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IEEE International technology Management Conference (ITMC)

作者： Jose M. Arias System Design and Management Program Fellow Engineering Systems Division Massachusetts Institute of Technology Cambridge MA USA

Productiveness is an issue when it comes to manufacturing. This paper discusses the advantages of using a system architecture approach within the context of product design and development. It shows how the philosophy behind the theory of systems architecting can induce lower costs and shorter schedules, without affecting the specification of the product under development. This also leads to the concept of product families.

关键词： Complexity theory Computer architecture Product design Organizations Manufacturing system analysis and design Context

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XXIV World Allergy Congress 2015 Seoul, Korea. 14-17 October 2015 Abstracts

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WORLD ALLERGY ORGANIZATION JOURNAL 2016年第1期9卷 1-206页

作者： [Anonymous] Korea University College of Medicine Guro Hospital Seoul South Korea College of Medicine Korea University Seoul South Korea Korea University Guro Hospital Seoul South Korea Seoul National University Boramae Hospital Seoul South Korea Division of Clinical Immunology Faculty of Medicine University of Debrecen Debrecen Hungary Meiji Pharmaceutical University Tokyo Japan Suri Medical Foundation Hospital Uttar Pradesh State India Shahid Beheshti University Tehran Iran Airlangga University Teaching Hospital Surabaya Indonesia Tokyo Metropolitan Police Hospital Tokyo Japan Shinichiro KogaSamsung Changwon Hospital Seoul South Korea Sapporo Tokushukai Hospital Sapporo Japan Department of Dermatology Yonsei University College of Medicine Seoul South Korea Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul South Korea Sureyyapasa Chest Diseases and Chest Surgery Training Hospital Istanbul Turkey Kangnam Sacred Heart Hospital Seoul South Korea Sakai City Medical Center Sakai Japan Osaka University Suita Japan Yonsei University College of Medicine Seoul South Korea Osaka-Minami Medical Center Kawachinagano Japan Inha University College of Medicine Incheon South Korea Inha University Hospital Incheon South Korea Center for Rhinology and Allergology Wiesbaden Wiesbaden Germany Leti Pharma Gmbh Witten Germany Postgraduate Institute of Medical Education and Research Chandigarh India West Bengal Technical University Kolkata India Institute of Microbiology Academy of Sciences of the Czech Republic Prague Czech Republic Seoul National University Hospital Seoul South Korea Ent and Allergy Centre(INDIA) Panchkula India University of Santo Tomas Hospital Manila Philippines University of Santo Tomas Faculty of Medicine Manila Philippines Kyung Hee University Hospital at Gang-Dong Seoul South Korea Sangji University Wonju South Korea Division of Allergy and Immunology Department of Internal Medicine Yonsei University Colle

A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendritic cells Katsuhiko Matsui, Saki Tamai, Reiko Ikeda A5 An evaluation of variousallergens in cases of allergic bronchial asthma at lucknow and neighbouring districts by intradermal skintest Drsushil Suri, Dranu Suri A6 Evaluation ferqency of ADHD in childhood asthma Marzieh Heidarzadeh Arani A7 Steven johnson syndrome caused by typhoid fever in a child Azwin Lubis, Anang Endaryanto A8 Chronic Bronchitis with Radio Contrast Media Hypersensitivity: A Case with Hypothesized GINA Step 1 Asthma Shinichiro Koga A9 The association between asthma and depression in Korean adult : An analysis of the fifth korea national health and nutrition examination survey (2010-2012) Lee Ju Suk A10 Management of allergic disease exacerbations in pregnancy Yasunobu Tsuzuki A11 Subcutaneous immunotherapy mouse model for atopic dermatitis Seo Hyeong Kim, Jung U Shin, Ji Yeon Noh, Shan Jin, Shan Jin, Hemin Lee, Jungsoo Lee, Chang Ook Park, Kwang Hoon Lee, Kwang Hoon Lee A12 Atopic disease and/or atopy are risk factors for local anesthetic allergy in patients with history of hypersensitivity reactions to drugs? Fatma Merve Tepetam A13 Food hypersensitivity in patients with atopic dermatitis in Korea Chun Wook Park, Jee Hee Son, Soo Ick Cho, Yong Se Cho, Yun Sun Byun, Yoon Seok Yang, Bo Young Chung, Hye One Kim, Hee Jin Cho A14 Anaphylaxis caused by an ant (Brachyponera chinensis) in Japan Yoshinori Katada, Toshio Tanaka, Akihiko Nakabayashi, Koji Nishida, Kenichi A

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Identification and implementation of patterns towards a model of environmental sustainability

Identification and implementation of patterns towards a mode...

