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检索条件"机构=Systems Biology and Computer Science Program"
178 条 记 录,以下是41-50 订阅
排序:
Prediction of protein subcellular localization in single cells
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Nature Methods 2025年 1-11页
作者: Zhang, Xinyi Tseo, Yitong Bai, Yunhao Chen, Fei Uhler, Caroline Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA United States Eric and Wendy Schmidt Center Broad Institute of MIT and Harvard Cambridge MA United States Computational and Systems Biology Program Massachusetts Institute of Technology Cambridge MA United States Broad Institute of MIT and Harvard Cambridge MA United States Department of Stem Cell and Regenerative Biology Harvard University Cambridge MA United States
The subcellular localization of a protein is important for its function, and its mislocalization is linked to numerous diseases. Existing datasets capture limited pairs of proteins and cell lines, and existing protein...
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An Open-Source Knowledge Graph Ecosystem for the Life sciences
arXiv
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arXiv 2023年
作者: Callahan, Tiffany J. Tripodi, Ignacio J. Stefanski, Adrianne L. Cappelletti, Luca Taneja, Sanya B. Wyrwa, Jordan M. Casiraghi, Elena Matentzoglu, Nicolas A. Reese, Justin Silverstein, Jonathan C. Hoyt, Charles Tapley Boyce, Richard D. Malec, Scott A. Unni, Deepak R. Joachimiak, Marcin P. Robinson, Peter N. Mungall, Christopher J. Cavalleri, Emanuele Fontana, Tommaso Valentini, Giorgio Mesiti, Marco Gillenwater, Lucas A. Santangelo, Brook Vasilevsky, Nicole A. Hoehndorf, Robert Bennett, Tellen D. Ryan, Patrick B. Hripcsak, George Kahn, Michael G. Bada, Michael Baumgartner, William A. Hunter, Lawrence E. Computational Bioscience Program University of Colorado Anschutz Medical Campus AuroraCO80045 United States Department of Biomedical Informatics Columbia University Irving Medical Center New YorkNY10032 United States Computer Science Department Interdisciplinary Quantitative Biology University of Colorado Boulder BoulderCO80301 United States AnacletoLab Computer Science Department University of Milan 20122 Italy Intelligent Systems Program University of Pittsburgh PittsburghPA15260 United States Department of Physical Medicine and Rehabilitation School of Medicine University of Colorado Anschutz Medical Campus AuroraCO80045 United States Division of Environmental Genomics and Systems Biology Lawrence Berkeley National Laboratory BerkeleyCA94720 United States Semanticly Ltd Athens Greece Department of Biomedical Informatics University of Pittsburgh School of Medicine PittsburghPA15206 United States Laboratory of Systems Pharmacology Harvard Medical School BostonMA02115 United States Division of Translational Informatics University of New Mexico School of Medicine AlbuquerqueNM87131 United States SIB Swiss Institute of Bioinformatics Basel Switzerland Berlin Institute of Health at Charité-Universitatsmedizin Berlin10117 Germany ELLIS European Laboratory for Learning and Intelligent Systems Germany Department of Biomedical Informatics University of Colorado School of Medicine AuroraCO80045 United States Data Collaboration Center Critical Path Institute 1840 E River Rd. Suite 100 TucsonAZ85718 United States Computer Electrical and Mathematical Sciences & Engineering Division Computational Bioscience Research Center King Abdullah University of Science and Technology Thuwal23955-6900 Saudi Arabia Department of Pediatrics University of Colorado School of Medicine AuroraCO80045 United States Janssen Research and Development RaritanNJ08869 United States Division of General Internal Medicine University of Colorado School of Medicine A
Translational research requires data at multiple scales of biological organization. Advancements in sequencing and multi-omics technologies have increased the availability of these data, but researchers face significa... 详细信息
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Finding shortest and nearly shortest path nodes in large substantially incomplete networks
arXiv
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arXiv 2022年
