sytematic Innovation.

关键词： Elderly Power scooter Sudden unintended acceleration (SUA) TRIZ

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Applications of engineered biochar in remediation of heavy metal(loid)s pollution from wastewater: Current perspectives toward sustainable development goals

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Science of the Total Environment 2024年 926卷 171859页

作者： Tran, Thien-Khanh Huynh, Loan Nguyen, Hoang-Lam Nguyen, Minh-Ky Lin, Chitsan Hoang, Tuan-Dung Hung, Nguyen Tri Q. Nguyen, X. Hoan Chang, S. Woong Nguyen, D. Duc Advanced Applied Sciences Research Group Dong Nai Technology University Bien Hoa City76100 Viet Nam Faculty of Technology Dong Nai Technology University Bien Hoa City76100 Viet Nam Department of Civil Engineering McGill University Montreal Canada Faculty of Environment and Natural Resources Nong Lam University Hamlet 6 Linh Trung Ward Thu Duc City Ho Chi Minh City700000 Viet Nam Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan School of Chemistry and Life Science Hanoi University of Science and Technology No. 1 Dai Co Viet Hai Ba Trung Hanoi100000 Viet Nam Vietnam National University Hanoi - School of Interdisciplinary Sciences and Arts 144 Xuan Thuy Street Cau Giay District Hanoi100000 Viet Nam Ho Chi Minh City University of Industry and Trade Ho Chi Minh City Viet Nam Department of Civil & Energy System Engineering Kyonggi University Suwon16227 Korea Republic of Institute of Applied Technology and Sustainable Development Nguyen Tat Thanh University Ho Chi Minh City700000 Viet Nam

Environmental pollution of heavy metal(loid)s (HMs) caused adverse impacts, has become one of the emerging concerns and challenges worldwide. Metal(loid)s can pose significant threats to living organisms even when present in trace levels within environmental matrices. Extended exposure to these substances can lead to adverse health consequences in humans. Removing HM-contaminated water and moving toward sustainable development goals (SDGs) is critical. In this mission, biochar has recently gained attention in the environmental sector as a green and alternative material for wastewater removal. This work provides a comprehensive analysis of the remediation of typical HMs by biochars, associated with an understanding of remediation mechanisms, and gives practical solutions for ecologically sustainable. Applying engineered biochar in various fields, especially with nanoscale biochar-aided wastewater treatment approaches, can eliminate hazardous metal(loid) contaminants, highlighting an environmentally friendly and low-cost method. Surface modification of engineered biochar with nanomaterials is a potential strategy that positively influences its sorption capacity to remove contaminants. The research findings highlighted the biochars' ability to adsorb HM ions based on increased specific surface area (SSA), heightened porosity, and forming inner-sphere complexes with oxygen-rich groups. Utilizing biochar modification emerged as a viable approach for addressing lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), and chromium (Cr) pollution in aqueous environments. Most biochars investigated demonstrated a removal efficiency >90 % (Cd, As, Hg) and can reach an impressive 99 % (Pb and Cr). Furthermore, biochar and advanced engineered applications are also considered alternative solutions based on the circular economy. © 2024 Elsevier B.V.

关键词： Nanostructured materials

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Observation of the dual quantum spin Hall insulator by density-tuned correlations in a van der Waals monolayer

arXiv

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arXiv 2024年

作者： Tang, Jian Ding, Thomas Siyuan Chen, Hongyu Gao, Anyuan Qian, Tiema Huang, Zumeng Sun, Zhe Han, Xin Strasser, Alex Li, Jiangxu Geiwitz, Michael Shehabeldin, Mohamed Belosevich, Vsevolod Wang, Zihan Wang, Yiping Watanabe, Kenji Taniguchi, Takashi Bell, David C. Wang, Ziqiang Fu, Liang Zhang, Yang Qian, Xiaofeng Burch, Kenneth S. Shi, Youguo Ni, Ni Chang, Guoqing Xu, Su-Yang Ma, Qiong Department of Physics Boston College Chestnut HillMA United States Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore Singapore Department of Chemistry and Chemical Biology Harvard University CambridgeMA United States Department of Physics and Astronomy and California NanoSystems Institute University of California Los Angeles Los AngelesCA United States Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing China Department of Materials Science and Engineering Texas A&M University College StationTX United States Department of Physics and Astronomy University of Tennessee KnoxvilleTN United States Min H. Kao Department of Electrical Engineering and Computer Science University of Tennessee KnoxvilleTN United States Research Center for Electronic and Optical Materials National Institute for Materials Science Tsukuba Japan Research Center for Materials Nanoarchitectonics National Institute for Materials Science Tsukuba Japan Harvard John A. Paulson School of Engineering and Applied Sciences The Center for Nanoscale system Harvard University CambridgeMA United States Department of Physics Massachusetts Institute of Technology CambridgeMA United States CIFAR Azrieli Global Scholars program CIFAR Toronto Canada

The convergence of topology and correlations represents a highly coveted realm in the pursuit of novel quantum states of matter [1, 2]. Introducing electron correlations to a quantum spin Hall (QSH) insulator can lead to the emergence of a fractional topological insulator and other exotic time-reversal-symmetric topological order [3- 10], not possible in quantum Hall and Chern insulator systems. However, the QSH insulator with quantized edge conductance remains rare, let alone that with significant correlations. In this work, we report a novel dual QSH insulator within the intrinsic monolayer crystal of TaIrTe4, arising from the interplay of its single-particle topology and density-tuned electron correlations. At charge neutrality, monolayer TaIrTe4 demonstrates the QSH insulator that aligns with single-particle band structure calculations, manifesting enhanced nonlocal transport and quantized helical edge conductance. Interestingly, upon introducing electrons from charge neutrality, TaIrTe4 only shows metallic behavior in a small range of charge densities but quickly goes into a new insulating state, entirely unexpected based on TaIrTe4's single-particle band structure. This insulating state could arise from a strong electronic instability near the van Hove singularities (VHS), likely leading to a charge density wave (CDW). Remarkably, within this correlated insulating gap, we observe a resurgence of the QSH state, marked by the revival of nonlocal transport and quantized helical edge conduction. Our observation of helical edge conduction in a CDW gap could bridge spin physics and charge orders. The discovery of a dual QSH insulator introduces a new method for creating topological flat minibands via CDW superlattices, which offer a promising platform for exploring time-reversal-symmetric fractional phases and electromagnetism [3-5, 11, 12]. Copyright © 2024, The Authors. All rights reserved.

关键词： Charge density waves

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