检索结果-内蒙古大学图书馆

Permeable polydimethylsiloxane microneedles for the delivery of traditional Chinese medicine elemene

Journal of Pharmaceutical Analysis 2025年第2期15卷 477-479页

作者： Qingchang Tian Mengmeng Liu Yiqiu Wang Zhaoming Li Daizhou Zhang Tian Xie Shuling Wang School of Pharmacy Hangzhou Normal UniversityHangzhou311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou311121China Shandong Key Laboratory of Mucosal and Skin Administration Technology Shandong Freda Pharmaceutical Group Co.Ltd.Jinan250101China Shandong Engineering Research Center of Novel Sustained and Controlled Release Formulations and Targeted Drug Delivery Systems Shandong Academy of Pharmaceutical SciencesJinan250101China Department of Neurology The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityFuzhou350003China

Microneedles(MNs)have attracted increasing attention as a transdermal delivery system(TDDS)[1].However,traditional volatile Chinese medicines cannot be dissolved in conventional soluble MN materials,such as hyaluronic acid and chitosan,making it difficult for many traditional Chinese medicine ingredients to be applied to ***(ELE)was successfully isolated from Curcuma longa,and has numerous antitumor and curative effects[2].

关键词： permeable polydimethylsiloxane volatile chinese medicines elemene microneedles traditional chinese medicine ingredients curcuma longaand traditional chinese medicine hyaluronic acid

来源：评论

学校读者我要写书评

暂无评论

Efficient Cutting of Submarine Pipelines by Linear-Shaped Charge 30th

Efficient Cutting of Submarine Pipelines by Linear-Shaped Ch...

引用

30th International Conference on Computational and Experimental engineering and Sciences, ICCES 2024

作者： Zhang, Shenhe Wang, Longkan Yang, Shuxin Zong, Zhi Zhang, Zhifan State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial Equipment School of Naval Architecture Engineering Dalian University of Technology Dalian116024 China China Ship Research and Development Academy Beijing100192 China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration Shanghai200240 China

ISBN: (纸本)9783031687747

Directional explosive cutting method has been applied to the cutting, maintenance and even destruction of submarine pipelines because of the high cutting speed and low risk to adjacent components. This paper develops a three-dimensional numerical model for the damage effects on the pipe induced by the Linear-Shaped Charge (LSC). The explosive is 50 kg TNT. The internal diameter of the pipe is 871 mm, and the thickness of the steel wall is 34 mm. The standoff distance is set to 1.0 times the height of the LSC and an air cavity is added in front of the liner for better jet formation effect. The pipe is filled with air, and the bottom of the pipeline is anchored to the seabed. Due to the symmetry of the numerical model, a quarter of the numerical model is established in order to improve the calculating efficiency. The FSI (Fluid-Structure Interaction) is taken into consideration. Based on structured-arbitrary Lagrange Euler (S-ALE) method, the damage process of the pipeline under the coupling load of the jet penetration, hydrostatic pressure, shock wave and bubble is investigated. According to the numerical simulation results, the pipe is immediately destroyed under the combined effect of the load. The results indicate that it is possible to effectively cut the pipelines by using a linear-shaped charge technique. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

关键词： Submarine pipelines

来源：评论

学校读者我要写书评

暂无评论

Terrain Classification Method Using Nir or Rgb Camera with a Cnn-Based Fusion of Vision and a Reduced-Order Proprioception Model

SSRN

引用

SSRN 2024年

作者： Chen, Hsiao-Yu Sang, I-Chen Norris, William R. Soylemezoglu, Ahmet Nottage, Dustin University of Illinois Urbana-Champaign Industrial & Enterprise Systems Engineering United States U.S. Army Engineers Engineering Research and Development Center Construction Engineering Research Laboratory United States

Terrain classification is a crucial technology for assessing terrain traversability and further assists in monitoring control and operation modes for various types of ground vehicles. The soil characteristics from the terrain can be acquired by ground vehicles adopting various sensors and physics-based dynamic feedback. Among all sensor categories, visual sensors are able to provide the most abundant information about the texture and color of terrain. However, the visual feature is limited by the amount of light available, especially in outdoor environments. This article proposes a robust terrain classification framework that fuses visual appearance and proprioceptive signals with a reduced-order model in order to solve the challenges posed by low-light conditions. The proposed 1D CNN model is based on raw signals from the camera’s internal IMU and the vehicle’s encoder, which can smoothly adapt to various vehicle platforms without being constrained by vehicular dimension limitations. Furthermore, the visual classification framework adapts to low-light conditions by utilizing a fuzzy tuner to adjust parameters in the PE process. The experimental results show that the proposed model can classify eight outdoor terrain classes with an average accuracy of 95.9% when using a visible band camera and 99.7% under the same experimental setup but replaced using an NIR band camera. © 2024, The Authors. All rights reserved.