作者: Kitsak, Maksim Ganin, Alexander Elmokashfi, Ahmed Cui, Hongzhu Eisenberg, Daniel A. Alderson, David L. Korkin, Dmitry Linkov, Igor Faculty of Electrical Engineering Mathematics and Computer Science Delft University of Technology Delft Netherlands Network Science Institute Northeastern University BostonMA02115 United States Department of Systems and Information Engineering University of Virginia CharlottesvilleVA22904 United States U.S. Army Engineer Research and Development Center Contractor Concord MA01742 United States Simula Metropolitan Center for Digital Engineering Oslo Norway Bioinformatics and Computational Biology Program Worcester Polytechnic Institute WorcesterMA01609 United States Institute for Genomic Medicine Columbia University Medical Center New YorkNY United States Operations Research Department Naval Postgraduate School MontereyCA93943 United States Data Science Program Worcester Polytechnic Institute WorcesterMA01609 United States Computer Science Department Worcester Polytechnic Institute WorcesterMA01609 United States U.S. Army Engineer Research and Development Center Environmental Laboratory Concord MA01742 United States
Dynamic processes on networks, be it information transfer in the Internet, contagious spreading in a social network, or neural signaling, take place along shortest or nearly shortest paths. Unfortunately, our maps of ... 详细信息
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International Workshop on Applications of Probability and Statistics to biology,July 11-13,2019--In Honor of Professor Minping Qian’s 80th Birthday
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Quantitative biology 2020年 第2期8卷 177-186页
作者: Minghua Deng Jianfeng Feng Hong Qian Lin Wan Fengzhu Sun Center for Quantitative Biology Peking UniversityBeijing 100871China LMAM Center for Statistical ScienceSchool of Mathematical SciencesPeking UniversityBeijing 100871China Institute of Science and Technology for Brain-inspired Intelligence Fudan UniversityShanghai 200433China School of Mathematical Sciences Fudan UniversityShanghai 200433China Centre for Computational Systems Biology Fudan UniversityShanghai 200433China Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence at Fudan University Ministry of EducationShanghai 200433China Department of Computer Science University of WarwickCoventryCV47ALUnited Kingdom Department of Applied Mathematics University of WashingtonSeattleWA 98195USA NCMIS Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China Quantitative and Computational Biology Program University of Southern CaliforniaLos AngelesCA 90089USA
The International Workshop on Applications of Probability and Statistics to biology(APSB)was successfully held in Shanghai,China,July 11-13,*** workshop was hosted by the Institute of science and Technology for Brain-... 详细信息
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Multimodal Whole Slide Foundation Model for Pathology
arXiv
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arXiv 2024年
作者: Ding, Tong Wagner, Sophia J. Song, Andrew H. Chen, Richard J. Lu, Ming Y. Zhang, Andrew Vaidya, Anurag J. Jaume, Guillaume Shaban, Muhammad Kim, Ahrong Williamson, Drew F.K. Chen, Bowen Almagro-Perez, Cristina Doucet, Paul Sahai, Sharifa Chen, Chengkuan Komura, Daisuke Kawabe, Akihiro Ishikawa, Shumpei Gerber, Georg Peng, Tingying Le, Long Phi Mahmood, Faisal Department of Pathology Mass General Brigham Harvard Medical School BostonMA United States Data Science Program Dana-Farber Cancer Institute BostonMA United States Cancer Program Broad Institute of Harvard and MIT CambridgeMA United States John A. Paulson School of Engineering and Applied Sciences Harvard University CambridgeMA United States Helmholtz Munich German Research Center for Environment and Health Munich Germany School of Computation Information and Technology Technical University of Munich Munich Germany Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology CambridgeMA United States Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology CambridgeMA United States Department of Pathology Pusan National University Busan Korea Republic of Department of Pathology and Laboratory Medicine Emory University School of Medicine AtlantaGA United States Harvard Data Science Initiative Harvard University CambridgeMA United States Department of Systems Biology Harvard Medical School BostonMA United States Department of Preventive Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan Division of Pathology National Cancer Center Exploratory Oncology Research & Clinical Trial Center Chiba Japan
