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International Symposium on Object-Oriented Real-Time Distributed Computing

作者： Yogesh D. Barve Himanshu Neema Zhuangwei Kang Hongyang Sun Aniruddha Gokhale Thomas Roth Department of Electrical Engineering and Computer Science Vanderbilt University Nashville TN USA Smart Grid and Cyber-Physical Systems Program Office Engineering Laboratory National Institute of Standards and Technology Gaithersburg MD USA

ISBN: (数字)9781728169583

ISBN: (纸本)9781728169590

A co-simulation may comprise several heterogeneous federates with diverse spatial and temporal execution characteristics. In an iterative time-stepped simulation, a federation exhibits the Bulk Synchronous Parallel (BSP) computation paradigm in which all federates perform local operations and synchronize with their peers before proceeding to the next round of computation. In this context, the lowest performing (i.e., slowest) federate dictates the progression of the federation logical time. One challenge in co-simulation is performance profiling for individual federates and entire federations. The computational resource assignment to the federates can have a large impact on federation performance. Furthermore, a federation may comprise federates located on different physical machines as is the case for cloud and edge computing environments. As such, distributed profiling and resource assignment to the federation is a major challenge for operationalizing the co-simulation execution at scale. This paper presents the Execution Performance Profiling and Optimization (EXPPO) methodology, which addresses these challenges by using execution performance profiling at each simulation execution step and for every federate in a federation. EXPPO uses profiling to learn performance models for each federate, and uses these models in its federation resource recommendation tool to solve an optimization problem that improves the execution performance of the co-simulation. Using an experimental testbed, the efficacy of EXPPO is validated to show the benefits of performance profiling and resource assignment in improving the execution runtimes of co-simulations while also minimizing the execution cost.

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Charge and Energy Transfer Dynamics of Hybridized Exciton-Polaritons in 2D Halide Perovskites

arXiv

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arXiv 2023年

作者： Anantharaman, Surendra B. Lynch, Jason Stevens, Christopher E. Munley, Christopher Li, Chentao Hou, Jin Zhang, Hao Torma, Andrew Darlington, Thomas Coen, Francis Li, Kevin Majumdar, Arka Schuck, P. James Mohite, Aditya Harutyunyan, Hayk Hendrickson, Joshua R. Jariwala, Deep Department of Electrical and Systems Engineering University of Pennsylvania PhiladelphiaPA19104 United States KBR Inc. BeavercreekOH45431 United States Air Force Research Laboratory Sensors Directorate Wright-Patterson Air Force Base OH45433 United States Department of Physics University of Washington SeattleWA98195 United States Department of Physics Emory University AtlantaGA30322 United States Department of Chemical and Biomolecular Engineering Rice University HoustonTX77005 United States Department of Materials Science and Nanoengineering Rice University HoustonTX77005 United States Applied Physics Program Smalley‐Curl Institute Rice University HoustonTX77005 United States Department of Mechanical Engineering Columbia University New YorkNY10027 United States Department of Electrical and Computer Engineering University of Washington SeattleWA98195 United States

Excitons, bound electron-hole pairs, in Two-Dimensional Hybrid Organic Inorganic Perovskites (2D HOIPs) are capable of forming hybrid light-matter states known as exciton-polaritons (E-Ps) when the excitonic medium is confined in an optical cavity. In the case of 2D HOIPs, they can self-hybridize into E-Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the excitons. However, the fundamental properties of these self-hybridized E-Ps in 2D HOIPs, including their role in ultrafast energy and/or charge transfer at interfaces, remain unclear. Here, we demonstrate that > 0.5 µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E-P modes. These E-Ps have high Q factors (> 100) and modulate the optical dispersion for the crystal to enhance sub-gap absorption and emission. Through varying excitation energy and ultrafast measurements, we also confirm energy transfer from higher energy upper E-Ps to lower energy, lower E-Ps. Finally, we also demonstrate that E-Ps are capable of charge transport and transfer at interfaces. Our findings provide new insights into charge and energy transfer in E-Ps opening new opportunities towards their manipulation for polaritonic devices. © 2023, CC BY.

