检索结果-内蒙古大学图书馆

Molecular biomarkers for amyotrophic lateral sclerosis

Current Bioinformatics 2008年第1期8卷 87-92页

作者： Hwang, Chi-Shin Hsieh, Chia-Hung Liu, Guan-Ting Chen, Si-Yi Tschen, Johnannes Scheng-Ming Chang, Hao-Teng Department of Neurology Taipei City Hospital Zhongxiao Branch Taipei Taiwan Graduate Institute of Basic Medical Science and Ph.D Program for Aging Taiwan Graduate Institute of Molecular Systems Biomedicine Taichung Taiwan Master Programs of Life Science College of Life Sciences National Chung Hsin University Taichung Taiwan Biotechnology Department Ming Dao University Taichung Taiwan China Medical University Hospital Taichung Taiwan

Amyotrophic lateral sclerosis (ALS) is a complicated and devastating neurodegenerative disease. To date, its diagnosis is still mainly based on clinical symptoms and electromyographic findings. High rates of misdiagnosis and delayed diagnosis are the major hurdles in ALS treatment. Thus, searching for biomarkers to improve clinical diagnosis of ALS is a highly desirable goal. Here we review current potential biomarkers derived from the various pathogenic mechanisms of ALS, including those involved in oxidative stress, synaptic excitotoxicity, neuroinflammation and the autoimmune response. Oxidative stress results from genetic mutation or an increase in protein aggregation, synaptic excitotoxicity arising from elevated levels of glutamate and d-serine, and the neuroinflammation occurring from elevated levels of inflammatory molecules and cytokine receptors. Some of these biomarkers could be used for monitoring the disease progression and to assess effectiveness of treatment for ALS. We conclude that neuroinflammation plays a crucial role in ALS, which may lead to a better understanding of this devastating disease and ultimately to a cure. In addition, the identification of new biomarkers would undoubtedly provide critical insights into the pathogenesis of ALS. © 2013 Bentham science Publishers.

关键词： Biomarkers

来源：评论

学校读者我要写书评

暂无评论

Tfe Solberg Award

引用

Naval Engineers Journal 2009年第5期112卷

作者： dr. Roy L. Streit Since 1992 Dr. Streit has focused a significant amount of his energy to assignment problems in acoustic warfare data fusion systems. This work led him to the formulation of the PDD Principle a broadly useful theoretical method that enables the derivation of new classes of discrete-continuous estimation algorithms for solving assignment problems without requiring enumeration and pruning. In recognition of his outstanding work in this area Dr. Streit received the NAVSEA Scientist of the Year Award for 1997. Dr. Streit has also been pursuing avenues for analyzing the loss in broadband detection performance of an acoustic array in the presence of interferences. Because examining all possible separations between the signal and many interferers is infeasible he has proposed a Poisson process model for the number and location (s) of the interferers. In this same time period Dr. Streit has also been investigating issues in environmental modeling and localization by proposing a novel integral method for solving the bearings-only target motion analysis problem which enables a natural heuristic for compensating for mismatch between the model predictions and the real world. Most recently Dr. Streit has proposed the Numerical ACoustic Hull ARray (NACHAR) Project as a revolutionary and ambitious approach to hull array design. Its premise is that optimizing the detection capability of large hull arrays requires the full integration of hull sensor array and beamformer design processes. Because NACHAR crosses an unusual number of technical disciplines it involves researchers from several departments. The diversity of Dr. Streif s technical background makes him uniquely suited to lead the project Dr. Streifs truly impressive scientific achievements are complemented by a noteworthy list of professional activities that accentuate his value to Division Newport and the Navy. He represents the United States in The Technical Cooperation Program Maritime Activities Panel 9 (Sonar Technology) and participates in the Division New

for his significant engineering research and development in sonar array research and acoustic transient signals as set forth in the following