The field of computational pathology has been transformed with recent advances in foundation models that encode histopathology region-of-interests (ROIs) into versatile and transferable feature representations via sel... 详细信息
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*** - A plug-and-play solution for online systems medicine and network-based drug repurposing
arXiv
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arXiv 2023年
作者: Maier, Andreas Hartung, Michael Abovsky, Mark Adamowicz, Klaudia Bader, Gary D. Baier, Sylvie Blumenthal, David B. Chen, Jing Elkjaer, Maria L. Garcia-Hernandez, Carlos Helmy, Mohamed Hoffmann, Markus Jurisica, Igor Kotlyar, Max Lazareva, Olga Levi, Hagai List, Markus Lobentanzer, Sebastian Loscalzo, Joseph Malod-Dognin, Noel Manz, Quirin Matschinske, Julian Mee, Miles Oubounyt, Mhaned Pico, Alexander R. Pillich, Rudolf T. Poschenrieder, Julian M. Pratt, Dexter Pržulj, Nataša Sadegh, Sepideh Saez-Rodriguez, Julio Sarkar, Suryadipto Shaked, Gideon Shamir, Ron Trummer, Nico Turhan, Ugur Wang, Ruisheng Zolotareva, Olga Baumbach, Jan Institute for Computational Systems Biology University of Hamburg Hamburg Germany Division of Orthopaedic Surgery Schroeder Arthritis Institute Data Science Discovery Centre Osteoarthritis Research Program Krembil Research Institute UHN Toronto Canada Data Science Discovery Centre for Chronic Diseases Krembil Research Institute University Health Network 60 Leonard Avenue 5KD-407 TorontoONM5T 0S8 Canada Department of Molecular Genetics University of Toronto TorontoON Canada The Donnelly Centre University of Toronto TorontoON Canada Department of Computer Science University of Toronto TorontoON Canada Princess Margaret Cancer Centre University Health Network TorontoON Canada The Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital TorontoON Canada TUM School of Life Sciences Technical University of Munich Munich Germany Erlangen91052 Germany Department of Medicine University of California San Diego 9500 Gilman Drive La Jolla CA92093 United States Department of Neurology Odense University Hospital Odense Denmark Institute of Clinical Research University of Southern Denmark Odense Denmark Institute of Molecular Medicine University of Southern Denmark Odense Denmark Barcelona08034 Spain Institute for Advanced Study Lichtenbergstrasse 2a GarchingD-85748 Germany Technical University of Munich Germany National Institute of Diabetes Digestive and Kidney Diseases BethesdaMD20892 United States Departments of Medical Biophysics and Computer Science University of Toronto Toronto Canada Institute of Neuroimmunology Slovak Academy of Sciences Bratislava Slovakia Heidelberg69120 Germany Heidelberg Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg69117 Germany Blavatnik School of Computer Science Tel-Aviv University Tel-Aviv Israel Heidelberg University Faculty of Medicine Heidelberg University Hospital Institute for Computational Biomedicine Bioquant Heidelberg Germany Department of Medicine Bri
In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and ... 详细信息
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Enriching and Characterizing T-Cell Repertoires from 3' Barcoded Single-Cell Whole Transcriptome Amplification Products
arXiv
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arXiv 2022年
作者: Jivanjee, Tasneem Ibrahim, Samira Nyquist, Sarah K. James Gatter, G. Bromley, Joshua D. Jaiswal, Swati Berger, Bonnie Behar, Samuel M. Christopher Love, J. Shalek, Alex K. Institute for Medical Engineering & Science Department of Chemistry Massachusetts Institute of Technology CambridgeMA United States Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology CambridgeMA United States Ragon Institute of MGH MIT and Harvard CambridgeMA United States Broad Institute of MIT and Harvard CambridgeMA United States Massachusetts Institute of Technology CambridgeMA United States Program in Computational and Systems Biology Massachusetts Institute of Technology CambridgeMA United States Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology CambridgeMA United States Microbiology Graduate Program Massachusetts Institute of Technology CambridgeMA02139 United States Department of Microbiology and Physiological Systems University of Massachusetts Medical School WorcesterMA United States Department of Mathematics Massachusetts Institute of Technology CambridgeMA United States Department of Chemical Engineering Massachusetts Institute of Technology CambridgeMA United States
