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A Two-stage Reconfiguration in Network Function Virtualization: Toward Service Function Chain Optimization

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IEEE Transactions on Network and Service Management 2025年

作者： Assis, Karcius D. R. Almeida, Raul C. Baghban, Hojjat Santos, Alex F. Boutaba, Raouf Electrical and Computer Engineering Department Salvador Brazil University of Waterloo David R. Cheriton School of Computer Science Canada Department of Electronics and Systems Recife Brazil Chang Gung University Department of Artificial Intelligence Taiwan Chang Gung University College of Intelligent Computing Taiwan Center of Science and Technology in Energy and Sustainability Brazil Postgraduate Program in Computer Science Bahia Brazil

Network Function Virtualization (NFV), as a promising paradigm, speeds up the service deployment by separating network functions from proprietary devices and deploying them on common servers in the form of software. Any service in NFV-enabled networks is achieved as a Service Function Chain (SFC) which consists of a series of ordered Virtual Network Functions (VNFs). However, migration of VNFs for more flexible services within a dynamic NFV-enabled network is a key challenge to be addressed. Current VNF migration studies mainly focus on single VNF migration decisions without considering the sharing and concurrent migration of VNF instances. In this paper, we assume that each deployed VNF is used by multiple SFCs and deal with the optimal placement for the contemporaneous migration of VNFs based on the actual network situation. We formalize the VNF migration and SFC reconfiguration problem as a mathematical model, which aims to minimize the VNF migration between nodes or the total number of core changes per node. The approach is a two-stage MILP based on optimal order to solve the reconfiguration. Extensive evaluation shows that the proposed approach can reduce the change in terms of location or number of cores per node in a 6-node and 14-node networks while ensuring network latency compared with the model without reconfiguration. © 2004-2012 IEEE.

关键词： Network function virtualization

Knowledge-Informed Machine Learning for Cancer Diagnosis and Prognosis: A review

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arXiv 2024年

作者： Mao, Lingchao Wang, Hairong Hu, Leland S. Tran, Nhan L. Canoll, Peter D. Swanson, Kristin R. Li, Jing H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology AtlantaGA30332 United States Mathematical NeuroOncology Lab Precision Neurotherapeutics Innovation Program Mayo Clinic Arizona 5777 East Mayo Blvd Support Services Building Suite 2-700 PhoenixAZ85054 United States Department of Radiology Mayo Clinic Arizona 5777 E. Mayo Blvd PhoenixAZ85054 United States School of Computing Informatics and Decision Systems Engineering Arizona State University 699 S Mill Ave TempeAZ85281 United States Department of Neurosurgery Mayo Clinic Arizona 5777 E. Mayo Blvd PhoenixAZ85054 United States Department of Cancer Biology Mayo Clinic Arizona 5777 E. Mayo Blvd PhoenixAZ85054 United States Department of Pathology and Cell Biology Columbia University Medical Center 630 West 168th Street New YorkNY10032 United States

Cancer remains one of the most challenging diseases to treat in the medical field. Machine learning has enabled in-depth analysis of rich multi-omics profiles and medical imaging for cancer diagnosis and prognosis. Despite these advancements, machine learning models face challenges stemming from limited labeled sample sizes, the intricate interplay of high-dimensionality data types, the inherent heterogeneity observed among patients and within tumors, and concerns about interpretability and consistency with existing biomedical knowledge. One approach to surmount these challenges is to integrate biomedical knowledge into data-driven models, which has proven potential to improve the accuracy, robustness, and interpretability of model results. Here, we review the state-of-the-art machine learning studies that adopted the fusion of biomedical knowledge and data, termed knowledge-informed machine learning, for cancer diagnosis and prognosis. Emphasizing the properties inherent in four primary data types including clinical, imaging, molecular, and treatment data, we highlight modeling considerations relevant to these contexts. We provide an overview of diverse forms of knowledge representation and current strategies of knowledge integration into machine learning pipelines with concrete examples. We conclude the review article by discussing future directions to advance cancer research through knowledge-informed machine *** Codes 92B99 Copyright © 2024, The Authors. All rights reserved.

