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Wildlife-microbiome interactions and disease: exploring opportunities for disease mitigation across ecological scales

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Drug Discovery Today: Disease Models 2018年 28卷 105-115页

作者： Williams, Candace L. Caraballo-Rodríguez, Andrés Mauricio Allaband, Celeste Zarrinpar, Amir Knight, Rob Gauglitz, Julia M. Institute for Conservation Research San Diego Zoo Global United States Collaborative Mass Spectrometry Innovation Center Skaggs School of Pharmacy and Pharmaceutical Sciences University of California La Jolla San Diego 92307 CA United States Biomedical Sciences Graduate Program University of California La Jolla San Diego 92307 CA United States Department of Medicine University of California La Jolla San Diego 92307 CA United States Veterans Affairs San Diego Healthcare System San Diego California University of California La Jolla San Diego 92307 CA United States Department of Pediatrics University of California La Jolla San Diego 92037 CA United States Department of Bioengineering University of California La Jolla San Diego 92093 CA United States Department of Computer Science and Engineering University of California La Jolla San Diego 92093 CA United States Center for Microbiome Innovation University of California La Jolla San Diego 92307 CA United States

Captive wildlife are a unique set of animals, whose diverse host–microbe symbioses are underexplored. Compared to their wild counterparts they are particularly susceptible to a variety of diseases, many of which have explicit or purported links to the microbiome. In this perspective, we will examine how the microbiome influences gastrointestinal disorders, metabolic dysregulation, reproduction, and disease susceptibility in captive wildlife. Investigation of wildlife, and specifically captive wildlife, affords a unique opportunity to gain understanding of the broad diversity of the associated microbiota and learn from nature's molecular and microbial responses to disease. Studies like these could lead to the discovery of new interventions, ranging from dietary changes to the use of microbes or their natural products as treatment. Intervention strategies can lead to the discovery of medically relevant small molecules and the development of a novel platform for N-of-1 targeted medical investigations. © 2019 Elsevier Ltd

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Pale Red Dot: A Large, Robust Architecture for Human Settlements on Mars

Pale Red Dot: A Large, Robust Architecture for Human Settlem...

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Accelerating Space Commerce, Exploration, and New Discovery Conference, ASCEND 2023

作者： Lordos, George Hoying, Madelyn McKinney, Lanie Webb, Alisa Lin, Yuying Martin, Estelle Beilstein, John Miller, Duncan Villegas, David Sepulveda, Francisco AlSadah, Yousif Iyer, Divya O’Neill, Cormac Patel, Palak Garcia, Ignacio Arzuaga Azzouz, H. Chan, Wing Lam Eyre, Ezra Gleason, Dane Romero, Elizabeth Arias, Liliana Orozco, Omar Gentgen, Chloe Latyshev, Kir Hoffman, Jeffrey de Weck, Olivier Ikinci, Meltem Lordos, Alexandros Aeronautics and Astronautics Massachusetts Institute of Technology 33-409 CambridgeMA02139 United States Massachusetts Institute of Technology Harvard-MIT Health Sciences and Technology Program and MIT Aeronautics and Astronautics 33-409 CambridgeMA02139 United States Massachusetts Institute of Technology CambridgeMA02139 United States Aeronautics and Astronautics Massachusetts Institute of Technology 77 Mass Ave. 33-409 CambridgeMA02139 United States System Design and Management Massachusetts Institute of Technology 77 Mass Ave. E40-300 CambridgeMA02139 United States Mechanical Engineering Massachusetts Institute of Technology 77 Mass Ave. 33-409 CambridgeMA02139 United States Civil and Environmental Engineering Massachusetts Institute of Technology 77 Mass Ave. CambridgeMA02139 United States Electrical Engineering Massachusetts Institute of Technology 77 Mass Ave. CambridgeMA02139 United States Nuclear Science and Engineering Massachusetts Institute of Technology 77 Mass Ave. CambridgeMA02139 United States Computer Science and Engineering Massachusetts Institute of Technology 77 Mass Ave. CambridgeMA02139 United States Massachusetts Institute of Technology 77 Mass Ave. 37-219 CambridgeMA02139 United States Massachusetts Institute of Technology 77 Mass Ave. 33-410 CambridgeMA02139 United States Behavioral Economics University of Cyprus Nicosia Cyprus Department of Psychology University of Cyprus Nicosia Cyprus

