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Workshop on imaging science development for cancer prevention and preemption

Cancer Biomarkers 2007年第1期3卷 1-33页

作者： Kelloff, Gary J. Sullivan, Daniel C. Baker, Houston Clarke, Lawrence P. Nordstrom, Robert Tatum, James L. Dorfman, Gary S. Jacobs, Paula Berg, Christine D. Pomper, Martin G. Birrer, Michael J. Tempero, Margaret Higley, Howard R. Petty, Brenda Gumbs Sigman, Caroline C. Maley, Carlo Sharma, Prateek Wax, Adam Ginsberg, Gregory G. Dannenberg, Andrew J. Hawk, Ernest T. Messing, Edward M. Grossman, H. Barton Harisinghani, Mukesh Bigio, Irving J. Griebel, Donna Henson, Donald E. Fabian, Carol J. Ferrara, Katherine Fantini, Sergio Schnall, Mitchell D. Zujewski, Jo Anne Hayes, Wendy Klein, Eric A. DeMarzo, Angelo Ocak, Iclal Ketterling, Jeffrey A. Tempany, Clare Shtern, Faina Parnes, Howard L. Gomez, Jorge Srivastava, Sudhir Szabo, Eva Lam, Stephen Seibel, Eric J. Massion, Pierre McLennan, Geoffrey Cleary, Kevin Suh, Robert Burt, Randall W. Pfeiffer, Ruth M. Hoffman, John M. Roy, Hemant K. Wang, Thomas Limburg, Paul J. El-Deiry, Wafik S. Papadimitrakopoulou, Vali Hittelman, Walter N. MacAulay, Calum Veltri, Robert W. Solomonzz, Diane Jeronimo, Jose Richards-Kortum, Rebecca Johnson, Karen A. Viner, Jaye L. Stratton, Steven P. Rajadhyaksha, Milind Dhawan, Atam NIH/NCI/DCTD Cancer Imaging Program Bethesda MD United States NIH/NCI/DCTD Cancer Imaging Program NCI-Frederick Frederick MD United States NIH/NCI/DCP Early Detection Research Group Bethesda MD United States The Johns Hopkins University School of Medicine Departments of Radiology Pharmacology and Oncology Division of Neuroradiology Baltimore MD United States NIH/NCI/CCR Cell and Cancer Biology Branch Bethesda MD United States University of California San Francisco Department of Medicine Division of Medical Oncology San Francisco CA United States CCS Associates Inc. Mountain View CA United States Wistar Institute Molecular and Cellular Oncogenesis Program Philadelphia PA United States University of Kansas School of Medicine VA Hospital Kansas City MO United States Duke University Department of Biomedical Engineering Medical Physics Program Durham NC United States University of Pennsylvania School of Medicine Department of Gastroenterology Philadelphia PA United States New York Presbyterian Hospital Weill Medical College of Cornell University New York NY United States NIH/NCI/OD Office of Centers for Training and Resources Bethesda MD United States University of Rochester Medical Center Department of Urology Rochester NY United States University of Texas MD Anderson Cancer Center Department of Urology Houston TX United States Massachusetts General Hospital Abdominal Imaging/Interventional Radiology Boston MA United States Boston University Biomedical Engineering Electrical and Computer Engineering and Physics Boston MA United States NIH/NCI/DCP Gastrointestinal and Other Cancers Research Group Bethesda MD United States The George Washington University Cancer Institute Office of Cancer Prevention and Control Washington DC United States University of Kansas Cancer Center Clinical Oncology Kansas City KS United States University of California Davis Department of Biomedical Engineering Davis CA United States Tufts University De

The concept of intraepithelial neoplasm (IEN) as a near-obligate precursor of cancers has generated opportunities to examine drug or device intervention strategies that may reverse or retard the sometimes lengthy process of carcinogenesis. Chemopreventive agents with high therapeutic indices, well-monitored for efficacy and safety, are greatly needed, as is development of less invasive or minimally disruptive visualization and assessment methods to safely screen nominally healthy but at-risk patients, often for extended periods of time and at repeated intervals. Imaging devices, alone or in combination with anticancer drugs, may also provide novel interventions to treat or prevent precancer.