关键词：

来源：评论

学校读者我要写书评

暂无评论

TRACKING CONTROL IN THE PRESENCE OF NONLINEAR dYNAMIC FRICTIONAL EFFECTS: ROBOT EXTENSION

引用

Asian Journal of Control 2008年第3期1卷

作者： M. Feemster d.M. dawson A. Behal W. dixon Matthew Feemster received the B.S degree in Electrical Engineering from Clemson University Clemson South Carolina in December 1994. Upon graduation he remained at Clemson University and received the M.S. degree in Electrical Engineering in 1997. During this time he also served as a research/teaching assistant. His research work focused on the design and implementation of various nonlinear control algorithms with emphasis on the induction motor and mechanical systems with friction present. He is currently working toward his Ph.D. degree in Electrical Engineering at Clemson University. Darren M. Dawson was born in 1962 in Macon Georgia. He received an Associate Degree in Mathematics from Macon Junior College in 1982 and a B.S. Degree in Electrical Engineering from the Georgia Institute of Technology in 1984. He then worked for Westinghouse as a control engineer from 1985 to 1987. In 1987 he returned to the Georgia Institute of Technology where he received the Ph.D. Degree in Electrical Engineering in March 1990. During this time he also served as a research/teaching assistant. In July 1990 he joined the Electrical and Computer Engineering Department and the Center for Advanced Manufacturing (CAM) at Clemson University where he currently holds the position of Professor. Under the CAM director's supervision he currently leads the Robotics and Manufacturing Automation Laboratory which is jointly operated by the Electrical and Mechanical Engineering departments. His main research interests are in the fields of nonlinear based robust adaptive and learning control with application to electro-mechanical systems including robot manipulators motor drives magnetic bearings flexible cables flexible beams and high-speed transport systems. Aman Behal was born in India in 1973. He received his Masters Degree in Electrical Engineering from Indian Institute of Technology Bombay in 1996. He is currently working towards a Ph.D in Controls and Robotics at Clemson University. His research focuses on the control of no

In this paper, we extend the observer/control strategies previously published in [25] to an n -link, serially connected, direct drive, rigid link, revolute robot operating in the presence of nonlinear friction effects modeled by the Lu-Gre model. In addition, we also present a new adaptive control technique for compensating for the nonlinear parameterizable Stribeck effects. Specifically, an adaptive observer/controller scheme is developed which contains a feedforward approximation of the Stribeck effects. This feedforward approximation is used in a composite controller/observer strategy which forces the average square integral of the position tracking error to an arbitrarily small value. Experimental results are included to illustrate the performance of the proposed controllers.

关键词： Friction compensation nonlinear control

来源：评论

学校读者我要写书评

暂无评论

MOdELING ANd CONTROL OF ELEVATORS BY STATECHARTS

引用

Asian Journal of Control 2008年第2期6卷

作者： Yi-Sheng Huang Sheng-Luen Chung Mu-der Jeng Department of Aeronautical Engineering Chung Cheng Institute of Technology National Defense University Tashi Taoyuan 335 Taiwan R.O.C. Department of Electrical Engineering National Taiwan University of Science and Technology Taipei 106 Taiwan R.O.C. Department of Electrical Engineering National Taiwan Ocean University Kellung 202 Taiwan R.O.C. MuDer Jeng received the Ph.D. degree in computer and systems engineering from Rensselaer Polytechnic Institute Troy NY in 1992. Since August 1992 Dr. Jeng has been with National Taiwan Ocean University Keelung Taiwan where he is currently a full Professor at the Department of Electrical Engineering. His current research interests include Petri nets discrete event systems computer integrated manufacturing semiconductor factory automation embedded systems. Dr. Jeng is the author/co-author of over 120 book chapters journal papers and conference papers. Dr. Jeng received the Franklin V. Taylor Outstanding Paper Award from the IEEE Systems Man and Cybernetics Society in 1993. He was granted the Research Award by the National Science Council of Taiwan annually from 1994 to 2000. He is an Associate Editor for IEEE Transactions on Systems Man and Cybernetics-Part A IEEE Transactions on Robotics and Automation IEEE Transactions on Robotics and serves on the Editorial Board of International Journal of Computer Integrated Manufacturing. He has been a Guest Editor for eight leading journals. Dr. Jeng is the Chair of the Technical Committee on Discrete Event Systems of the IEEE SMC Society and the Founding Chair of the Technical Committee on Semiconductor Factory Automation of the IEEE Robotics and Automation Society. He served as the Exhibitions Chair of 2003 IEEE International Conference on Robotics and Automation and the Special Sessions Chair of 2004 IEEE International Conference on Networking Sensing and Control. He serves as a Program Co-Chair of 2005 IEEE International Conference on Networking Sensing and Control and the Organization Commit

Statechart has been utilized as a visual formalism for the modeling of complex and interactive systems for its illuminating features on describing properties of causality, concurrency, and synchronization. This paper presents the application of satechart to the modeling, design and implementation of an elevator system, whose system behavior involves aggregating complexity of state descriptions, and imposition of underlying control policy. Based on the operational flow of an elevator, we derive the associated statechart model by looking into the inherent hierarchical structure of the elevator. The advantage of the proposed approach is the clear presentation of system behavior in terms of conditions and events that cause the transitions in system dynamics. Implementation of the controlled elevator based on the modeled statechart is also presented.