ISBN: (数字)9781624107054

ISBN: (纸本)9781624107054

We propose a ten-yearMars mission to establish Earth-independence and support efficient, safe, and sustainable science and exploration goals. The campaign begins with a series of precursor missions, starting with the Artemis program, followed by robotic missions to performsite surveys and selection, de-risk technologies, and to start stockpiling in-situ water and propellant. Robotic Cargo Starships would depart first in 2035 to deliver and deploy approximately 5,800 tons of habitats, nuclear microreactors, farmmodules, manufacturing and ISRU systems. In 2040, two Crew Starships carrying 36 persons would land onMars to establish two close-proximity villages. The lifecycle cost is estimated at $81 billion, with a peak annual cost of $6.6 billion. To meet RASC-AL competition requirements, intended to motivate the exploration of highly self-reliant architecture concepts, resupply from Earth was constrained to only 5 metric tons every two years and minimum surface endurance was set at 7 years. The risks to human life and to critical systems increase exponentially over a minimally-resupplied, 7-10 year mission toMars. Our approach focused on identifying capabilities to mitigate known and unknown risks. Using a high-fidelity crew time model, we found that large architectures, with their economies of scale and productivity gains from specialization, are essential to robustly support the necessary capabilities. The model also shows that small 7-year missions of 12 persons or less cannot provide value in terms of free surface traverse time for science and exploration. Given the necessity of a large, complex architecture, we then sought out efficiencies and synergies (value engineering) in order to make the mission feasible and affordable. In the process, we identified more benefits that are enabled only by large missions, including the creation of a true community on Mars with sufficient social complexity for humans to thrive, and the geopolitically compelling option to inclu

关键词： Value engineering

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Chitosan for Biofunctionalization of Microsystems

Chitosan for Biofunctionalization of Microsystems

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IEEE/NLM Life science systems and Applications Workshop

作者： Stephan T. Koev Michael A. Powers Vlad Badilita Hyunmin Yi William E. Bentley Gregory F. Payne Gary W. Rubloff Reza Ghodssi Institute for Systems Research ISR University of Maryland College Park MD USA University System of Maryland Adelphi MD US Department of Materials Science and Engineering University of Maryland College Park MD USA Department of Chemical Engineering University of Maryland College Park MD 20742 University of Maryland Biotechnology Institute (UMBI) University of Maryland College Park MD 20742 Bioengineering Graduate Program University of Maryland College Park MD 20742 University of Maryland College Park MD USA University of Maryland Biotechnology Institute College Park MD USA Institute for Systems Research (ISR) University of Maryland College Park MD 20742 Department of Materials Science and Engineering University of Maryland College Park MD 20742 Department of Electrical and Computer Engineering University of Maryland College Park MD 20742 Institute for Systems Research (ISR) University of Maryland College Park MD 20742

ISBN: (纸本)1424402778

We present the use of the polysaccharide chitosan for immobilizing biomolecules on microfabricated device surfaces. The main advantages of chitosan are its abundance of primary amine groups and its ability to be electrodeposited. Biomolecules are easily attached to chitosan 's amines by standard glutaraldehyde chemistry. The electrodeposition of chitosan allows accurate spatial and temporal control of biomolecule placement. We have demonstrated this biofunctionalization method for two different bioMEMS devices: a biophotonic sensor and a micromechanical biosensor. We have successfully assembled probe DNA on each of them and detected hybridization with target DNA as a demonstration of sensor operation. Here, we briefly present the fabrication procedure and testing results for both of these bioMEMS sensing devices

关键词： DNA Biosensors Molecular biophysics Probes Micromechanical devices Optical sensors Optical surface waves Optical interferometry Assembly Biomedical optical imaging

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The association for the advancement of artificial intelligence 2020 workshop program

The association for the advancement of artificial intelligen...