关键词： Charge transfer

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KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection

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Science (New York, N.Y.) 2025年第6735期387卷 eadn2337页

作者： Fagerberg, Eric Attanasio, John Dien, Christine Singh, Jaiveer Kessler, Emily A. Abdullah, Leena Shen, Jian Hunt, Brian G. Connolly, Kelli A. De Brouwer, Edward He, Jiaming Iyer, Nivedita R. Buck, Jessica Borr, Emily R. Damo, Martina Foster, Gena G. Giles, Josephine R. Huang, Yina H. Tsang, John S. Krishnaswamy, Smita Cui, Weiguo Joshi, Nikhil S. Department of Immunobiology Yale University School of Medicine New Haven CT United States Program in Computational Biology & Bioinformatics Yale University New Haven CT United States Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth NH United States Department of Pathology Feinberg School of Medicine at Northwestern University Chicago IL United States Department of Genetics and Computer Science Yale University School of Medicine New Haven CT United States Department of Medicine University of Chicago Chicago IL United States Section of Hematology Department of Internal Medicine Yale University School of Medicine New Haven CT United States Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Philadelphia PA United States Institute for Immunology Perelman School of Medicine University of Pennsylvania Philadelphia PA United States Parker Institute for Cancer Immunotherapy Perelman School of Medicine University of Pennsylvania Philadelphia PA United States Yale Center for Systems and Engineering Immunology Yale University School of Medicine New Haven CT United States New Haven CT United States Department of Biomedical Engineering Yale University New Haven CT United States Computational Biology and Bioinformatics Program Yale University CT USA New Haven United States Applied Math Program Yale University New Haven CT United States

Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress differentiation toward alternative fates remains unclear. We employed in vivo CRISPR-Cas9-based perturbation sequencing to assess the role of ~40 transcription factors (TFs) and epigenetic modulators in T cell fate decisions. Unexpectedly, we found that knockout of the TF Klf2 resulted in aberrant differentiation to exhausted-like CD8 T cells during acute infection. KLF2 was required to suppress the exhaustion-promoting TF TOX and to enable the TF TBET to drive effector differentiation. KLF2 was also necessary to maintain a polyfunctional tumor-specific progenitor state. Thus, KLF2 provides effector CD8 T cell lineage fidelity and suppresses the exhaustion program.

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Taming cluster synchronization

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Chaos, Solitons & Fractals 2025年 199卷

作者： Cinzia Tomaselli Lucia Valentina Gambuzza Gui-Quan Sun Stefano Boccaletti Mattia Frasca Modeling and Engineering Risk and Complexity Program Scuola Superiore Meridionale Naples 80138 Italy Department of Electrical Electronics and Computer Science Engineering University of Catania Catania 95125 Italy Complex Systems Research Center Shanxi University Shanxi Taiyuan 030006 China Sino-Europe Complex Science Center North University of China Shanxi Taiyuan 030051 China Institute of Interdisciplinary Intelligent Science Ningbo Univ. of Technology Ningbo China CNR - Institute of Complex Systems Sesto Fiorentino I-50019 Italy

Synchronization is a widespread phenomenon observed across natural and artificial networked systems. It often manifests itself by clusters of units exhibiting coincident dynamics. These clusters are a direct consequence of the organization of the Laplacian matrix eigenvalues into spectral localized blocks. We show how the concept of spectral blocks can be leveraged to design straightforward yet powerful controllers able to fully manipulate cluster synchronization of a generic network, thus shaping at will its parallel functioning. Specifically, we demonstrate how to induce the formation of spectral blocks in networks where such structures would not exist, and how to achieve precise mastering over the synchronizability of individual clusters by dictating the sequence in which each of them enters or exits the synchronization stability region as the coupling strength varies. Our results underscore the pivotal role of cluster synchronization control in shaping the parallel operation of networked systems, thereby enhancing their efficiency and adaptability across diverse applications.