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Aircraft maintenance technology education: Integrating asynchronous technology & virtual reality

Aircraft maintenance technology education: Integrating async...

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113th Annual ASEE Conference and Exposition, 2006

作者： Sadasivan, Sajay Vembar, Deepak Stringfellow, Paris Washburn, Carl Duchowski, Andrew Gramopadhye, Anand Cemson University Department of Industrial Engineering Clemson University SC United States Department of Computer Science Clemson University SC United States Greenville Tech United States Aircraft Maintenance Program Greenville Technical College United States Department of Computer Science Clemson University United States Industrial Engineering Department Advanced Technology Systems Laboratory Clemson University SC United States

This paper describes a research program with an objective to develop and implement an interactive virtual reality (VR) model of the aircraft inspection maintenance process for asynchronous delivery. Existing approaches have not been able to mimic accurately the complexity of the aircraft maintenance process, reporting limited transfer capabilities and student preparedness for the workplace. This use of virtual reality technology will enable educators to create and students to experience the complex aircraft maintenance environment in an educational classroom, a setting where it has not yet been successfully created using traditional multimedia-based technologies. This model will emphasize the curriculum development and workplace preparedness needed by modern aircraft maintenance technology for local, state and national audiences. The primary objectives of this research are curriculum enhancement and assessment of VR as a pedagogical tool. This innovative approach is the first effort to extend tested VR technology to the aircraft maintenance technology curriculum in a two-year college. The outcome of this research will lead to the following: an innovative, high-impact model for curriculum application in aircraft maintenance technology for college students and industry employees;an increased workplace pool of aircraft maintenance technicians prepared for the transition from learning to workforce;a program providing the use of VR technology as a pedagogical tool. The successful completion of this effort will fill a state and national need for well-prepared students entering the aircraft maintenance industry and will provide a better understanding of the use of VR as a pedagogical tool. © American Society for engineering Education, 2006.

关键词： Aircraft

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Variability modeling in a Component-based Domain engineering Process 1

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9th International Conference on Software Reuse, ICSR 2006

作者： Blois, Ana Paula Terra Bacelo De Oliveira, Regiane Felipe Maia, Natanael Werner, Cláudia Becker, Karin Federal University of Rio de Janeiro COPPE/UFRJ System Engineering and Computer Science Program P.O. Box 68511 21945-970 - Rio de Janeiro - RJ Brazil PUCRS Catholic University of Rio Grande do Sul Prédio 30 - Bloco 4 90619-900 - Porto Alegre - RS Brazil

ISBN: (数字)9783540346074

ISBN: (纸本)3540346066

Domain engineering (DE) and Component-based Development (CBD) are approaches that focus on reuse. On the one hand, DE methods emphasize variability modeling in analysis phase. On the other hand, most CBD methods gude on the development of components, with a minor focus on reusability properties. This paper presents an approach to support variability modeling, in a Component-based Domain engineering Process. © Springer-Verlag Berlin Heidelberg 2006.

关键词： Software engineering

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Predicting Probability of Mortality in the Neonatal Intensive Care Unit

Predicting Probability of Mortality in the Neonatal Intensiv...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Dajie Zhou Monique Frize Program of Systems Science University of Ottawa Ottawa ONT Canada Department of Systems and Computer Engineering Carleton University and the School of Information Technology and Engineering University of Ottawa Ottawa ONT Canada

Artificial neural networks can be trained to predict outcomes in a neonatal intensive care unit (NICU). This paper expands on past research and shows that neural networks trained by the maximum likelihood estimation criterion will approximate the `a posteriori probability' of NICU mortality. A gradient ascent method for the weight update of three-layer feed-forward neural networks was derived. The neural networks were trained on NICU data and the results were evaluated by performance measurement techniques, such as the Receiver Operating Characteristic Curve and the Hosmer-Lemeshow test. The resulting models applied as mortality prognostic screening tools are presented

关键词： Pediatrics Neural networks Artificial neural networks Maximum likelihood estimation Measurement Testing Feedforward systems Feedforward neural networks Resource management Cities and towns

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A neural model for sonar-based navigation in obstacle fields

A neural model for sonar-based navigation in obstacle fields

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IEEE International Symposium on Circuits and systems (ISCAS)