关键词： Cameras

来源：评论

学校读者我要写书评

暂无评论

DEVELOPING A COMPOUND THREAT RISK FRAMEWORK FOR MILITARY systems 42

DEVELOPING A COMPOUND THREAT RISK FRAMEWORK FOR MILITARY SYS...

引用

42nd International Annual Conference of the American Society for engineering Management: engineering Management and The New Normal

作者： Richards, John Richards, James Rinaudo, Christina Callaghan, Caitlin Nallar, Melisa Elliot, Kyle Elliot, Tyler Larsen, Peter Institute for Systems Engineering US Army Engineer Research and Development Center United States Cold Regions Research and Engineering Laboratory US Army Engineer Research and Development Center United States Berkeley Laboratory United States

ISBN: (纸本)9798985333404

Every day, decision makers must allocate resources based on the best available information at the time. Military installations face a variety of threats which, when compounded, challenge sustained functionality of their supporting and supported deployable systems. Considering the compounding and interdependent impacts of the threats, both specified (what is known) and unspecified (what is not known) and incorporating the investments needed to address these threats would add value to the decision-making process. Current risk management practices are generally evaluated via scenario analysis that do not consider compound threats, thus resulting in limited risk management solutions. Current practices also challenge the ability of decision makers to increase resilience against such threats. The Resilient Installation Support against Compound Threats Analysis and Mitigation for Equipment and Resources (RISC TAMER) Framework establishes a decision support structure to identify and categorize system components, compound threats and risks, and system relationships to provide decision makers with more complete and comprehensive information from which to base their resilience-related decisions, both for prevention and response. In particular, this framework focuses on the ground vehicle systems operating on installations and their associated risks and threats. This paper focuses on the development process for the framework, which will eventually be expanded to optimize resilience enhancements for a wide variety of deployable systems in order to implement resilience strategies to protect assets, to increase adaptability, and to support power projection and global operations. © American Society for engineering Management, 2021

关键词： Risk management

来源：评论

学校读者我要写书评

暂无评论

Cryo-EM structures of human m6A writer complexes

引用

细胞研究（英文版） 2022年第11期32卷 982-994页

作者： Shichen Su Shanshan Li Ting Deng Minsong Gao Yue Yin Baixing Wu Chao Peng Jianzhao Liu Jinbiao Ma Kaiming Zhang State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and DevelopmentMultiscale Research Institute of Complex SystemsDepartment of Biochemistry and BiophysicsSchool of Life SciencesFudan UniversityShanghaiChina MOE Key Laboratory for Cellular Dynamics and Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhuiChina MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiangChina National Facility for Protein Science in Shanghai Zhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of ScienceShanghaiChina State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and DevelopmentMultiscale Research Institute of Complex SystemsDepartment of Biochemistry and BiophysicsSchool of Life SciencesFudan UniversityShanghaiChina Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineRNA Biomedical InstituteMedical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouGuangdongChina

N6-methyladenosine(m6A)is the most abundant ribonucleotide modification among eukaryotic messenger *** m6A"writer"consists of the catalytic subunit m6A-METTL complex(MAC)and the regulatory subunit m6A-METTL-associated complex(MACOM),the latter being essential for enzymatic ***,we report the cryo-electron microscopy(cryo-EM)structures of MACOM at a 3.0-A resolution,uncovering that WTAP and VIRMA form the core structure of MACOM and that ZC3H13 stretches the conformation by binding ***,the 4.4-? resolution cryo-EM map of the MACOM-MAC complex,combined with crosslinking mass spectrometry and GST pull-down analysis,elucidates a plausible model of the m6A writer complex,in which MACOM binds to MAC mainly through WTAP and METTL3 *** combination with in vitro RNA substrate binding and m6A methyltransferase activity assays,our results illustrate the molecular basis of how MACOM assembles and interacts with MAC to form an active m6A writer complex.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Method of adaptive learning feature model fusion and verification based on metamodels 3

Method of adaptive learning feature model fusion and verific...

