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NAVAL ENGINEERS JOURNAL 1997年第3期109卷 313-327页

作者： Yagla, JJ Dr. Jon J. Yagla:received his B.A. in science (physics) from the State College of Iowa in 1965. He received his M.S. degree in engineering mechanics in 1968 and his Ph.D in aerospace engineering and engineering science in 1981 from Arizona State University. He has conducted research and development in ballistics dynamics missiles and weapon launchers. He was test conductor for the gun and missile test firigs in the reactivated USS Iowa class batteships. He provided technical oversight of the reinvestigation of the Iowa 16-inch gun explosion. He has given three previous ASNE papers on internal ballistics of weapon launchers design of missiles and launchers of underwater shock and gun test firigns in Iowa class battleships. He is the principal mechanical engineer in the Combat Systems Safety and Engineering Division at the Naval Surface Warfare Center Dahlgren Division

The Concentric Canister Launcher (CCL) is a new concept for launching munitions from surface ships. Each concentric launcher provides a self-contained gas management system and a complete set of launcher electronics. These innovations provide the naval architect new versatility in the design of warships, significant cost and weight advantages, and improved performance when compared to existing missile launching systems.

关键词： Warships

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Using design of Experiments, sensitivity analysis, and hybrid simulation to evaluate changes to a software development process: A case study

Using Design of Experiments, sensitivity analysis, and hybri...

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作者： Wakeland, Wayne W. Martin, Robert H. Raffo, david Systems Science Ph.D. Program Portland State University P.O. Box 751 Portland OR 97207 United States Software Management Consulting 2017 Maple Terrace West Linn OR 97068 United States School of Business Administration Portland State University P.O. Box 751 Portland OR United States Portland State University P.O. Box 751 Portland OR 97207 United States

Hybrid simulation models combine the high-level project issues of System dynamics models with the process detail of discrete event simulation models. Hybrid models not only capture the best of both of these simulation paradigms, but they also are able to address new issues that are important in managing complex real-world development projects that neither the System dynamics nor discrete Event simulation paradigms are able to address alone. In order to reap the full benefits from a simulation model, a structured approach for analyzing model results is necessary. This article applies design of Experiments (dOE) and broad range sensitivity analysis (BRSA) to a hybrid system dynamics and discrete event simulation model of a software development process. dOE is used to analyse the interaction effects, such as the degree to which the impact of the process change depends on worker motivation, schedule pressure and other project environmental variables. The sensitivity of the model to parameter changes over a broad range of plausible values is used to analyse the non-linear aspects of the model. The end result is a deeper insight into the conditions under which the process change will succeed, and improved recommendations for process change design and implementation. In this particular study, significant interactions and non-linearities were revealed, supporting the hypothesis that consideration of these complex effects is essential for insightful interpretation of model results and effective decision-making. Copyright © 2004 John Witey & Sons, Ltd.

关键词： Software engineering

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Modeling intracranial fluid flows and volumes during traumatic brain injury to better understand pressure dynamics

Modeling intracranial fluid flows and volumes during traumat...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： W. Wakeland J. McNames M. Aboy d. Hollemon B. Goldstein Systems Science Ph.D. Program Portland State University Portland OR USA Biomedical Signal Processing Laboratory Electrical and Computer Engineering Portland State University Portland OR USA Complex Systems Laboratory Division of Pediatric Critical Care Oregon Health and Sciences University Portland OR USA

We describe a computer model of intracranial pressure (ICP) dynamics that evaluates clinical treatment options for elevated ICP during traumatic brain injury (TBI). The model uses fluid volumes as primary state variables and explicitly models fluid flows as well as the resistance, compliance, and pressure associated with each intra- and extracranial compartment (arteries and arterioles, capillary bed, veins, venous sinus, ventricles, and brain parenchyma). The model evaluates clinical events and therapies such as intraand extra-parenchymal hemorrhage, cerebral edema, cerebrospinal fluid drainage, mannitol administration, head elevation, and mild hyperventilation. The model is able to replicate observed clinical behavior in many cases, including elevated ICP associated with severe cerebral edema following subdural, epidural, or intraparenchymal hematoma. The model also mimics cerebrovascular regulatory mechanisms that are activated during TBI.