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作者： Bang, Grace Barash, Guy Bea, Ryan Cali, Jacques Castillo-Effen, Mauricio Chen, Xin Cynthia Chhaya, Niyati Dhoopar, Rohan Dumancic, Sebastijan Espinoza, Huáscar Farchi, Eitan Fioretto, Ferdinando Fuentetaja, Raquel Galley, Michel Geib, Christopher Hernández-Orallo, José Huang, Xiaowei Keren, Sarah Kim, Seokhwan Jaidka, Kokil Liu, Xiaomo Lu, Tyler Ma, Zhiqiang Mallah, Richard McDermid, John Michalowski, Martin Mirsky, Reuth Héigeartaigh, Seán Ó. Ramachandran, Deepak Segovia-Aguas, Javier Shaban-Nejad, Arash Shehory, Onn Shwartz, Vered Srivastava, Siddharth Talamadupula, Kartik Tang, Jian Zhang, Dell Zhang, Jian S&P Global. Western Digital University of Southampton United Kingdom Blue Prism Group PLC Lockheed Martin's Advanced Technology Laboratories ArlingtonVA United States University of Hong Kong Hong Kong Adobe Research Google Research Katholieke Universiteit Leuven Belgium Commissariat à ĺÉnergie Atomique France IBM Research Department of Electrical Engineering and Computer Science Syracuse University United States Universidad Carlos III de Madrid Spain Microsoft Research AI SIFT LLC Universitat Politècnica de València Spain Leverhulme Centre for the Future of Intelligence United Kingdom Department of Computer Science University of Liverpool United Kingdom National University of Singapore Singapore Harvard School of Engineering and Applied Sciences in the of Fields of Multiagent Environment Design and Goal Recognition Design Amazon Alexa AI Future of Life Institute United States University of York Assuring Autonomy International Program United Kingdom University of Minnesota School of Nursing MinneapolisMN United States University of Texas at Austin AustinTX United States Institut de Robòtica i Informàtica Industrial Spanish Council for Scientific Research Technical University of Catalonia Spain Oak Ridge National Laboratory Center for Biomedical Informatics Department of Pediatrics University of Tennessee Health Science Center United States Bar Ilan University Israel University of Washington SeattleWA United States Autonomous Agents and Intelligent Robots lab of the School of Computing Informatics Decision Systems Arizona State University United States DiDi AI Labs School of Industrial and System Engineering Georgia Institute of Technology United States University of London United Kingdom Microsoft Azure

The Association for the Advancement of Artificial Intelligence 2020 Workshop program included twenty-three workshops covering a wide range of topics in artificial intelligence. This report contains the required reports, which were submitted by most, but not all, of the workshop chairs. Copyright © 2020, Association for the Advancement of Artificial Intelligence. All rights reserved.

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Plug-and-play stability for intracortical brain-computer interfaces: a one-year demonstration of seamless brain-to-text communication 23

Plug-and-play stability for intracortical brain-computer int...

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Proceedings of the 37th International Conference on Neural Information Processing systems

作者： Chaofei Fan Nick Hahn Foram Kamdar Donald Avansino Guy H. Wilson Leigh Hochberg Krishna V. Shenoy Jaimie M. Henderson Francis R. Willett Department of Computer Science Stanford University Department of Neurosurgery Stanford University Howard Hughes Medical Institute at Stanford University Department of Neuroscience Stanford University School of Engineering and Carney Institute for Brain Science Brown University and VA RR & D Center for Neurorestoration and Neurotechnology VA Providence Healthcare System and Center for Neurotechnology and Neurorecovery Department of Neurology Massachusetts General Hospital Harvard Medical School Bio-X Program Stanford University and Department of Neurobiology Stanford University and Department of Bioengineering Stanford University and Wu Tsai Neurosciences Institute Stanford University and Howard Hughes Medical Institute at Stanford University and Department of Electrical Engineering Stanford University Department of Neurosurgery Stanford University and Wu Tsai Neurosciences Institute Stanford University

Intracortical brain-computer interfaces (iBCIs) have shown promise for restoring rapid communication to people with neurological disorders such as amyotrophic lateral sclerosis (ALS). However, to maintain high performance over time, iBCIs typically need frequent recalibration to combat changes in the neural recordings that accrue over days. This requires iBCI users to stop using the iBCI and engage in supervised data collection, making the iBCI system hard to use. In this paper, we propose a method that enables self-recalibration of communication iBCIs without interrupting the user. Our method leverages large language models (LMs) to automatically correct errors in iBCI outputs. The self-recalibration process uses these corrected outputs ("pseudo-labels") to continually update the iBCI decoder online. Over a period of more than one year (403 days), we evaluated our Continual Online Recalibration with Pseudo-labels (CORP) framework with one clinical trial participant. CORP achieved a stable decoding accuracy of 93.84% in an online handwriting iBCI task, significantly outperforming other baseline methods. Notably, this is the longest-running iBCI stability demonstration involving a human participant. Our results provide the first evidence for long-term stabilization of a plug-and-play, high-performance communication iBCI, addressing a major barrier for the clinical translation of iBCIs.

