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检索条件"机构=Systems Biology and Computer Science Program"
179 条 记 录,以下是1-10 订阅
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Ecology, Spatial Structure, and Selection Pressure Induce Strong Signatures in Phylogenetic Structure
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Artificial life 2025年 第2期31卷 129-152页
作者: Moreno, Matthew Andres Rodriguez-Papa, Santiago Dolson, Emily University of Michigan Department of Ecology and Evolutionary Biology Center for the Study of Complex Systems Michigan Institute for Data and AI in Society Michigan State University Department of Computer Science and Engineering Michigan State University Department of Computer Science and Engineering Program in Ecology Evolution Behavior
Evolutionary dynamics are shaped by a variety of fundamental, generic drivers, including spatial structure, ecology, and selection pressure. These drivers impact the trajectory of evolution and have been hypothesized ... 详细信息
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Protein codes promote selective subcellular compartmentalization
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science (New York, N.Y.) 2025年 第6738期387卷 1095-1101页
作者: Kilgore, Henry R. Chinn, Itamar Mikhael, Peter G. Mitnikov, Ilan Van Dongen, Catherine Zylberberg, Guy Afeyan, Lena Banani, Salman F. Wilson-Hawken, Susana Lee, Tong Ihn Barzilay, Regina Young, Richard A. Whitehead Institute for Biomedical Research Cambridge MA United States Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology (MIT) Cambridge MA United States Abdul Latif Jameel Clinic for Machine Learning in Health MIT Cambridge MA United States Department of Biology MIT Cambridge MA United States Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA United States Computational and Systems Biology Program MIT Cambridge MA United States
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. In this study, we demonstrate that proteins with...
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ALPINE: An Interpretable Approach for Decoding Phenotypes from Multi-condition Sequencing Data  29th
ALPINE: An Interpretable Approach for Decoding Phenotypes ...
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29th International Conference on Research in Computational Molecular biology, RECOMB 2025
作者: Lee, Wei-Hao Li, Lechuan Dannenfelser, Ruth Yao, Vicky Systems Synthetic and Physical Biology Graduate Program Rice University Houston United States Department of Computer Science Rice University Houston United States Ken Kennedy Institute Rice University Houston United States Rice Synthetic Biology Institute Rice University Houston United States
Advancements in sequencing technology have expanded data availability, capturing diverse phenotypic traits and biological perturbations. However, increased resolution also raises complexity, as studies now examine mul... 详细信息
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Testing the Inference Accuracy of Accelerator-Friendly Approximate Phylogeny Tracking
Testing the Inference Accuracy of Accelerator-Friendly Appro...
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Computational Intelligence in Artificial Life and Cooperative Intelligent systems (ALIFE-CIS), IEEE Symposium on
作者: Matthew Andres Moreno Anika Ranjan Emily Dolson Luis Zaman Department of Ecology and Evolutionary Biology University of Michigan Ann Arbor United States Center for the Study of Complex Systems University of Michigan Ann Arbor United States Michigan Institute for Data and AI in Society University of Michigan Ann Arbor United States Undergraduate Research Opportunities Program University of Michigan Ann Arbor United States Department of Computer Science and Engineering Michigan State University East Lansing United States Program in Ecology Evolution and Behavior Michigan State University East Lansing United States
computer simulations are an important tool for studying the mechanics of biological evolution. In particular, agent-based approaches provide an opportunity to collect high-quality records of ancestry relationships. Su... 详细信息
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Testing the Inference Accuracy of Accelerator-Friendly Approximate Phylogeny Tracking
Testing the Inference Accuracy of Accelerator-Friendly Appro...
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2025 IEEE Symposium on Computational Intelligence in Artificial Life and Cooperative Intelligent systems, ALIFE-CIS 2025
作者: Moreno, Matthew Andres Ranjan, Anika Dolson, Emily Zaman, Luis University of Michigan Department of Ecology and Evolutionary Biology Ann Arbor United States Center for the Study of Complex Systems University of Michigan Ann Arbor United States Michigan Institute for Data and Ai in Society University of Michigan Ann Arbor United States Undergraduate Research Opportunities Program University of Michigan Ann Arbor United States Michigan State University Department of Computer Science and Engineering East Lansing United States Program in Ecology Evolution and Behavior Michigan State University East Lansing United States
computer simulations are an important tool for studying the mechanics of biological evolution. In particular, agent-based approaches provide an opportunity to collect high-quality records of ancestry relationships. Su... 详细信息
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Biomedical data and AI
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science China Life sciences 2025年 第5期68卷 1536-1540页
作者: Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I
The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integratin...