关键词： Complex networks Dynamical systems Cluster synchronization Control Spectral blocks

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Artificial intelligence for modelling infectious disease epidemics

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Nature 2025年第8051期638卷 623-635页

作者： Kraemer, Moritz U. G. Tsui, Joseph L.-H. Chang, Serina Y. Lytras, Spyros Khurana, Mark P. Vanderslott, Samantha Bajaj, Sumali Scheidwasser, Neil Curran-Sebastian, Jacob Liam Semenova, Elizaveta Zhang, Mengyan Unwin, H. Juliette T. Watson, Oliver J. Mills, Cathal Dasgupta, Abhishek Ferretti, Luca Scarpino, Samuel V. Koua, Etien Morgan, Oliver Tegally, Houriiyah Paquet, Ulrich Moutsianas, Loukas Fraser, Christophe Ferguson, Neil M. Topol, Eric J. Duchêne, David A. Stadler, Tanja Kingori, Patricia Parker, Michael J. Dominici, Francesca Shadbolt, Nigel Suchard, Marc A. Ratmann, Oliver Flaxman, Seth Holmes, Edward C. Gomez-Rodriguez, Manuel Schölkopf, Bernhard Donnelly, Christl A. Pybus, Oliver G. Cauchemez, Simon Bhatt, Samir Pandemic Sciences Institute University of Oxford Oxford United Kingdom Department of Biology University of Oxford Oxford United Kingdom Department of Electrical Engineering and Computer Science University of California Berkeley Berkeley CA United States UCSF UC Berkeley Joint Program in Computational Precision Health Berkeley CA United States Division of Systems Virology Department of Microbiology and Immunology The Institute of Medical Science The University of Tokyo Tokyo Japan Section of Epidemiology Department of Public Health University of Copenhagen Copenhagen Denmark Oxford Vaccine Group University of Oxford and NIHR Oxford Biomedical Research Centre Oxford United Kingdom Department of Epidemiology and Biostatistics Imperial College London London United Kingdom Department of Computer Science University of Oxford Oxford United Kingdom School of Mathematics University of Bristol Bristol United Kingdom MRC Centre for Global Infectious Disease Analysis School of Public Health Imperial College London London United Kingdom Department of Statistics University of Oxford Oxford United Kingdom Doctoral Training Centre University of Oxford Oxford United Kingdom Institute for Experiential AI Northeastern University MA Boston Thailand Santa Fe Institute Santa Fe NM United States World Health Organization Regional Office for Africa Brazzaville Congo WHO Hub for Pandemic and Epidemic Intelligence Health Emergencies Programme World Health Organization Berlin Germany Centre for Epidemic Response and Innovation (CERI) School for Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa African Institute for Mathematical Sciences (AIMS) South Africa Muizenberg Cape Town South Africa Genomics England London United Kingdom Scripps Research La Jolla CA United States Department of Biosystems Science and Engineering ETH Zürich Basel Switzerland Swiss Institute of Bioinformatics Lausanne Switzerland The Ethox Centre Nuffield

Infectious disease threats to individual and public health are numerous, varied and frequently unexpected. Artificial intelligence (AI) and related technologies, which are already supporting human decision making in economics, medicine and social science, have the potential to transform the scope and power of infectious disease epidemiology. Here we consider the application to infectious disease modelling of AI systems that combine machine learning, computational statistics, information retrieval and data science. We first outline how recent advances in AI can accelerate breakthroughs in answering key epidemiological questions and we discuss specific AI methods that can be applied to routinely collected infectious disease surveillance data. Second, we elaborate on the social context of AI for infectious disease epidemiology, including issues such as explainability, safety, accountability and ethics. Finally, we summarize some limitations of AI applications in this field and provide recommendations for how infectious disease epidemiology can harness most effectively current and future developments in AI. © Springer Nature Limited 2025.

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Development of hydroxyapatite-enhanced membrane for nanoplastics removal: Multiple scenarios and mechanism exploration

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Journal of hazardous materials 2025年 495卷 138781页

作者： Mengna Li Guohe Huang Shuguang Wang Jing Huang Zeyuan Xu Environmental Systems Engineering Program University of Regina Regina Saskatchewan S4S 0A2 Canada China-Canada Center of Energy Environment and Sustainability Research UR-SDU School of Environmental Science and Engineering Shandong University Qingdao 266237 China. China-Canada Center of Energy Environment and Sustainability Research UR-SDU School of Environmental Science and Engineering Shandong University Qingdao 266237 China. Electronic address: huangg@uregina.ca. Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and Engineering Shandong University Qingdao 266237 China. Environmental Systems Engineering Program University of Regina Regina Saskatchewan S4S 0A2 Canada. Department of Electrical Computer and Biomedical Engineering University of Pavia Pavia 27100 Italy.

