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检索条件"机构=Systems Science Ph.D Program"
177 条 记 录,以下是41-50 订阅
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Glycyrrhizic acid conjugates with amino acid methyl esters target the main protease, exhibiting antiviral activity against wild-type and nirmatrelvir-resistant SARS-CoV-2 variants
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Antiviral research 2024年 227卷 105920页
作者: Uyen Nguyen phuong Le Yu-Jen Chang Chih-Hao Lu Yeh Chen Wen-Chi Su Shao-Ting Chao Lia A Baltina Svetlana F Petrova Sin-Rong Li Mien-Chie Hung Michael M C Lai Lidia A Baltina Cheng-Wen Lin Graduate Institute of Biological Science and Technology China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan. The Ph.D. Program of Biotechnology and Biomedical Industry China Medical University Taichung Taiwan. The Ph.D. Program of Biotechnology and Biomedical Industry China Medical University Taichung Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan. Department of Food Science and Biotechnology National Chung Hsing University Taichung 402 Taiwan. Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan. Ufa Institute of Chemistry Ufa Federal Research Center of the Russian Academy of Sciences Russia. Department of Laboratory Medicine China Medical University Hospital Taichung 404327 Taiwan. Research Center for Cancer Biology China Medical University Taichung 404327 Taiwan Center for Molecular Medicine China Medical University Hospital Taichung 404327 Taiwan. Institute of Molecular Biology Academia Sinica Taipei 115201 Taiwan. Ufa Institute of Chemistry Ufa Federal Research Center of the Russian Academy of Sciences Russia. Electronic address: baltina@anrb.ru. Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan. Electronic address: cwlin@mail.cmu.edu.tw.
COVId-19 pandemic is predominantly caused by SARS-CoV-2, with its main protease, Mpro, playing a pivotal role in viral replication and serving as a potential target for inhibiting different variants. In this study, po... 详细信息
来源: 评论
Combining virtual screening with cis-/trans-cleavage enzymatic assays effectively reveals broad-spectrum inhibitors that target the main proteases of SARS-CoV-2 and MERS-CoV
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Antiviral research 2023年 216卷 105653页
作者: Yu-Jen Chang Uyen Nguyen phuong Le Jia-Jun Liu Sin-Rong Li Shao-Ting Chao Hsueh-Chou Lai Yu-Feng Lin Kai-Cheng Hsu Chih-Hao Lu Cheng-Wen Lin The Ph.D. Program of Biotechnology and Biomedical Industry China Medical University Taichung Taiwan. Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan Graduate Institute of Biological Sciences and Technology China Medical University Taichung Taiwan. Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan. Department of Laboratory Medicine China Medical University Hospital Taichung Taiwan. Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan. Division of Hepato-Gastroenterology Department of Internal Medicine China Medical University Hospital Taichung Taiwan. Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan. Graduate Institute of Cancer Biology and Drug Discovery Taipei Medical University Taipei Taiwan. The Ph.D. Program of Biotechnology and Biomedical Industry China Medical University Taichung Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan. Electronic address: chlu@nycu.edu.tw. Graduate Institute of Biological Sciences and Technology China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan. Electronic address: cwlin@mail.cmu.edu.tw.
The main protease (M) of SARS-CoV-2 is essential for viral replication, which suggests that the M is a critical target in the development of small molecules to treat COVId-19. This study used an in-silico prediction a... 详细信息
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Correction to: Long noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival
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Journal of biomedical science 2022年 第1期29卷 59页
作者: Ruei Liang Yan Chiu Lin Luan Chun Chieh Liao Li Heng Liu Fei Yun Chen Hsin Yi Chen Ruey Hwa Chen Institute of Biological Chemistry Academia Sinica Taipei 115 Taiwan. Institute of Molecular Medicine College of Medicine National Taiwan University Taipei 100 Taiwan. Genome and Systems Biology Degree Program College of Life Science National Taiwan University Taipei 106 Taiwan. Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Institute of Biological Chemistry Academia Sinica Taipei 115 Taiwan. rhchen@gate.sinica.edu.tw. Institute of Molecular Medicine College of Medicine National Taiwan University Taipei 100 Taiwan. rhchen@gate.sinica.edu.tw. Genome and Systems Biology Degree Program College of Life Science National Taiwan University Taipei 106 Taiwan. rhchen@gate.sinica.edu.tw.