关键词： Knowledge representation

What we should learn from pandemic publishing

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arXiv 2024年

作者： Sikdar, Satyaki Venturini, Sara Charpignon, Marie-Laure Kumar, Sagar Rinaldi, Francesco Tudisco, Francesco Fortunato, Santo Majumder, Maimuna S. Luddy School of Informatics Computing and Engineering Indiana University BloomingtonIN United States Department of Computer Science Loyola University Chicago ChicagoIL United States Senseable City Laboratory Massachusetts Institute of Technology CambridgeMA United States Department of Mathematics "Tullio Levi-Civita" University of Padova Padova Italy Institute for Data Systems and Society Massachusetts Institute of Technology CambridgeMA United States Network Science Institute Northeastern University BostonMA United States School of Mathematics The University of Edinburgh Edinburgh United Kingdom School of Mathematics Gran Sasso Science Institute L’Aquila Italy Department of Pediatrics Harvard Medical School BostonMA United States Computational Health Informatics Program Boston Children’s Hospital BostonMA United States

Since the emergence of COVID-19, discussions of ongoing pandemic-related research have accounted for an unprecedented share of media coverage and debate in the public sphere1. The urgency of the pandemic forced researchers to operate on an accelerated timeline, as both policymakers and the public relied on the most current evidence to guide their decisions and behaviors. With high demand for rapid pandemic-related insights and lower barriers to entry via preprint servers, the volume of COVID-19 articles skyrocketed2. The pressing need for research triggered the participation of many researchers with expertise in the science of infectious disease outbreaks (‘outbreak scientists’), who were joined by researchers from other disciplines (‘bellwethers’) and more junior researchers still in training (‘newcomers’) with the common goal of advancing the frontiers of pandemic science and informing policy decisions3. Please see Box 1 for details of this taxonomy. © 2024, CC BY-NC-ND.

关键词： COVID-19

Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma

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Biomedicine and Pharmacotherapy 2023年 166卷 115429-115429页

作者： Hsieh, Chiao-Hui Huang, Chen-Tsung Cheng, Yi-Sheng Hsu, Chun-Hua Hsu, Wen-Ming Chung, Yun-Hsien Liu, Yen-Lin Yang, Tsai-Shan Chien, Chia-Yu Lee, Yu-Hsuan Huang, Hsuan-Cheng Juan, Hsueh-Fen Department of Life Science National Taiwan University Taipei Taiwan Center for Computational and Systems Biology National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Institute of Plant Biology National Taiwan University Taipei Taiwan Genome and Systems Biology Degree Program National Taiwan University and Academia Sinica Taipei Taiwan Department of Agricultural Chemistry National Taiwan University Taipei Taiwan Department of Surgery National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan Department of Pediatrics School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung University Taipei Taiwan Center for Advanced Computing and Imaging in Biomedicine Taipei Taiwan

Neuroblastoma, a childhood cancer affecting the sympathetic nervous system, continues to challenge the development of potent treatments due to the limited availability of druggable targets for this aggressive illness. Recent investigations have uncovered that phosphoglycerate dehydrogenase (PHGDH), an essential enzyme for de novo serine synthesis, serves as a non-oncogene dependency in high-risk neuroblastoma. In this study, we show that homoharringtonine (HHT) acts as a PHGDH inhibitor, inducing intricate alterations in cellular metabolism, and thus providing an efficient treatment for neuroblastoma. We have experimentally verified the reliance of neuroblastoma on PHGDH and employed molecular docking, thermodynamic evaluations, and X-ray crystallography techniques to determine the bond interactions between HHT and PHGDH. Administering HHT to treat neuroblastoma resulted in effective cell elimination in vitro and tumor reduction in vivo. Metabolite and functional assessments additionally disclosed that HHT treatment suppressed de novo serine synthesis, initiating intricate metabolic reconfiguration and oxidative stress in neuroblastoma. Collectively, these discoveries highlight the potential of targeting PHGDH using HHT as a potent approach for managing high-risk neuroblastoma. © 2023 The Authors

关键词： Computational molecular docking Drug discovery High-risk neuroblastoma Metabolic reprogramming Molecular target therapy Phosphoglycerate dehydrogenase