引用

3rd International Symposium on Computer Applications and Information systems, ISCAIS 2024

作者： Wang, Chenyu Zhu, Yi Wu, Zixin Hao, Guosheng School of Computer Science and Technology Jiangsu Normal University Xuzhou221000 China Jiangsu Province Education Informatization Engineering Technology Research Center Jiangsu Normal University Xuzhou221000 China The Key Laboratory of the Software Development and Verification Technology The Ministry of Industry and Information Technology Nanjing University of Aeronautics and Astronautics Nanjing210016 China

ISBN: (纸本)9781510681316

As the advancement of computer technique and artificial intelligence technology, education based on computer technology has become a hot topic, and the wave of educational informatization is rising. Among them, adaptive learning has received widespread attention as a type of educational informatization technology. However, the current adaptive learning feature models use different semantics to describe each other, and the models lack meta model level explanations, resulting in a lack of further operability of the models and difficulty in integrating with each other. In order to solve these problems, our paper proposes a fusion and verification method for learning feature adaptive models based on meta models. Above all, an adaptive learning feature meta model is proposed, which defines the construction rules of the adaptive learning feature model at meta model level, so that different models can be fused using the same set of semantic rules. Then, at the meta model level, transform the learning model into a requirement model. Finally, using formal methods, validate the fused feature model, which can make sure of the semantic consistency between the previous and subsequent models. This article demonstrates the entire process through a model fusion experiment. The experimental results indicate that this method is correct and feasible in promoting feature model fusion without adaptive learning. © 2024 SPIE.

关键词： Informatization

来源：评论

学校读者我要写书评

暂无评论

Low CXCR6 expression drives extracellular matrix remodeling and enhances cell proliferation in OSCC

引用

Genes & Diseases 2025年第1期12卷 5-8页

作者： Yang Xun Hua Yang Yilong Ai Honglin Li Hua You Fang Liu Department of Basic Medicine and Biomedical Engineering School of MedicineFoshan UniversityFoshanGuangdong 528000China Foshan Stomatological Hospital FoshanGuangdong 528000China Laboratory for Excellence in Systems Biomedicine of Pediatric Oncology Department of Pediatric Hematology and OncologyChildren's Hospital of Chongqing Medical UniversityChongqing 401122China Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 401122China Centre for Translational Stem Cell Biology Hong Kong 999077China

Oral cancer,primarily oral squamous cell carcinoma(OscC),is one of the most common cancer types *** incidence of oscC continues to rise,with approximately 377,713 new cases and 177,757 deaths reported worldwide by 2020.1 Despite advancements in diagnosis and treatment,the 5-year survival rate for OscC patients has remained at 60%-67%over the last two decades(SEER database:https://***/).This consistent rise in morbidity and lack of survival improvement have made OscC a public concern.

关键词： diagnosis cancer remodeling

来源：评论

学校读者我要写书评

暂无评论

Preparation of TPM–NCs–gel and its effect on subcutaneous abscess caused by Staphylococcus aureus

Journal of Holistic Integrative Pharmacy

引用

Journal of Holistic Integrative Pharmacy 2025年第1期6卷 41-49页

作者： Quanwei Xie Feirong Zhou Runan He Lianbao Ye Zonghao Lin Xiangyu Nie Yuanzheng Wei Chuqin Yu Centre for Drug Research and Development Guangdong Pharmaceutical University/Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems/Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System Guangzhou 510006 China Guangdong Provincial Biotechnology Research Institute (Guangdong Laboratory Animal Monitoring Center) Guangzhou 510663 China

Objective The insoluble compound 1,1′-(2,4,6-trihydroxy-1,3-phenylene)bis(3-methylbutan-1-one) (TPM) is used in preparing a TPM nanocrystals gel (TPM–NCs–gel), and its in vitro antibacterial activity and therapeutic effect on subcutaneous abscesses caused by Staphylococcus aureus were evaluated. Methods The effect of a prescription technology on the particle size of a TPM–NCs suspension was investigated using a single factor, and the TPM–NCs prescription was optimized using a Box–Behnken design. A TPM–NCs–gel was prepared using hydroxyethyl cellulose–HHX (HEC–HHX) as a gel matrix and characterized. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of TPM–NCs–gel were determined with the microdilution method. The susceptibility of Staphylococcus aureus to mupirocin ointment, TPM–NCs–gel, and TPM–gel was evaluated by the disk diffusion method. The efficacy of the TPM–NCs–gel for subcutaneous abscess caused by Staphylococcus aureus was evaluated using a mouse model. Results The optimized TPM–NCs prescription consisted of Tween 80 and TPGS (2.47%), TPM (1.24%) and mannitol (2.32%). The size of the TPM–NCs was 98.2 ± 3.9 nm, and the polydispersion coefficient (PDI) was 0.235 ± 0.023. The particle size and PDI of the TPM–NCs–gel were 112.4 ± 7.3 nm and 0.148 ± 0.068, respectively. The MIC and MBC were both 2.98 μg/mL. After 12 days of administration, the bacteria in the abscess site of 2% TPM–NCs–gel experimental group were cleared, the inflammatory cells were reduced, and the skin structure was remodeled. Conclusion After TPM was prepared into TPM–NCs–gel, the antibacterial activity was enhanced, Staphylococcus aureus at the site of abscess was effectively removed, and wound healing was promoted.