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SWEET: a single-sample network inference method for deciphering individual features in disease
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Briefings in bioinformatics 2023年 第2期24卷 bbad032页
作者: Hsin-Hua Chen Chun-Wei Hsueh Chia-Hwa Lee Ting-Yi Hao Tzu-Ying Tu Lan-Yun Chang Jih-Chin Lee Chun-Yu Lin Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu 300 Taiwan. School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei 110 Taiwan. Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Otolaryngology-Head and Neck Surgery Tri-Service General Hospital National Defense Medical Center Taipei 110 Taiwan. Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu 300 Taiwan. Institute of Data Science and Engineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan. Center for Intelligent Drug Systems and Smart Bio-devices National Yang Ming Chiao Tung University Hsinchu 300 Taiwan. School of Dentistry Kaohsiung Medical University Kaohsiung 807 Taiwan.
Recently, extracting inherent biological system information (e.g. cellular networks) from genome-wide expression profiles for developing personalized diagnostic and therapeutic strategies has become increasingly impor... 详细信息
来源: 评论
Author Correction: Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy
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Nature biotechnology 2025年 2025 Feb 3页
作者: Feifei Zhang Ryan d Chow Emily He Chuanpeng dong Shan Xin daniyal Mirza Yanzhi Feng Xiaolong Tian Nipun Verma Medha Majety Yueqi Zhang Guangchuan Wang Sidi Chen Department of Genetics Yale University School of Medicine New Haven CT USA. System Biology Institute Yale University West Haven CT USA. Center for Cancer Systems Biology Yale University West Haven CT USA. M.D.-Ph.D. Program Yale University West Haven CT USA. Molecular Cell Biology Genetics and Development Program Yale University New Haven CT USA. Yale College New Haven CT USA. Immunobiology Program Yale University New Haven CT USA. Department of Therapeutic Radiology Yale University School of Medicine New Haven CT USA. Department of Genetics Yale University School of Medicine New Haven CT USA. guangchuan.wang@***. System Biology Institute Yale University West Haven CT USA. guangchuan.wang@***. Center for Cancer Systems Biology Yale University West Haven CT USA. guangchuan.wang@***. Key Laboratory of Multi-Cell Systems Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Shanghai China. guangchuan.wang@***. Department of Genetics Yale University School of Medicine New Haven CT USA. sidi.chen@yale.edu. System Biology Institute Yale University West Haven CT USA. sidi.chen@yale.edu. Center for Cancer Systems Biology Yale University West Haven CT USA. sidi.chen@yale.edu. M.D.-Ph.D. Program Yale University West Haven CT USA. sidi.chen@yale.edu. Molecular Cell Biology Genetics and Development Program Yale University New Haven CT USA. sidi.chen@yale.edu. Yale College New Haven CT USA. sidi.chen@yale.edu. Immunobiology Program Yale University New Haven CT USA. sidi.chen@yale.edu. Department of Neurosurgery Yale University School of Medicine New Haven CT USA. sidi.chen@yale.edu. Yale Comprehensive Cancer Center Yale University School of Medicine New Haven CT USA. sidi.chen@yale.edu. Yale Stem Cell Center Yale University School of Medicine New Haven CT USA. sidi.chen@yale.edu. Yale Center for Biomedical Data Science Yale University School of Medicine New Have
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Persistence and dynamic structures of diverse cephalosporinase genes in nontyphoidal Salmonella in cross-sectional surveillance in Taiwan
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International Journal of Antimicrobial Agents 2023年 第4期62卷 106944-106944页
作者: Lee, Yuarn-Jang Chang, Yu-Chu Lee, I-Hui Ho, Kuo-Hao Fang, Shiuh-Bin Lauderdale, Tsai-Ling Chen, Ting-Wen Chen, Ku-Chung Huang, Chih-Hung Huang, Tzu-Wen Division of Infectious Diseases Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Division of Infectious Diseases Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Biochemistry and Molecular Cell Biology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Microbiology and Immunology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan Division of Pediatric Gastroenterology and Hepatology Department of Pediatrics Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Department of Medical Research Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Department of Pediatrics School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Master Program in Clinical Pharmacogenomics and Pharmacoproteomics College of Pharmacy Taipei Medical University Taipei Taiwan National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Zhunan Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Chemical Engineering and Biotechnology Institute of Chemical Engineering National Taipei University of Technology Taipei Taiwan
Objectives: Nontyphoidal Salmonella (NTS) is a major foodborne pathogen causing from acute gastroenteritis to bacteraemia, particularly in paediatric and elderly patients. Antimicrobial resistance of NTS, especially r... 详细信息
来源: 评论
Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq
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Nature communications 2025年 第1期16卷 4785页
作者: Hefei Zhang Xuhang Li dongyuan Song Onur Yukselen Shivani Nanda Alper Kucukural Jingyi Jessica Li Manuel Garber Albertha J M Walhout Department of Systems Biology University of Massachusetts Chan Medical School Worcester MA USA. Bioinformatics Interdepartmental Ph.D. Program University of California Los Angeles CA USA. Department of Genetics and Genome Sciences University of Connecticut Health Center Farmington CT USA. Via Scientific Inc. Cambridge MA USA. Pathology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA. Department of Genomics and Computational Biology University of Massachusetts Chan Medical School Worcester MA USA. Department of Statistics and Data Science Department of Biostatistics Department of Computational Medicine and Department of Human Genetics University of California Los Angeles CA USA. Department of Genomics and Computational Biology University of Massachusetts Chan Medical School Worcester MA USA. manuel.garber@umassmed.edu. Department of Systems Biology University of Massachusetts Chan Medical School Worcester MA USA. marian.walhout@umassmed.edu.