Deep curriculum learning in task space for multi-class based mammography diagnosis

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arXiv 2021年

作者： Luo, Jun Arefan, Dooman Zuley, Margarita Sumkin, Jules Wu, Shandong Intelligent Systems Program School of Computing and Information University of Pittsburgh PittsburghPA United States Department of Radiology University of Pittsburgh PittsburghPA United States Magee-Womens Hospital University of Pittsburgh Medical Center PittsburghPA United States Department of Biomedical Informatics University of Pittsburgh PittsburghPA United States Department of Bioengineering University of Pittsburgh PittsburghPA United States

Mammography is used as a standard screening procedure for the potential patients of breast cancer. Over the past decade, it has been shown that deep learning techniques have succeeded in reaching near-human performance in a number of tasks, and its application in mammography is one of the topics that medical researchers most concentrate on. In this work, we propose an end-to-end Curriculum Learning (CL) strategy in task space for classifying the three categories of Full-Field Digital Mammography (FFDM), namely Malignant, Negative, and False recall. Specifically, our method treats this three-class classification as a "harder" task in terms of CL, and create an "easier" sub-task of classifying False recall against the combined group of Negative and Malignant. We introduce a loss scheduler to dynamically weight the contribution of the losses from the two tasks throughout the entire training process. We conduct experiments on an FFDM datasets of 1,709 images using 5-fold cross validation. The results show that our curriculum learning strategy can boost the performance for classifying the three categories of FFDM compared to the baseline strategies for model training. Copyright © 2021, The Authors. All rights reserved.

关键词： Curricula

FaSTrack: A modular framework for real-time motion planning and guaranteed safe tracking

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arXiv 2021年

作者： Chen, Mo Herbert, Sylvia L. Hu, Haimin Pu, Ye Fisac, Jaime F. Bansal, Somil Han, SooJean Tomlin, Claire J. School of Computing Science Simon Fraser University Canada Department of Mechanical and Aerospace Engineering UC San Diego United States Department of Electrical Engineering Princeton University United States Department of Electrical and Electronic Engineering University of Melbourne Australia Department of Electrical Engineering and Computer Sciences UC Berkeley United States Control and Dynamical Systems Program California Institute of Technology United States

Real-time, guaranteed safe trajectory planning is vital for navigation in unknown environments. However, real-time navigation algorithms typically sacrifice robustness for computation speed. Alternatively, provably safe trajectory planning tends to be too computationally intensive for real-time replanning. We propose FaSTrack, Fast and Safe Tracking, a framework that achieves both real-time replanning and guaranteed safety. In this framework, real-time computation is achieved by allowing any trajectory planner to use a simplified planning model of the system. The plan is tracked by the system, represented by a more realistic, higher-dimensional tracking model. We precompute the tracking error bound (TEB) due to mismatch between the two models and due to external disturbances. We also obtain the corresponding tracking controller used to stay within the TEB. The precomputation does not require prior knowledge of the environment. We demonstrate FaSTrack using Hamilton-Jacobi reachability for precomputation and three different real-time trajectory planners with three different tracking-planning model pairs. Copyright © 2021, The Authors. All rights reserved.

关键词： Trajectories

A dual-mode deep transfer learning (D2TL) system for breast cancer detection using contrast enhanced digital mammograms

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IISE Transactions on Healthcare systems Engineering 2019年第4期9卷 357-370页

作者： Wang, Kun Patel, Bhavika K. Wang, Lujia Wu, Teresa Zheng, Bin Li, Jing Industrial Engineering Program at School of Computing Informatics and Decision Systems Engineering Arizona State University Tempe United States Department of Radiology Mayo Clinic in Arizona Scottsdale United States School of Electrical and Computer Engineering College of Engineering University of Oklahoma Norman United States

