To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 1...
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90% of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.
This paper proposes a multiobjective heuristic search approach to support a project portfolio selection technique on scenarios with a large number of candidate projects. The original formulation for the technique requ...
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ISBN:
(纸本)9781450311786
This paper proposes a multiobjective heuristic search approach to support a project portfolio selection technique on scenarios with a large number of candidate projects. The original formulation for the technique requires analyzing all combinations of candidate projects, which is unfeasible when more than a few alternatives are available. We have used a multiobjective genetic algorithm to partially explore the search space of project combinations and select the most effective ones. We present an experimental study based on four project selection problems that compares the results found by the genetic algorithm to those yielded by a non-systematic search procedure. Results show evidence that the project selection technique can be used in large-scale scenarios and that GA presents better results than simpler search strategy. Copyright is held by the author/owner(s).
Organizations have been relying on collaboration for productivity improvement and knowledge sharing. The first step to foster collaboration in organizations is to make it explicit. With this aim, the Collaboration Mat...
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Organizations have been relying on collaboration for productivity improvement and knowledge sharing. The first step to foster collaboration in organizations is to make it explicit. With this aim, the Collaboration Mat...
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Organizations have been relying on collaboration for productivity improvement and knowledge sharing. The first step to foster collaboration in organizations is to make it explicit. With this aim, the Collaboration Maturity Model (CollabMM) was proposed and evaluated. The lessons learned during model applications in previous work pointed out the need to review both the model and its evaluation instruments. A literature review also showed some improvement opportunities. Therefore, the objective of this work is to develop a roadmap to highlight the main opportunities of evolution in CollabMM. These opportunities will compose our research agenda in this topic and guide future work.
Emerging 64 bitOSpsilas supply a huge amount of memory address space that is essential for new applications using very large data. It is expected that the memory in connected nodes can be used to store swapped pages e...
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Emerging 64 bitOSpsilas supply a huge amount of memory address space that is essential for new applications using very large data. It is expected that the memory in connected nodes can be used to store swapped pages efficiently, especially in a dedicated cluster which has a high-speed network such as 10 GbE and Infiniband. In this paper, we propose the distributed large memory system (DLM), which provides very large virtual memory by using remote memory distributed over the nodes in a cluster. The performance of DLM programs using remote memory is compared to ordinary programs using local memory. The results of STREAM, NPB and Himeno benchmarks show that the DLM achieves better performance than other remote paging schemes using a block swap device to access remote memory. In addition to performance, DLM offers the advantages of easy availability and high portability, because it is a user-level software without the need for special hardware. To obtain high performance, the DLM can tune its parameters independently from kernel swap parameters. We also found that DLMpsilas independence of kernel swapping provides more stable behavior.
作者：
Markle, Stephen P.CDR. STEPHEN P. MARKLE
USN (REt.)P.E.a retired US Navy Engineering Duty Officer and is the Engineering Director for Navalis Environmental Systems. His active duty assignments included the staff of the Chief of Naval Operations Director of Surface Warfare as Section Head for Surface Combatant Maintenance and Modernization Program Executive Office Expeditionary Warfare as Assistant Project Manager for the (TAKE 1)Class Programand as Deputy Director
Environmental Programs Division at Naval Sea Systems Command. He is a 1993 graduate of the Naval Construction and Engineering Program at the Massachusetts Institute of Technology where he received a Naval Engineers Degree and Master of Science in Mechanical Engineering. Since 1995 he has authored thirteen published technical papers dealing with environmental issues. CDR Markle is the recipient of Fiscal Year 2001 Individual Environmental Quality Awards and Environmental Excellence in Weapon System Acquisition Team Awards from Naval Sea Systems Command Chief of Naval Operations Secretary of the Navy and Secretary of Defense and the 2001 ASNE “Jimmie Hamilton” award. He is a Professional Engineer registered in the State of New York and Commonwealth of Virginia. He serves as the Chair of the Joint ASNE/SNAME Committee on Environmental Engineering and also as Chair of ASTM Ships and Marine Technology Marine Environmental Protection Subcommittee (F25.06).
Regulations governing the discharge of sewage from ships have been in force since the early 1970's. In response, the marine industry has developed ever more complex systems and processes for managing these wastes....
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Regulations governing the discharge of sewage from ships have been in force since the early 1970's. In response, the marine industry has developed ever more complex systems and processes for managing these wastes. The first compliance method involved holding wastes until they could be legally discharged;as technology advanced, treatment systems were developed and installed to enable discharge within regulated waters. As the size and number of ships as increased with maturation of the ocean tourism business, more restrictive regulations have been enacted to minimize the impact on sensitive waters. The trend is toward increasing regulation of both sewage and graywater. The most recent action occurred on 12 October 2005 when the Governor of California signed into law Senate Bill 771 regulating most ship liquid discharges within state waters. This paper describes the development of an innovative advanced wastewater treatment technology, based on advanced oxidation, bearing in mind the lessons learned from systems developed by industry over the past thirty years.
Many components are usually created within a Domain engineering (DE) process. These components may exchange a great number of messages among them, and many times this interaction occurs within a specific group of comp...
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With the increase in adoption of remote work groups and teams working in non-collocated environments, several opportunities for interaction have been lost. Contact with colleagues and discovery of opportunities, previ...
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With the increase in adoption of remote work groups and teams working in non-collocated environments, several opportunities for interaction have been lost. Contact with colleagues and discovery of opportunities, previously easy due to physical proximity, is made harder with distance. In this paper, we describe an agent-based framework to assist users in finding opportunities for interaction that may have been overlooked.
Creativity has become an important asset in today'sfast changing environment. It is especially important indesign, which demands innovative solutions for *** believe that creativity can and should beencouraged in ...
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Creativity has become an important asset in today'sfast changing environment. It is especially important indesign, which demands innovative solutions for *** believe that creativity can and should beencouraged in work groups. In this paper, we proposea framework for supporting creativity in problemsolving. Through the use of problem, domain and usermodels and information retrieval and agent technology,we hope to support creative cooperative work.
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