Antigen-specific T cells play an essential role in immunoregulation and many diseases such as cancer. Characterizing the T cell receptor (TCR) sequences that encode T cell specificity is critical for elucidating the a... 详细信息
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The estrous cycle modulates hippocampal spine dynamics, dendritic processing, and spatial coding
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Neuron 2025年
作者: Wolcott, Nora S. Redman, William T. Karpinska, Marie Jacobs, Emily G. Goard, Michael J. Department of Molecular Cellular and Developmental Biology University of California Santa Barbara Santa Barbara 93106 CA United States Interdepartmental Graduate Program in Dynamical Neuroscience University of California Santa Barbara Santa Barbara 93106 CA United States Intelligent Systems Center Johns Hopkins University Applied Physics Laboratory Laurel 20723 MD United States Department of Computer Science University of California Santa Barbara Santa Barbara 93106 CA United States Department of Psychological & Brain Sciences University of California Santa Barbara Santa Barbara 93106 CA United States Ann S. Bowers Women's Brain Health Initiative University of California Santa Barbara Santa Barbara 93106 CA United States Neuroscience Research Institute University of California Santa Barbara Santa Barbara 93106 CA United States
Histological evidence suggests that the estrous cycle exerts a powerful influence on CA1 neurons in the mammalian hippocampus. Decades have passed since this landmark observation, yet how the estrous cycle shapes dend... 详细信息
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Direct Comparison of RT-ddPCR and Targeted Amplicon Sequencing for SARS-CoV-2 Mutation Monitoring in Wastewater
SSRN
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SSRN 2022年
作者: Lou, Esther G. Sapoval, Nicolae McCall, Camille Bauhs, Lauren Carlson-Stadler, Russell Kalvapalle, Prashant Lai, Yanlai Palmer, Kyle Penn, Ryker Rich, Whitney Wolken, Madeline Ensor, Katherine B. Hopkins, Loren Treangen, Todd J. Stadler, Lauren B. Department of Civil and Environmental Engineering Rice University 6100 Main Street MS 519 HoustonTX77005 United States Department of Computer Science Rice University 6100 Main Street HoustonTX77005 United States Systems Synthetic and Physical Biology Graduate Program Rice University 6100 Main Street HoustonTX77005 United States Houston Health Department 8000 N. Stadium Dr. HoustonTX77054 United States Department of Statistics Rice University 6100 Main Street MS 138 HoustonTX77005 United States
Over the course of the COVID-19 pandemic, variants of SARS-CoV-2 have emerged that are more contagious and more likely to cause breakthrough infections. Targeted amplicon sequencing approach is a gold standard for ide... 详细信息
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Colloidal Structure and Proton Conductivity of the Gel within the Electrosensory Organs of Cartilaginous Fishes
SSRN
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SSRN 2021年
作者: Phillips, Molly Wheeler, Alauna Robinson, Matthew J. Leppert, Valerie Jia, Manping Rolandi, Marco Hirst, Linda S. Amemiya, Chris T. Department of Biology University of Washington SeattleWA98195 United States Department of Molecular and Cell Biology University of California Merced MercedCA95343 United States Department of Physics University of California Merced MercedCA95343 United States Department of Materials Science and Engineering University of California Merced MercedCA95343 United States Department of Electrical and Computer Engineering Baskin School of Engineering University of California Santa Cruz Santa CruzCA95064 United States Quantitative and Systems Biology Program University of California Merced MercedCA95343 United States
Cartilaginous fishes possess gel-filled tubular sensory organs called Ampullae of Lorenzini (AoL) that are used to detect electric fields. Although recent studies have identified various components of AoL gel, it has ... 详细信息
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