作者： T.K. Horiuchi Institute for Systems Research & The Neuroscience and Cognitive Science Program Electrical and Computer Engineering Department University of Maryland College Park MD USA

The rapid control of sonar-guided vehicles through obstacle fields has been a goal of robotics for decades. How sensory data is represented strongly affects how obstacles and goal information can be combined to select a direction of travel. While typical approaches combine attractive and repulsive effects to directly determine steering, we are investigating an algorithm that evaluates multiple directions simultaneously followed by a winner-take-all (WTA) function which then guides steering. In this paper we describe a neuromorphic VLSI implementation of this algorithm using the inherent echo delay to create a range-dependent gain in a 'race-to-first-spike' neural WTA circuit. The chip was fabricated in a commercially-available 0.5 mum CMOS process and in this paper we present preliminary test results

关键词： Sonar navigation Robot sensing systems Neurons Automotive engineering Neuroscience Cognitive science Educational institutions Control systems Vehicles Cognitive robotics

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Predicting probability of mortality in the neonatal intensive care unit

Predicting probability of mortality in the neonatal intensiv...

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28th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBS'06

作者： Dajie, Zhou Frize, Monique IEEE Program of Systems Science University of Ottawa 800 King Edward Ottawa Ont. K1N 6N5 Canada Department of Systems and Computer Engineering Carleton University University of Ottawa 1125 Colonel By Drive Ottawa Ont. K1S 5B5 Canada

ISBN: (纸本)1424400325

Artificial neural networks can be trained to predict outcomes in a neonatal intensive care unit (NICU). This paper expands on past research and shows that neural networks trained by the maximum likelihood estimation criterion will approximate the 'a posteriori probability' of NICU mortality. A gradient ascent method for the weight update of three-layer feed-forward neural networks was derived. The neural networks were trained on NICU data and the results were evaluated by performance measurement techniques, such as the Receiver Operating Characteristic Curve and the Hosmer-Lemeshow test The resulting models applied as mortality prognostic screening tools are presented. © 2006 IEEE.

关键词： Neonatal monitoring

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Communications infrastructure generation for modular FPGA reconfiguration

Communications infrastructure generation for modular FPGA re...

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IEEE International Conference on Field-programmable Technology (FPT)

作者： Shannon Koh Oliver Diessel School of Computer Science and Engineering University of New South Wales Sydney Australia Embedded Real-Time and Operation Systems (ERTOS) Program NICTA Australia

Modules that are swapped dynamically at run-time on an FPGA have varying communication needs over time. In order to support this, we aim to generate a wiring infrastructure that caters for the dynamically-changing module interfaces. This, however, imposes a regular structure for laying out modules on a device, which may result in longer inter-module wiring paths as compared to traditional methods where the netlists are flattened. This paper studies placing modules within a structured layout to compare resulting circuit speeds with those obtained by traditional methods. Our results indicate that the difference in critical path delay is high at very low utilisation, but that the overhead is absorbed as the number of modules and interconnection density increases to realistic levels. The authors conclude that implementing such a wiring infrastructure has manageable overheads while having the added advantage of being amenable to dynamic reconfiguration

关键词： Field programmable gate arrays Wiring Australia Runtime Circuits Logic devices Reconfigurable logic computer science Real time systems Operating systems

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COMMA: A Communications Methodology for Dynamic Module Reconfiguration in FPGAs

COMMA: A Communications Methodology for Dynamic Module Recon...

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Annual IEEE Symposium on Field-programmable Custom Computing Machines (FCCM)

作者： Shannon Koh Oliver Diessel School of Computer Science & Engineering University of New South Wales Sydney Australia Embedded Real Time and Operation Systems Program National ICT Australia NICTA Sydney Australia

On-going improvements in the scaling of FPGA device sizes and time-to-market pressures encourage the use of module-oriented design flows [3], while economic factors favour the reuse of smaller devices for high performance computational tasks. One of the core problems in proposing dynamic modular reconfiguration approaches is supporting the differing communications needs of the sequence of modules configured over time [2]. Proposals to date have not focussed on communications issues. Moreover, they have advocated the use of specific protocols [4], or they cannot be readily implemented [1], or they suffer from high overheads [5], or rely upon deprecated features such as tri-state lines [7]. In contrast, we propose a methodology for the rapid deployment of a communications infrastructure that provides the wires required by dynamic modules and allows users to implement the protocols they want. Our aim is to support new tiled dynamically reconfigurable architectures such as Virtex-4, as well as mature device families.

