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Micro valve system for individual cell transportation in microfluidic chip

Micro valve system for individual cell transportation in mic...

20th Anniversary MHS 2009 and Micro-Nano Global COE - 2009 International Symposium on Micro-NanoMechatronics and Human Science

作者： Hasegawa, Akiyuki Ohara, Kenichi Takubo, Tomohito Department of Systems Innovation Graduate School of Engineering Science Osaka University 1-3 Machikaneyama Toyonaka Osaka 560-8531 Japan

ISBN: (纸本)9781424450954

Recently, micro valves to control some kinds of fluids in channels in a microchip have been developed. Now we pay attention to in-chip somatic cell cloning with microfluidic technology. There are some steps, cell supply, cutting, sorting, coupling, fusion and so on, for this work. And we focused on a cell supply system spending cells one by one in microfluidic chip, and attempt to transport an individual cell to objective course by the control of pressure valves. Here, we made three kinds valves, a) open channel 2-layer valve, b) open channel 3-layer valve, and c) close channel 2-layer valve. We compare these valves about interception condition of micro channel flow and time to take for open/close. And then we evaluated them with suitable for the smooth cell transportation by these comparisons. ©2009 IEEE.

关键词： Microfluidics

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On-chip disposable compact vision system

On-chip disposable compact vision system

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20th Anniversary MHS 2009 and Micro-Nano Global COE - 2009 International Symposium on Micro-NanoMechatronics and Human Science

作者： Uvet, Huseyin Hasegawa, Akiyuki Ohara, Kenichi Takubo, Tomohito Mae, Yasushi Arai, Tatsuo Department of Systems Innovation Graduate School of Engineering Science Osaka University 1-3 Machikaneyama Toyonaka Osaka 560-8531 Japan

ISBN: (纸本)9781424450954

The interest in dynamically tuning lens has attracted great attention to fabricate compact vision systems. Here, we discuss the fabrication and characterization of a simple, tunable, yet fully disposable, except imaging sensor, microfluidic-based optical device. The desired compact system is structured on a PDMS micro fluidic. Tunable lens actuated by flow pressure (2mm in diameter) is controlled by a syringe pump. The contrast value is provided by introduction of Melanin cover between image sensor, lens and PDMS chip. With the advantage of automatic focal change, an inaccurate detection of an object is eliminated by shifting focal plane. ©2009 IEEE.

关键词： Object detection

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A new multi-scale micromanipulation system with dexterous motion

A new multi-scale micromanipulation system with dexterous mo...

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20th Anniversary MHS 2009 and Micro-Nano Global COE - 2009 International Symposium on Micro-NanoMechatronics and Human Science

作者： Avci, Ebubekir Ohara, Kenichi Takubo, Tomohito Mae, Yasushi Arai, Tatsuo Department of Systems Innovation Graduate School of Engineering Science Osaka University 1-3 Machikaneyama Toyonaka Osaka 560-8531 Japan

ISBN: (纸本)9781424450954

Micro robotics is a significant area to be able to manipulate micro level objects dexterously. Until now, various micro manipulation systems have been presented. In micro environment, different kinds of objects have different dimensions. Some of them are a few micrometers (μm) such as donor cells, some of them are more than a hundred μm such as egg cells. At this point, a manipulator which has multi-scale manipulation ability can manipulate different size objects. Otherwise, for different diameter objects, different micro-hands are necessary. Furthermore, when we want to manipulate micro objects, manipulation distance is not always same. Because, with micro hand, we do not just want to grasp or rotate the objects, sometimes we could also want to carry the object from one micro environment to another one. Therefore, workspace of micro manipulator is also important for various micro tasks. In this paper, we propose a new micro manipulation system which includes parallel mechanism for grasping and releasing tasks. This new system has ability of multi-scale manipulation, which means manipulation of different size objects with same micro hand. Moreover, short distance (nm) and long distances carriage (mm) are feasible with this micro manipulator. ©2009 IEEE.

