Indonesia had been suffered by earthquake and tsunami for many centuries. Since many lives have taken by tsunami strikes, alert and response system are very important as important part of Disaster Risk Reduction, espe...
Indonesia had been suffered by earthquake and tsunami for many centuries. Since many lives have taken by tsunami strikes, alert and response system are very important as important part of Disaster Risk Reduction, especially in area with high population density. This research conducted in Kangkung fishing village in Bandar Lampung coastal area which is an earthquake and tsunami prone area. The aim of the research is to study alert and response of Community Based Disaster Risk Reduction. The research conducted by qualitative method and purposive-descriptive approach. There were 53 respondents which participated in the survey and interview. It is reported that 'Smart Resilient City' model suitable for community needs of alert and response of earthquake and tsunami disaster. This research meets conclusion that 'Smart Resilient City' model may become a great solution in Community Based Disaster Risk Reduction to cope with the hazard of earthquake and tsunami comprehensively and sustainably.
Continuous glucose monitoring(CGM) technology has grown rapidly to track real-time blood glucose levels and trends with improved sensor accuracy. The ease of use and wide availability of CGM will facilitate safe and e...
Continuous glucose monitoring(CGM) technology has grown rapidly to track real-time blood glucose levels and trends with improved sensor accuracy. The ease of use and wide availability of CGM will facilitate safe and effective decision making for diabetes management. Here, we developed an attention-based deep learning model, CGMformer, pretrained on a well-controlled and diverse corpus of CGM data to represent individual's intrinsic metabolic state and enable clinical applications. During pretraining, CGMformer encodes glucose dynamics including glucose level, fluctuation, hyperglycemia, and hypoglycemia into latent space with self-supervised learning. It shows generalizability in imputing glucose value across five external datasets with different populations and metabolic states(MAE = 3.7 mg/d L). We then fine-tuned CGMformer towards a diverse panel of downstream tasks in the screening of diabetes and its complications using task-specific data, which demonstrated a consistently boosted predictive accuracy over direct fine-tuning on a single task(AUROC = 0.914 for type 2 diabetes(T2D) screening and 0.741 for complication screening). By learning an intrinsic representation of an individual's glucose dynamics,CGMformer classifies non-diabetic individuals into six clusters with elevated T2D risks, and identifies a specific cluster with lean body-shape but high risk of glucose metabolism disorders, which is overlooked by traditional glucose measurements. Furthermore, CGMformer achieves high accuracy in predicting an individual's postprandial glucose response with dietary modelling(Pearson correlation coefficient = 0.763)and helps personalized dietary recommendations. Overall, CGMformer pretrains a transformer neural network architecture to learn an intrinsic representation by borrowing information from a large amount of daily glucose profiles, and demonstrates predictive capabilities fine-tuned towards a broad range of downstream applications, holding promise for the ear
This paper presents a comprehensive high impedance fault model for real-time environment. This model offers different types of ground surface and high impedance faults. Experimental results show that it is suitable fo...
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Range verification of therapeutic proton beam is crucial in proton therapy to confirm the irradiation field for ensuring effects and safety of the treatment. The irradiation field reconstruction using prompt gamma-ray...
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ISBN:
(数字)9781728141640
ISBN:
(纸本)9781728141657
Range verification of therapeutic proton beam is crucial in proton therapy to confirm the irradiation field for ensuring effects and safety of the treatment. The irradiation field reconstruction using prompt gamma-rays generated from excited nuclides by proton beam has being studied for the purpose of precision medicine. A simulation tool based on fundamental physics processes employs an important role to understand intermediate relationship between physics interactions and detected observables, and to optimize a detector system with its analysis method. Previously, we reported on the simulation study about an irradiation field reconstruction by using prompt gamma-rays of whole energy range. In this study, we analyzed the energy spectrum and reconstructed the image of irradiation field by using prompt gamma-rays corresponding to a particular energy peak. The simulation was performed for proton beam with a target placed at the isocenter by using Geant4 based particle therapy system simulation framework. A simple tubular detector was placed around the target, in which the kinetic energy and the detected position of each gamma-ray were recorded. The irradiation field was then reconstructed in the ordered subset expectation maximization method. The reconstructed irradiation fields were compared with the dose distribution in the target. The peak positions of these depth distributions were compared each other and discussed about the range verification of therapeutic proton beam.
This work presents a real-time model of high impedance fault. The model allows full relay validation including different types of ground surface. The model is incorporated into OPAL-RT simulator and implemented in Hyp...
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Background: Improving the accessibility of screening diabetic kidney disease (DKD) and differentiating isolated diabetic nephropathy from non-diabetic kidney disease (NDKD) are two major challenges in the field of dia...