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Nanoparticle Based Printed Sensors on Paper for Detecting Chemical Species

Nanoparticle Based Printed Sensors on Paper for Detecting Ch...

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IEEE Electronic Components and Technology Conference

作者： Jack Lombardi Mark D. Poliks Wei Zhao Shan Yan Ning Kang Jing Li Jin Luo Chuan-Jian Zhong Ziang Pan Mihdhar Almihdhar Benjamin S. Hsiao Madina L. Zabran Sandeep S. Mittal Kanad Ghose Department of System Science and Industrial Engineering State University of New York at Binghamton Binghamton NY USA Materials Science & Engineering Program State University of New York at Binghamton Binghamton NY USA Department of Chemistry State University of New York at Binghamton Binghamton NY USA Department of Chemistry State University of New York at Stony Brook NY USA Department of Computer Science State University of New York at Binghamton Binghamton NY USA

There has been an increasing need of technologies to manufacturing chemical and biological sensors for various applications ranging from environmental monitoring to human health monitoring. Currently, manufacturing of most chemical and biological sensors relies on a variety of standard microfabrication techniques, such as physical vapor deposition and photolithography, and materials such as metals and semiconductors. Though functional, they are hampered by high cost materials, rigid substrates, and limited surface area. Paper based sensors offer an intriguing alternative that is low cost, mechanically flexible, has the inherent ability to filter and separate analytes, and offers a high surface area, permeable framework advantageous to liquid and vapor sensing. However, a major drawback is that standard microfabrication techniques cannot be used in paper sensor fabrication. To fabricate sensors on paper, low temperature additive techniques must be used, which will require new manufacturing processes and advanced functional materials. In this work, we focus on using aerosol jet printing as a high-resolution additive process for the deposition of ink materials to be used in paper-based sensors. This technique can use a wide variety of materials with different viscosities, including materials with high porosity and particles inherent to paper. One area of our efforts involves creating interdigitated microelectrodes on paper in a one-step process using commercially available silver nanoparticle and carbon black based conductive inks. Another area involves use of specialized filter papers as substrates, such as multi-layered fibrous membrane paper consisting of a poly(acrylonitrile) nanofibrous layer and a nonwoven poly(ethylene terephthalate) layer. The poly(acrylonitrile) nanofibrous layer are dense and smooth enough to allow for high resolution aerosol jet printing. With additively fabricated electrodes on the paper, molecularly-functionalized metal nanoparticles are d

关键词： Sensor packaging Disposable Emerging materials Flexible electronics Wearable and medical electronics Novel materials and processing

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Analysis of user readiness toward ICT usage at small medium enterprise in south tangerang

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Journal of Physics: Conference Series 2018年第1期1007卷

作者： D Napitupulu M Syafrullah R Rahim D. Abdullah MI Setiawan Research Center for Quality System & Testing Technology Indonesian Institute of Sciences Tangerang Selatan Banten Indonesia Program of Master of Computer Science Universitas Budi Luhur Indonesia School of Computer and Communication Engineering Universiti Malaysia Perlis Malaysia Department of Informatics Universitas Malikussaleh Aceh Indonesia Department of Civil Engineering Narotama University Surabaya Indonesia

Utilization of Information and Communication Technology (ICT) is still relatively low in the level of SMEs due to various limitations ranging from access to capital, till the marketing network. ICT is present to provide the ability for SMEs in improving the benefits and competitive advantage of the organization. This study aims to determine the level of readiness of SMEs in utilizing technology, especially ICT. The methodology used is a survey to see the technology readiness of 107 SMEs in South Tangerang selected by purposive sampling. The approach used is TRI (Technology Readiness Index) which is the individual perception of technology based on four criteria that is optimism, innovativeness, discomfort and insecurity. The results showed that the optimism and innovativeness variables significantly positively influence the technology readiness while the variables of discomfort and insecurity also significantly positively influence the readiness of ICT.