关键词： Statechart interactive systems elevator

来源：评论

学校读者我要写书评

暂无评论

Mitigating industrial pollution along the Atlantic coast of Cameroon: An overview of government efforts

引用

Environmentalist 2006年第1期26卷 41-50页

作者： Alemagi, dieudonne Oben, Pius M. Ertel, Jürgen Environmental and Resource Management Ph.D Program Department of Industrial Sustainability Brandenburg University of Technology Cottbus Germany Department of Geology and Environmental Science University of Buea Cameroon Department of Industrial Sustainability Brandenburg University of Technology Cottbus Germany

This paper presents an overview of the initiatives that have been formulated by the government of Cameroon to address the problem of industrial pollution. It also prescribes robust recommendations that could be employed to save the Atlantic coast of Cameroon from industrial pollutants. After the participation of Cameroon in the Earth Summit in Rio de Janeiro in 1992, the government took a significant step to overhaul its institutional framework, legal framework and policy framework vis-à-vis the regulation of industrial pollution. Under the auspices of the United Nation Industrial development Organisation (UNIdO), the Gulf of Guinea Large Marine Ecosystem Project aimed at sustaining the health of the Atlantic coast of Cameroon by ensuring treatment of industrial wastes, oil spills, sewage and heavy metals was implemented (1995-1999). Based upon careful analysis, however, the paper argues that these efforts have had little or no discernable impacts and that industrial activities along the Atlantic coast of Cameroon are still a major threat to safety, health and the environment. With a considerable number of hurdles that still persist, sufficient environmental improvement in industrial pollution along the Atlantic coast of Cameroon is far-fetched. Nevertheless, the paper concludes that marked environmental improvement can be obtained if: (i) competent personnel are appointed in ministries that play an active role in mitigating industrial pollution (ii) research partnerships are forged with local universities (iii) industrial machinery and equipment are improved (iv) inter institutional conflicts are addressed (v) a more collaborative forum between stakeholders is established (vi) adequate monitoring is instituted. © 2006 Springer science + Business Media, Inc.

关键词： Atlantic coast of Cameroon Environmental improvement Industrial pollution Institutional framework Legal framework Policy framework

来源：评论

学校读者我要写书评

暂无评论

An agent-based model of trade with distance-based transaction cost

An agent-based model of trade with distance-based transactio...

引用

Summer Computer Simulation Conference 2006, SCSC 2006, Part of the 2006 Summer Simulation Multiconference, SummerSim 2006

作者： Venkat, Kumar Wakeland, Wayne W. Surya Technologies Inc. 4888 NW Bethany Blvd. Portland OR 97229 United States Systems Science Ph.D. Program Portland State University Portland OR 97207 United States

ISBN: (纸本)9781622763528

This paper describes an application of agent-based modeling to investigate the effect of a distance-based transaction cost on trade. Long-distance trade is rapidly increasing, but may ultimately be constrained by our ability to move material goods between sellers and buyers. Unlike information exchange, trade in material goods is dependent on the price of oil and vulnerable to future scarcities of oil. In addition, there are growing concerns about greenhouse gas emissions from long-distance transportation. Our purpose in this study is to take the first step in understanding the impact of a distance constraint on free global trade using a simple artificial economy. We use the perspective of agent-based computational economics to model two different scenarios of random initial allocations of goods among traders, and investigate the response of the economy as a distance-based transaction cost is applied. We show that a geographically skewed initial allocation of goods performs poorly, while a more uniform initial distribution responds in a highly resilient way as the transaction cost is varied. Underlying this resilience is the emergence of a stable trade network that has some of the properties of scale-free networks.

关键词： Commerce

来源：评论

学校读者我要写书评

暂无评论

Is lean necessarily green?

Is lean necessarily green?

引用

50th Annual Meeting of the International Society for the systems sciences 2006, ISSS 2006

作者： Venkat, Kumar Wakeland, Wayne Surya Technologies Inc. 4888 NW Bethany Blvd. Portland OR 97229 United States Systems Science Ph.D. Program Portland State University P.O. Box 751 Portland OR 97207 United States

ISBN: (纸本)9781622767557

In this paper, we investigate the environmental performance of lean supply chains using carbon dioxide emissions as the key performance indicator. Lean is based on the premise that compressing time reveals hidden quality problems and that their resolution leads to more efficient, cost-effective business processes. If time compression always implies lower emissions, then a leaner system is always greener as measured by emissions. If time compression does not always lead to lower emissions, then further changes to the lean system may be required in order to make it greener. We use a simulation model of a generic supply chain as well as two representative examples of supply chains to examine this. Our analysis shows that supply chain emissions are highly sensitive to the frequency and mode of delivery of goods as well as the type and amount of inventory stored at each company. Our results suggest that lean supply chains are not necessarily green, although they could turn out to be green in certain cases. The main impediment appears to be distance. While lean supply chains typically have lower emissions due to reduced inventory levels, the frequent replenishment at every point in the provision stream generally tends to increase the emissions. If a lean supply chain is located entirely within a small region, then it would almost certainly be green from an emissions perspective due to the low levels of inventory and short shipping distances. As distances increase along the supply chain, it is quite possible for lean and green to be in conflict, leading to tradeoffs as well as additional opportunities for optimization.