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Background: Improving the accessibility of screening diabetic kidney disease (DKD) and differentiating isolated diabetic nephropathy from non-diabetic kidney disease (NDKD) are two major challenges in the field of diabetes care. We aimed to develop and validate an artificial intelligence (AI) deep learning system to detect DKD and isolated diabetic nephropathy from retinal fundus images. Methods: In this population-based study, we developed a retinal image-based AI-deep learning system, DeepDKD, pretrained using 734 084 retinal fundus images. First, for DKD detection, we used 486 312 retinal images from 121 578 participants in the Shanghai Integrated Diabetes Prevention and Care system for development and internal validation, and ten multi-ethnic datasets from China, Singapore, Malaysia, Australia, and the UK (65 406 participants) for external validation. Second, to differentiate isolated diabetic nephropathy from NDKD, we used 1068 retinal images from 267 participants for development and internal validation, and three multi-ethnic datasets from China, Malaysia, and the UK (244 participants) for external validation. Finally, we conducted two proof-of-concept studies: a prospective real-world study with 3 months' follow-up to evaluate the effectiveness of DeepDKD in screening DKD;and a longitudinal analysis of the effectiveness of DeepDKD in differentiating isolated diabetic nephropathy from NDKD on renal function changes with 4·6 years' follow-up. Findings: For detecting DKD, DeepDKD achieved an area under the receiver operating characteristic curve (AUC) of 0·842 (95% CI 0·838–0·846) on the internal validation dataset and AUCs of 0·791–0·826 across external validation datasets. For differentiating isolated diabetic nephropathy from NDKD, DeepDKD achieved an AUC of 0·906 (0·825–0·966) on the internal validation dataset and AUCs of 0·733–0·844 across external validation datasets. In the prospective study, compared with the metadata model, DeepDKD could detect DKD wit
The coatings on fruits after harvested was applied to maintain the appearance and quality up to the consumer's hands. This study aimed to maintain color and reduce the level of decay of salak madu during storage. ...
The coatings on fruits after harvested was applied to maintain the appearance and quality up to the consumer's hands. This study aimed to maintain color and reduce the level of decay of salak madu during storage. Salak madu was obtained from Madding Fresh, trader and supplier salak from Sleman, Yogyakarta. The salak was coated with Aloe vera gel (20% and 50%) and beeswax (3, 6, and 10%). All samples were stored at 25–28 °C. The parameters used to measure the effect of treatment are skin color, percentage of decay, and weight loss. Observations were carried out for 12 days. The results of this study were found that dyeing on a coating made from Aloe vera 50% was able to slow down weight loss and percentage of decay until the 6 days, while Aloe vera 30% was better at maintaining color changes during storage. Beeswax 3% coating can slow down discoloration and percentage of decay until 6 days of storage. Long-term storage (12 days) with beeswax 10% was better in maintaining changes in the quality of salak madu, while for short-term storage (6 days), beeswax 3% gives better results.
Although numerous drugs are practiced to control malaria and its vectors, more recently, eco-friendly control tools have been proposed to battle its etiologic agents. Thus, using green bionanotechnology approaches, we...
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Although numerous drugs are practiced to control malaria and its vectors, more recently, eco-friendly control tools have been proposed to battle its etiologic agents. Thus, using green bionanotechnology approaches, we aimed to synthesize palladium nanoparticles (Pd NPs) from the macroalgae Sargassum fusiforme (Sf), its potential antiparasitic activity against P. falciparum, as well as its possible cytotoxicity, in HeLa cells. After the biosynthesis of the PdSf NPs, their characterization was carried out by UV-Vis, FESEM, and EDX analyses, and their hydrodynamic size, zeta potential, and surface area were determined. Furthermore, the functional groups of the PdSf NPs were analyzed by FT-IR and GC-MS. While PdSf NPs had an IC of 7.68 μg/mL (Chloroquine (CQ)-s) and 16.42 μg/mL, S. fusiforme extract had an IC of 14.38 μg/mL (CQ-s) and 35.27 μg/mL (CQ-r). With an IC value of 94.49 μg/mL, PdSf NPs exhibited the least toxic effect on the HeLa cells. The Lipinski rule of five and ADMET prediction were used to assess the in silico models of caffeine acid hexoside and quercetin 7-O-hexoside for the presence of drug-like properties. Pathogenic proteins, primarily responsible for motility, binding, and disease-causing, were the target of the structurally based docking studies between plant-derived compounds and pathogenic proteins. Thus, our study pioneered promising results that support the potential antiplasmodial activity of eco-friendly synthesized PdSf NPs using S. fusiforme extract against P. falciparum, opening perspectives for further exploration into the use of these NPs in malaria therapy.
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