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25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

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BMC NEUROscience 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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Plug-and-Play Stability for Intracortical Brain-computer Interfaces: A One-Year Demonstration of Seamless Brain-to-Text Communication

arXiv

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arXiv 2023年

作者： Fan, Chaofei Hahn, Nick Kamdar, Foram Avansino, Donald Wilson, Guy H. Hochberg, Leigh Shenoy, Krishna V. Henderson, Jaimie M. Willett, Francis R. Bio-X Program Stanford University United States Department of Neuroscience Stanford University United States Department of Neurosurgery Stanford University United States Department of Neurobiology Stanford University United States Department of Bioengineering Stanford University United States Department of Computer Science Stanford University United States Wu Tsai Neurosciences Institute Stanford University United States Howard Hughes Medical Institute Stanford University United States Department of Electrical Engineering Stanford University United States School of Engineering Carney Institute for Brain Science Brown University United States VA RR&D Center for Neurorestoration and Neurotechnology VA Providence Healthcare System United States Center for Neurotechnology and Neurorecovery Department of Neurology Massachusetts General Hospital Harvard Medical School United States

关键词： Brain computer interface

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FULL-WAVE SOLUTION OF DIELECTRIC LOADED WAVE-GUIDES AND SHIELDED MICROSTRIPS UTILIZING FINITE-DIFFERENCE AND THE CONJUGATE-GRADIENT METHOD

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INTERNATIONAL JOURNAL OF MICROWAVE AND MILLIMETER-WAVE computer-AIDED engineering 1991年第4期1卷 346-357页

作者： NARAYANAN, V MANELA, M LADE, RK SARKAR, TK Department of Electrical and Computer Engineering Syracuse University Syracuse New York 13244-1240 Viswanathan Narayanan was born in Bangalore India on December 14 1965. He received the BE degree in Electronics and Communications from B.M.S. College of Engineering Bangalore in 1988. He joined the Department of Electrical Engineering at Syracuse University for his graduate studies in 1989 where he is currently a research assistant. His research interests are in microwave measurements numerical electromagnetics and signal processing. Biographies and photos are not available for M. Manela and R. K. Lade. Tapan K. Sarkar (Sf69-M'76-SM'X1) was born in Calcutta. India on August 2 1948. He received the BTech degree from the Indian Institute of Technology Kharagpur India in 1969 the MScE degree from the University of New Brunswick Fredericton Canada in 1971. and the MS and PhD degrees from Syracuse University. Syracuse NY in 1975. From 1975-1976 he was with the TACO Division of the General Instruments Corporation. He was with the Rochester Institute of Technology (Rochester NY) from 1976-1985. He was a Research Fellow at the Gordon Mckay Laboratory Harvard University Cambridge MA from 1977 to 1978. He is now a Professor in the Department of Electrical and Computer Engineering Syracuse University. His current research interests deal with numerical solutions of operator equations arising in electromagnetics and signal processing with application to system design. He obtained one of the “ best solution” awards in May 1977 at the Rome Air Development Center (RADC) Spectral Estimation Workshop. He has authored or coauthored more than 154 journal articles and conference papers and has written chapters in eight books. Dr. Sarkar is a registered professional engineer in the state of New York. He received the Best Paper Award of the IEEE Transactions on Electromagnetic Compatibility in 1979. He was an Associate Editor for feature articles of the lEEE Antennas arid Propagation Sociefy Newsletter and was

Dynamic analysis of waveguide structures containing dielectric and metal strips is presented. The analysis utilizes a finite difference frequency domain procedure to reduce the problem to a symmetric matrix eigenvalue problem. Since the matrix is also sparse, the eigenvalue problem can be solved quickly and efficiently using the conjugate gradient method resulting in considerable savings in computer storage and time. Comparison is made with the analytical solution for the loaded dielectric waveguide case. For the microstrip case, we get both waveguide modes and quasi-TEM modes. The quasi-TEM modes in the limit of zero frequency are checked with the static analysis which also uses finite difference. Some of the quasi-TEM modes are spurious. This article describes their origin and discusses how to eliminate them. Numerical results are presented to illustrate the principles.

关键词： Waveguides

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