Nanoplastics (NPs) are widespread in wastewater systems and more toxic than microplastics (MPs), necessitating effective removal techniques. Although membranes can effectively remove MPs, their efficiency and mechanisms for NPs removal require further study. A novel hydroxyapatite functionalized PVDF (HAPF) membrane was developed for NPs removal. The optimized HAPF membrane was prepared via a one-step method with 800 mg/L HAP at pH 7.3 for 8 hours. It achieved a water flux of 4376.44 LMH, 3.4 times higher than that of the pristine PVDF membrane, while maintaining a polystyrene (PS) NPs rejection above 99.5 %. The HAPF membrane maintained 95 % of its pure water flux when treating wastewater with only PS NPs, but exhibited severe flux decline under varying conditions, such as surface-functionalized PS NPs, pH changes, or coexisting contaminants. Among these, the presence of MgSO alongside PS NPs caused the most severe water flux reduction, with the HAPF membrane undergoing complete blocking, followed by the formation of a cake layer. XDLVO results revealed that there is an attractive interaction between the HAPF membrane and PS NPs, primarily driven by acid-base interaction. The HAPF membrane exhibited significantly lower R and R values than the PVDF membrane and achieved a flux recovery rate of 92.94 % over multiple fouling-cleaning cycles. Its water flux was 18.9 times that of the PVDF membrane during long-term filtration. The developed HAPF membrane holds significant potential for advanced water treatment and fouling resistance .

关键词： Coexisting pollutants Hermia theory Hydroxyapatite functionalized PVDF (HAPF) membrane Nanoplastic removal XDLVO theory

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Analysis of the passive fragments influence in broadband signals with manipulated information entropy on the data transmission reliability

Analysis of the passive fragments influence in broadband sig...

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2019 IEEE International Scientific-Practical Conference: Problems of Infocommunications Science and Technology, PIC S and T 2019

作者： Melnychuk, Stepan Manuliak, Iryna National Technical University of Oil and Gas Computer Systems and Networks Department of Ivano-Frankivsk Ivano-Frankivsk Ukraine Engineering of King Danylo University Department of Information Technology and Program Ivano-Frankivsk Ukraine

ISBN: (纸本)9781728141848

Current methods of digitally processing communication signals, which are distorted in the computer systems communication channels, are often based on the use of amplitude, phase and spectral characteristics. Correlation methods are also used to ensure immunity. A common disadvantage of these methods is the need for significant computational cost. One of the partial solutions to the described problem may be to use the signals probabilistic characteristics, in particular information entropy. This approach is based on the representation of digital message bits to the corresponding fragments of broadband signals with manipulated information entropy. In fact, signals are formed on the basis of random processes with normal distribution of possible states. The use of passive fragments in such signals can reduce the energy cost of data transmission. When passing through a communication channel, passive fragments are filled with their own channel noise. As a result, the channel's own noise extends the number of possible signal amplitude states and can be used to improve the resolution. According to the results of studies, the dependence of the probability of distortion of the information message binary symbol on the normalized signal/noise ratio is obtained. It is shown that the use of passive fragments improves noise immunity by 3-4 dB within the normalized signal/noise ratio at the input from-5 dB to 14 dB. However, at 14 dB or more, noise immunity worsens. Thus, the main scope of the proposed method can be problematic channels with low signal/noise ratio. © 2019 IEEE.

关键词： Correlation methods

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Understanding automated and human-based technical debt identification approaches-a two-phase study

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Journal of the Brazilian computer Society 2019年第1期25卷 1页

作者： Spínola, Rodrigo O. Zazworka, Nico Vetro, Antonio Shull, Forrest Seaman, Carolyn Graduate Program in Systems and Computer Salvador University State University of Bahia SalvadorBahia Brazil Elsevier Frankfurt Germany Nexa Center for Internet & Society DAUIN Politecnico di Torino Torino Italy Carnegie Mellon University Software Engineering Institute ArlingtonVA United States Department of Information Systems University of Maryland Baltimore County BaltimoreMD United States