关键词： Micromanipulators

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Analysis on misconducts and inappropriate practices by Japan's nuclear power utilities and assessment of their corrective measures

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Transactions of the Atomic Energy Society of Japan 2010年第4期9卷 347-359页

作者： Torikai, Seishi Ozawa, Michihiro Kanegae, Naomichi Tani, Masaaki Madarame, Haruki Miyakoshi, Naoki Research and Development Division Institute of Applied Energy 1-14-2 Nishi-Shinbashi Minato-ku Tokyo 105-0003 Japan Nuclear Power Business Development and Management Division Hitachi-GE Nuclear Energy Ltd. Akihabara Daibiru Building 1-18-13 Soto-Kanda Chiyoda-ku Tokyo 101-8608 Japan Department of Mechanical Engineering Shibaura Institute of Technology 3-7-5 Toyosu Koto-ku Tokyo 135-8548 Japan Corporate Affairs Department Tokyo Electric Power Company 1-1-3 Uchisaiwai-cho Chiyoda-ku Tokyo 100-8560 Japan Ex-Nuclear Professional School Graduate School of Engineering University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan Nuclear Energy Systems Headquarters Mitsubishi Heavy Industries Ltd. 2-16-5 Konan Minato-ku Tokyo 108-8215 Japan

On March 30, 2007, Japan's electric utilities reported the results of a complete review of their powergenerating units to the Nuclear and Industrial Safety Agency of the Ministry of Economy, Trade, and Industry (METI). The Ethics Committee of the Atomic Energy Society of Japan (AESJ) then recommended an assessment method to analyze the seriousness of the problems from multiple perspectives in order to support the public's understanding of the reported problems. Accordingly, the Ethics Committee conducted the assessment. The assessment considered each reported problem associated with nuclear power-generating units and the preventive measures completed between June 2007 and September 2008 (corrective measures continued beyond that period). The results were presented at the autumn conferences of AESJ in 2007 and 2008, and are discussed in this report. © Atomic Energy Society of Japan.

关键词： Accident prevention

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In-use stock of copper analysis using satellite nighttime light observation data

In-use stock of copper analysis using satellite nighttime li...

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作者： Takahashi, Kazue Ichino Terakado, Ryutaro Nakamura, Jiro Daigo, Ichiro Matsuno, Yasunari Adachi, Yoshihiro Department of Material Engineering Graduate School of Engineering University of Tokyo Tokyo 113-8656 Japan NTT Energy and Environment Systems Laboratories Nippon Telegraph and Telephone Corporation Atsugi 243-0198 Japan

We have developed a novel methodology for analyzing the worldwide copper stock-in-use by using nighttime light images. Radiance calibrated nighttime light imaged data (RCD) for the entire world has been assembled from the Defense Meteorological Satellite program (DMSP) Operational Linescan System (OLS) by the National Geophysical Data Center. It has been recognized that the intensity of nighttime light is strongly associated with such aspects of human settlement as population density and energy consumption. We assumed that the presence of light implies the use of electrical conducting material, namely copper. The stock-in-use data for copper in Japan, North America, Australia and China were obtained from previous material flow analysis studies. We analyzed the relationship between light accumulation and the size of the copper stock in those countries. A significant correlation was found and the feasibility of this method was confirmed. We employed this method to analyze the stock-in-use in other Asian countries. The in-use stock of copper was correlated with the gross domestic product (GDP). ©2009 The Thermoelectrics Society of Japan.