关键词： Supply chains

来源：评论

学校读者我要写书评

暂无评论

Experience-Based Identification and Control via Higher-Level Learning and Context discernment

Experience-Based Identification and Control via Higher-Level...

引用

International Joint Conference on Neural Networks (IJCNN)

作者： G.G. Lendaris NW Computational Intelligence Laboratory (NWCIL) & Systems Science Ph.D. Program Portland State University Portland OR USA

In AI systems so far developed, more knowledge (typically stored as "rules") entails slower processing; in the case of humans, the more knowledge attained (in the form of experience), the speed/efficiency of performing new related tasks is improved. Experience-based (EB) identification and control is explored with the objective of achieving more human-like processes for 'intelligent' computing agents. The notion of experience is being successfully addressed via a novel concept for applying reinforcement learning (RL), called HLLA -higher level learning algorithm. The key idea is to re-purpose the RL method (to a "higher level") such that instead of creating an optimal controller for a given task, an already achieved collection of such solutions for a variety of related contexts is provided (as an experience repository), and HLLA creates a strategy for optimally selecting a solution from the repository. The selection process is triggered by the agent becoming aware that a change in context has occurred, followed by the agent seeking information about what changed -a process here called context discernment - and finally, by selection. Typically, context discernment entails a form of system identification (SId); substantial enhancement of SId is also achieved via the EB methods. Examples are given.

关键词： Context awareness Humans Control systems Learning Optimal control System identification Artificial intelligence Context modeling Computational intelligence Laboratories

来源：评论

学校读者我要写书评

暂无评论

Release of gold nanoparticles from phytomined biomass by enzymatic digestion

Release of gold nanoparticles from phytomined biomass by enz...

引用

2006 AIChE Annual Meeting

作者： Marshall, A.T. Haverkamp, R.G. davies, C.E. Parsons, J.G. Gardea-Torresdey, J.L. Van Agterveld, d. Institute of Technology and Engineering Massey University Private Bag 11222 Palmerston North New Zealand Environmental Science and Engineering Ph.D Program and Department of Chemistry University of Texas at EI Paso 500 West University Avenue EI Paso TX 79968-0513 United States Akzo Nobel Research and Technology Chemicals Department of Chemicals Analytics and Physics Microstructure Analysis and Atomic Spectrometry P.O. Box 9300 6800 SB Arnhem Netherlands

ISBN: (纸本)081691012X

Gold nanoparticles are produced in some plants when soluble gold is present in the growth medium nutrients. Release and recovery of this gold by pyrolysis can sinter the particles, and enzymatic digestion is proposed as an alternative. Brassica juncea grown on soil containing low levels of gold, copper and silver (22-48 mg Au kg-1, 44-45 mg Cu kg-1 and 0-31 mg Ag kg -1 respectively) contained gold at weight concentrations circa 1000 ppm dry matter. 55-60 wt% of the dried plant matter was solubilised by enzymatic digestion, but 50-60% of the gold initially present was lost to solution during the digestion. XANES analysis shows that gold is present in the plant in approximately equal quantities in the metallic (Auo) and oxidized (Au+1) states. The gold lost during digestion is thought to be gold present in the plant in a soluble form (Au+1).

关键词： Gold nanoparticles

来源：评论

学校读者我要写书评

暂无评论

Meeting the Information Assurance Crisis in the U.S. Now

引用

EdPACS 2006年第6期28卷 1-14页

作者： Corey Schou deborah Frincke Charles Reynolds James Frost The Associate Dean of Information Systems Programs at Idaho State University (ISU) in Pocatello and the director of the Center for Decision Support. Currently he serves as the Chair of the National Colloquium on Information System Security Education. Schou also directs the ISU National Center of Excellence in Information Assurance Education and the ISU Technology Innovation Center. Contact Corey Schou one of the authors of this article and the Chair of the NCISSE by email at Schou@*** for help in finding additional ways to address the issues raised in this article. A member of the University of Idaho College of Engineering faculty. She graduated from the University of California at Davis. Frincke is the co-director and co-founder of the university's Center for Secure and Dependable Software (CSDS). She was the program chair for the 2nd International Workshop on Recent Advances in Intrusion Detection (RAID). A professor of Computer Science at the College of Integrated Science and Technology at James Madison University in Harrisonburg Virginia. He holds a Ph.D. in computer science from the University of Texas at Austin and a BA in philosophy from the University of Houston. Reynolds is the Director of Information System Security Education at James Madison University. Since 1997 Reynolds has led the development of the first remote Internet-based curriculum that leads to an M.S. degree in computer science with a concentration in information security. Thus far 160 students have completed this program. A professor of computer information systems at Idaho State University and the manager of its Simplot Decision Support Center.

T he only difference etween evolution and revolution is the speed at which each occurs.

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：