关键词： TPM Nanocrystal Gel Staphylococcus aureus Subcutaneous abscess

来源：评论

学校读者我要写书评

暂无评论

Switching adaptive finite-time attitude control for a cross-media vehicle

Switching adaptive finite-time attitude control for a cross-...

引用

第43届中国控制会议

作者： Shichong Wu Menglei Tu Fei Liao Wenhua Wu Lingli Xie Mingqing Lu School of Systems Science and Engineering Sun Yat-sen University Aerospace Technology Institute China Aerodynamics Research and Development Center Cross-Media Vehicle Research Center China Aerodynamics Research and Development Center School of Mathematics Sun Yat-sen University Science and Technology on Underwater Vehicle Laboratory Harbin Engineering University

ISBN: (数字)9789887581581

ISBN: (纸本)9798350366907

The switching adaptive finite-time attitude control is proposed for a slender body cross-media vehicle under unknown hydrodynamics and external *** dynamics regarding the attitude of the vehicle is *** the neural network and the nonlinear disturbance observer are combined and designed to solve both the unknown hydrodynamics and external *** on the above techniques,a switching adaptive finite-time control scheme is developed for the attitude control of the vehicle,which reduces the conservation of the controller compared with the existing methods and also ensures the finite-time convergence of the system's ***,the effectiveness of the presented scheme is verified via the simulation.

关键词： Cross-media vehicle Switching control Finite-time control Neural network Nonlinear disturbance observer

来源：评论

学校读者我要写书评

暂无评论

Reversible Data Hiding With Secret Encrypted Image Sharing and Adaptive Coding

引用

IEEE Internet of Things Journal 2025年第13期12卷 23933-23945页

作者： Fang, Guangtian Wang, Feng Zhao, Chenbin Qin, Chuan Chang, Ching-Chun Chang, Chin-Chen Fujian University of Technology College of Computer Science and Mathematics Fuzhou350118 China Fujian University of Technology College of Computer Science and Mathematics Key Laboratory of Big Data Mining and Applications Fuzhou350118 China Monash University Faculty of IT Department of Software Systems and Cybersecurity VIC3800 Australia Ministry of Education School of Cyber Science and Engineering Key Laboratory of Aerospace Information Security and Trusted Computing Wuhan430072 China University of Shanghai for Science and Technology School of Optical-Electrical and Computer Engineering Shanghai200093 China Feng Chia University Information and Communication Security Research Center Taichuang 40724 Taiwan Feng Chia University Department of Information Engineering and Computer Science Taichung40724 Taiwan

To ensure the security of image information and facilitate efficient management in the cloud, the utilization of reversible data hiding in encrypted images (RDHEI) has emerged as pivotal. However, most existing RDHEI schemes suffer from lower security and limited embedding capacity. To tackle these challenges, we propose a reversible data hiding with secret encrypted image sharing and adaptive coding scheme. Specifically, in the encryption phase, we introduce an improved secret sharing (SS) encryption method based on the chinese remainder theorem for polynomials (CRTP). This method not only improves the security of encrypted images but also vacates a larger room for embedding. In the embedding phase, we introduce an adaptive coding embedding approach using XOR preservation (XORP) and huffman coding, which provides high embedding capacity. Experimental results and security analysis demonstrate that our proposed encryption method achieves optimal values in security indicators for encrypted images, such as information entropy, histograms, NPCR and UACI. The proposed embedding method is superior to some state-of-the-art schemes in terms of embedding capacity. Furthermore, in datasets BOSSBase and BOWS2, the average embedding rates of the proposed embedding approach can reach 2.1745 bpp and 2.0656 bpp, respectively. © 2025 IEEE.

关键词： Cryptography Encryption Security Data mining Adaptive coding Correlation Cloud computing Polynomials Image coding Streaming media

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：