关键词： Copper

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Risk-based assessment of arsenic-affected aquacultural water in blackfoot disease hyperendemic areas

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Stochastic Environmental Research and Risk Assessment 2009年第5期23卷 603-612页

作者： Jang, Cheng-Shin Lin, Kao-Hung Liu, Chen-Wuing Lin, Ming-Chao Department of Leisure and Recreation Management Kainan University Luzhu Taoyuan 33857 Taiwan Sustainable Environment Research Center National Cheng Kung University Tainan 701 Taiwan Department of Bioenvironmental Systems Engineering National Taiwan University Taipei 106 Taiwan General Education Center Graduate Institute of Environmental Management Nanhua University Dalin Chia-Yi 62248 Taiwan

This work explored a risk-based arsenic (As) regulation in farmed pond water by ingesting tilapia (Oreochromis mossambicus) in blackfoot disease hyperendemic areas and discussed a rational As regulation in pond water. Monte Carlo analysis was used to propagate the parameter uncertainty and to assess probabilistically regulation risks. A dynamic scheme of groundwater management was proposed that curves of utilization ratios against As concentrations in groundwater were established based on the risk-based regulation. The 5th to 95th percentiles of risks range from 3.5 × 10-7 to 6.0 × 10-5 via ingesting the farmed tilapia under the current As regulation in farmed pond water in Taiwan, 50 μg/L. To compare to inorganic As regulation in drinking water, the current As regulation in farmed pond water does not pose a great threat to human health, but it is unsafe. Therefore, this study suggests that the regulation of As in farmed pond water is revised to be 25 μg/L. © Springer-Verlag 2008.

关键词： Groundwater

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Applying model-based data engineering to evaluate the alignment of information modeled within JC3IEDM, MSDL, and MATREX-FOM

Applying model-based data engineering to evaluate the alignm...

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Fall Simulation Interoperability Workshop 2009, 2009 Fall SIW

作者： Ustun, Anil Tolk, Andreas Diallo, Saikou Department of Engineering Management and Systems Engineering Old Dominion University Norfolk VA 23529 United States Virginia Modeling Analysis and Simulation Center Old Dominion University Norfolk VA 23529 United States

ISBN: (纸本)9781615674015

The need for a common representation of entities and their relations to support the easier composition and federation of independently developed solutions in support of the user has been identified and addressed in several papers presented during recent simulation interoperability workshop. One of the underlying assumptions is that standards derived from the same conceptual domain can easily be converted into each others, as they deal with the same concepts. In a project conducted for the U.S. Army's program Executive Office (PEO) Soldier, three of such solutions for military operations (with focus on the land forces) were utilized to capture the underlying concepts of land warfare: the Joint Consultation, Command and Control Information Exchange Data Model (JC3IEDM), the Military Scenario Description Language (MSDL), and the Modeling Architecture for Technology, Research, and Experimentation (MATREX) Federation Object Model (FOM). When we applied the methods of Model-based Data engineering (MBDE) we observed, that these three standards are not conceptually as well aligned as we assumed. We identified several significant gaps. The findings of this paper will contribute to support designers, engineers and project managers in a better way to understand, (1) which data are needed operationally, (2) how gaps can be identified regarding supporting standards, (3) how the gaps can be closed, and (4) what data transformation must be conducted when dealing with different standards in data-rich integration projects to ensure cost-efficient and operationally effective solutions. Copyright © (2009) by SISO - Simulation Interoperability Standards Organization.

关键词： Interoperability

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Quantifying the resiliency of an academic program decision support methodology using complexity-induced vulnerability assessment

Quantifying the resiliency of an academic program decision s...

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30th Annual National Conference of the American Society for engineering management 2009, ASEM 2009

作者： Calida, Behnido Y. Gheorghe, Adrian V. Unal, Resit Old Dominion University Norfolk VA United States Old Dominion University Norfolk VA United States Department of Engineering Management and Systems Engineering Old Dominion University Norfolk VA United States

ISBN: (纸本)9781617381058

Academic departments need to assess and upgrade their existing programs and course offerings for important reasons such as: i) to regularly evaluate a curricula's structure, ii) to maintain competitiveness, iii) to evaluate the resiliency of a given academic program, and iv) to ensure its relevance to the fast changing environment and context. This paper aims to demonstrate the complexity-derived concept of 'vulnerability' and how it applies to difficult decisionmaking situations. We use a graph theory-based complexity perspective as a tool to supplement decision making in assessing a department's course offering. Specifically, we can regard Old Dominion University College of engineering's engineering management and systems engineering (EMSE) department or specifically its graduate program offering as a multi-component (many body) system consisting of its internal connectivity (i.e. combination of course offering as member interactions) defining structural complexity and as a source of vulnerability. We explore an alternate methodology that combines the state-of-the-art in clustering text analysis as well as complexity-induced vulnerability quantitative techniques recently developed for risk quantification of complex systems. Copyright© (2009) by the American Society for engineering management.