关键词： Brain modeling Brain injuries Fluid dynamics Blood Logic Laboratories Fluid flow Medical treatment Signal processing Cranial pressure

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Serotonin and hypothalamic control of hunger: a review

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Revista da Associação Médica Brasileira (English Edition) 2011年第1期57卷 74-77页

作者： Fernanda de Matos Feijó Marcello Casaccia Bertoluci Cíntia Reis M. Sc. in Medicine - Medical Sciences Universidade Federal do Rio Grande do Sul – UFRGS Porto Alegre RS Ph.D in Medicine - Medical Sciences UFRGS Associate Professor Department of Intern Medicine UFRGS Professor Medical Science Post-Graduation Program UFRGS Post-Graduation Program Coordinating Committee Member UFRGS Porto Alegre RS M. Sc. in Medicine - Medical Sciences UFRGS Porto Alegre RS

This paper reviews the involvement of the serotonergic system in controlling food intake and satiety. It is of great interest to understand this system relevance in physiologic control of energy balance and obesity. Over 35-year research suggests that serotonin (5-HT) plays an important role in satiety. Thus, serotonergic system has been a viable target in weight control. 5-HT shows control over hunger and satiety through different receptors with discrete functions. 5-HT2C receptor seems to be the most important one in the relationship between food intake and energy balance. In this review, serotonergic system mechanisms involved in food intake control and satiety will be discussed.

关键词： Serotonin serotonin 5-HT2C receptor appetite regulation satiety response hypothalamus

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Characteristic of platelet-rich plasma and its effects on improving neurogenic erectile dysfunction

Characteristic of platelet-rich plasma and its effects on im...

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GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年会

作者： Yi-No Wu Kuo-Chiang Chen Chien-Chih Wu Han-Sun Chiang Ph.D Program in Nutrition & Food Science Graduate Institute of Basic Medicine Fu Jen Catholic University New Taipei City TaiwanChina Department of Urology Cathay General Hospital TaipeiTaiwan China School of Medicine Taipei Medical University TaipeiTaiwan China Department of Urology Taipei Medical University Hospital Taipei Taiwan China

Platelet-rich plasma (PRP) containing autologous thrombocyte growth factors is applied in regenerative medicine, but the lack of an optimized PRP preparation protocol causes unstable therapeutic *** aim of this study was to optimize the PRP preparation method to obtain the largest amount of growth factors released and compare the effects of PRP from different preparation methods in restoring of erectile function in bilateral cavernous nerve (CN) injury rat *** in vivo experiments used Sprague-dawley male rats (n=24) which were randomly divided into four groups of equal numbers: (Ⅰ) sham operation;(Ⅱ) vehicle only (which underwent bilateral nerve crushing without treatment);(Ⅲ) general PRP;and (Ⅳ) optimized PRP containing the largest amount of platelet-derived growth factor (PdGF)-AB (groups 3 and 4 underwent bilateral CN crushing with an immediate injection of the respective PRP into the corpus cavernosum).The intracavernous pressure (ICP) of all rats was *** demonstrated that in the PRP group prepared with the anticoagulant, ACd-A, the amount of PdGF-AB released was statistically higher than those of the other groups (P<0.05).Greater concentrations of PdGF-AB were measured in PRP after chitosan treatment compared to treatment with a solvent or other activating ***, storing PRP at-20 ℃ resulted in a significant increase in PdGF-AB released compared to storage at other *** optimized PRP prepared by stimulation with chitosan and incubated at-20 ℃ for 15 days had the largest amount of PdGF-AB and showed a synergistic effect on release (P<0.05).The functional outcome measurement revealed improvement after bilateral CN injury occurred in the group treated with optimized *** was concluded that optimized PRP with a high level of growth factors was more stable, and its injection into the corpus cavernosum facilitated recovery of erectile function.

关键词： Platelet-rich plasma (PRP) neurogenic erectile dysfunction bilateral cavernous nerve (CN) injury platelet-derived growth factor (PdGF)-AB

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Author Correction: Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy

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Nature biotechnology 2025年 2025 Feb 3页