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Mapping dihydropteroate synthase evolvability through identification of a novel evolutionarily critical substructure
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International Journal of Biological Macromolecules 2025年 311卷 143325页
作者: Sanyal, Dwipanjan Shivram, A. Pandey, Deeptanshu Banerjee, Suharto Uversky, Vladimir N. Muzata, Danny Chivukula, Aneesh Sreevallabh Jasuja, Ravi Chattopadhyay, Krishnananda Chowdhury, Sourav Structural Biology and Bioinformatics Division CSIR-Indian Institute of Chemical Biology Kolkata India Department of Computer Science and Information Systems Birla Institute of Technology and Science-Pilani Hyderabad India Department of Biological Sciences Birla Institute of Technology and Science-Pilani Hyderabad India Max Delbrück Center for Molecular Medicine Berlin Germany Research Program in Men's Health: Aging and Metabolism Brigham and Women's Hospital Harvard Medical School BostonMA United States USF Health Byrd Alzheimer's Research Institute Morsani College of Medicine University of South Florida TampaFL33612 United States
Protein evolution shapes pathogen adaptation-landscape, particularly in developing drug resistance. The rapid evolution of target proteins under antibiotic pressure leads to escape mutations, resulting in antibiotic r... 详细信息
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Multilevel modeling and value of information in clinical trial decision support
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BMC systems biology 2014年 第1期8卷 6-6页
作者: Cui, Yuanyuan Murphy, Brendan Gentilcore, Anastasia Sharma, Yugal Minasian, Lori M. Kramer, Barnett S. Coates, Paul M. Gohagan, John K. Klenk, Juergen Tidor, Bruce Computer Science and Artificial Intelligence Laboratory and Program in Computational and Systems Biology Massachusetts Institute of Technology Cambridge 02139 MA United States
BACKGROUND: Clinical trials are the main method for evaluating safety and efficacy of medical interventions and have produced many advances in improving human health. The Women's Health Initiative overturned a hal...
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BPS2025 - Systematic embedding of biomechanics within dynamical graph grammars with application to actin networks in dendritic spine heads
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Biophysical Journal 2025年 第3期124卷 206a-206a页
作者: Eric Mjolsness Matthew Hur Thomas M. Bartol Terrence J. Sejnowski Departments of Computer Science and Mathematics University of California Irvine Irvine CA USA Mathematical Computational and Systems Biology Program University of California Irvine Irvine CA USA Computational Neurobiology Laborartory Salk Institute for Biological Studies San Diego CA USA
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Pan-cancer analysis of CDC7 in human tumors: Integrative multi-omics insights and discovery of novel marine-based inhibitors through machine learning and computational approaches
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computers in biology and Medicine 2025年 190卷 110044-110044页
作者: Saif, Ahmed Islam, Md. Tarikul Raihan, Md. Obayed Yousefi, Niloofar Rahman, Md. Ajijur Faridi, Hafeez Hasan, Al Riyad Hossain, Mirza Mahfuj Saleem, Rasha Mohammed Albadrani, Ghadeer M. Al-Ghadi, Muath Q. Ahasan Setu, Md. Ali Kamel, Mohamed Abdel-Daim, Mohamed M. Aktaruzzaman, Md. Department of Pharmacy Faculty of Science University of Rajshahi Rajshahi6205 Bangladesh Department of Genetic Engineering and Biotechnology Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Jashore7408 Bangladesh Department of Pharmaceutical Sciences College of Health Sciences and Pharmacy Chicago State University ChicagoIL United States Department of Industrial Engineering and Management Systems University of Central Florida USA OrlandoFL United States Department of Pharmacy Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Department of Computer Science and Engineering Faculty of Engineering and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Department of Laboratory Medicine Faculty of Applied Medical Sciences Al-Baha University Al-Baha65431 Saudi Arabia Department of Biology College of Science Princess Nourah bint Abdulrahman University 84428 Riyadh11671 Saudi Arabia Department of Zoology College of Science King Saud University P.O. Box 2455 Riyadh11451 Saudi Arabia Department of Microbiology Faculty of Biological Science and Technology Jashore University of Science and Technology Jashore7408 Bangladesh Department of Medicine and Infectious Diseases Faculty of Veterinary Medicine Cairo University Giza12211 Egypt Department of Pharmaceutical Sciences Pharmacy Program Batterjee Medical College P.O. Box 6231 Jeddah21442 Saudi Arabia Pharmacology Department Faculty of Veterinary Medicine Suez Canal University Ismailia41522 Egypt
Cancer remains a significant global health challenge, with the Cell Division Cycle 7 (CDC7) protein emerging as a potential therapeutic target due to its critical role in tumor proliferation, survival, and resistance.... 详细信息
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