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33rd Annual International Conference of the American Society for engineering Management 2012, ASEM 2012 - Agile Management: Embracing Change and Uncertainty in engineering Management

作者： Gandhi, S. Jimmy Perez, Santiago Rushton, Danial Cloutier, Robert Bozkurt, Ipek Pinto, C. Ariel Department California State University Northridge United States Zicklin School of Business Baruch College City University of New York United States School of System and Enterprises Stevens Institute of Technology United States Engineering Management Program University of Houston Clear Lake United States Department of Engineering Management and Systems Engineering Old Dominion University United States

ISBN: (纸本)9781627482820

Much like the Quality Revolution did in the 1980's, corporate sustainability has the potential to drive significant changes in the processes and structure of various organizations in the coming decade. With a rapidly growing global population and an ever increasing global demand for resources (Population-Resource-Center, 2012). Sustainability has emerged as one of the primary challenges that organizations will have to deal with in the 21st century. An increasing realization among business executives that profitability by itself is not enough as a measure of success is also driving the increased adoption of sustainable practices in the corporate world (Lowitt and Grimsley, 2009). Many of the non-financial concerns associated with sustainability are being rapidly recognized as ways to provide shareholder value in the long run. Although sustainability in the corporate world should emphasize economic, environmental and social sustainability, in this paper we will concentrate on the environmental issue and present a new model of best-of-breed practices for implementing environmental sustainability into an organization. To help develop this model we will examine the current literature, including a review of various case studies of corporations engaging in environmentally sustainable practices. We aim to identify practices that have been successful in various organizations and can be generalized and applied to other corporations. We believe that such a model can contribute to the understanding of, and the successful implementation of, environmentally sustainable practices throughout the corporate world. Copyright, American Society for engineering Management, 2012.

关键词： Sustainable development

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Community of Intelligence: The Secret Behind Intelligence-Led Policing

Community of Intelligence: The Secret Behind Intelligence-Le...

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European Intelligence and Security Informatics Conference (EISIC)

作者： Mariëlle den Hengst Jan ter Mors System Engineering Lectureship Intelligence Polish Academy Delft University of Technology Netherlands National Intelligence Program Dutch Police Force Netherlands

Intelligence-led policing is the use of analyzed information by decision makers to decide on police resources. Analysis is very important in this and increasingly needs to be a collaborative effort: tools, techniques and the complexity of crimes far exceeds the capacity and expertise of any single analyst. Analysts have to collaborate to create an understanding. In this paper we describe how the Dutch police force has built a community of intelligence in which analysts can collaborate to create intelligence reports for intelligence-led policing.

关键词： Europe Security Informatics

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Optical mapping of transcriptional factor binding sites on single DNA molecules using nanofluidic devices

Optical mapping of transcriptional factor binding sites on s...

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16th International Conference on Miniaturized systems for Chemistry and Life Sciences, MicroTAS 2012

作者： Sriram, K.K. Yeh, Jia-Wei Lin, Yii-Lih Chang, Yi-Ren Chou, Chia-Fu Institute of Physics Academia Sinica Taiwan Nanoscience and Technology/Taiwan International Graduate Program Academia Sinica Taiwan Department of Engineering and System Sciences National Tsing Hua University Taiwan Genomic Research Center Academia Sinica Taiwan Research Center for Applied Sciences Academia Sinica Taiwan

ISBN: (纸本)9780979806452

Transcriptional factors (TF) are proteins that bind to specific bases of DNA using DNA binding domains to carry out the process of transcription. Identification of TF binding sites is essential for understanding the regulatory circuits that control cellular processes such as cell division and differentiation as well as metabolic and physiological balance [1]. In this work, we deploy a proof-of-concept method adopting bio-conjugation, nanofluidic devices and single molecule techniques for direct mapping of TF binding sites on field stretched single DNA molecules. Here we demonstrated a simple and robust system for TF binding site identification, complementary to the existing techniques practiced in this field.

关键词： Binding sites

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Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

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Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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A microassembly process to realize angular vertical comb electrodes for a gimbal-less two-axis electrostatic scanner

A microassembly process to realize angular vertical comb ele...

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IEEE International Conference on Micro Electro Mechanical systems

作者： Min-Ho Jun Seunghwan Moon Jong-Hyun Lee Graduate School of Information and Mechatronics Gwangju Institute of Science and Technology Gwangju South Korea Graduate-program of Medical System Engineering Gwangju Institute of Science and Technology Gwangju South Korea

This paper proposes a microassembly process that easily realizes a gimbal-less two-axis electrostatic MEMS scanner with fixed angular vertical comb electrodes (FAVCs). The fabrication steps can be remarkably reduced by employing a microassembly, as there is no need to add an insulation layer and conduct a multi-step etching process for SVCs. The reduction in the number of fabrication steps also improves the device yield and reduces fabrication errors. The proposed scanner can be readily applied to various optical applications, as the slow axis is driven by quasi-static operation, allowing the amplitude of the scanning angle to remain constant within a specific frequency range.