Transcriptomes provide highly informative molecular phenotypes that, combined with gene perturbation, can connect genotype to phenotype. An ultimate goal is to perturb every gene and measure transcriptome changes, how...
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development and validation of a novel combinational index of liquid biopsy biomarker for longitudinal lung cancer patient management
The journal of liquid biopsy
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The journal of liquid biopsy 2024年 6卷 100167页
作者: Min-Yi Liao Yun-Jie Hao Ching-Shan Luo Ching-Mei Chen Po-Hao Feng Hsin-Yu Yang da-Jeng Yao Kang-Yun Lee Fan-Gang Tseng Department of Power Mechanical Engineering National Tsing Hua University Hsinchu 30013 Taiwan. Department of Engineering and System Science National Tsing Hua University Hsinchu 30013 Taiwan. International Ph.D. Program in Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan. TMU Research Center of Thoracic Medicine Taipei Medical University Taipei 11031 Taiwan. Division of Pulmonary Medicine Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Nano Science and Technology Program National Tsing Hua University Hsinchu 30013 Taiwan. Institute of Nano Engineering and Micro Systems (NEMS) National Tsing Hua University Hsinchu 30013 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu 30013 Taiwan.
Objectives:Many cancer biomarkers such as the circulating tumor cells/microemboli (CTCs/CTM) have been reported significant associations with clinical outcomes. However, different biomarkers have different sensitiviti... 详细信息
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Association between high-density lipoprotein and functional outcome of ischemic stroke patients in a Taiwanese population
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Lipids in health and disease 2024年 第1期23卷 275页
作者: Ting-Chun Lin Chun-Yao Huang Yu-Ling Li Hung-Yi Chiou Chaur-Jong Hu Jiann-Shing Jeng Sung-Chun Tang Lung Chan Li-Ming Lien Huey-Juan Lin Chu-Chien Lin Yi-Chen Hsieh Department of Neurosurgery Hokkaido University Sapporo Japan. Division of Cardiology and Cardiovascular Research Center Department of Internal Medicine Taipei Medical University Hospital Taipei Taiwan. Taipei Heart Institute Taipei Medical University Taipei Taiwan. Institute of Population Health Sciences National Health Research Institutes Miaoli County Taiwan. School of Public Health College of Public Health Taipei Medical University Taipei Taiwan. Department of Neurology Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan. School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Taipei Neuroscience Institute Taipei Medical University Taipei Taiwan. Department of Neurology National Taiwan University Hospital Taipei Taiwan. Department of Neurology Shin Kong Wu Ho-Su Memorial Hospital Taipei Taiwan. Department of Neurology Chi-Mei Medical Center Tainan 71004 Taiwan. Ph.D Program of Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei City Taiwan. ychsieh@tmu.edu.tw.
despite recent findings indicating a paradoxical association between high-density lipoprotein cholesterol (HdL-C) levels and cardiovascular disease (CVd) mortality, the impact of HdL-C on subsequent outcomes after isc... 详细信息
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Learner Characteristics as Consequences of Active Learning
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Journal of physics: Conference Series 2019年 第1期1340卷
作者: Jiratchaya phala Suthida Chamrat Ph.D student Doctor of Philosophy Program in Education (Science education) Faculty of Education Chiang Mai university Department of Curriculum Instruction and Learning Faculty of Education Chiang Mai University
This paper aims to explore the consequences of active learning implementation toward students' characteristics. Literature reviewing, and synthesizing intend to delineate the framework of active learning driven cl...
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