作者： Feifei Zhang Ryan d Chow Emily He Chuanpeng dong Shan Xin daniyal Mirza Yanzhi Feng Xiaolong Tian Nipun Verma Medha Majety Yueqi Zhang Guangchuan Wang Sidi Chen Department of Genetics Yale University School of Medicine New Haven CT USA. System Biology Institute Yale University West Haven CT USA. Center for Cancer Systems Biology Yale University West Haven CT USA. M.D.-Ph.D. Program Yale University West Haven CT USA. Molecular Cell Biology Genetics and Development Program Yale University New Haven CT USA. Yale College New Haven CT USA. Immunobiology Program Yale University New Haven CT USA. Department of Therapeutic Radiology Yale University School of Medicine New Haven CT USA. Department of Genetics Yale University School of Medicine New Haven CT USA. guangchuan.wang@***. System Biology Institute Yale University West Haven CT USA. guangchuan.wang@***. Center for Cancer Systems Biology Yale University West Haven CT USA. guangchuan.wang@***. Key Laboratory of Multi-Cell Systems Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Shanghai China. guangchuan.wang@***. Department of Genetics Yale University School of Medicine New Haven CT USA. sidi.chen@yale.edu. System Biology Institute Yale University West Haven CT USA. sidi.chen@yale.edu. Center for Cancer Systems Biology Yale University West Haven CT USA. sidi.chen@yale.edu. M.D.-Ph.D. Program Yale University West Haven CT USA. sidi.chen@yale.edu. Molecular Cell Biology Genetics and Development Program Yale University New Haven CT USA. sidi.chen@yale.edu. Yale College New Haven CT USA. sidi.chen@yale.edu. Immunobiology Program Yale University New Haven CT USA. sidi.chen@yale.edu. Department of Neurosurgery Yale University School of Medicine New Haven CT USA. sidi.chen@yale.edu. Yale Comprehensive Cancer Center Yale University School of Medicine New Haven CT USA. sidi.chen@yale.edu. Yale Stem Cell Center Yale University School of Medicine New Haven CT USA. sidi.chen@yale.edu. Yale Center for Biomedical Data Science Yale University School of Medicine New Have

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Book reviews

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Roeper Review 1999年第1期22卷 66页

作者： Hebert, Thomas P [a] Assistant Professor of Educational Psychology College of Education The University of Georgia [b] Professor in the Department of Educational Foundations University of Wisconsin-Whitewater Whitewater [c] Storyteller and Enrichment Consultant Creative Arts in Learning Graduate Program Lesley College [d] Early Childhood Education Garrett Community College McHenry MD [e] Ph.D student in Sociology Northwestern University Illinois [f] Assistant professor of educational psychology Indiana University Bloomington [g] A high school science teacher doctoral student in science education Indiana University Bloomington

Reviews the book `Bibliotherapy With Young People: Librarians and Mental Health Professionals Working Together,' by Beth and Carol doll.

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Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq

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Nature communications 2025年第1期16卷 4785页

作者： Hefei Zhang Xuhang Li dongyuan Song Onur Yukselen Shivani Nanda Alper Kucukural Jingyi Jessica Li Manuel Garber Albertha J M Walhout Department of Systems Biology University of Massachusetts Chan Medical School Worcester MA USA. Bioinformatics Interdepartmental Ph.D. Program University of California Los Angeles CA USA. Department of Genetics and Genome Sciences University of Connecticut Health Center Farmington CT USA. Via Scientific Inc. Cambridge MA USA. Pathology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA. Department of Genomics and Computational Biology University of Massachusetts Chan Medical School Worcester MA USA. Department of Statistics and Data Science Department of Biostatistics Department of Computational Medicine and Department of Human Genetics University of California Los Angeles CA USA. Department of Genomics and Computational Biology University of Massachusetts Chan Medical School Worcester MA USA. manuel.garber@umassmed.edu. Department of Systems Biology University of Massachusetts Chan Medical School Worcester MA USA. marian.walhout@umassmed.edu.

Transcriptomes provide highly informative molecular phenotypes that, combined with gene perturbation, can connect genotype to phenotype. An ultimate goal is to perturb every gene and measure transcriptome changes, however, this is challenging, especially in whole animals. Here, we present 'Worm Perturb-Seq (WPS)', a method that provides high-resolution RNA-sequencing profiles for hundreds of replicate perturbations at a time in living animals. WPS introduces multiple experimental advances combining strengths of Caenhorhabditis elegans genetics and multiplexed RNA-sequencing with a novel analytical framework, EmpirdE. EmpirdE leverages the unique power of large transcriptomic datasets and improves statistical rigor by using gene-specific empirical null distributions to identify dEGs. We apply WPS to 103 nuclear hormone receptors (NHRs) and find a striking 'pairwise modularity' in which pairs of NHRs regulate shared target genes. We envision the advances of WPS to be useful not only for C. elegans, but broadly for other models, including human cells.