关键词： Field programmable gate arrays Pins Wiring Australia Protocols computer science Design engineering Real time systems Operating systems Time to market

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ISHM implementation for Constellation systems

ISHM implementation for Constellation Systems

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AIAA/ASME/SAE/ASEE 42nd Joint Propulsion Conference

作者： Figueroa, Fernando Holland, Randy Schmalzel, John Duncavage, Dan Crocker, Alan Alena, Rick NASA Stennis Space Center Stennis Space Center MS 39529 Rowan University Dept. of Electrical and Computer Engineering Glassboro NJ 08028 NASA Johnson Space Center Houston TX 77058 NASA Ames Research Center Moffett Field CA 94035 Science and Technology Division EA41 Stennis Space Center MS 39529 AIAA Department of Electrical and Computer Engineering Rowan University Glassboro NJ 08028 International Space Station Program OD NASA Johnson Space Center Houston TX 77058 Systems Division Mission Operations Directorate DF NASA Johnson Space Center Houston TX 77058 Intelligent Systems Division MS 269-4 Moffett Field CA 94035

ISBN: (纸本)1563478188

This paper addresses methodic implementation of a credible ISHM capability for elements of Constellation systems. ISHM capability must be implemented by a combination of on-board and ground elements, each contributing to determining the health of systems in the most effective manner. Implementation of ISHM capability must evolve continuously to reach higher and higher levels of functional capability. The implication is that a sustainable approach must be defined in order to accomplish a believable capability. This paper describes the methodology, the elements, and the technology to implement ISHM capability throughout the life cycle of elements of Constellation systems, reaching beyond individual elements that might have a limited life while the constellation moves on.

关键词： Spacecraft propulsion

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Real-time organ motion tracking and fast image registration system for MRI-guided surgery

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systems and computers in Japan 2006年第1期37卷 83-92页

作者： Tokuda, Junichi Hirano, Masaya Tsukamoto, Tetsuji Dohi, Takeyoshi Hata, Nobuhiko Graduate School of Information Science and Technology University of Tokyo Tokyo 113-8656 Japan GE Yokogawa Medical Systems Ltd. Hino 191-8503 Japan International Society for Computer-Aided Surgery Japan Society for Computer-Aided Surgery Japan Society for Magnetic Resonance in Medicine GE Yokogawa Medical Systems Ltd. Imaging Application Tech. Center MR Group R and D Laboratory Technology Center GE Yokogawa Medical Systems Ltd. Society for Magnetic Resonance in Medicine Graduate School of Information Science and Technology Society for Life Support Technology Japan Society for Organ Preservation Biology and Medicine Society for Precision Engineering Society for Medical Image Computing and Computer Assisted Intervention International Union for Physics and Engineering Sciences in Medicine JSMEBE Japan Society for Life Assistance Technology Brigham and Women's Hospital Harvard Medical School MR Therapy Program

The advantage of magnetic resonance imaging (MRI)-guided surgery, in which MR images taken during surgery are used to guide the surgery, has been recognized recently. However, there is a problem, due to long imaging time of MRI, that it is difficult to capture the respiratory organ motion. It is often a constraint that the patient must hold his or her breath, especially in the treatment of the abdominal region. Consequently, this paper proposes a method of eliminating this constraint in MRI-guided surgery by real-time monitoring of the movement of the organ involved in the surgery by means of the signal derived from MRI. Specifically, the navigator echo is extracted in imaging during surgery. The movement of the organ involved in surgery is detected on the basis of the change in the calculated projection profile, and the results are presented to the surgeon. In this study, the procedure is built into a 1.5-T clinical MRI system. The feasibility of the proposed system was examined under clinical conditions by evaluating its accuracy and delay in a phantom experiment, and also in an in vivo experiment on the liver of a volunteer. The results are reported in this paper. © 2005 Wiley Periodicals, Inc.

关键词： Motion estimation

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