Context: The technical debt (TD) concept inspires the development of useful methods and tools that support TD identification and management. However, there is a lack of evidence on how different TD identification tools could be complementary and, also, how human-based identification compares with them. Objective: To understand how to effectively elicit TD from humans, to investigate several types of tools for TD identification, and to understand the developers’ point of view about TD indicators and items reported by tools. Method: We asked developers to identify TD items from a real software project. We also collected the output of three tools to automatically identify TD and compared the results in terms of their locations in the source code. Then, we collected developers’ opinions on the identification process through a focus group. Results: Aggregation seems to be an appropriate way to combine TD reported by developers. The tools used cannot help in identifying many important TD types, so involving humans is necessary. Developers reported that the tools would help them to identify TD faster or more accurately and that project priorities and current development activities are important to be considered together, along with the values of principal and interest, when deciding to pay off a debt. Conclusion: This work contributes to the TD landscape, which depicts an understanding between different TD types and how they are best discovered. © 2019, The Author(s).

关键词： Software engineering

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Bio-inspired Butterfly-shaped Patch Antenna Array for 2.4 GHz WLAN Applications

Bio-inspired Butterfly-shaped Patch Antenna Array for 2.4 GH...

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Antennas and Propagation Society International Symposium

作者： M. A. Oliveira S. M. A. Morais J. I. L. Araujo G. K. F. Serres A. J. R. Serres P. F. Silva P. H. F. Silva A. G. D'Assunção Graduation Program in Electrical Engineering Federal University of Campina Grande Campina Grande Brazil Graduation Program in Computer Engineering and Systems State University of Maranhão São Luís Brazil Graduation Program in Electrical Engineering Federal Institute of Education Science and Technology of Paraíba João Pessoa Brazil Federal University of Rio Grande do Norte Natal Brazil

ISBN: (数字)9781728166704

ISBN: (纸本)9781728166711

The design of a bio-inspired butterfly-shaped patch antenna array, generated by polar transformations, covering the wireless local area network (WLAN) band at 2.4 GHz (2.400-2.483 GHz), with similar and dissimilar elements is presented in this paper. The dissimilar bio-inspired antenna presented a bandwidth of 96MHz covering the IEEE802.11b, g band, maximum gain of 8.64dBi, concentrated half power beamwidth of 52 degrees and front-to-back ratio of 15.21dB.

关键词： Wireless LAN Protocols Shape Patch antennas Meetings Bandwidth Antenna arrays

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A computational framework for longitudinal medication adherence prediction in breast cancer survivors: A social cognitive theory based approach

arXiv

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arXiv 2025年

作者： Kaur, Navreet Gonzales, Manuel Alcaraz, Cristian Garcia Gong, Jiaqi Wells, Kristen J. Barnes, Laura E. Department of Systems and Information Engineering University of Virginia CharlottesvilleVA United States SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology San DiegoCA United States Department of Computer Science The University of Alabama TuscaloosaAL United States Department of Psychology San Diego State University San DiegoCA United States

Non-adherence to medications is a critical concern since nearly half of patients with chronic illnesses do not follow their prescribed medication regimens, leading to increased mortality, costs, and preventable human distress. Amongst stage 0-3 breast cancer survivors, adherence to long-term adjuvant endocrine therapy (i.e., Tamoxifen and aromatase inhibitors) is associated with a significant increase in recurrence-free survival. This work aims to develop multi-scale models of medication adherence to understand the significance of different factors influencing adherence across varying time frames. We introduce a computational framework guided by Social Cognitive Theory for multi-scale (daily and weekly) modeling of longitudinal medication adherence. Our models employ both dynamic medication-taking patterns in the recent past (dynamic factors) as well as less frequently changing factors (static factors) for adherence prediction. Additionally, we assess the significance of various factors in influencing adherence behavior across different time scales. Our models outperform traditional machine learning counterparts in both daily and weekly tasks in terms of both accuracy and specificity. Daily models achieved an accuracy of 87.25% (Precision – 92.04%, Recall – 93.15%, Specificity – 77.50%), and weekly models, an accuracy of 76.04% (Precision – 75.83%, Recall – 85.80%, Specificity – 72.30%). Notably, dynamic past medication-taking patterns prove most valuable for predicting daily adherence, while a combination of dynamic and static factors is significant for macro-level weekly adherence patterns. While our models exhibit strong predictive performance, they are constrained by potential cohort-specific biases, reliance on self-reported adherence data, and a limited understanding of the context around non-adherence. Future research will focus on external validation across diverse populations and explore the real-world implementation of sensor-rich systems for a more compre

关键词： Endocrinology

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