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Revolutionary Energy Harvesting: Gravity-driven Piezocatalysts for Sustainable Hydrogen Production in MoS2@Mo2CTx systems

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Advanced Energy Materials 2024年第39期14卷

作者： Lin, Hsun-Yen Wu, Jyh Ming Department of Materials Science and Engineering National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu300 Taiwan Ph.D Program in Prospective Functional Materials Industry National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu300 Taiwan High Entropy Materials Center National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu300 Taiwan

Hydrogen (H2) is mainly produced using steam methane reforming, electrolysis, and gasification, which require external energy and special catalysts. A new catalyst by combining MoS2 nanoflowers (NFs) with metal carbide/nitride nanosheets (Mo2CTx MXene) to create a nanosheet bending moment. The MoS2@Mo2CTx heterostructures achieve a production rate of 1164.8 µmol g−1 h−1 under an application of mechanical force, 4.01 and 3.06 times higher than Mo2CTx and MoS2 alone, due to enhanced charge transfer from MoS2's piezoelectricity and Mo2CTx's conductivity. This study introduces a pioneering methodology that harnesses gravitational energy as a continuous mechanical force, simulated using a peristaltic pump, to drive the piezocatalytic hydrogen evolution reaction (HER), achieving a notable hydrogen production rate of 454.1 µmol g−1 over 24 hours and demonstrating a sustained capability for hydrogen generation. The theoretical calculation results validate the piezoelectric potential in water-flow-pressure triggered HER systems. The piezocatalytic HER system, assuming powered by the Hoover dam, will produce 290.9 kmoles of hydrogen per ton daily, equivalent to utilizing 19 150 kWh of energy in the electrocatalytic system. The simulated gravity-driven water flow using MoS2@Mo2CTx piezocatalysts for H2 generation demonstrates superior efficiency by eliminating common thermal energy conversion losses, marking a significant breakthrough in sustainable hydrogen production technologies. © 2024 Wiley-VCH GmbH.

关键词： Molybdenum compounds

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Improving the Concentration of Students With Attention deficit Hyperactivity disorder and Autism Spectrum disorder: Electroencephalographic Analysis on the Effect of Learning Activity Interventions

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International Journal of Intelligent Technologies & Applied Statistics 2020年第1期13卷 49-63页

作者： Ming-Hseuh Tsai Sy-Ruen Huang Shao-Chin Chang Yu-Ling Lo Yun-Chieh Lu Research Center for Education Systems and Policy National Academy f or Educational Research New Taipei City Taiwan Chung Chou University of Science and Technology Changhua County Taiwan Ph.D. Program of Electrical and Communications Engineering Feng-Chia University Taichung City Taiwan Department of Early Childhood Education Asia University Taichung City Taiwan

This study examined whether the learning concentration of students with attention deficit hyperactivity disorder (AdHd) or autism spectrum disorder (ASd) can be improved through participation in one-on-one learning activities. A total of 13 students with AdHd or ASd were recruited to participate in various weekly one-on-one learning activities, in an effort to improve the concentration of students with special needs. Brainwave data were collected through electroencephalography and analyzed to explore students' concentration performance in different learning activities. To achieve the objective of this study, a multi-baseline design (ABAB), a type of single-subject design method, was employed. The experiment spanned 21 weeks, covering a fall and a spring semester: the first three weeks were defined as the 1st baseline phase, the 4th to 10th weeks as the 1st experimental phase, the 11th to 13th weeks as the 2nd baseline phase, and the 14th to 21th weeks as the 2nd experimental phase. The learning activities took place in the morning self-study period once a week, and the experiment was only suspended during two of the weeks because of school events. The purpose of the two baseline phases was to collect students' brainwave data. Students' brainwaves were measured for two minutes under two scenarios; first, while they were relaxed with eyes looking straight ahead; second, they were reading a passage. The purpose of the two experimental phases was to gradually enhance students' concentration by training them to perceive their own emotions through brainwave lamps. Initial results yielded different brainwave data for students with different types of disorders. After participating in the training on learning concentration, some students demonstrated improved concentration; however, after the 2nd experimental phase, students' concentration declined. The reason was that the activities in both experimental phases were identical, and thus, they no longer provoked students' inte

关键词： Attention def icit hyperactivity disorder (AdHd) Autism spectrum disorder (ASd) Brainwave test Concentration

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