关键词： Microassembly Springs Electrostatics Silicon Optical device fabrication Mirrors

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Three dimensional attitude estimation via the triad algorithm and a time-varying complementary filter

ASME 2012 5th Annual Dynamic Systems and Control Conference ...

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ASME 2012 5th Annual Dynamic systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012 2012年 1卷 157-165页

作者： Wang, Yizhou Chang-Siu, Evan Brown, Matthew Tomizuka, Masayoshi Almajed, Mohammed I. Alsuwaidan, Badr N. Mechanical System Control Laboratory Department of Mechanical Engineering University of California Berkeley CA 94720-1740 United States National Satellite Technology Program King Abdulaziz City for Science and Technology Riyadh 11555 Saudi Arabia

ISBN: (纸本)9780791845295

An innovative implementation of attitude estimation in 3 degrees of freedom (3-DOF) combining the TRIAD algorithm [1] and a time-varying nonlinear complementary filter (TVCF) is derived. This work is inspired by the good performance of the TVCF in 1-DOF [2] developed for applications limited to small mobile platforms with low computational power. To demonstrate robust 3-DOF estimation, information from vector and rate-gyroscope measurements are fused. Simulation and experimental results demonstrate comparable performance to the extended Kalman filter (EKF) and improved performance over alternative methods such as sole gyroscope rate-integration and the TRIAD algorithm without the TVCF as a pre-filter. Copyright © 2012 by ASME.

关键词： Gyroscopes

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Cross-plane Seebeck coefficient and thermal conductivity of CuFeSe2 thin film

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AIP Conference Proceedings 2012年第1期1449卷 405-408页

作者： P. C. Lee M. N. Ou J. Y. Luo M. K. Wu Y. Y. Chen Department of Engineering and System Science National TsingHua University Hsinchu Taiwan 30013 R.O.C. and Nano Science and Technology Program Taiwan International Graduate Program Institute of Taiwan Institute of Physics Academia Sinica 128 Academia Road Sec. 2. Nankang Taipei 115 Taiwan

The CuFeSe2 is a member of the I-III-VI2 semiconductors, whereas it shows different physical properties from the chalcopyrite family, include the tetragonal structure, the small band gap ∼0.16 eV and the weak magnetic behavior. Only a few articles focused on this material in recent years. The measurements of the Seebeck coefficient and thermal conductivity of the high quality CuFeSe2 thin film could provide valuable information for its thermal application. In this report, a CuFeSe2 thin film with thickness ∼200 nm on SiO2/Si substrate was prepared by pulse laser deposition (PLD). The highly crystallized film shows a preferred orientation (h 0 0) normal to the film surface. Two pairs of heater/sensor Au strips were thermally deposited on the thin film and substrate separately for thermal conductivity measurement using differential 3ω method. The Seebeck coefficient across the film plane was directly measured by two additional EMF probes below and above the film with temperature gradient generated by heater/sensor at frequency 2ω. The temperature dependence of thermal conductivity and Seebeck coefficient were measured in a wide temperature range from 150 to 300 K. The room-temperature thermal conductivity and Seebeck coefficient are obtained to be 3.5 W/m-K and −108 μV/K respectively.

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Design Pattern Usage in Grid Computing

Design Pattern Usage in Grid Computing

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International Conference on Broadband, Wireless Computing, Communication and Applications (BWCCA)

作者： Markus Aleksy Makoto Takizawa Leonard Barolli Industrial Software System Program ABB Corporate Research Center Germany Germany Department of Computer and Information Science Seikei University Tokyo Japan Department of Information and Communication Engineering Fukuoka Institute of Technology Fukuoka Japan

The recent advances in Grid and Cloud computing make new types of applications possible. At the same time, they require an infrastructure to implement heterogeneous computing resources time and cost-savely. Here, approaches that utilize design patterns, i.e., proven solutions to existing problems, seem to provide a good approach to enable these kind of applications. In this paper, we investigated which design patterns are already used in the area of Grid computing nowadays. After a brief description of the literature study design, we present our findings which include the discovered design patterns, corresponding categories, and application areas.

关键词： Grid computing Parallel processing Cloud computing Conferences Concurrent computing USA Councils

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