Full-field digital mammography (FFDM) and magnetic resonance imaging (MRI) are gold-standard techniques for breast cancer detection. The newly contrast-enhanced digital mammography (CEDM) integrates the complementary strengths of FFDM and MRI, and is being incorporated into the practice of leading institutions. The current clinical practice using CEDM is sub-optimal because it is primarily based on clinicians' trained eyes. Automated diagnostic systems under the conventional machine learning paradigm suffer from drawbacks, such as the requirement for precise segmentation, extraction of shallow features that do not suffice for diagnostic images, and adoption of a sequential design without a global objective. We propose a deep learning (DL)-empowered diagnostic system using CEDM, the core of which is a novel dual-mode deep transfer learning (D2TL) model. The proposed system is innovative in several aspects, including (1) a dual-mode deep architecture design;(2) use of transfer learning to facilitate robust model estimation under small sample-size;(3) development of visualization techniques to help interpret the model results and facilitate inter- and intra-tumor malignancy quantification;and (4) minimization of human bias. We apply D2TL to classify benign vs. malignant tumors using the CEDM data collected from the Mayo Clinic in Arizona. D2TL outperforms competing models and approaches. © 2019, © 2019 “IISE”.

关键词： breast cancer Deep learning imaging-based diagnosis transfer learning

Intelligent E-commerce for Special Needs 7

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Intelligent E-commerce for Special Needs

7th International Conference on Cyber and IT Service Management, CITSM 2019

作者： Warnars, Diana Teresia Spits Putra, Leonardo Primadala Logiansa Warnars, Harco Leslie Hendric Spits Utomo, Wiranto Herry School of Information Systems Bina Nusantara University Information Systems Department Jakarta11480 Indonesia BINUS Graduate Program Doctor of Computer Science Bina Nusantara University Computer Science Department Jakarta11480 Indonesia Department of Magister Science of Information Technology Faculty of Computing President University Bekasi17550 Indonesia

ISBN: (纸本)9781728129099

Special need is a person who need assistance for their disabilities which include medical, physical, mental or psychological such as person with autism, down syndrome, dyslexia, Attention Deficit Hyperactivity Disorder (ADHD), multiple sclerosis, schizophrenia, cystic fibrosis, cerebral palsy, muscular dystrophy, blindness, deafness, epilepsy, chronic asthma and so on. In this proposed research idea about intelligent E-commerce for special needs, we limited to four types of difficulties such as hearing difficulty, vision difficulty, language difficulty, and learning difficulty. In this paper, we interest in those special needs persons who can use e-commerce and how to model a system that can help them to joy and easy to join with e-commerce. For some, this intelligent e-commerce is not only for shopping only but will become part of their healing for special needs in order to engage with daily human activities and increase their daily confidence in life. This paper also a preliminary investigation that can be used for Ph.D. or Doctoral research degree who is interested in building e-commerce framework for people with a special need or disability. © 2019 IEEE.

关键词： Electronic commerce

Mixing-Specific Data Augmentation Techniques for Improved Blind Violin/Piano Source Separation

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Mixing-Specific Data Augmentation Techniques for Improved Bl...

IEEE Workshop on Multimedia Signal Processing

作者： Ching-Yu Chiu Wen-Yi Hsiao Yin-Cheng Yeh Yi-Hsuan Yang Alvin Wen-Yu Su Graduate Program of Multimedia Systems and Intelligent Computing National Cheng Kung University and Academia Sinica Taiwan Yating Music Team Taiwan AI Labs Taiwan Research Center for IT Innovation Academia Sinica Taiwan National Cheng Kung University Taiwan

ISBN: (数字)9781728193205

ISBN: (纸本)9781728193236

Blind music source separation has been a popular and active subject of research in both the music information retrieval and signal processing communities. To counter the lack of available multi-track data for supervised model training, a data augmentation method that creates artificial mixtures by combining tracks from different songs has been shown useful in recent works. Following this light, we examine further in this paper extended data augmentation methods that consider more sophisticated mixing settings employed in the modern music production routine, the relationship between the tracks to be combined, and factors of silence. As a case study, we consider the separation of violin and piano tracks in a violin piano ensemble, evaluating the performance in terms of common metrics, namely SDR, SIR, and SAR. In addition to examining the effectiveness of these new data augmentation methods, we also study the influence of the amount of training data. Our evaluation shows that the proposed mixing-specific data augmentation methods can help improve the performance of a deep learning-based model for source separation, especially in the case of small training data.

关键词： Training Source separation Training data Production Data models Multiple signal classification Music information retrieval