关键词： Graph theory

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The development and implementation of an expanded capstone design experience by replacing an internship course

The development and implementation of an expanded capstone d...

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2009 ASEE Annual Conference and Exposition

作者： Horton, E. Delbert Elam, Matthew Cranor, Ben Texas A and M University Commerce United States Department of Industrial Engineering Department of Industrial Engineering and Technology Texas A and M University Commerce United States Technology Management Graduate Program Texas A and M University Commerce United States

The Industrial engineering (IE) program at the authors' university receives continued feedback from industry, the IE program Industry Advisory Board (IAB), and student evaluations. This feedback indicated the program needed to provide the senior-level students with a more realistic industry experience. Currently, the IE internship course, IE 471, and Industrial systems Design (IE capstone course), IE 495, are in the IE program curriculum to introduce and provide the senior engineering student an insight into the industrial world. These two courses were evaluated according to the continuous improvement plan for the Accreditation Board for engineering and Technology (ABET) and changes were recommended. The IE 471 Internship is offered to give students an occupational experience in an industrial facility. Students and faculty have experienced several disappointing obstacles in executing this IE 471 internship course, including students being unable to convince industry to hire them for an internship course. The students in the authors' IE program are generally nontraditional students. They are generally older students with family and other responsibilities in addition to their education goals. They are generally working 40 hours per week to support the family and meeting a full-time student curriculum. These students are reluctant to give up their current employment and to work for one semester as an intern. These internships are at minimum wage without benefits for the student and his/her family. The student's current job may not be available when he/she returns after the internship. The disappointments the faculty experience stem from students requesting the faculty advisor to consider using their current job responsibilities as their internship. For example, the student may be working as a sales clerk at a cell phone retail store. This position would have no engineering problems or experience. This paper focuses on the development and implementation of a replacement

关键词： Students

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Incomplete Balancing Domain Decomposition for Large scale 3-D non-stationary incompressible flow problems

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IOP Conference Series: Materials Science and engineering 2010年第1期10卷

作者： Q H Yao H Kanayama M Ognio H Notsu Department of Intelligent Machinery and Systems Graduate School of Engineering Kyushu University 744 Motooka Nishi-ku Fukuoka 819-0395 Japan School of Mechanical and Automotive Engineering South China University of Technology Guangzhou 510640 China Department of Mechanical Engineering Faculty of Engineering Kyushu University 744 Motooka Nishi-ku Fukuoka 819-0395 Japan Research Center for Hydrogen Industrial Use and Storage (HYDROGENIUS) National Institute of Advanced Industrial Science and Technology (AIST) Japan

To solve large scale 3-D non-stationary incompressible flow problems, an algorithm to perform an Incomplete Balancing Domain Decomposition (IBDD) is constructed in this work; as an improvement of the Balancing Domain Decomposition (BDD) method, it reduce the computation cost of the coarse problem by replacing the exact balancing procedure with an inexact balancing procedure; the nonlinear convection term of the Navier-Stokes equation is approximated by a characteristic-curve method, which is advantageous as it renders the matrix for linear equations symmetric, thus enabling the Conjugate Gradient (CG) method to be used together with the Schur complement system of Domain Decomposition Method (DDM); the algorithms are all implemented in parallel by the Hierarchical Domain Decomposition Method (HDDM) system, and the program provides solvability for models of over 10 million degrees of freedom (DOF).

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